Journal article
Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma
Abstract
MYC-driven medulloblastoma (MB) is an aggressive pediatric brain tumor characterized by therapy resistance and disease recurrence. Here, we integrated data from unbiased genetic screening and metabolomic profiling to identify multiple cancer-selective metabolic vulnerabilities in MYC-driven MB tumor cells, which are amenable to therapeutic targeting. Among these targets, dihydroorotate dehydrogenase (DHODH), an enzyme that catalyzes de novo …
Authors
Gwynne WD; Suk Y; Custers S; Mikolajewicz N; Chan JK; Zador Z; Chafe SC; Zhai K; Escudero L; Zhang C
Journal
Cancer Cell, Vol. 40, No. 12, pp. 1488–1502.e7
Publisher
Elsevier
Publication Date
December 2022
DOI
10.1016/j.ccell.2022.10.009
ISSN
1535-6108