Half-Life Concept

subject area of

• 18 F-Labeled perfluorocarbon droplets for positron emission tomography imaging  Academic Article
• A Barbourin-albumin Fusion Protein that Is Slowly Cleared In Vivo Retains the Ability to Inhibit Platelet Aggregation In Vitro  Academic Article
• A Multicenter Study of Recombinant Factor VIII (RecombinateTM) in Previously Treated Patients with Hemophilia A  Academic Article
• A Phase 1 Study of Mapatumumab (Fully Human Monoclonal Antibody to TRAIL-R1) in Patients with Advanced Solid Malignancies  Academic Article
• A comparison of methods for prediction of pharmacokinetics when switching to extended half-life products in hemophilia A patients  Academic Article
• A long-half-life, high-affinity P-selectin inhibitor  Academic Article
• A personalized limited sampling approach to better estimate terminal half‐life of FVIII concentrates  Academic Article
• A phase I study of oxidized raffinose cross-linked human hemoglobin  Academic Article
• A preliminary application of a haemophilia value framework to emerging therapies in haemophilia  Academic Article
• A shorter plasma half life does not predict less drug accumulation.  Academic Article
• Antibiotics for pneumonia therapy  Academic Article
• Anticoagulation Therapy in Children  Academic Article
• Characterization of a long-acting recombinant human serum albumin-atrial natriuretic factor (ANF) expressed in Pichia pastoris  Academic Article
• Clinical pharmacology of propafenone.  Academic Article
• Comparative pharmacokinetics of two extended half‐life FVIII concentrates (Eloctate and Adynovate) in adolescents with hemophilia A: Is there a difference?  Academic Article
• Comparison of single subject and population‐based pharmacokinetics for optimizing prophylaxis with simoctocog alfa in patients with haemophilia A  Academic Article
• Converting factor and nonfactor usage into a single metric to facilitate benchmarking the resources consumed for haemophilia care across jurisdictions and over time  Academic Article
• Decreased platelet thrombogenecity in association with increased platelet turnover and vascular damage  Academic Article
• Differential modes of chemical decay for early and late lambda messenger RNA  Academic Article
• Dipyridamole disposition after chronic administration: Effect of aspirin  Academic Article
• Direct comparison of two extended half-life PEGylated recombinant FVIII products: a randomized, crossover pharmacokinetic study in patients with severe hemophilia A  Academic Article
• Dose-finding and pharmacokinetics of therapeutic doses of tinzaparin in pediatric patients with thromboembolic events  Academic Article
• Drugs???some basic concepts  Academic Article
• Effect of chronic contractile activity on mRNA stability in skeletal muscle  Academic Article
• Effect on Intragastric pH of a PPI with a Prolonged Plasma Half-Life: Comparison between Tenatoprazole and Esomeprazole on the Duration of Acid Suppression in Healthy Male Volunteers  Academic Article
• Effects of Dronedarone Started Rapidly After Amiodarone Discontinuation  Academic Article
• Effects of Temperature and Relative Humidity on the Stability of Paper-Immobilized Antibodies  Academic Article
• Effects of Unfractionated Heparin, Dermatan Sulfate and Low Molecular Weight Heparin on Vessel Wall Permeability in Rabbits  Academic Article
• Effects of genetic fusion of factor IX to albumin on in vivo clearance in mice and rabbits  Conference Paper
• Effects of the herbicide surfactant MON 0818 on oviposition and viability of eggs of the ramshorn snail (Planorbella pilsbryi)  Academic Article
• Efficacy of a high purity, chemically treated and nanofiltered factor IX concentrate for continuous infusion in haemophilia patients undergoing surgery  Academic Article
• Eight days of cyclosporine overdose: a case report.  Academic Article
• Evaluation of a novel structural model to describe the endogenous release of lead from bone  Academic Article
• Experimental investigation of the delivery pathway of ultrasmall superparamagnetic iron oxide to lymph nodes  Academic Article
• Extending the lifetime of anticoagulant oligodeoxynucleotide aptamers in blood  Academic Article
• Factor VIII concentrate for hemophilia: comparison of two heat-treated products.  Academic Article
• Factor VIIa gets even bigger  Academic Article
• Favorable Pharmacokinetic Characteristics of Extended-Half-Life Recombinant Factor VIII BAY 94-9027 Enable Robust Individual Profiling Using a Population Pharmacokinetic Approach  Academic Article
• Feasibility of Using Recombinant Factor VIIa in Continuous Infusion  Academic Article
• Fibrinogen Has a Rapid Turnover in the Healthy Newborn Lamb  Academic Article
• Frequency of administration of short half-life nonsteroidal anti-inflammatory analgesics (NSAID's): studies with ibuprofen.  Academic Article
• Fusion to Human Serum Albumin Extends the Circulatory Half-Life and Duration of Antithrombotic Action of the Kunitz Protease Inhibitor Domain of Protease Nexin 2  Academic Article
• Geriatric Bone Lead Metabolism in a Female Nonhuman Primate Population  Academic Article
• Growth hormone-releasing factor analogs with hydrophobic residues at position 19. Effects on growth hormone releasing activity in vitro and in vivo, stability in blood plasma in vitro, and secondary structure  Academic Article
• Heparin kinetics in venous thrombosis and pulmonary embolism.  Academic Article
• In vivo anticoagulant properties of a novel nucleotide-based thrombin inhibitor and demonstration of regional anticoagulation in extracorporeal circuits  Academic Article
• Increased heparin clearance in experimental pulmonary embolism.  Academic Article
• Kinetics and Thermodynamics of Sucrose Hydrolysis from Real-Time Enthalpy and Heat Capacity Measurements  Academic Article
• Lamotrigine pharmacokinetics in patients receiving felbamate  Academic Article
• Lead concentrations in tibial and calcaneal bone in relation to the history of lead exposure  Academic Article
• Linking Endogenous Factor Xa Activity, a Biologically Relevant Pharmacodynamic Marker, to Edoxaban Plasma Concentrations and Clinical Outcomes in the ENGAGE AF-TIMI 48 Trial  Academic Article
• Loading dose of digoxin in renal failure.  Academic Article
• Long-acting recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) in children  Academic Article
• Low molecular weight heparins  Academic Article
• Metabolism and distribution of the virus-encoded serine proteinase inhibitor SERP-1 in healthy rabbits  Academic Article
• Metabolism of rabbit plasma-derived factor VII in relation to prothrombin in rabbits  Academic Article
• Milk thistle and indinavir: a randomized controlled pharmacokinetics study and meta-analysis  Academic Article
• Modulation of Clearance of Recombinant Serum Albumin by Either Glycosylation or Truncation  Academic Article
• Mutation of Any Site of N-Linked Glycosylation Accelerates the In Vivo Clearance of Recombinant Rabbit Antithrombin  Academic Article
• Nitric oxide and anti-cancer therapy  Academic Article
• On Glucose Transport and Non-enzymic Glycation of Proteins In Vivo  Academic Article
• On the Use of Location and Occupancy Factors for Estimating External Exposure From Deposited Radionuclides  Academic Article
• Ontogeny and tissue distribution of alpha-1-antitrypsin of the mouse  Academic Article
• PHARMACOKINETICS AND PHARMACODYNAMICS OF ATRACURIUM WITH AND WITHOUT PREVIOUS SUXAMETHONIUM ADMINISTRATION  Academic Article
• Periprocedural Management and Approach to Bleeding in Patients Taking Dabigatran  Academic Article
• Pharmacokinetics and pharmacodynamics of intra-graft iloprost in femorodistal bypass surgery  Academic Article
• Pharmacokinetics and the transition to extended half-life factor concentrates: communication from the SSC of the ISTH  Academic Article
• Pharmacokinetics of High-Dose Abetimus Sodium in Normal Subjects With Specific Assessment of Effect on Coagulation  Academic Article
• Pharmacokinetics of NSAID with special reference to the elderly.  Academic Article
• Pharmacology of the low-molecular-weight heparins  Academic Article
• Plasma levels and tricyclic antidepressant therapy: Part 2. Pharmacokinetic, clinical and toxicologic aspects  Academic Article
• Position of residues in transmembrane peptides with respect to the lipid bilayer: a combined lipid Noes and water chemical exchange approach in phospholipid bicelles.  Academic Article
• Post-exercise cardiac troponin I release and clearance in normal Standardbred racehorses.  Academic Article
• Potent Antithrombin Activity and Delayed Clearance From the Circulation Characterize Recombinant Hirudin Genetically Fused to Albumin  Academic Article
• Problems in the interpretation of the in vivo measurement of calcium by the argon-37 method: an investigation of inert-gas elimination in humans.  Academic Article
• Proceedings: Platelet survival, fibrinolytic activity, antithrombin II (AT III) level and fibrinogen survival in venous thromboembolism (VTE).  Academic Article
• Prolonged Antithrombin Activity of Low-Molecular-Weight Heparins  Academic Article
• Propafenone disposition kinetics in cardiac arrhythmia  Academic Article
• Protein Engineering Thrombin for Optimal Specificity and Potency of Anticoagulant Activity in Vivo  Academic Article
• Randomised clinical trial: the safety and efficacy of long-acting octreotide in patients with portal hypertension  Academic Article
• Rapid Insulin-like Growth Factor-1-induced Changes in Granulosa Cell Thrombospondin-1 Expression In Vitro  Academic Article
• Recent developments in the clinical pharmacology of rolapitant: subanalyses in specific populations  Academic Article
• Regulation of thrombospondin-1 expression through AU-rich elements in the 3′UTR of the mRNA  Academic Article
• Relation of Blood Counts during Clozapine Treatment to Serum Concentrations of Clozapine and Nor-Clozapine  Academic Article
• Relationship Between Dose, Anticoagulant Effect and the Clinical Efficacy and Safety of Heparin  Conference Paper
• Review of enoxaparin and its clinical applications in venous and arterial thromboembolism  Academic Article
• Sequential evaluation of prostate edema after permanent seed prostate brachytherapy using CT-MRI fusion  Academic Article
• Serum Melatonin Response to Melatonin Administration in the Syrian Hamster  Academic Article
• Single-dose pharmacokinetics of intravenous ampicillin plus sulbactam in healthy elderly and young adult subjects  Academic Article
• Spironolactone Metabolism: Steady-State Serum Levels of the Sulfur-Containing Metabolites  Academic Article
• Studies of the Metabolism of Asialotransferrins: The Mechanism for the Hypercatabolism of Human Asialotransferrin in the Rabbit  Academic Article
• Switching from standard to extended half‐life FVIII prophylaxis in haemophilia A: Comparison of factor product use, bleed rates and pharmacokinetics  Academic Article
• Switching to extended half-life products in Canada - preliminary data  Academic Article
• TAFIa (CPU) is generatedin vivoat levels that can substantially affect fibrinolysis in chimpanzees in response to thrombin generation  Academic Article
• Tailoring treatment of haemophilia B: accounting for the distribution and clearance of standard and extended half-life FIX concentrates  Academic Article
• Terminal half‐life of FVIII and FIX according to age, blood group and concentrate type: Data from the WAPPS database  Academic Article
• The Roles of Selected Arginine and Lysine Residues of TAFI (Pro-CPU) in Its Activation to TAFIa by the Thrombin-Thrombomodulin Complex  Academic Article
• The discovery and characterization of a novel nucleotide-based thrombin inhibitor  Academic Article
• The gastrointestinal tolerability and safety of oral bisphosphonates  Academic Article
• The influence of changing dose rate patterns from inhaled beta-gamma emitting radionuclide on lung cancer  Academic Article
• The pharmacokinetics of isoxicam in elderly patients with rheumatoid arthritis  Academic Article
• The sex-related differences in aspirin pharmacokinetics in rabbits and man and its relationship to antiplatelet effects  Academic Article
• Thrombotic thrombocytopenic purpura: a syndrome of intravascular platelet consumption.  Academic Article
• Trimethoprim-Sulfamethoxazole Pharmacokinetics during Continuous Ambulatory Peritoneal Dialysis (CAPD)  Academic Article