Half-Life Concept

subject area of

• 18 F-Labeled perfluorocarbon droplets for positron emission tomography imaging  Journal Articles
• Post Exercise Cardiac Troponin I Release and Clearance in Normal Standardbred Racehorses  Journal Articles
• A Barbourin-albumin Fusion Protein that Is Slowly Cleared In Vivo Retains the Ability to Inhibit Platelet Aggregation In Vitro  Journal Articles
• A Multicenter Study of Recombinant Factor VIII (RecombinateTM) in Previously Treated Patients with Hemophilia A  Journal Articles
• A Phase 1 Study of Mapatumumab (Fully Human Monoclonal Antibody to TRAIL-R1) in Patients with Advanced Solid Malignancies  Journal Articles
• A comparison of methods for prediction of pharmacokinetics when switching to extended half-life products in hemophilia A patients  Journal Articles
• A long-half-life, high-affinity P-selectin inhibitor  Journal Articles
• A multicenter, open-label, prospective, randomized, dose-ranging pharmacokinetic study of the anti-TNF-α antibody afelimomab in patients with sepsis syndrome  Journal Articles
• A personalized limited sampling approach to better estimate terminal half‐life of FVIII concentrates  Journal Articles
• A phase 1 study of OSI-211 given as an intravenous infusion days 1, 2, and 3 every three weeks in patients with solid cancers  Journal Articles
• A phase I study of oral ZD 1839 given daily in patients with solid tumors: IND.122, a study of the Investigational New Drug Program of the National Cancer Institute of Canada Clinical Trials Group  Journal Articles
• A phase I study of oxidized raffinose cross-linked human hemoglobin  Journal Articles
• A preliminary application of a haemophilia value framework to emerging therapies in haemophilia  Journal Articles
• A shorter plasma half life does not predict less drug accumulation.  Journal Articles
• Activated thrombin‐activatable fibrinolysis inhibitor is generated in vivo at levels that can substantially affect fibrinolysis in chimpanzees in response to thrombin generation  Journal Articles
• Antibiotics for pneumonia therapy  Journal Articles
• Anticoagulation Therapy in Children  Journal Articles
• Canadian clinical experience on switching from standard half‐life recombinant factor VIII (rFVIII), octocog alfa, to extended half‐life rFVIII, damoctocog alfa pegol, in persons with haemophilia A ≥ 12 years followed in a Comprehensive Hemophilia Care Program in Canada  Journal Articles
• Characterization of a long-acting recombinant human serum albumin-atrial natriuretic factor (ANF) expressed in Pichia pastoris  Journal Articles
• Comparative pharmacokinetics of two extended half‐life FVIII concentrates (Eloctate and Adynovate) in adolescents with hemophilia A: Is there a difference?  Journal Articles
• Comparison of single subject and population‐based pharmacokinetics for optimizing prophylaxis with simoctocog alfa in patients with haemophilia A  Journal Articles
• Converting factor and nonfactor usage into a single metric to facilitate benchmarking the resources consumed for haemophilia care across jurisdictions and over time  Journal Articles
• Cyclooxygenase Inhibitors and the Antiplatelet Effects of Aspirin  Journal Articles
• Decreased platelet thrombogenecity in association with increased platelet turnover and vascular damage  Journal Articles
• Deep mutational scanning and massively parallel kinetics of plasminogen activator inhibitor-1 functional stability to probe its latency transition  Journal Articles
• Differential modes of chemical decay for early and late lambda messenger RNA  Journal Articles
• Dipyridamole disposition after chronic administration: Effect of aspirin  Journal Articles
• Direct comparison of two extended half-life PEGylated recombinant FVIII products: a randomized, crossover pharmacokinetic study in patients with severe hemophilia A  Journal Articles
• Dose-finding and pharmacokinetics of therapeutic doses of tinzaparin in pediatric patients with thromboembolic events  Journal Articles
• Drugs???some basic concepts  Journal Articles
• Effect of chronic contractile activity on mRNA stability in skeletal muscle  Journal Articles
• Effect on Intragastric pH of a PPI with a Prolonged Plasma Half-Life: Comparison between Tenatoprazole and Esomeprazole on the Duration of Acid Suppression in Healthy Male Volunteers  Journal Articles
• Effects of Temperature and Relative Humidity on the Stability of Paper-Immobilized Antibodies  Journal Articles
• Effects of Unfractionated Heparin, Dermatan Sulfate and Low Molecular Weight Heparin on Vessel Wall Permeability in Rabbitsa  Journal Articles
• Effects of genetic fusion of factor IX to albumin on in vivo clearance in mice and rabbits  Conferences
• Effects of the herbicide surfactant MON 0818 on oviposition and viability of eggs of the ramshorn snail (Planorbella pilsbryi)  Journal Articles
• Efficacy of a high purity, chemically treated and nanofiltered factor IX concentrate for continuous infusion in haemophilia patients undergoing surgery  Journal Articles
• Eight days of cyclosporine overdose: a case report.  Journal Articles
• Evaluation of a novel structural model to describe the endogenous release of lead from bone  Journal Articles
• Extending the lifetime of anticoagulant oligodeoxynucleotide aptamers in blood  Journal Articles
• Extension of the circulatory half-life of recombinant ecallantide via albumin fusion without loss of anti-kallikrein activity  Journal Articles
• Factor VIII concentrate for hemophilia: comparison of two heat-treated products.  Journal Articles
• Factor VIIa gets even bigger  Journal Articles
• Factor product utilization and health outcomes in patients with haemophilia A and B on extended half‐life concentrates: A Canadian observational study of real‐world outcomes  Journal Articles
• Favorable Pharmacokinetic Characteristics of Extended-Half-Life Recombinant Factor VIII BAY 94-9027 Enable Robust Individual Profiling Using a Population Pharmacokinetic Approach  Journal Articles
• Feasibility of Using Recombinant Factor VIIa in Continuous Infusion  Journal Articles
• Fibrinogen Has a Rapid Turnover in the Healthy Newborn Lamb  Journal Articles
• Frequency of administration of short half-life nonsteroidal anti-inflammatory analgesics (NSAID's): studies with ibuprofen.  Journal Articles
• Fusion to Human Serum Albumin Extends the Circulatory Half-Life and Duration of Antithrombotic Action of the Kunitz Protease Inhibitor Domain of Protease Nexin 2  Journal Articles
• Geriatric Bone Lead Metabolism in a Female Nonhuman Primate Population  Journal Articles
• Heparin kinetics in venous thrombosis and pulmonary embolism.  Journal Articles
• Increased heparin clearance in experimental pulmonary embolism.  Journal Articles
• Lead concentrations in tibial and calcaneal bone in relation to the history of lead exposure  Journal Articles
• Linking Endogenous Factor Xa Activity, a Biologically Relevant Pharmacodynamic Marker, to Edoxaban Plasma Concentrations and Clinical Outcomes in the ENGAGE AF-TIMI 48 Trial  Journal Articles
• Loading dose of digoxin in renal failure.  Journal Articles
• Long-acting recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) in children  Journal Articles
• Low molecular weight heparins  Journal Articles
• Metabolism and distribution of the virus-encoded serine proteinase inhibitor SERP-1 in healthy rabbits  Journal Articles
• Metabolism of rabbit plasma-derived factor VII in relation to prothrombin in rabbits  Journal Articles
• Milk thistle and indinavir: a randomized controlled pharmacokinetics study and meta-analysis  Journal Articles
• Modulation of Clearance of Recombinant Serum Albumin by Either Glycosylation or Truncation  Journal Articles
• Mutation of Any Site of N-Linked Glycosylation Accelerates the In Vivo Clearance of Recombinant Rabbit Antithrombin  Journal Articles
• Nitric oxide and anti-cancer therapy  Journal Articles
• On Glucose Transport and Non-enzymic Glycation of Proteins In Vivo  Journal Articles
• On the Use of Location and Occupancy Factors for Estimating External Exposure From Deposited Radionuclides  Journal Articles
• Ontogeny and tissue distribution of alpha-1-antitrypsin of the mouse  Journal Articles
• PHARMACOKINETICS AND PHARMACODYNAMICS OF ATRACURIUM WITH AND WITHOUT PREVIOUS SUXAMETHONIUM ADMINISTRATION  Journal Articles
• Periprocedural Management and Approach to Bleeding in Patients Taking Dabigatran  Journal Articles
• Pharmacokinetics and pharmacodynamics of intra-graft iloprost in femorodistal bypass surgery  Journal Articles
• Pharmacokinetics and the transition to extended half‐life factor concentrates: communication from the SSC of the ISTH  Journal Articles
• Pharmacokinetics of High‐Dose Abetimus Sodium in Normal Subjects With Specific Assessment of Effect on Coagulation  Journal Articles
• Pharmacology of the low-molecular-weight heparins  Journal Articles
• Plasma levels and tricyclic antidepressant therapy: Part 2. Pharmacokinetic, clinical and toxicologic aspects  Journal Articles
• Position of residues in transmembrane peptides with respect to the lipid bilayer: a combined lipid Noes and water chemical exchange approach in phospholipid bicelles.  Journal Articles
• Potent Antithrombin Activity and Delayed Clearance From the Circulation Characterize Recombinant Hirudin Genetically Fused to Albumin  Journal Articles
• Problems in the interpretation of the in vivo measurement of calcium by the argon-37 method: an investigation of inert-gas elimination in humans.  Journal Articles
• Proceedings: Platelet survival, fibrinolytic activity, antithrombin II (AT III) level and fibrinogen survival in venous thromboembolism (VTE).  Journal Articles
• Prolonged Antithrombin Activity of Low-Molecular-Weight Heparins  Journal Articles
• Prolonging the circulatory half-life of C1 esterase inhibitor via albumin fusion.  Journal Articles
• Quetiapine fumarate overdose: Clinical and pharmacokinetic lessons from extreme conditions  Journal Articles
• Randomised clinical trial: the safety and efficacy of long‐acting octreotide in patients with portal hypertension  Journal Articles
• Rapid Insulin-like Growth Factor-1-induced Changes in Granulosa Cell Thrombospondin-1 Expression In Vitro  Journal Articles
• Recent developments in the clinical pharmacology of rolapitant: subanalyses in specific populations  Journal Articles
• Recombinant factor VIII Fc fusion protein for first-time immune tolerance induction: final results of the verITI-8 study  Journal Articles
• Regulation of thrombospondin-1 expression through AU-rich elements in the 3′UTR of the mRNA  Journal Articles
• Relation of Blood Counts during Clozapine Treatment to Serum Concentrations of Clozapine and Nor-Clozapine  Journal Articles
• Relationship Between Dose, Anticoagulant Effect and the Clinical Efficacy and Safety of Heparin  Conferences
• Review of enoxaparin and its clinical applications in venous and arterial thromboembolism  Journal Articles
• Sequential evaluation of prostate edema after permanent seed prostate brachytherapy using CT-MRI fusion  Journal Articles
• Serum Melatonin Response to Melatonin Administration in the Syrian Hamster  Journal Articles
• Single-dose pharmacokinetics of intravenous ampicillin plus sulbactam in healthy elderly and young adult subjects  Journal Articles
• Site-Specific Antibody Conjugation Using Modified Bisected N-Glycans: Method Development and Potential toward Tunable Effector Function  Journal Articles
• Spironolactone Metabolism: Steady‐State Serum Levels of the Sulfur‐Containing Metabolites  Journal Articles
• Studies of the Metabolism of Asialotransferrins: The Mechanism for the Hypercatabolism of Human Asialotransferrin in the Rabbit  Journal Articles
• Switching from standard to extended half‐life FVIII prophylaxis in haemophilia A: Comparison of factor product use, bleed rates and pharmacokinetics  Journal Articles
• Switching to extended half‐life products in Canada – preliminary data  Journal Articles
• Tailoring treatment of haemophilia B: accounting for the distribution and clearance of standard and extended half-life FIX concentrates  Journal Articles
• Terminal half‐life of FVIII and FIX according to age, blood group and concentrate type: Data from the WAPPS database  Journal Articles
• The Roles of Selected Arginine and Lysine Residues of TAFI (Pro-CPU) in Its Activation to TAFIa by the Thrombin-Thrombomodulin Complex  Journal Articles
• The gastrointestinal tolerability and safety of oral bisphosphonates  Journal Articles
• The influence of changing dose rate patterns from inhaled beta-gamma emitting radionuclide on lung cancer  Journal Articles
• The pharmacokinetics of isoxicam in elderly patients with rheumatoid arthritis  Journal Articles
• The pharmacokinetics of oral indoramin during pregnancy.  Journal Articles
• The sex-related differences in aspirin pharmacokinetics in rabbits and man and its relationship to antiplatelet effects  Journal Articles
• The von Willebrand factor–binding aptamer rondaptivon pegol as a treatment for severe and nonsevere hemophilia A  Journal Articles
• Thrombotic thrombocytopenic purpura: a syndrome of intravascular platelet consumption.  Journal Articles
• Trimethoprim-Sulfamethoxazole Pharmacokinetics during Continuous Ambulatory Peritoneal Dialysis (CAPD)  Journal Articles