Ontogeny and tissue distribution of alpha-1-antitrypsin of the mouse

alpha 1-Antitrypsin is the second most abundant proteinase inhibitor in plasma. The fact that it is a globular glycoprotein of relatively small size (Mr 53 500) allows it access to a wide variety of fluids and tissue sites. alpha 1-Antitrypsin has been purified from mouse plasma by affinity chromatography and ion exchange. The purified protein exhibits homogeneity on polyacrylamide electrophoresis, but electrophoretic heterogeneity on crossed …