Journal article
The sex-related differences in aspirin pharmacokinetics in rabbits and man and its relationship to antiplatelet effects
Abstract
There are a number of reports which suggest that the antithrombotic effect of aspirin is limited to males. It is unclear whether this effect is due to sex-related differences in the effect of aspirin on platelets, the vessel wall, or the pharmacokinetics of aspirin. To test these possibilities we examined the sex-related differences in (1) vessel wall PGI2 release and its inhibition by and recovery from aspirin in rabbits; (2) the effects of …
Authors
Buchanan MR; Rischke JA; Butt R; Turpie AGG; Hirsh J; Rosenfeld J
Journal
Thrombosis Research, Vol. 29, No. 2, pp. 125–139
Publisher
Elsevier
Publication Date
January 1983
DOI
10.1016/0049-3848(83)90134-2
ISSN
0049-3848