Diet, High-Fat Concept

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• 4-phenylbutyrate and valproate treatment attenuates the progression of atherosclerosis and stabilizes existing plaques  Journal Articles
• 5-HT promotes pancreatic α-to-β cell transdifferentiation.  Journal Articles
• A Metabolic Enhancer Protects against Diet-Induced Obesity and Liver Steatosis and Corrects a Pro-Atherogenic Serum Profile in Mice  Journal Articles
• A Multi-Ingredient Supplement Protects against Obesity and Infertility in Western Diet-Fed Mice  Journal Articles
• A Novel Multi-Ingredient Supplement Activates a Browning Program in White Adipose Tissue and Mitigates Weight Gain in High-Fat Diet-Fed Mice  Journal Articles
• A distinct role of STING in regulating glucose homeostasis through insulin sensitivity and insulin secretion  Journal Articles
• A short term high-fat high-sucrose diet in mice impairs optic nerve recovery after injury and this is not reversed by exercise  Journal Articles
• AHNAK deficiency promotes browning and lipolysis in mice via increased responsiveness to β-adrenergic signalling  Journal Articles
• Adverse metabolic effects of a hypercaloric, high-fat diet in rodents precede observable changes in body weight  Journal Articles
• Alterations in fecal β-defensin-3 secretion as a marker of instability of the gut microbiota  Journal Articles
• Anti-Inflammatory Effects of Tanshinone IIA on Atherosclerostic Vessels of Ovariectomized ApoE-/- Mice are Mediated by Estrogen Receptor Activation and Through the ERK Signaling Pathway  Journal Articles
• Anti-obesity effect of taurine through inhibition of adipogenesis in white fat tissue but not in brown fat tissue in a high-fat diet-induced obese mouse model  Journal Articles
• BRSK2 in pancreatic β cells promotes hyperinsulinemia-coupled insulin resistance and its genetic variants are associated with human type 2 diabetes  Journal Articles
• Bifidobacterial carbohydrate/nucleoside metabolism enhances oxidative phosphorylation in white adipose tissue to protect against diet-induced obesity  Journal Articles
• Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis  Journal Articles
• Bruton’s tyrosine kinase (BTK) inhibitors alter blood glucose and insulin in obese mice but reduce inflammation independent of BTK  Journal Articles
• Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle  Journal Articles
• Deletion of Macrophage-Specific Glycogen Synthase Kinase (GSK)-3α Promotes Atherosclerotic Regression in Ldlr−/− Mice  Journal Articles
• Determining the effects of paternal obesity on sperm chromatin at histone H3 lysine 4 tri-methylation in relation to the placental transcriptome and cellular composition.  Journal Articles
• Diet-induced hepatic steatosis abrogates cell-surface LDLR by inducing de novo PCSK9 expression in mice  Journal Articles
• Diet-induced obesity alters intestinal monocyte-derived and tissue-resident macrophages and increases intestinal permeability in female mice independent of tumor necrosis factor  Journal Articles
• Dietary Nitrate and Corresponding Gut Microbiota Prevent Cardiac Dysfunction in Obese Mice  Journal Articles
• Dietary intervention preserves β cell function in mice through CTCF-mediated transcriptional reprogramming  Journal Articles
• Dietary sugar lowers immunity and microbiota that protect against metabolic disease  Journal Articles
• Different Th17 immunity in gut, liver, and adipose tissues during obesity: the role of diet, genetics, and microbes  Journal Articles
• Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human  Journal Articles
• Effect of diet composition on energy expenditure during weight loss: the POUNDS LOST Study  Journal Articles
• Effect of dietary pulse intake on established therapeutic lipid targets for cardiovascular risk reduction: a systematic review and meta-analysis of randomized controlled trials  Journal Articles
• Effect of high-fat and high-carbohydrate diets on pulmonary O₂uptake kinetics during the transition to moderate-intensity exercise  Journal Articles
• Effects of Obesity-Associated Chronic Inflammation on Peripheral Blood Immunophenotype Are Not Mediated by TNF in Female C57BL/6J Mice  Journal Articles
• Effects of the pesticide deltamethrin on high fat diet-induced obesity and insulin resistance in male mice  Journal Articles
• Endoplasmic Reticulum Stress and Glycogen Synthase Kinase-3β Activation in Apolipoprotein E–Deficient Mouse Models of Accelerated Atherosclerosis  Journal Articles
• Enhanced Lipid Oxidation and Maintenance of Muscle Insulin Sensitivity Despite Glucose Intolerance in a Diet-Induced Obesity Mouse Model  Journal Articles
• Erasure of DNA methylation in rat fetal germ cells is sex-specific and sensitive to maternal high-fat diet.  Journal Articles
• Exercise Improves Cancer-free Survival and Health Span in a Model of Radiation-induced Cancer  Journal Articles
• Expression of miRNA-29 in Pancreatic β Cells Promotes Inflammation and Diabetes via TRAF3  Journal Articles
• Fas mutation reduces obesity by increasing IL-4 and IL-10 expression and promoting white adipose tissue browning  Journal Articles
• Fecal transplant from resveratrol-fed donors improves glycaemia and cardiovascular features of the metabolic syndrome in mice  Journal Articles
• Fructose, pregnancy and later life impacts  Journal Articles
• GDF10 blocks hepatic PPARγ activation to protect against diet-induced liver injury  Journal Articles
• GDF15 promotes weight loss by enhancing energy expenditure in muscle  Journal Articles
• Galectin-3 impairs calcium transients and β-cell function  Journal Articles
• Genetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistance  Journal Articles
• Glycogen Synthase Kinase 3α Deficiency Attenuates Atherosclerosis and Hepatic Steatosis in High Fat Diet–Fed Low Density Lipoprotein Receptor–Deficient Mice  Journal Articles
• Gut microbiota impairs insulin clearance in obese mice  Journal Articles
• Gut microbiota-based vaccination engages innate immunity to improve blood glucose control in obese mice  Journal Articles
• Heat shock protein-27 attenuates foam cell formation and atherogenesis by down-regulating scavenger receptor-A expression via NF-κB signaling  Journal Articles
• High Fat-High Fructose Diet-Induced Changes in the Gut Microbiota Associated with Dyslipidemia in Syrian Hamsters  Journal Articles
• High-fat diet-induced lipidome perturbations in the cortex, hippocampus, hypothalamus, and olfactory bulb of mice  Journal Articles
• High-intensity exercise training increases the diversity and metabolic capacity of the mouse distal gut microbiota during diet-induced obesity  Journal Articles
• High‐fat diet intake modulates maternal intestinal adaptations to pregnancy and results in placental hypoxia, as well as altered fetal gut barrier proteins and immune markers  Journal Articles
• Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis  Journal Articles
• Inhibitory Antibodies against PCSK9 Reduce Surface CD36 and Mitigate Diet-Induced Renal Lipotoxicity  Journal Articles
• Insulin resistance corresponds with a progressive increase in NOD1 in high fat diet-fed mice  Journal Articles
• Intestinal permeability and peripheral immune cell composition are altered by pregnancy and adiposity at mid- and late-gestation in the mouse  Journal Articles
• Intestinal scavenger receptor class B type I as a novel regulator of chylomicron production in healthy and diet-induced obese states  Journal Articles
• Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function  Journal Articles
• Long term but not short term exposure to obesity related microbiota promotes host insulin resistance  Journal Articles
• Long-term effects of a maternal high-fat: high-fructose diet on offspring growth and metabolism and impact of maternal taurine supplementation  Journal Articles
• Maternal High-Fat Diet-Induced Loss of Fetal Oocytes Is Associated with Compromised Follicle Growth in Adult Rat Offspring1  Journal Articles
• Maternal high-fat diet during pregnancy and lactation affects factors that regulate cell proliferation and apoptosis in the testis of adult progeny  Journal Articles
• Maternal nutritional history modulates the hepatic IGF–IGFBP axis in adult male rat offspring  Journal Articles
• Maternal perinatal diet induces developmental programming of bone architecture  Journal Articles
• Mechanisms and treatments for severe, steroid‐resistant allergic airway disease and asthma  Journal Articles
• Metabolic dysfunction following weight regain compared to initial weight gain in a high-fat diet-induced obese mouse model  Journal Articles
• Metabolomics Reveals Metabolically Healthy and Unhealthy Obese Individuals Differ in their Response to a Caloric Challenge  Journal Articles
• Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity  Journal Articles
• Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss  Journal Articles
• Metformin-induced reductions in tumor growth involves modulation of the gut microbiome  Journal Articles
• Myeloid GSK3α Deficiency Reduces Lesional Inflammation and Neovascularization during Atherosclerotic Progression.  Journal Articles
• Nature, nurture or nutrition? Impact of maternal nutrition on maternal care, offspring development and reproductive function  Journal Articles
• Obesity Resistance and Enhanced Insulin Sensitivity in Ahnak-/- Mice Fed a High Fat Diet Are Related to Impaired Adipogenesis and Increased Energy Expenditure  Journal Articles
• Obesity during pregnancy results in maternal intestinal inflammation, placental hypoxia, and alters fetal glucose metabolism at mid-gestation  Journal Articles
• Obesity-Induced Structural and Neuronal Plasticity in the Lateral Orbitofrontal Cortex.  Journal Articles
• PDZK1 in leukocytes protects against cellular apoptosis and necrotic core development in atherosclerotic plaques in high fat diet fed ldl receptor deficient mice  Journal Articles
• Paternal obesity induces placental hypoxia and sex-specific impairments in placental vascularization and offspring metabolism  Journal Articles
• Peripheral Serotonin Controls Dietary Fat Absorption and Chylomicron Secretion via 5-HT4 Receptor in Males.  Journal Articles
• Postbiotics engage IRF4 in adipocytes to promote sex‐dependent changes in blood glucose during obesity  Journal Articles
• Postbiotics for NOD2 require nonhematopoietic RIPK2 to improve blood glucose and metabolic inflammation in mice  Journal Articles
• Preclinical Assessment of Leptin Transport into the Cerebrospinal Fluid in Diet‐Induced Obese Minipigs  Journal Articles
• RIPK2 Dictates Insulin Responses to Tyrosine Kinase Inhibitors in Obese Male Mice  Journal Articles
• RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network  Journal Articles
• Restoration of the ER stress response protein TDAG51 in hepatocytes mitigates NAFLD in mice  Journal Articles
• Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-β1  Journal Articles
• Scriptaid enhances skeletal muscle insulin action and cardiac function in obese mice  Journal Articles
• Skeletal Muscle Mitochondrial Morphology Negatively Affected in Mice Lacking Xin  Journal Articles
• Small rodent models of atherosclerosis  Journal Articles
• Sphingosine-1-Phosphate Receptor 1, Expressed in Myeloid Cells, Slows Diet-Induced Atherosclerosis and Protects against Macrophage Apoptosis in Ldlr KO Mice  Journal Articles
• The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK  Journal Articles
• The miR-203/ZBTB20/MAFA Axis Orchestrates Pancreatic β-Cell Maturation and Identity During Weaning and Diabetes.  Journal Articles
• The “crosstalk” between gut microbiota, metabolites and genes in diet-induced hepatic steatosis mice intervened with Cordyceps guangdongensis polysaccharides  Journal Articles
• Trophoblast Invasion and Blood Vessel Remodeling Are Altered in a Rat Model of Lifelong Maternal Obesity  Journal Articles