Clinical Protocols Concept

subject area of

• 2008 update of international guidelines for the management of severe sepsis and septic shock: should we change our current clinical practice?  Journal Articles
• A Citywide Prehospital Protocol Increases Access to Stroke Thrombolysis in Toronto  Journal Articles
• A Framework for Assessing Scientific Merit in Ethical Review of Clinical Research  Journal Articles
• A Phase I Study of Adenovirus Mediated Gene Transfer of Interleukin 2 cDNA into Metastatic Breast Cancer or Melanoma. The Toronto Hospital, Toronto, Ontario, Canada  Journal Articles
• A Practical Guide for Treatment of Rapidly Progressive ADPKD with Tolvaptan  Journal Articles
• A Provincial Assessment of the Barriers and Utilization of Enhanced Recovery After Colorectal Surgery  Journal Articles
• A Randomized Pragmatic Trial of Changing to and Stepping Down Fluticasone/Formoterol in Asthma  Journal Articles
• A Randomized Trial of Paracentesis plus Intraperitoneal Tumor Necrosis Factor-α versus Paracentesis Alone in Patients with Symptomatic Ascites from Recurrent Ovarian Carcinoma  Journal Articles
• A Theory-Driven System for the Specification of Rehabilitation Treatments  Journal Articles
• A cognitive perspective on medical expertise  Journal Articles
• A comparison of intestinal microbiota in a population of low-risk infants exposed and not exposed to intrapartum antibiotics: The Baby & Microbiota of the Intestine cohort study protocol  Journal Articles
• A double-blind, randomized controlled trial to compare the effect of biannual peripheral magnetic resonance imaging, radiography and standard of care disease progression monitoring on pharmacotherapeutic escalation in rheumatoid and undifferentiated inflammatory arthritis: study protocol for a randomized controlled trial  Journal Articles
• A methodological survey on reporting of pilot and feasibility trials for physiotherapy interventions: a study protocol  Journal Articles
• A model for estimating the costs and burdens of breast cancer diagnosis and treatment in Canada.  Journal Articles
• A multi-method review of home-based chemotherapy  Journal Articles
• A multicenter survey of Ontario intensive care unit nurses regarding the use of sedatives and analgesics for adults receiving mechanical ventilation  Journal Articles
• A patient decision aid for antidepressant use in pregnancy: study protocol for a randomized controlled trial  Journal Articles
• A pilot randomized controlled trial of 7 versus 14 days of antibiotic treatment for bloodstream infection on non-intensive care versus intensive care wards  Journal Articles
• A protocol for a Canadian prospective observational study of decision-making on active surveillance or surgery for low-risk papillary thyroid cancer  Journal Articles
• A protocol for developing early warning score models from vital signs data in hospitals using ensembles of decision trees  Journal Articles
• A randomized trial to assess the impact of an antithrombotic decision aid in patients with nonvalvular atrial fibrillation: the DAAFI trial protocol [ISRCTN14429643]  Journal Articles
• A review of randomized controlled trials comparing the effectiveness of hand held computers with paper methods for data collection  Journal Articles
• A study protocol for a randomised controlled trial evaluating clinical effects of platelet transfusion products: the Pathogen Reduction Evaluation and Predictive Analytical Rating Score (PREPAReS) trial  Journal Articles
• A trial to determine whether septic shock-reversal is quicker in pediatric patients randomized to an early goal-directed fluid-sparing strategy versus usual care (SQUEEZE): study protocol for a pilot randomized controlled trial  Journal Articles
• ABCDEF Bundle Practices for Critically Ill Children: An International Survey of 161 PICUs in 18 Countries*  Journal Articles
• Accounting for treatment by center interaction in sample size determinations and the use of surrogate outcomes in the pessary for the prevention of preterm birth trial: a simulation study  Journal Articles
• Acute stroke: evaluation and treatment.  Journal Articles
• Advancing Rehabilitation Practice Through Improved Specification of Interventions  Journal Articles
• All-arthroscopic versus mini-open repair of small or moderate-sized rotator cuff tears: A protocol for a randomized trial [NCT00128076]  Journal Articles
• An Optimized Clinical Regimen for the Oncolytic Virus PV701  Journal Articles
• An analysis of protocols and publications suggested that most discontinuations of clinical trials were not based on preplanned interim analyses or stopping rules  Journal Articles
• Aneurysmal SubArachnoid Hemorrhage—Red Blood Cell Transfusion And Outcome (SAHaRA): a pilot randomised controlled trial protocol  Journal Articles
• Análisis interino en ensayos clínicos: una guía metodológica  Journal Articles
• Appraisal of clinical practice guidelines for management of paediatric type 2 diabetes mellitus using the AGREE II instrument: a systematic review protocol  Journal Articles
• Assessment of clinically relevant bleeding as a surrogate outcome for major bleeding: validation by meta‐analysis of randomized controlled trials  Journal Articles
• Assisted partner notification services to augment HIV testing and linkage to care in Kenya: study protocol for a cluster randomized trial  Journal Articles
• Association between body mass index and suicidal behaviors: a systematic review protocol  Journal Articles
• Back to the future: the pyramids of rheumatoid arthritis.  Journal Articles
• Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE): study protocol for a pilot randomized controlled trial  Journal Articles
• Becoming and staying physically active in adolescents with cerebral palsy: protocol of a qualitative study of facilitators and barriers to physical activity  Journal Articles
• Brain Activity and Cognitive Status in Pediatric Patients: Development of a Clinical Assessment Protocol  Journal Articles
• Brain activity and language assessment using event-related potentials: development of a clinical protocol  Journal Articles
• CYCLE pilot: a protocol for a pilot randomised study of early cycle ergometry versus routine physiotherapy in mechanically ventilated patients  Journal Articles
• Can an antimicrobial stewardship program reduce length of stay of immune-competent adult patients admitted to hospital with diagnosis of community-acquired pneumonia? Study protocol for pragmatic controlled non-randomized clinical study  Journal Articles
• Canada-DONATE study protocol: a prospective national observational study of the medical management of deceased organ donors  Journal Articles
• Challenges in the conduct of large simple trials of important generic questions in resource-poor settings: The CREATE and ECLA trial program evaluating GIK (glucose, insulin and potassium) and low-molecular-weight heparin in acute myocardial infarction  Journal Articles
• Changing Physicians' Behavior Using Combined Strategies and an Evidence-Based Protocol  Journal Articles
• Chronic pain self-management support with pain science education and exercise (COMMENCE): study protocol for a randomized controlled trial  Journal Articles
• Clinical Issues and Research in Respiratory Failure from Severe Acute Respiratory Syndrome  Journal Articles
• Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit  Journal Articles
• Clinical Research Designs: Quantitative Studies  Journal Articles
• Clinical review: Mechanical ventilation in severe asthma.  Journal Articles
• Clinician perspectives on protocols designed to minimize sedation  Journal Articles
• Clopidogrel in acute coronary syndromes: Where are we now?  Journal Articles
• Coagulation/Complement Activation and Cerebral Hypoperfusion in Relapsing-Remitting Multiple Sclerosis  Journal Articles
• Combining high-frequency oscillatory ventilation and recruitment maneuvers in adults with early acute respiratory distress syndrome: The Treatment with Oscillation and an Open Lung Strategy (TOOLS) Trial pilot study*  Journal Articles
• Comparing the feasibility, acceptability, clinical-, and cost-effectiveness of mental health e-screening to paper-based screening on the detection of depression, anxiety, and psychosocial risk in pregnant women: a study protocol of a randomized, parallel-group, superiority trial  Journal Articles
• Comparison of Adult Diabetic Ketoacidosis Treatment Protocols From Canadian Emergency Departments  Journal Articles
• Comparison of Radiation Doses and Best-Practice Use for Myocardial Perfusion Imaging in US and Non-US Laboratories  Journal Articles
• Congenital hypothyroidism: diagnosis and management.  Journal Articles
• Considerations for the Selection of Time-Limited Walk Tests Poststroke: A Systematic Review of Test Protocols and Measurement Properties  Journal Articles
• Content analysis of bowel protocols for the management of constipation in adult critically ill patients  Journal Articles
• Continuous gastrostomy tube feedings and the head of the bed dilemma: how low can you go?  Journal Articles
• Cord pilot trial - immediate versus deferred cord clamping for very preterm birth (before 32 weeks gestation): study protocol for a randomized controlled trial  Journal Articles
• Corticosteroid treatment for community-acquired pneumonia - the STEP trial: study protocol for a randomized controlled trial  Journal Articles
• Current worldwide nuclear cardiology practices and radiation exposure: results from the 65 country IAEA Nuclear Cardiology Protocols Cross-Sectional Study (INCAPS)  Journal Articles
• Daily Sedation Interruption in Mechanically Ventilated Critically Ill Patients Cared for With a Sedation Protocol  Journal Articles
• Deciding what type of evidence and outcomes to include in guidelines: article 5 in integrating and coordinating efforts in COPD guideline development. An official ATS/ERS workshop report  Journal Articles
• Decision aid on radioactive iodine treatment for early stage papillary thyroid cancer: update to study protocol with follow-up extension  Journal Articles
• Defining anabolic resistance: implications for delivery of clinical care nutrition  Journal Articles
• Delayed educational reminders for long-term medication adherence in ST-elevation myocardial infarction (DERLA-STEMI): Protocol for a pragmatic, cluster-randomized controlled trial  Journal Articles
• Depression and anxiety during the perinatal period  Journal Articles
• Description and Results of a Comprehensive Care Protocol for Overnight-Stay Spine Surgery in Adults  Journal Articles
• Design and rationale for RE-VERSE AD: A phase 3 study of idarucizumab, a specific reversal agent for dabigatran  Journal Articles
• Design considerations for randomised trials in orthopaedic fracture surgery  Journal Articles
• Designing and implementing a comparative effectiveness study of two strategies for delivering high quality CHD prevention: Methods and participant characteristics for the Heart to Health study  Journal Articles
• Determining the impact of a new physiotherapist-led primary care model for back pain: protocol for a pilot cluster randomized controlled trial  Journal Articles
• Development and feasibility testing of decision support for patients who are candidates for a prophylactic implantable defibrillator: a study protocol for a pilot randomized controlled trial  Journal Articles
• Development of a Conservative Protocol to Return Children and Youth to Activity Following Concussive Injury  Journal Articles
• Development of a bedside-applicable ultrasound protocol to estimate fat mass index derived from whole body dual-energy x-ray absorptiometry scans  Journal Articles
• Development of protocols for randomized sham-controlled trials of complex treatment interventions: Japanese acupuncture for endometriosis-related pelvic pain.  Journal Articles
• Displaced supracondylar fractures of the humerus in children  Journal Articles
• Early detection and intervention for obsessive-compulsive disorder in childhood and adolescence  Journal Articles
• Economic evaluation of the prophylaxis for thromboembolism in critical care trial (E-PROTECT): study protocol for a randomized controlled trial  Journal Articles
• Effect of Tinnitus Retraining Therapy vs Standard of Care on Tinnitus-Related Quality of Life: A Randomized Clinical Trial.  Journal Articles
• Effect of a Postoperative Multimodal Opioid-Sparing Protocol vs Standard Opioid Prescribing on Postoperative Opioid Consumption After Knee or Shoulder Arthroscopy  Journal Articles
• Effect of the introduction of helical CT on radiation dose in the investigation of pulmonary embolism  Journal Articles
• Effectiveness of a cognitive-behavioral therapy (CBT) manualized program for clinically anxious children: study protocol of a randomized controlled trial  Journal Articles
• Effectiveness of pharmaceutical care at discharge in the emergency department: study protocol of a randomized controlled trial  Journal Articles
• Effects of medical and non-medical cannabis use in older adults: protocol for a scoping review  Journal Articles
• Efficacy of ultra-micronized palmitoylethanolamide (um-PEA) in geriatric patients with chronic pain: study protocol for a series of N-of-1 randomized trials  Journal Articles
• Efficacy, safety, and treatment burden of treat-and-extend versus alternative anti-VEGF regimens for nAMD: a systematic review and meta-analysis  Journal Articles
• Encuesta nacional sobre los conocimientos impartidos en escuelas de medicina de Colombia sobre rehidratación parenteral en niños eutróficos mayores de un año con deshidratación por enfermedad diarreicaIván  Journal Articles
• Endovascular repair of ruptured abdominal aortic aneurysms: A systematic review and meta-analysis  Journal Articles
• Enhanced Recovery After Surgery (ERAS) protocols following emergency intra-abdominal surgery: A systematic review and meta-analysis protocol  Journal Articles
• Estimating the Reduction in the Radiation Burden From Nuclear Cardiology Through Use of Stress-Only Imaging in the United States and Worldwide  Journal Articles
• Evaluating probiotics for the prevention of ventilator-associated pneumonia: a randomised placebo-controlled multicentre trial protocol and statistical analysis plan for PROSPECT  Journal Articles
• Evaluation and Management of Skeletal Health in Celiac Disease: Position Statement  Journal Articles
• Evaluation of an initiation protocol of 4 mg of warfarin for atrial fibrillation in the outpatient setting.  Journal Articles
• Evidence-based postoperative replantation protocols.  Journal Articles
• Exposure to bats: updated recommendations  Journal Articles
• FLUID trial: a protocol for a hospital-wide open-label cluster crossover pragmatic comparative effectiveness randomised pilot trial  Journal Articles
• Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis  Journal Articles
• Failure of Anticoagulant Thromboprophylaxis  Journal Articles
• Fit for School Study protocol: early child growth, health behaviours, nutrition, cardiometabolic risk and developmental determinants of a child’s school readiness, a prospective cohort  Journal Articles
• Fixation using alternative implants for the treatment of hip fractures (FAITH): design and rationale for a multi-centre randomized trial comparing sliding hip screws and cancellous screws on revision surgery rates and quality of life in the treatment of femoral neck fractures  Journal Articles
• Forearm Pronation and Supination  Journal Articles
• Fractionated manganese‐enhanced MRI  Journal Articles
• Frequency of Screening for Weaning From Mechanical Ventilation: Two Contemporaneous Proof-of-Principle Randomized Controlled Trials*  Journal Articles
• Frequent Hemodialysis Network (FHN) randomized trials: Study design  Journal Articles
• GISSI-3: effects of lisinopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after acute myocardial infarction. Gruppo Italiano per lo Studio della Sopravvivenza nell'infarto Miocardico.  Journal Articles
• GRADE guidelines: 14. Going from evidence to recommendations: the significance and presentation of recommendations  Journal Articles
• Glycerin suppositories used prophylactically in premature infants (supp): A pilot randomized controlled trial  Journal Articles
• Good Outcome Associated with a Standardized Treatment Protocol Using Selective Postoperative Radiation in Patients with Clinical Stage I Adenocarcinoma of the Endometrium  Journal Articles
• Guidelines for Reporting Outcomes in Trial Protocols  Journal Articles
• HELPinKids&Adults Knowledge Synthesis of the Management of Vaccination Pain and High Levels of Needle Fear  Journal Articles
• Health care utilisation and costs associated with different treatment protocols for newly diagnosed childhood acute lymphoblastic leukaemia: A population-based study in Ontario, Canada  Journal Articles
• Helical CTPA in the investigation of pulmonary embolism: a 6-year review  Journal Articles
• Hip fracture evaluation with alternatives of total hip arthroplasty versus hemiarthroplasty (HEALTH): protocol for a multicentre randomised trial  Journal Articles
• How to write a surgical clinical research protocol: literature review and practical guide  Journal Articles
• Human Albumin Administration in Subarachnoid Hemorrhage: Results of an International Survey  Journal Articles
• Human Gene Marker/Therapy Clincal Protocols (Complete Updated Listings)  Journal Articles
• Hyperbaric Oxygen in Lower Limb Trauma (HOLLT); protocol for a randomised controlled trial  Journal Articles
• Hypothermia Pediatric Head Injury Trial: The Value of a Pretrial Clinical Evaluation Phase  Journal Articles
• Identification of Cancer Care and Protocol Characteristics Associated With Recruitment in Breast Cancer Clinical Trials  Journal Articles
• Identifying Prioritization Criteria to Supplement Critical Care Triage Protocols for the Allocation of Ventilators during a Pandemic Influenza  Journal Articles
• Identifying process and outcome indicators of successful transitions from child to adult mental health services: protocol for a scoping review  Journal Articles
• Impact of emergency department probiotic treatment of pediatric gastroenteritis: study protocol for the PROGUT (Probiotic Regimen for Outpatient Gastroenteritis Utility of Treatment) randomized controlled trial  Journal Articles
• Impact of hospital lockdown secondary to COVID-19 and past pandemics on surgical practice: A living rapid systematic review  Journal Articles
• Impact of routine in-hospital assessment of low-density lipoprotein levels and standardized orders on statin therapy in patients undergoing percutaneous coronary interventions.  Journal Articles
• Implementation of a Same-Day Discharge Protocol Following Total Laparoscopic Hysterectomy  Journal Articles
• Implementation of a data management program in a pediatric cancer unit in a low income country  Journal Articles
• Implementation trial of the basic life support termination of resuscitation rule: Reducing the transport of futile out-of-hospital cardiac arrests  Journal Articles
• Implementing evidence-based recommended practices for the management of patients with mild traumatic brain injuries in Australian emergency care departments: study protocol for a cluster randomised controlled trial  Journal Articles
• Implementing highly specialized and evidence-based pediatric eating disorder treatment: protocol for a mixed methods evaluation  Journal Articles
• Improved outcome for children with acute lymphoblastic leukemia: results of Dana-Farber Consortium Protocol 91-01  Journal Articles
• Improvement evident but still necessary in clinical practice guideline quality: a systematic review  Journal Articles
• Improving access to community-based pulmonary rehabilitation: 3R protocol for real-world settings with cost-benefit analysis  Journal Articles
• Improving children’s health and development in British Columbia through nurse home visiting: a randomized controlled trial protocol  Journal Articles
• Improving communication with patients in post-traumatic amnesia: development and impact of a clinical protocol  Journal Articles
• Instituto Nacional de Ciência e Tecnologia em Medicina Translacional (INCT-TM): abordagens metodológicas  Journal Articles
• Intention-to-treat analysis may be more conservative than per protocol analysis in antibiotic non-inferiority trials: a systematic review  Journal Articles
• Intention-to-treat principle.  Journal Articles
• Intermittent versus continuous oxygen saturation monitoring for infants hospitalised with bronchiolitis: study protocol for a pragmatic randomised controlled trial  Journal Articles
• Intrapleural Dornase and Tissue Plasminogen Activator in pediatric empyema (DTPA): a study protocol for a randomized controlled trial  Journal Articles
• Knowledge Translation Interventions for Critically Ill Patients  Journal Articles
• Letter reply to GRADE guidelines articles 14 and 15  Journal Articles
• Letters Regarding Article by Mehilli et al, "Randomized Clinical Trial of Abciximab in Diabetic Patients Undergoing Elective Percutaneous Coronary Interventions After Treatment With a High Loading Dose of Clopidogrel" * Response  Journal Articles
• Longitudinal Youth in Transition Study (LYiTS): protocol for a multicentre prospective cohort study of youth transitioning out of child and adolescent mental health services at age 18  Journal Articles
• MATERNAL VITAMIN D SUPPLEMENTATION DURING PREGNANCY AND LACTATION TO PROMOTE INFANT GROWTH IN DHAKA, BANGLADESH (MDIG TRIAL): A RANDOMIZED CONTROLLED TRIAL  Conferences
• Magnesium Sulphate for Eclampsia and Fetal Neuroprotection: A Comparative Analysis of Protocols Across Canadian Tertiary Perinatal Centres  Journal Articles
• Magnesium nebulization utilization in management of pediatric asthma (MagNUM PA) trial: study protocol for a randomized controlled trial  Journal Articles
• Management of Ontario children with acute lymphoblastic leukemia by the Dana-Farber Cancer Institute protocols.  Journal Articles
• Management of post-traumatic stress disorder  Journal Articles
• Management of urinary retention after surgical repair of hip fracture.  Journal Articles
• Massive hemorrhage protocol survey: Marked variability and absent in one-third of hospitals in Ontario, Canada  Journal Articles
• Massive transfusion in paediatric and adolescent trauma patients: Incidence, patient profile, and outcomes prior to a massive transfusion protocol  Journal Articles
• Maternal vitamin D supplementation during pregnancy and lactation to promote infant growth in Dhaka, Bangladesh (MDIG trial): study protocol for a randomized controlled trial  Journal Articles
• Mechanical Ventilator Weaning Protocols Driven by Nonphysician Health-Care Professionals  Journal Articles
• Medication use and its impact on high-cost health care users among older adults: protocol for the population-based matched cohort HiCOSTT study  Journal Articles
• Metformin in adults with type 1 diabetes: Design and methods of REducing with MetfOrmin Vascular Adverse Lesions (REMOVAL): An international multicentre trial  Journal Articles
• Moving forward in clinical research with master protocols  Journal Articles
• Nortriptyline in knee osteoarthritis (NortIKA Study): study protocol for a randomised controlled trial  Journal Articles
• Optimizing antibiotics in residents of nursing homes: protocol of a randomized trial  Journal Articles
• Optimizing life success through residential immersive life skills programs for youth with disabilities: study protocol of a mixed-methods, prospective, comparative cohort study  Journal Articles
• Oral surgery in patients with hereditary bleeding disorders  Journal Articles
• Outcomes in the offspring of mothers with pre-diabetes during pregnancy: a protocol for a systematic review  Journal Articles
• Pain Squad+ smartphone app to support real-time pain treatment for adolescents with cancer: protocol for a randomised controlled trial  Journal Articles
• Pattern of carboplatin-induced emesis  Journal Articles
• Periodic health examination, 1993 update: 2. Lowering the blood total cholesterol level to prevent coronary heart disease. Canadian Task Force on the Periodic Health Examination.  Journal Articles
• Perioperative bridging interruption with heparin for the patient receiving long-term anticoagulation  Journal Articles
• Perioperative multimodal optimisation in patients undergoing surgery for fractured neck of femur  Journal Articles
• Perspectives on evidence based practice in ABI rehabilitation. “Relevant Research”: Who decides?  Journal Articles
• Phase II study of amonafide: results of treatment and lessons learned from the study of an investigational agent in previously untreated patients with extensive small-cell lung cancer.  Journal Articles
• Post-Transient Ischemic Attack Early Stroke Stratification: The ABCD2 Prognostic Aid  Journal Articles
• Practical Model-Based Dose Finding in Early-Phase Clinical Trials  Journal Articles
• Practical management of bleeding in patients receiving non-vitamin K antagonist oral anticoagulants  Journal Articles
• Practising evidence-based medicine: the design and implementation of a multidisciplinary team-driven extubation protocol  Journal Articles
• Preconditioning Shields Against Vascular Events in Surgery (SAVES), a multicentre feasibility trial of preconditioning against adverse events in major vascular surgery: study protocol for a randomised control trial  Journal Articles
• Prehospital evaluation and economic analysis of different coronary syndrome treatment strategies - PREDICT - Rationale, Development and Implementation  Journal Articles
• Preparing a research protocol to improve chances for success  Journal Articles
• Preparing reports for publication and responding to reviewers' comments  Journal Articles
• Prevalence, Risk Factors, and Outcomes of Delirium in Mechanically Ventilated Adults*  Journal Articles
• Prevalence, risk factors, and outcomes associated with physical restraint use in mechanically ventilated adults  Journal Articles
• Prevention of Clostridium difficile Infection: A Systematic Survey of Clinical Practice Guidelines  Journal Articles
• Primary prophylaxis in severe haemophilia should be started at an early age but can be individualized  Journal Articles
• Procalcitonin-guided antibiotic use versus a standard approach for acute respiratory tract infections in primary care: study protocol for a randomised controlled trial and baseline characteristics of participating general practitioners [ISRCTN73182671]  Journal Articles
• Progression and Management of Duodenal Neoplasia in Familial Adenomatous Polyposis  Journal Articles
• Proposed motor development assessment protocol for epidemiological studies in children  Journal Articles
• Protocol adherence for continuously titrated interventions in randomized trials: an overview of the current methodology and case study  Journal Articles
• Protocol for a phase III, non-inferiority, randomised comparison of a new fibrinogen concentrate versus cryoprecipitate for treating acquired hypofibrinogenaemia in bleeding cardiac surgical patients: the FIBRES trial  Journal Articles
• Protocol for a randomized controlled clinical trial investigating the effectiveness of Fast muscle Activation and Stepping Training (FAST) for improving balance and mobility in sub-acute stroke  Journal Articles
• Protocol implementation during the COVID-19 pandemic: experiences from a randomized trial of stress ulcer prophylaxis  Journal Articles
• Protocol of the COSMIN study: COnsensus-based Standards for the selection of health Measurement INstruments  Journal Articles
• Protocols to Improve the Care of Critically Ill Pediatric and Adult Patients  Journal Articles
• Protocol‐based treatment for children with cancer in low income countries in Latin America: A report on the recent meetings of the Monza International School of Pediatric Hematology/Oncology (MISPHO)—Part II  Journal Articles
• Quality and methods of developing practice guidelines  Journal Articles
• Quantitative bias analysis for external control arms using real-world data in clinical trials: a primer for clinical researchers  Journal Articles
• RIGHT for acupuncture: An extension of the RIGHT statement for clinical practice guidelines on acupuncture  Journal Articles
• Radiation from CT scans in paediatric trauma patients: Indications, effective dose, and impact on surgical decisions  Journal Articles
• Rationale and design of the Primary pREvention strategies at the community level to Promote Adherence of treatments to pREvent cardiovascular diseases trial number (CTRI/2012/09/002981)  Journal Articles
• Rationale, design, and methods for Canadian alliance for healthy hearts and minds cohort study (CAHHM) – a Pan Canadian cohort study  Journal Articles
• Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial  Journal Articles
• Re-evaluating the Inhibition of Stress Erosions (REVISE): a protocol for pilot randomized controlled trial  Journal Articles
• Recall of ICU Stay in Patients Managed With a Sedation Protocol or a Sedation Protocol With Daily Interruption  Journal Articles
• Recommended Clinical Practices for Maximizing Peritoneal Dialysis Clearances  Journal Articles
• Recruitment patterns in a large international randomized controlled trial of perioperative care in cancer patients  Journal Articles
• Reporting of planned statistical methods in published surgical randomised trial protocols: a protocol for a methodological systematic review  Journal Articles
• Results of Dana-Farber Cancer Institute Consortium protocols for children with newly diagnosed acute lymphoblastic leukemia (1981–1995)  Journal Articles
• Risks and Benefits of Oral Anticoagulation Compared With Clopidogrel Plus Aspirin in Patients With Atrial Fibrillation According to Stroke Risk  Journal Articles
• Rivaroxaban for Preventing Venous Thromboembolism in High-Risk Ambulatory Patients with Cancer: Rationale and Design of the CASSINI Trial  Journal Articles
• Role of patient preferences in clinical practice guidelines: a multiple methods study using guidelines from oncology as a case  Journal Articles
• Sepsis survivors monitoring and coordination in outpatient health care (SMOOTH): study protocol for a randomized controlled trial.  Journal Articles
• Sleep to lower elevated blood pressure: study protocol for a randomized controlled trial  Journal Articles
• SodiUm SeleniTe Adminstration IN Cardiac Surgery (SUSTAIN CSX-trial): study design of an international multicenter randomized double-blinded controlled trial of high dose sodium-selenite administration in high-risk cardiac surgical patients  Journal Articles
• Solute Clearance Approach to Adequacy of Peritoneal Dialysis  Journal Articles
• Standardising costs or standardising care? Qualitative evaluation of the implementation and impact of a hospital funding reform in Ontario, Canada  Journal Articles
• Standardized Care Is Better Than Individualized Care for the Majority of Critically Ill Patients  Journal Articles
• Steroids In caRdiac Surgery (SIRS) trial: acute kidney injury substudy protocol of an international randomised controlled trial  Journal Articles
• Steroids in fluid and/or vasoactive infusion dependent pediatric shock: study protocol for a randomized controlled trial  Journal Articles
• Strategic use of new generation antidepressants for depression: SUN(^_^) D protocol update and statistical analysis plan  Journal Articles
• Student-observed surgical safety practices across an urban regional health authority.  Journal Articles
• Studies of Left Ventricular Dysfunction (SOLVD)—Rationale, design and methods: Two trials that evaluate the effect of enalapril in patients with reduced ejection fraction  Journal Articles
• Study protocol for a randomized, controlled, superiority trial comparing the clinical and cost- effectiveness of integrated online mental health assessment-referral-care in pregnancy to usual prenatal care on prenatal and postnatal mental health and infant health and development: the Integrated Maternal Psychosocial Assessment to Care Trial (IMPACT)  Journal Articles
• Study to prospectively evaluate reamed intramedually nails in patients with tibial fractures (S.P.R.I.N.T.): Study rationale and design  Journal Articles
• Subgroup Analysis of Trials Is Rarely Easy (SATIRE): a study protocol for a systematic review to characterize the analysis, reporting, and claim of subgroup effects in randomized trials  Journal Articles
• Subgroup analyses in randomised controlled trials: cohort study on trial protocols and journal publications  Journal Articles
• Suggestions for the management of factor VIII inhibitors  Journal Articles
• Supporting the improvement and management of prescribing for urinary tract infections (SIMPle): protocol for a cluster randomized trial  Journal Articles
• Sustained Aeration of Infant Lungs (SAIL) trial: study protocol for a randomized controlled trial  Journal Articles
• Systematic review and network meta-analysis of interventions for fibromyalgia: a protocol  Journal Articles
• Systematic review of basket trials, umbrella trials, and platform trials: a landscape analysis of master protocols  Journal Articles
• Tailoring treatment of haemophilia B: accounting for the distribution and clearance of standard and extended half-life FIX concentrates  Journal Articles
• The ACHRU-CPP versus usual care for older adults with type-2 diabetes and multiple chronic conditions and their family caregivers: study protocol for a randomized controlled trial  Journal Articles
• The Back to School asthma study: the effect of montelukast on asthma burden when initiated prophylactically at the start of the school year  Journal Articles
• The COSMIN study reached international consensus on taxonomy, terminology, and definitions of measurement properties for health-related patient-reported outcomes  Journal Articles
• The Canadian Biomarker Integration Network in Depression (CAN-BIND): magnetic resonance imaging protocols  Journal Articles
• The Effect of Change in a Labour Management Protocol on Caesarean Section Rate in Nulliparous Women  Journal Articles
• The Evaluation of an Interdisciplinary Pain Protocol in Long Term Care  Journal Articles
• The HAART cell phone adherence trial (WelTel Kenya1): a randomized controlled trial protocol  Journal Articles
• The Methodological Approach Used to Develop the 2013 Pain, Agitation, and Delirium Clinical Practice Guidelines for Adult ICU Patients  Journal Articles
• The PARADIGHM (physicians advancing disease knowledge in hypoparathyroidism) registry for patients with chronic hypoparathyroidism: study protocol and interim baseline patient characteristics  Journal Articles
• The Quality Initiative in Rectal Cancer (QIRC) trial: study protocol of a cluster randomized controlled trial in surgery  Journal Articles
• The Rehabilitation Treatment Specification System: Implications for Improvements in Research Design, Reporting, Replication, and Synthesis  Journal Articles
• The SYGMA programme of phase 3 trials to evaluate the efficacy and safety of budesonide/formoterol given ‘as needed’ in mild asthma: study protocols for two randomised controlled trials  Journal Articles
• The Use of Bowel Protocols in Critically Ill Adult Patients: A Systematic Review and Meta-Analysis  Journal Articles
• The cardiac MRI substudy to ongoing telmisartan alone and in combination with ramipril global endpoint trial/telmisartan randomized assessment study in ACE-intolerant subjects with cardiovascular disease: analysis protocol and baseline characteristics  Journal Articles
• The development of a treatment pathway for dermal regenerative matrix (DRM)  Journal Articles
• The effect of berberine on insulin resistance in women with polycystic ovary syndrome: detailed statistical analysis plan (SAP) for a multicenter randomized controlled trial  Journal Articles
• The effect of the video game Mindlight on anxiety symptoms in children with an Autism Spectrum Disorder  Journal Articles
• The effect of weekly text-message communication on treatment completion among patients with latent tuberculosis infection: study protocol for a randomised controlled trial (WelTel LTBI)  Journal Articles
• The effectiveness of a Supported Self-management task-shifting intervention for adult depression in Vietnam communities: study protocol for a randomized controlled trial  Journal Articles
• The effectiveness of interventions to treat obesity in survivors of childhood brain tumors: a systematic review protocol  Journal Articles
• The end of early-goal directed therapy?  Journal Articles
• The impact of chronic pain on opioid addiction treatment: a systematic review protocol  Journal Articles
• The impact of syndromic treatment of sexually transmitted diseases on genital shedding of HIV-1  Journal Articles
• The predictors of Enhanced Recovery After Surgery utilization and practice variations in elective colorectal surgery: a provincial survey  Journal Articles
• The rationale and design of the Beta‐blocker to LOwer CArdiovascular Dialysis Events (BLOCADE) Feasibility Study  Journal Articles
• Thromboembolism in children with acute lymphoblastic leukaemia treated on Dana‐Farber Cancer Institute protocols: effect of age and risk stratification of disease  Journal Articles
• Thromboprophylaxis for hospitalized medical patients: A Multicenter Qualitative study  Journal Articles
• Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial  Journal Articles
• Treatment of Acute Otitis Media in Children  Journal Articles
• Treatment of Pediatric Diabetic Ketoacidosis in Canada: A Review of Treatment Protocols from Canadian Pediatric Emergency Departments  Journal Articles
• Trial of Repeated Analgesia with Kangaroo Mother Care (TRAKC Trial)  Journal Articles
• Two doses of rivaroxaban versus aspirin for prevention of recurrent venous thromboembolism  Journal Articles
• Understanding developmental language disorder - the Helsinki longitudinal SLI study (HelSLI): a study protocol  Journal Articles
• Using Problem-Based Case Studies to Learn About Knowledge Translation Interventions: An Inside Perspective  Journal Articles
• Using decision thresholds for ranking treatments in network meta-analysis results in more informative rankings  Journal Articles
• V. Guidelines for Sedation and Analgesia During Mechanical Ventilation General Overview  Journal Articles
• Validation of a new test that assesses functional performance of the upper extremity and neck (FIT-HaNSA) in patients with shoulder pathology  Journal Articles
• Validation of stroke-specific protocols for the 10-meter walk test and 6-minute walk test conducted using 15-meter and 30-meter walkways  Journal Articles
• Variability in clinical laboratory practice in testing for disorders of platelet function  Journal Articles
• Variation in diurnal sedation in mechanically ventilated patients who are managed with a sedation protocol alone or a sedation protocol and daily interruption  Journal Articles
• Waiving confidentiality for the greater good  Journal Articles
• XANTUS: rationale and design of a noninterventional study of rivaroxaban for the prevention of stroke in patients with atrial fibrillation  Journal Articles
• “Employment and arthritis: making it work” a randomized controlled trial evaluating an online program to help people with inflammatory arthritis maintain employment (study protocol)  Journal Articles
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