Clinical Protocols
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subject area of
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2008 update of international guidelines for the management of severe sepsis and septic shock: should we change our current clinical practice? Academic Article
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A Citywide Prehospital Protocol Increases Access to Stroke Thrombolysis in Toronto Academic Article
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A Framework for Assessing Scientific Merit in Ethical Review of Clinical Research Academic Article
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A Phase I Study of Adenovirus Mediated Gene Transfer of Interleukin 2 cDNA into Metastatic Breast Cancer or Melanoma. The Toronto Hospital, Toronto, Ontario, Canada Academic Article
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A Practical Guide for Treatment of Rapidly Progressive ADPKD with Tolvaptan Academic Article
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A Provincial Assessment of the Barriers and Utilization of Enhanced Recovery After Colorectal Surgery Academic Article
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A Randomized Pragmatic Trial of Changing to and Stepping Down Fluticasone/Formoterol in Asthma Academic Article
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A Randomized Trial of Paracentesis plus Intraperitoneal Tumor Necrosis Factor-α versus Paracentesis Alone in Patients with Symptomatic Ascites from Recurrent Ovarian Carcinoma Academic Article
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A Theory-Driven System for the Specification of Rehabilitation Treatments Academic Article
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A cognitive perspective on medical expertise Academic Article
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A comparison of intestinal microbiota in a population of low-risk infants exposed and not exposed to intrapartum antibiotics: The Baby & Microbiota of the Intestine cohort study protocol Academic Article
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A double-blind, randomized controlled trial to compare the effect of biannual peripheral magnetic resonance imaging, radiography and standard of care disease progression monitoring on pharmacotherapeutic escalation in rheumatoid and undifferentiated inflammatory arthritis: study protocol for a randomized controlled trial Academic Article
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A methodological survey on reporting of pilot and feasibility trials for physiotherapy interventions: a study protocol Academic Article
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A multi-centre randomised trial to compare the effectiveness of geriatrician-led admission avoidance hospital at home versus inpatient admission Academic Article
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A multi-method review of home-based chemotherapy Academic Article
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A multicenter survey of Ontario intensive care unit nurses regarding the use of sedatives and analgesics for adults receiving mechanical ventilation Academic Article
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A narrative review of dermatologic protocols for primary care medical service trips in Latin America and the Caribbean Academic Article
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A patient decision aid for antidepressant use in pregnancy: study protocol for a randomized controlled trial Academic Article
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A pilot randomized controlled trial of 7 versus 14 days of antibiotic treatment for bloodstream infection on non-intensive care versus intensive care wards Academic Article
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A protocol for a Canadian prospective observational study of decision-making on active surveillance or surgery for low-risk papillary thyroid cancer Academic Article
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A protocol for developing early warning score models from vital signs data in hospitals using ensembles of decision trees Academic Article
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A randomized trial to assess the impact of an antithrombotic decision aid in patients with nonvalvular atrial fibrillation: the DAAFI trial protocol [ISRCTN14429643] Academic Article
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A review of randomized controlled trials comparing the effectiveness of hand held computers with paper methods for data collection Academic Article
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A study protocol for a randomised controlled trial evaluating clinical effects of platelet transfusion products: the Pathogen Reduction Evaluation and Predictive Analytical Rating Score (PREPAReS) trial Academic Article
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A trial to determine whether septic shock-reversal is quicker in pediatric patients randomized to an early goal-directed fluid-sparing strategy versus usual care (SQUEEZE): study protocol for a pilot randomized controlled trial Academic Article
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ABCDEF Bundle Practices for Critically Ill Children: An International Survey of 161 PICUs in 18 Countries* Academic Article
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Accounting for treatment by center interaction in sample size determinations and the use of surrogate outcomes in the pessary for the prevention of preterm birth trial: a simulation study Academic Article
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Acute stroke: evaluation and treatment. Academic Article
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Adaptive platform trials: definition, design, conduct and reporting considerations Academic Article
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Advancing Rehabilitation Practice Through Improved Specification of Interventions Academic Article
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All-arthroscopic versus mini-open repair of small or moderate-sized rotator cuff tears: A protocol for a randomized trial [NCT00128076] Academic Article
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An Official American Thoracic Society/American College of Chest Physicians Clinical Practice Guideline: Liberation from Mechanical Ventilation in Critically Ill Adults. Rehabilitation Protocols, Ventilator Liberation Protocols, and Cuff Leak Tests Academic Article
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An Optimized Clinical Regimen for the Oncolytic Virus PV701 Academic Article
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An analysis of protocols and publications suggested that most discontinuations of clinical trials were not based on preplanned interim analyses or stopping rules Academic Article
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Aneurysmal SubArachnoid Hemorrhage—Red Blood Cell Transfusion And Outcome (SAHaRA): a pilot randomised controlled trial protocol Academic Article
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Análisis interino en ensayos clínicos: una guía metodológica Academic Article
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Applying the ICF framework to study changes in quality-of-life for youth with chronic conditions Academic Article
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Appraisal of clinical practice guidelines for management of paediatric type 2 diabetes mellitus using the AGREE II instrument: a systematic review protocol Academic Article
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Assessment of clinically relevant bleeding as a surrogate outcome for major bleeding: validation by meta‐analysis of randomized controlled trials Academic Article
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Association between body mass index and suicidal behaviors: a systematic review protocol Academic Article
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BETTER HEALTH: Durham -- protocol for a cluster randomized trial of BETTER in community and public health settings Academic Article
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Back to the future: the pyramids of rheumatoid arthritis. Academic Article
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Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE): study protocol for a pilot randomized controlled trial Academic Article
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Becoming and staying physically active in adolescents with cerebral palsy: protocol of a qualitative study of facilitators and barriers to physical activity Academic Article
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Brain Activity and Cognitive Status in Pediatric Patients: Development of a Clinical Assessment Protocol Academic Article
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Brain activity and language assessment using event-related potentials: development of a clinical protocol Academic Article
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CYCLE pilot: a protocol for a pilot randomised study of early cycle ergometry versus routine physiotherapy in mechanically ventilated patients Academic Article
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Can an antimicrobial stewardship program reduce length of stay of immune-competent adult patients admitted to hospital with diagnosis of community-acquired pneumonia? Study protocol for pragmatic controlled non-randomized clinical study Academic Article
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Canada-DONATE study protocol: a prospective national observational study of the medical management of deceased organ donors Academic Article
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Challenges in the conduct of large simple trials of important generic questions in resource-poor settings: The CREATE and ECLA trial program evaluating GIK (glucose, insulin and potassium) and low-molecular-weight heparin in acute myocardial infarction Academic Article
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Changing Physicians' Behavior Using Combined Strategies and an Evidence-Based Protocol Academic Article
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Chronic pain self-management support with pain science education and exercise (COMMENCE): study protocol for a randomized controlled trial Academic Article
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Clinical Issues and Research in Respiratory Failure from Severe Acute Respiratory Syndrome Academic Article
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Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit Academic Article
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Clinical Research Designs: Quantitative Studies Academic Article
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Clinical review: Mechanical ventilation in severe asthma. Academic Article
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Clinician perspectives on protocols designed to minimize sedation Academic Article
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Clopidogrel in acute coronary syndromes: Where are we now? Academic Article
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Combining high-frequency oscillatory ventilation and recruitment maneuvers in adults with early acute respiratory distress syndrome: The Treatment with Oscillation and an Open Lung Strategy (TOOLS) Trial pilot study* Academic Article
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Comparing the feasibility, acceptability, clinical-, and cost-effectiveness of mental health e-screening to paper-based screening on the detection of depression, anxiety, and psychosocial risk in pregnant women: a study protocol of a randomized, parallel-group, superiority trial Academic Article
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Comparison of Adult Diabetic Ketoacidosis Treatment Protocols From Canadian Emergency Departments Academic Article
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Comparison of Radiation Doses and Best-Practice Use for Myocardial Perfusion Imaging in US and Non-US Laboratories Academic Article
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Congenital hypothyroidism: diagnosis and management. Academic Article
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Considerations for the Selection of Time-Limited Walk Tests Poststroke: A Systematic Review of Test Protocols and Measurement Properties Academic Article
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Content analysis of bowel protocols for the management of constipation in adult critically ill patients Academic Article
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Continuous gastrostomy tube feedings and the head of the bed dilemma: how low can you go? Academic Article
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Cord pilot trial - immediate versus deferred cord clamping for very preterm birth (before 32 weeks gestation): study protocol for a randomized controlled trial Academic Article
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Corticosteroid treatment for community-acquired pneumonia - the STEP trial: study protocol for a randomized controlled trial Academic Article
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Current worldwide nuclear cardiology practices and radiation exposure: results from the 65 country IAEA Nuclear Cardiology Protocols Cross-Sectional Study (INCAPS) Academic Article
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Daily Sedation Interruption in Mechanically Ventilated Critically Ill Patients Cared for With a Sedation Protocol Academic Article
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Deciding what type of evidence and outcomes to include in guidelines: article 5 in integrating and coordinating efforts in COPD guideline development. An official ATS/ERS workshop report Academic Article
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Decision aid on radioactive iodine treatment for early stage papillary thyroid cancer: update to study protocol with follow-up extension Academic Article
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Defining anabolic resistance Academic Article
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Delayed educational reminders for long-term medication adherence in ST-elevation myocardial infarction (DERLA-STEMI): Protocol for a pragmatic, cluster-randomized controlled trial Academic Article
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Delineating the Role of a Cohort of Clinical Research Nurses in a Pediatric Cooperative Clinical Trials Group Academic Article
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Depression and anxiety during the perinatal period Academic Article
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Description and Results of a Comprehensive Care Protocol for Overnight-Stay Spine Surgery in Adults Academic Article
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Design and rationale for RE-VERSE AD: A phase 3 study of idarucizumab, a specific reversal agent for dabigatran Academic Article
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Design considerations for randomised trials in orthopaedic fracture surgery Academic Article
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Designing and implementing a comparative effectiveness study of two strategies for delivering high quality CHD prevention: Methods and participant characteristics for the Heart to Health study Academic Article
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Determining the impact of a new physiotherapist-led primary care model for back pain: protocol for a pilot cluster randomized controlled trial Academic Article
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Development and feasibility testing of decision support for patients who are candidates for a prophylactic implantable defibrillator: a study protocol for a pilot randomized controlled trial Academic Article
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Development of a Conservative Protocol to Return Children and Youth to Activity Following Concussive Injury Academic Article
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Development of a bedside-applicable ultrasound protocol to estimate fat mass index derived from whole body dual-energy x-ray absorptiometry scans Academic Article
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Displaced supracondylar fractures of the humerus in children Academic Article
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Early detection and intervention for obsessive-compulsive disorder in childhood and adolescence Academic Article
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Economic evaluation of the prophylaxis for thromboembolism in critical care trial (E-PROTECT): study protocol for a randomized controlled trial Academic Article
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Effect of a Postoperative Multimodal Opioid-Sparing Protocol vs Standard Opioid Prescribing on Postoperative Opioid Consumption After Knee or Shoulder Arthroscopy Academic Article
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Effect of the introduction of helical CT on radiation dose in the investigation of pulmonary embolism Academic Article
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Effectiveness and cost-effectiveness of cognitive adaptation training as a nursing intervention in long-term residential patients with severe mental illness: study protocol for a randomized controlled trial Academic Article
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Effectiveness of pharmaceutical care at discharge in the emergency department: study protocol of a randomized controlled trial Academic Article
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Efficacy of ultra-micronized palmitoylethanolamide (um-PEA) in geriatric patients with chronic pain: study protocol for a series of N-of-1 randomized trials Academic Article
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Efficacy, safety, and treatment burden of treat-and-extend versus alternative anti-VEGF regimens for nAMD: a systematic review and meta-analysis Academic Article
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Encuesta nacional sobre los conocimientos impartidos en escuelas de medicina de Colombia sobre rehidratación parenteral en niños eutróficos mayores de un año con deshidratación por enfermedad diarreicaIván Academic Article
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Endovascular repair of ruptured abdominal aortic aneurysms: A systematic review and meta-analysis Academic Article
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Estimating the Reduction in the Radiation Burden From Nuclear Cardiology Through Use of Stress-Only Imaging in the United States and Worldwide Academic Article
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Evaluating probiotics for the prevention of ventilator-associated pneumonia: a randomised placebo-controlled multicentre trial protocol and statistical analysis plan for PROSPECT Academic Article
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Evaluation and Management of Skeletal Health in Celiac Disease: Position Statement Academic Article
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Evaluation of an initiation protocol of 4 mg of warfarin for atrial fibrillation in the outpatient setting. Academic Article
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Evaluation of multisystemic therapy pilot services in Services for Teens Engaging in Problem Sexual Behaviour (STEPS-B): study protocol for a randomized controlled trial Academic Article
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Evaluation of the effectiveness of robotic gait training and gait-focused physical therapy programs for children and youth with cerebral palsy: a mixed methods RCT Academic Article
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Exposure to bats: updated recommendations Academic Article
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FLUID trial: a protocol for a hospital-wide open-label cluster crossover pragmatic comparative effectiveness randomised pilot trial Academic Article
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Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis Academic Article
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Failure of Anticoagulant Thromboprophylaxis Academic Article
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Fit for School Study protocol: early child growth, health behaviours, nutrition, cardiometabolic risk and developmental determinants of a child's school readiness, a prospective cohort. Academic Article
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Fixation using alternative implants for the treatment of hip fractures (FAITH): design and rationale for a multi-centre randomized trial comparing sliding hip screws and cancellous screws on revision surgery rates and quality of life in the treatment of femoral neck fractures Academic Article
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Forearm Pronation and Supination Academic Article
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Fractionated manganese-enhanced MRI Academic Article
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Frequency of Screening for Weaning From Mechanical Ventilation Academic Article
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Frequent Hemodialysis Network (FHN) randomized trials: Study design Academic Article
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GISSI-3: effects of lisinopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after acute myocardial infarction. Gruppo Italiano per lo Studio della Sopravvivenza nell'infarto Miocardico. Academic Article
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GRADE guidelines: 14. Going from evidence to recommendations: the significance and presentation of recommendations Academic Article
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General practitioner use of a C-reactive protein point-of-care test to help target antibiotic prescribing in patients with acute exacerbations of chronic obstructive pulmonary disease (the PACE study): study protocol for a randomised controlled trial Academic Article
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Glycerin suppositories used prophylactically in premature infants (supp): A pilot randomized controlled trial Academic Article
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Good Outcome Associated with a Standardized Treatment Protocol Using Selective Postoperative Radiation in Patients with Clinical Stage I Adenocarcinoma of the Endometrium Academic Article
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Guidelines for Reporting Outcomes in Trial Protocols Academic Article
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HELPinKids&Adults Knowledge Synthesis of the Management of Vaccination Pain and High Levels of Needle Fear Academic Article
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Health care utilisation and costs associated with different treatment protocols for newly diagnosed childhood acute lymphoblastic leukaemia: A population-based study in Ontario, Canada Academic Article
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Helical CTPA in the investigation of pulmonary embolism: a 6-year review Academic Article
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Hip fracture evaluation with alternatives of total hip arthroplasty versus hemiarthroplasty (HEALTH): protocol for a multicentre randomised trial Academic Article
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How to write a surgical clinical research protocol: literature review and practical guide Academic Article
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Human Albumin Administration in Subarachnoid Hemorrhage: Results of an International Survey Academic Article
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Human Gene Marker/Therapy Clincal Protocols (Complete Updated Listings) Academic Article
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Hyperbaric Oxygen in Lower Limb Trauma (HOLLT); protocol for a randomised controlled trial Academic Article
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Hypothermia Pediatric Head Injury Trial: The Value of a Pretrial Clinical Evaluation Phase Academic Article
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Identification of Cancer Care and Protocol Characteristics Associated With Recruitment in Breast Cancer Clinical Trials Academic Article
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Identifying Prioritization Criteria to Supplement Critical Care Triage Protocols for the Allocation of Ventilators during a Pandemic Influenza Academic Article
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Identifying process and outcome indicators of successful transitions from child to adult mental health services: protocol for a scoping review Academic Article
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Impact of emergency department probiotic treatment of pediatric gastroenteritis: study protocol for the PROGUT (Probiotic Regimen for Outpatient Gastroenteritis Utility of Treatment) randomized controlled trial Academic Article
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Impact of hospital lockdown secondary to COVID-19 and past pandemics on surgical practice: A living rapid systematic review Academic Article
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Impact of routine in-hospital assessment of low-density lipoprotein levels and standardized orders on statin therapy in patients undergoing percutaneous coronary interventions. Academic Article
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Implementation of a Same-Day Discharge Protocol Following Total Laparoscopic Hysterectomy Academic Article
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Implementation of a data management program in a pediatric cancer unit in a low income country Academic Article
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Implementation trial of the basic life support termination of resuscitation rule: Reducing the transport of futile out-of-hospital cardiac arrests Academic Article
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Implementing evidence-based recommended practices for the management of patients with mild traumatic brain injuries in Australian emergency care departments: study protocol for a cluster randomised controlled trial Academic Article
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Implementing highly specialized and evidence-based pediatric eating disorder treatment: protocol for a mixed methods evaluation Academic Article
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Improved outcome for children with acute lymphoblastic leukemia: results of Dana-Farber Consortium Protocol 91-01 Academic Article
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Improvement evident but still necessary in clinical practice guideline quality: a systematic review Academic Article
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Improving access to community-based pulmonary rehabilitation: 3R protocol for real-world settings with cost-benefit analysis Academic Article
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Improving children’s health and development in British Columbia through nurse home visiting: a randomized controlled trial protocol Academic Article
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Improving communication with patients in post-traumatic amnesia: development and impact of a clinical protocol Academic Article
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Influenza and Respiratory Virus Surveillance, Vaccine Uptake, and Effectiveness at a Time of Cocirculating COVID-19: Protocol for the English Primary Care Sentinel System for 2020-2021 Academic Article
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Instituto Nacional de Ciência e Tecnologia em Medicina Translacional (INCT-TM): abordagens metodológicas Academic Article
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Intention-to-treat analysis may be more conservative than per protocol analysis in antibiotic non-inferiority trials: a systematic review Academic Article
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Intention-to-treat principle. Academic Article
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Intermittent versus continuous oxygen saturation monitoring for infants hospitalised with bronchiolitis: study protocol for a pragmatic randomised controlled trial. Academic Article
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Intrapleural Dornase and Tissue Plasminogen Activator in pediatric empyema (DTPA): a study protocol for a randomized controlled trial Academic Article
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Is a low transfusion threshold safe in critically ill patients with cardiovascular diseases? Academic Article
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Is stratification testing for treatment of chronic obstructive pulmonary disease exacerbations cost-effective in primary care? an early cost-utility analysis Academic Article
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Knowledge Translation Interventions for Critically Ill Patients Academic Article
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Letter reply to GRADE guidelines articles 14 and 15 Academic Article
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Letters Regarding Article by Mehilli et al, "Randomized Clinical Trial of Abciximab in Diabetic Patients Undergoing Elective Percutaneous Coronary Interventions After Treatment With a High Loading Dose of Clopidogrel" * Response Academic Article
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Longitudinal Youth in Transition Study (LYiTS): protocol for a multicentre prospective cohort study of youth transitioning out of child and adolescent mental health services at age 18 Academic Article
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Magnesium Sulphate for Eclampsia and Fetal Neuroprotection: A Comparative Analysis of Protocols Across Canadian Tertiary Perinatal Centres Academic Article
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Magnesium nebulization utilization in management of pediatric asthma (MagNUM PA) trial: study protocol for a randomized controlled trial Academic Article
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Management of Ontario children with acute lymphoblastic leukemia by the Dana-Farber Cancer Institute protocols. Academic Article
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Management of post-traumatic stress disorder Academic Article
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Management of urinary retention after surgical repair of hip fracture. Academic Article
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Massive hemorrhage protocol survey: Marked variability and absent in one-third of hospitals in Ontario, Canada Academic Article
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Massive transfusion in paediatric and adolescent trauma patients: Incidence, patient profile, and outcomes prior to a massive transfusion protocol Academic Article
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Maternal vitamin D supplementation during pregnancy and lactation to promote infant growth in Dhaka, Bangladesh (MDIG trial): study protocol for a randomized controlled trial Academic Article
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Mechanical Ventilator Weaning Protocols Driven by Nonphysician Health-Care Professionals Academic Article
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Medication use and its impact on high-cost health care users among older adults: protocol for the population-based matched cohort HiCOSTT study Academic Article
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Metformin in adults with type 1 diabetes: Design and methods of REducing with MetfOrmin Vascular Adverse Lesions (REMOVAL): An international multicentre trial Academic Article
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Moving forward in clinical research with master protocols Academic Article
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Nortriptyline in knee osteoarthritis (NortIKA Study): study protocol for a randomised controlled trial Academic Article
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Official Executive Summary of an American Thoracic Society/American College of Chest Physicians Clinical Practice Guideline: Liberation from Mechanical Ventilation in Critically Ill Adults Academic Article
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Optimizing antibiotics in residents of nursing homes: protocol of a randomized trial Academic Article
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Optimizing life success through residential immersive life skills programs for youth with disabilities: study protocol of a mixed-methods, prospective, comparative cohort study Academic Article
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Oral steroids for the resolution of otitis media with effusion (OME) in children (OSTRICH): study protocol for a randomised controlled trial Academic Article
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Oral surgery in patients with hereditary bleeding disorders Academic Article
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Outcomes in the offspring of mothers with pre-diabetes during pregnancy: a protocol for a systematic review Academic Article
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Pain Squad+ smartphone app to support real-time pain treatment for adolescents with cancer: protocol for a randomised controlled trial Academic Article
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Pattern of carboplatin-induced emesis Academic Article
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Periodic health examination, 1993 update: 2. Lowering the blood total cholesterol level to prevent coronary heart disease. Canadian Task Force on the Periodic Health Examination. Academic Article
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Perioperative bridging interruption with heparin for the patient receiving long-term anticoagulation Academic Article
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Perioperative multimodal optimisation in patients undergoing surgery for fractured neck of femur Academic Article
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Perspectives on evidence based practice in ABI rehabilitation. “Relevant Research”: Who decides? Academic Article
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Post-Transient Ischemic Attack Early Stroke Stratification: The ABCD2 Prognostic Aid Academic Article
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Practical Model-Based Dose Finding in Early-Phase Clinical Trials Academic Article
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Practical management of bleeding in patients receiving non-vitamin K antagonist oral anticoagulants Academic Article
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Practising evidence-based medicine: the design and implementation of a multidisciplinary team-driven extubation protocol. Academic Article
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Preconditioning Shields Against Vascular Events in Surgery (SAVES), a multicentre feasibility trial of preconditioning against adverse events in major vascular surgery: study protocol for a randomised control trial Academic Article
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Prehospital evaluation and economic analysis of different coronary syndrome treatment strategies - PREDICT - Rationale, Development and Implementation Academic Article
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Preparing a research protocol to improve chances for success Academic Article
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Preparing reports for publication and responding to reviewers' comments Academic Article
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Prevalence, Risk Factors, and Outcomes of Delirium in Mechanically Ventilated Adults* Academic Article
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Prevalence, risk factors, and outcomes associated with physical restraint use in mechanically ventilated adults Academic Article
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Prevention of Clostridium difficile Infection: A Systematic Survey of Clinical Practice Guidelines Academic Article
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Primary prophylaxis in severe haemophilia should be started at an early age but can be individualized Academic Article
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Procalcitonin-guided antibiotic use versus a standard approach for acute respiratory tract infections in primary care: study protocol for a randomised controlled trial and baseline characteristics of participating general practitioners [ISRCTN73182671] Academic Article
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Progression and Management of Duodenal Neoplasia in Familial Adenomatous Polyposis Academic Article
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Proposed motor development assessment protocol for epidemiological studies in children Academic Article
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Protocol adherence for continuously titrated interventions in randomized trials: an overview of the current methodology and case study Academic Article
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Protocol for a phase III, non-inferiority, randomised comparison of a new fibrinogen concentrate versus cryoprecipitate for treating acquired hypofibrinogenaemia in bleeding cardiac surgical patients: the FIBRES trial Academic Article
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Protocol for a randomised trial of higher versus lower intensity patient-provider communication interventions to reduce antibiotic misuse in two paediatric ambulatory clinics in the USA. Academic Article
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Protocol for a randomized controlled clinical trial investigating the effectiveness of Fast muscle Activation and Stepping Training (FAST) for improving balance and mobility in sub-acute stroke Academic Article
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Protocol of the COSMIN study: COnsensus-based Standards for the selection of health Measurement INstruments Academic Article
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Protocol-based treatment for children with cancer in low income countries in Latin America: A report on the recent meetings of the Monza International School of Pediatric Hematology/Oncology (MISPHO)-Part II Academic Article
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Protocolized versus non-protocolized weaning for reducing the duration of mechanical ventilation in critically ill adult patients Academic Article
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Protocolized versus non-protocolized weaning for reducing the duration of mechanical ventilation in critically ill adult patients Academic Article
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Protocolized vs. non-protocolized weaning for reducing the duration of mechanical ventilation in critically ill adult patients: Cochrane review protocol Academic Article
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Protocols to Improve the Care of Critically Ill Pediatric and Adult Patients Academic Article
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RIGHT for acupuncture: An extension of the RIGHT statement for clinical practice guidelines on acupuncture Academic Article
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Radiation from CT scans in paediatric trauma patients: Indications, effective dose, and impact on surgical decisions Academic Article
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Rationale and design of the Primary pREvention strategies at the community level to Promote Adherence of treatments to pREvent cardiovascular diseases trial number (CTRI/2012/09/002981) Academic Article
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Rationale, design, and methods for Canadian alliance for healthy hearts and minds cohort study (CAHHM) – a Pan Canadian cohort study Academic Article
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Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial Academic Article
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Re-evaluating the Inhibition of Stress Erosions (REVISE): a protocol for pilot randomized controlled trial Academic Article
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Recall of ICU Stay in Patients Managed With a Sedation Protocol or a Sedation Protocol With Daily Interruption Academic Article
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Recommended Clinical Practices for Maximizing Peritoneal Dialysis Clearances Academic Article
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Recruitment patterns in a large international randomized controlled trial of perioperative care in cancer patients Academic Article
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Reporting of planned statistical methods in published surgical randomised trial protocols: a protocol for a methodological systematic review Academic Article
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Results of Dana-Farber Cancer Institute Consortium protocols for children with newly diagnosed acute lymphoblastic leukemia (1981–1995) Academic Article
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Risks and Benefits of Oral Anticoagulation Compared With Clopidogrel Plus Aspirin in Patients With Atrial Fibrillation According to Stroke Risk Academic Article
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Rivaroxaban for Preventing Venous Thromboembolism in High-Risk Ambulatory Patients with Cancer: Rationale and Design of the CASSINI Trial Academic Article
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Role of patient preferences in clinical practice guidelines: a multiple methods study using guidelines from oncology as a case Academic Article
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Sleep to lower elevated blood pressure: study protocol for a randomized controlled trial Academic Article
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SodiUm SeleniTe Adminstration IN Cardiac Surgery (SUSTAIN CSX-trial): study design of an international multicenter randomized double-blinded controlled trial of high dose sodium-selenite administration in high-risk cardiac surgical patients Academic Article
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Solute Clearance Approach to Adequacy of Peritoneal Dialysis Academic Article
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Standardising costs or standardising care? Qualitative evaluation of the implementation and impact of a hospital funding reform in Ontario, Canada Academic Article
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Standardized Care Is Better Than Individualized Care for the Majority of Critically Ill Patients Academic Article
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Steroids In caRdiac Surgery (SIRS) trial: acute kidney injury substudy protocol of an international randomised controlled trial Academic Article
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Steroids in fluid and/or vasoactive infusion dependent pediatric shock: study protocol for a randomized controlled trial Academic Article
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Strategic use of new generation antidepressants for depression: SUN(^_^) D protocol update and statistical analysis plan Academic Article
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Studies of Left Ventricular Dysfunction (SOLVD)—Rationale, design and methods: Two trials that evaluate the effect of enalapril in patients with reduced ejection fraction Academic Article
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Study protocol for a randomized, controlled, superiority trial comparing the clinical and cost- effectiveness of integrated online mental health assessment-referral-care in pregnancy to usual prenatal care on prenatal and postnatal mental health and infant health and development: the Integrated Maternal Psychosocial Assessment to Care Trial (IMPACT) Academic Article
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Study to prospectively evaluate reamed intramedually nails in patients with tibial fractures (S.P.R.I.N.T.): Study rationale and design Academic Article
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Subgroup Analysis of Trials Is Rarely Easy (SATIRE): a study protocol for a systematic review to characterize the analysis, reporting, and claim of subgroup effects in randomized trials Academic Article
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Subgroup analyses in randomised controlled trials: cohort study on trial protocols and journal publications Academic Article
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Suggestions for the management of factor VIII inhibitors Academic Article
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Supporting the improvement and management of prescribing for urinary tract infections (SIMPle): protocol for a cluster randomized trial Academic Article
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Sustained Aeration of Infant Lungs (SAIL) trial: study protocol for a randomized controlled trial Academic Article
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Symptomatic venous thromboembolism after orthognathic operations: An audit Academic Article
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Systematic review and network meta-analysis of interventions for fibromyalgia: a protocol Academic Article
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Systematic review of basket trials, umbrella trials, and platform trials: a landscape analysis of master protocols Academic Article
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Tailoring treatment of haemophilia B: accounting for the distribution and clearance of standard and extended half-life FIX concentrates Academic Article
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The ACHRU-CPP versus usual care for older adults with type-2 diabetes and multiple chronic conditions and their family caregivers: study protocol for a randomized controlled trial Academic Article
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The Back to School asthma study: the effect of montelukast on asthma burden when initiated prophylactically at the start of the school year Academic Article
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The COSMIN study reached international consensus on taxonomy, terminology, and definitions of measurement properties for health-related patient-reported outcomes Academic Article
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The Canadian Biomarker Integration Network in Depression (CAN-BIND): magnetic resonance imaging protocols Academic Article
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The Effect of Change in a Labour Management Protocol on Caesarean Section Rate in Nulliparous Women Academic Article
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The Evaluation of an Interdisciplinary Pain Protocol in Long Term Care Academic Article
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The HAART cell phone adherence trial (WelTel Kenya1): a randomized controlled trial protocol Academic Article
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The Methodological Approach Used to Develop the 2013 Pain, Agitation, and Delirium Clinical Practice Guidelines for Adult ICU Patients Academic Article
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The PARADIGHM (physicians advancing disease knowledge in hypoparathyroidism) registry for patients with chronic hypoparathyroidism: study protocol and interim baseline patient characteristics Academic Article
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The Quality Initiative in Rectal Cancer (QIRC) trial: study protocol of a cluster randomized controlled trial in surgery Academic Article
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The Rehabilitation Treatment Specification System: Implications for Improvements in Research Design, Reporting, Replication, and Synthesis Academic Article
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The SYGMA programme of phase 3 trials to evaluate the efficacy and safety of budesonide/formoterol given ‘as needed’ in mild asthma: study protocols for two randomised controlled trials Academic Article
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The Use of Bowel Protocols in Critically Ill Adult Patients Academic Article
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The cardiac MRI substudy to ongoing telmisartan alone and in combination with ramipril global endpoint trial/telmisartan randomized assessment study in ACE-intolerant subjects with cardiovascular disease: analysis protocol and baseline characteristics Academic Article
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The effect of berberine on insulin resistance in women with polycystic ovary syndrome: detailed statistical analysis plan (SAP) for a multicenter randomized controlled trial Academic Article
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The effect of weekly text-message communication on treatment completion among patients with latent tuberculosis infection: study protocol for a randomised controlled trial (WelTel LTBI) Academic Article
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The effectiveness and cost-effectiveness of the Family Nurse Partnership home visiting programme for first time teenage mothers in England: a protocol for the Building Blocks randomised controlled trial Academic Article
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The effectiveness of a Supported Self-management task-shifting intervention for adult depression in Vietnam communities: study protocol for a randomized controlled trial Academic Article
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The effectiveness of interventions to treat obesity in survivors of childhood brain tumors: a systematic review protocol Academic Article
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The end of early-goal directed therapy? Academic Article
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The impact of chronic pain on opioid addiction treatment: a systematic review protocol Academic Article
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The predictors of Enhanced Recovery After Surgery utilization and practice variations in elective colorectal surgery: a provincial survey Academic Article
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The rationale and design of the Beta-blocker to LOwer CArdiovascular Dialysis Events (BLOCADE) Feasibility Study Academic Article
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Thromboembolism in children with acute lymphoblastic leukaemia treated on Dana-Farber Cancer Institute protocols: effect of age and risk stratification of disease Academic Article
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Thromboprophylaxis for hospitalized medical patients: A Multicenter Qualitative study Academic Article
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Thromboprophylaxis using combined intermittent pneumatic compression and pharmacologic prophylaxis versus pharmacologic prophylaxis alone in critically ill patients: study protocol for a randomized controlled trial Academic Article
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Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial Academic Article
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Treatment of Pediatric Diabetic Ketoacidosis in Canada: A Review of Treatment Protocols from Canadian Pediatric Emergency Departments Academic Article
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Trial of Repeated Analgesia with Kangaroo Mother Care (TRAKC Trial) Academic Article
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Two doses of rivaroxaban versus aspirin for prevention of recurrent venous thromboembolism Academic Article
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Understanding developmental language disorder - the Helsinki longitudinal SLI study (HelSLI): a study protocol Academic Article
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Unexplained infertility: a review of diagnosis, prognosis, treatment efficacy and management Academic Article
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Use of weaning protocols for reducing duration of mechanical ventilation in critically ill adult patients: Cochrane systematic review and meta-analysis Academic Article
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Using Problem-Based Case Studies to Learn About Knowledge Translation Interventions: An Inside Perspective Academic Article
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Using decision thresholds for ranking treatments in network meta-analysis results in more informative rankings Academic Article
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Validation of a new test that assesses functional performance of the upper extremity and neck (FIT-HaNSA) in patients with shoulder pathology Academic Article
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Validation of stroke-specific protocols for the 10-meter walk test and 6-minute walk test conducted using 15-meter and 30-meter walkways Academic Article
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Variability in clinical laboratory practice in testing for disorders of platelet function Academic Article
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Variation in diurnal sedation in mechanically ventilated patients who are managed with a sedation protocol alone or a sedation protocol and daily interruption Academic Article
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Waiving confidentiality for the greater good Academic Article
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XANTUS: rationale and design of a noninterventional study of rivaroxaban for the prevention of stroke in patients with atrial fibrillation Academic Article
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[MR imaging of ano-perineal suppurations]. Academic Article
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“Employment and arthritis: making it work” a randomized controlled trial evaluating an online program to help people with inflammatory arthritis maintain employment (study protocol) Academic Article
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“Push” versus “Pull” for mobilizing pain evidence into practice across different health professions: A protocol for a randomized trial Academic Article