Journal article
Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis
Abstract
BACKGROUND: Experimental data indicate that reducing factor XI levels attenuates thrombosis without causing bleeding, but the role of factor XI in the prevention of postoperative venous thrombosis in humans is unknown. FXI-ASO (ISIS 416858) is a second-generation antisense oligonucleotide that specifically reduces factor XI levels. We compared the efficacy and safety of FXI-ASO with those of enoxaparin in patients undergoing total knee …
Authors
Büller HR; Bethune C; Bhanot S; Gailani D; Monia BP; Raskob GE; Segers A; Verhamme P; Weitz JI
Journal
The New England Journal of Medicine, Vol. 372, No. 3, pp. 232–240
Publisher
Massachusetts Medical Society
Publication Date
January 15, 2015
DOI
10.1056/nejmoa1405760
ISSN
0028-4793