Benzamides Concept

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• A New Strategy for Preparing Molecular Imaging and Therapy Agents Using Fluorine-Rich (Fluorous) Soluble Supports  Journal Articles
• A phase II study of ispinesib (SB-715992) in patients with metastatic or recurrent malignant melanoma: a National Cancer Institute of Canada Clinical Trials Group trial  Journal Articles
• An evaluation of roflumilast and PDE4 inhibitors with a focus on the treatment of asthma  Journal Articles
• Assessing the Economic Value of a New Antidepressant  Journal Articles
• Betrixaban (PRT054021): pharmacology, Dose Selection and Clinical Studies  Journal Articles
• Betrixaban compared with warfarin in patients with atrial fibrillation: results of a phase 2, randomized, dose-ranging study (Explore-Xa)  Journal Articles
• Bruton’s tyrosine kinase (BTK) inhibitors alter blood glucose and insulin in obese mice but reduce inflammation independent of BTK  Journal Articles
• Cabazitaxel versus abiraterone or enzalutamide in poor prognosis metastatic castration-resistant prostate cancer: a multicentre, randomised, open-label, phase II trial  Journal Articles
• Capsaicin-induced airway obstruction in tracheally perfused guinea pig lungs.  Journal Articles
• Cerebral microbleeds and asundexian in non-cardioembolic ischemic stroke: Secondary analyses of the PACIFIC-STROKE randomized trial  Journal Articles
• Clinical and Molecular Studies of the Effect of Imatinib on Advanced Aggressive Fibromatosis (desmoid tumor)  Journal Articles
• Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non–Small Cell Lung Cancer  Journal Articles
• Comparison of Fatal or Irreversible Events With Extended‐Duration Betrixaban Versus Standard Dose Enoxaparin in Acutely Ill Medical Patients: An APEX Trial Substudy  Journal Articles
• Cost-effectiveness of enzalutamide versus apalutamide versus androgen deprivation therapy alone for the treatment of metastatic castration-sensitive prostate cancer in Canada  Journal Articles
• Current Incidence and Outcomes of Gastrointestinal Mesenchymal Tumors Including Gastrointestinal Stromal Tumors  Journal Articles
• Darexaban (YM150) versus enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: a randomised phase IIb dose confirmation study (ONYX-3)  Journal Articles
• Deep molecular responses achieved in patients with CML-CP who are switched to nilotinib after long-term imatinib  Journal Articles
• Determinants of Response to Roflumilast in Severe Chronic Obstructive Pulmonary Disease. Pooled Analysis of Two Randomized Trials  Journal Articles
• Dyspepsia  Journal Articles
• Effect of 1-Year Treatment with Roflumilast in Severe Chronic Obstructive Pulmonary Disease  Journal Articles
• Effect of Roflumilast and Inhaled Corticosteroid/Long-Acting β₂-Agonist on Chronic Obstructive Pulmonary Disease Exacerbations (RE²SPOND). A Randomized Clinical Trial  Journal Articles
• Effect of a leukotriene B4 receptor antagonist SC-53228 on ozone-induced airway hyperresponsiveness and inflammation in dogs.  Journal Articles
• Effect of extended‐duration thromboprophylaxis on venous thromboembolism and major bleeding among acutely ill hospitalized medical patients: a bivariate analysis  Journal Articles
• Effect of substituted benzamide drugs on rat striatal tyrosine hydroxylase  Journal Articles
• Effects of roflumilast in COPD patients receiving inhaled corticosteroid/long-acting β₂-agonist fixed-dose combination: RE²SPOND rationale and study design  Journal Articles
• Electrophysiological Evidence That Neurokinin A Acts Via NK‐1 Receptors in the Cat Dorsal Horn  Journal Articles
• Epigenetic therapy inhibits metastases by disrupting premetastatic niches  Journal Articles
• Esophageal gastrointestinal stromal tumor: report of 7 patients  Journal Articles
• Evaluation of bronchoconstriction induced by neurokinins and its inhibition by selective nonpeptide antagonists in conscious guinea pigs, using a double-chamber plethysmograph technique  Journal Articles
• Extended Thromboprophylaxis with Betrixaban in Acutely Ill Medical Patients  Journal Articles
• HDACi Delivery Reprograms Tumor-Infiltrating Myeloid Cells to Eliminate Antigen-Loss Variants  Journal Articles
• HDACi promotes inflammatory remodeling of the tumor microenvironment to enhance epitope spreading and antitumor immunity  Journal Articles
• Health-Related Quality of Life in Patients With Major Depression Who Are Treated With Moclobemide  Conferences
• Health-related quality of life in patients with major depression who are treated with moclobemide.  Journal Articles
• Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer  Journal Articles
• Identification of both NK₁ and NK₂ receptors in guinea‐pig airways  Journal Articles
• Imatinib Mesylate in Patients With Adenoid Cystic Cancers of the Salivary Glands Expressing c-kit: A Princess Margaret Hospital Phase II Consortium Study  Journal Articles
• Imatinib for Melanomas Harboring Mutationally Activated or Amplified KIT Arising on Mucosal, Acral, and Chronically Sun-Damaged Skin  Journal Articles
• Imatinib mesylate in children and adolescents with cancer  Journal Articles
• Inhibition of thrombin by antithrombin III in the presence of certain glycosaminoglycans found in the mammalian aorta  Journal Articles
• Inhibitors of Bacterial Cystathionine β-Lyase:  Leads for New Antimicrobial Agents and Probes of Enzyme Structure and Function  Journal Articles
• Involvement of NK1 and NK2 Receptors in Pulmonary Responses Elicited by Non-adrenergic, Non-cholinergic Vagal Stimulation in Guinea-pigs  Journal Articles
• Is There a Role for Betrixaban to Prevent Stroke in Medically Ill Patients?  Journal Articles
• Metabolic response by FDG-PET to imatinib correlates with exon 11 KIT mutation and predicts outcome in patients with mucosal melanoma  Journal Articles
• NK₁and NK₂Receptors Mediate Tachykinin and Resiniferatoxin-induced Bronchospasm in Guinea Pigs  Journal Articles
• NK₂ receptors mediate plasma extravasation in guinea‐pig lower airways  Journal Articles
• Neurokinin (NK₂) receptors mediate nonadrenergic noncholinergic contractile responses to electrical stimulation and resiniferatoxin in guinea pig trachea  Journal Articles
• New Anticoagulants for Atrial Fibrillation  Journal Articles
• PROLIFERATION OF GUINEA-PIG TRACHEAL EPITHELIAL-CELLS IN COCULTURE WITH RAT DORSAL-ROOT GANGLION NEURAL CELLS  Journal Articles
• PSA declines and survival in patients with metastatic castration-resistant prostate cancer treated with enzalutamide  Journal Articles
• Phase II study of ispinesib in recurrent or metastatic squamous cell carcinoma of the head and neck  Conferences
• Phosphodiesterase-4 inhibition in COPD  Journal Articles
• Potentiation of long-acting β2-agonist and glucocorticoid responses in human airway epithelial cells by modulation of intracellular cAMP  Journal Articles
• Profile of betrixaban and its potential in the prevention and treatment of venous thromboembolism  Journal Articles
• Prokinetics for functional dyspepsia  Journal Articles
• Proliferation of guinea pig tracheal epithelial cells in coculture with rat dorsal root ganglion neural cells  Journal Articles
• Prospective, Single-Arm Trial Evaluating Changes in Uptake Patterns on Prostate-Specific Membrane Antigen–Targeted ¹⁸F-DCFPyL PET/CT in Patients with Castration-Resistant Prostate Cancer Starting Abiraterone or Enzalutamide  Journal Articles
• RUBY-1: a randomized, double-blind, placebo-controlled trial of the safety and tolerability of the novel oral factor Xa inhibitor darexaban (YM150) following acute coronary syndrome  Journal Articles
• Roflumilast attenuates allergen-induced inflammation in mild asthmatic subjects  Journal Articles
• Roflumilast for asthma: Efficacy findings in mechanism of action studies  Journal Articles
• Roflumilast for asthma: Efficacy findings in non-placebo-controlled comparator and dosing studies  Journal Articles
• Roflumilast for asthma: Weighing the evidence  Journal Articles
• Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo‐controlled clinical trial  Journal Articles
• Safety and efficacy of an oral CCR3 antagonist in patients with asthma and eosinophilic bronchitis: a randomized, placebo‐controlled clinical trial  Journal Articles
• Safety of enzalutamide in patients with metastatic castration‐resistant prostate cancer previously treated with docetaxel: Expanded access in North America  Journal Articles
• Single photon emission tomography assessment of cerebral dopamine D2 receptor blockade in schizophrenia  Journal Articles
• Substance P-induced histamine release in tracheally perfused guinea pig lungs  Journal Articles
• Systemic Therapy in Men With Metastatic Castration-Resistant Prostate Cancer: American Society of Clinical Oncology and Cancer Care Ontario Clinical Practice Guideline  Journal Articles
• Tachykinin receptor antagonists inhibit hyperpnea-induced bronchoconstriction in guinea pigs.  Journal Articles
• The Effects of Extracellular Calcium-Sensing Receptor Ligands on the Contractility of Pregnant Human Myometrium In Vitro  Journal Articles
• The HDAC class I-specific inhibitor entinostat (MS-275) effectively relieves epigenetic silencing of the LAT2 gene mediated by AML1/ETO  Journal Articles
• The Non-Vitamin K Antagonist Oral Anticoagulants in Heart Disease: Section V—Special Situations  Journal Articles
• The effects of a CXCR1/CXCR2 antagonist on neutrophil migration in mild atopic asthmatic subjects  Journal Articles
• The mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms  Journal Articles
• Topical roflumilast for the treatment of psoriasis  Journal Articles
• XXIII International Association for Comparative Research on Leukemia and Related Diseases Symposium: from Molecular Pathogenesis to Targeted Therapy in Leukemia and Solid Tumors  Conferences