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Proliferation of guinea pig tracheal epithelial...
Journal article

Proliferation of guinea pig tracheal epithelial cells in coculture with rat dorsal root ganglion neural cells

Abstract

Neuropeptides secreted by sensory afferent nerves in airways may modulate growth of airway epithelial cells. To determine whether airway sensory C-fiber nerves secrete neuropeptides that stimulate airway epithelial cell proliferation, we measured S-phase traversal in guinea pig tracheal epithelial (GPTE) cells after coculture with rat dorsal root ganglion (DRG) cells. GPTE cells were grown in subconfluent culture on collagen-coated filters for …

Authors

White SR; Garland A; Gitter B; Rodger I; Alger LE; Necheles J; Nawrocki AR; Solway J

Journal

American Journal of Physiology-Lung Cellular and Molecular Physiology, Vol. 268, No. 6, pp. L957–L965

Publisher

American Physiological Society

Publication Date

June 1, 1995

DOI

10.1152/ajplung.1995.268.6.l957

ISSN

1040-0605

Associated Experts

Ian Rodger

Professor Emeritus, Faculty of Health Sciences
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Labels

Medical Subject Headings (MeSH)

AnimalsAnimals, NewbornBenzamidesBromodeoxyuridineCalcitonin Gene-Related PeptideCalcitonin Gene-Related Peptide Receptor AntagonistsCell CommunicationCell CycleCell DivisionCells, CulturedEpithelial CellsEpitheliumGanglia, SpinalGuinea PigsNeurokinin ANeurokinin-1 Receptor AntagonistsNeuronsPeptide FragmentsPiperidinesRatsRats, Sprague-DawleyReceptors, TachykininS PhaseTrachea

Fields of Research (FoR)

3201 Cardiovascular medicine and haematology3208 Medical physiology
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