Journal article
The effects of a CXCR1/CXCR2 antagonist on neutrophil migration in mild atopic asthmatic subjects
Abstract
BACKGROUND: Neutrophils are effector cells recruited to airways in patients with asthma. Migration of neutrophils occurs predominantly through activation of the CXCR1 and CXCR2 receptors by CXC chemokines, including IL-8 and Gro-α. The dual CXCR1/CXCR2 antagonist SCH 527123 has been developed to target neutrophil migration to alleviate airway neutrophilia. This study investigated the effects of SCH 527123 on neutrophil levels within the bone …
Authors
Todd CM; Salter BM; Murphy DM; Watson RM; Howie KJ; Milot J; Sadeh J; Boulet L-P; O'Byrne PM; Gauvreau GM
Journal
Pulmonary Pharmacology & Therapeutics, Vol. 41, , pp. 34–39
Publisher
Elsevier
Publication Date
12 2016
DOI
10.1016/j.pupt.2016.09.005
ISSN
1094-5539