Journal article
NK1 and NK2 Receptors Mediate Tachykinin and Resiniferatoxin-induced Bronchospasm in Guinea Pigs
Abstract
The present study characterized neurokinin receptor-mediated bronchoconstrictor responses in anesthetized guinea pigs. Thus, we have compared the actions of the selective neurokinin 1 (NK1) (CP-99,994) and neurokinin 2 (NK2) (SR-48,968) receptor antagonists against dose-response curves (DRC) induced by intravenously administered substance P (SP), neurokinin A (NKA), neurokinin B (NKB), beta Ala8-NKA (4-10),Sar9-Met(O2)11SP, and single dose …
Authors
Foulon DM; Champion E; Masson P; Rodger IW; Jones TR
Journal
American Journal of Respiratory and Critical Care Medicine, Vol. 148, No. 4_pt_1, pp. 915–921
Publisher
American Thoracic Society
Publication Date
October 1993
DOI
10.1164/ajrccm/148.4_pt_1.915
ISSN
1073-449X