Journal article
Neurokinin (NK2) receptors mediate nonadrenergic noncholinergic contractile responses to electrical stimulation and resiniferatoxin in guinea pig trachea
Abstract
In the present study we characterized the receptor(s) that mediates non-adrenergic non-cholinergic (NANC) contractions of isolated guinea pig cervical trachea, using CP-99,994, a selective neurokinin (NK1) receptor antagonist, and SR-48,968, a selective neurokinin (NK2) receptor antagonist. The activity of these two antagonists was determined against contractions to the selective agonists ([beta Ala8]NKA(4-10) for NK2 and [Sar9,Met(O2)11]SP for …
Authors
Charette L; Foulon D; Rodger IW; Jones TR
Journal
Canadian Journal of Physiology and Pharmacology, Vol. 72, No. 2, pp. 182–188
Publisher
Canadian Science Publishing
Publication Date
February 1, 1994
DOI
10.1139/y94-028
ISSN
0008-4212