Analgesics, Opioid Concept

subject area of

• 'INSPIRED' Approaches to Better Care for Patients with Advanced COPD  Academic Article
• A 2013 updated systematic review & meta-analysis of 36 randomized controlled trials; no apparent effects of non steroidal anti-inflammatory agents on the risk of bleeding after tonsillectomy  Academic Article
• A Randomized Double-Blind Crossover Comparison of Continuous and Intermittent Subcutaneous Administration of Opioid for Cancer Pain  Conference Paper
• A Randomized, Double-Blind, Crossover Comparison of the Efficacy and Safety of Oral Controlled-Release Tramadol and Placebo in Patients with Painful Osteoarthritis  Academic Article
• A Review of the Neurobiological Basis of Trauma-Related Dissociation and Its Relation to Cannabinoid- and Opioid-Mediated Stress Response: a Transdiagnostic, Translational Approach  Academic Article
• A survey of Canadian cancer patients’ perspectives on the characteristics and treatment of breakthrough pain  Academic Article
• Absence of cross-tolerance and the situational specificity of tolerance  Academic Article
• Acute neuropsychiatric findings in a patient receiving fentanyl for cancer pain  Academic Article
• Adaptation of stress-induced mucosal pathophysiology in rat colon involves opioid pathways  Academic Article
• Adding Gabapentin to a multimodal regimen does not reduce acute pain, opioid consumption or chronic pain after total hip arthroplasty  Academic Article
• Addressing inaccurate claims about the Canadian opioid guideline.  Academic Article
• Addressing the limitations of the CDC guideline for prescribing opioids for chronic noncancer pain  Academic Article
• Adverse Outcomes Associated with Prescription Opioids for Acute Low Back Pain: A Systematic Review and Meta-Analysis  Academic Article
• Adverse outcomes associated with opioid prescription for acute low back pain: a systematic review protocol  Academic Article
• An analysis of errors, discrepancies, and variation in opioid prescriptions for adult outpatients at a teaching hospital  Academic Article
• Analgesic, sedative, antipsychotic, and neuromuscular blocker use in Canadian intensive care units: a prospective, multicentre, observational study  Academic Article
• Apnea and Oxygen Desaturations in Children Treated with Opioids after Adenotonsillectomy for Obstructive Sleep Apnea Syndrome  Academic Article
• Are patients' goals in treatment associated with expected treatment outcomes? Findings from a mixed-methods study on outpatient pharmacological treatment for opioid use disorder.  Academic Article
• Assessing the impact of an opioid prescribing guideline for dentists in Ontario, Canada  Academic Article
• Association Between Socio-Demographic and Health Functioning Variables Among Patients with Opioid Use Disorder Introduced by Prescription: A Prospective Cohort Study.  Academic Article
• Association between cannabis use and treatment outcomes in patients receiving methadone maintenance treatment: a systematic review protocol  Academic Article
• Association of worker characteristics and early reimbursement for physical therapy, chiropractic and opioid prescriptions with workers’ compensation claim duration, for cases of acute low back pain: an observational cohort study  Academic Article
• Attitudes and self-reported practices of orthopedic providers regarding prescription opioid use  Academic Article
• Attitudes toward the Canadian Guideline for Safe and Effective Use of Opioids for Chronic Non-Cancer Pain: A qualitative study  Academic Article
• Auricular Acupuncture Reduces Intraoperative Fentanyl Requirement During Hip Arthroplasty - A Randomized Double-Blinded Study  Academic Article
• Auricular acupuncture for pain relief after total hip arthroplasty – a randomized controlled study  Academic Article
• Betamethasone does not seem to provide benefits in postoperative pain and swelling when added to ketorolac after placement of multiple implants  Academic Article
• Brief review: Obstetric care and perioperative analgesic management of the addicted patient  Academic Article
• Buprenorphine transdermal system in adults with chronic low back pain: A randomized, double-blind, placebo-controlled crossover study, followed by an open-label extension phase  Academic Article
• Canadian Guideline for Safe and Effective Use of Opioids for Chronic Non-Cancer Pain: Implications for Pain Physicians  Academic Article
• Cannabinoids in the Management of Musculoskeletal Pain  Academic Article
• Caregiver-fabricated illness in a child prescribed long-term opioids and benzodiazepines  Academic Article
• Characteristics of Referrals to an Inpatient Hospice and a Survey of General Practitioner Perceptions of Palliative Care  Academic Article
• Chronic exposure of neonatal rat adrenomedullary chromaffin cells to opioidsin vitroblunts both hypoxia and hypercapnia chemosensitivity  Academic Article
• Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2α and protein kinase A  Academic Article
• Clinical indications associated with opioid initiation for pain management in Ontario, Canada: a population-based cohort study  Academic Article
• Clonidine Does Not Reduce Pain or Opioid Consumption After Noncardiac Surgery  Academic Article
• Cochrane in CORR®: Interventions for the Reduction of Prescribed Opioid Use in Chronic Non-cancer Pain  Academic Article
• Cochrane in CORR®: Pre‐emptive and Preventive Opioids for Postoperative Pain in Adults Undergoing All Types of Surgery  Academic Article
• Comparative study of continuous extrapleural intercostal nerve block and lumbar epidural morphine in post-thoracotomy pain.  Academic Article
• Comparing the contribution of prescribed opioids to opioid-related hospitalizations across Canada: A multi-jurisdictional cross-sectional study  Academic Article
• Comparison of Opioid Prescribing Among Cancer and Noncancer Patients Aged 18–64: Analysis Using Administrative Data  Academic Article
• Construction of the Sophia Observation withdrawal Symptoms-scale (SOS) for critically ill children  Academic Article
• Continuous Intravenous Administration of Ketorolac Reduces Pain and Morphine Consumption After Total Hip or Knee Arthroplasty  Academic Article
• Contributions of prescribed and non-prescribed opioids to opioid related deaths: population based cohort study in Ontario, Canada  Academic Article
• Cost-effectiveness analysis of oxycodone with naloxone versus oxycodone alone for the management of moderate-to-severe pain in patients with opioid-induced constipation in Canada  Academic Article
• Daily Sedation Interruption in Mechanically Ventilated Critically Ill Patients Cared for With a Sedation Protocol  Academic Article
• Debating the opioid guidelines: context.  Academic Article
• Debating the opioid guidelines: corrections.  Academic Article
• Dental Opioid Prescription Characteristics and the Risk of New, Persistent Use  Academic Article
• Dexamethasone Perioperative Coanalgesia in Lumbar Spine Fusion  Academic Article
• Diagnosis, Characterization, and 3-Month Outcome After Detoxification of 39 Patients With Narcotic Bowel Syndrome  Academic Article
• Does Low Urine Creatinine Level Indicate the Presence of Urine Alcohol in Methadone Maintenance Treatment Patients?  Academic Article
• Does opiate premedication influence postoperative analgesia? A prospective study  Academic Article
• Effect of Intravenous Fentanyl on Ticagrelor Absorption and Platelet Inhibition Among Patients Undergoing Percutaneous Coronary Intervention  Academic Article
• Effect of Opioid Versus Non-Opioid Analgesia on Surgical Pleth Index and Biomarkers of Surgical Stress During Neurosurgery for Brain Tumors: Preliminary Findings.  Academic Article
• Efficacy and safety of controlled-release oxycodone and standard therapies for postoperative pain after knee or hip replacement.  Academic Article
• Emergency Department–initiated Interventions for Patients With Opioid Use Disorder: A Systematic Review  Academic Article
• Enhanced recovery after surgery (ERAS) pathways in breast reconstruction: systematic review and meta-analysis of the literature  Academic Article
• Epidural Opioid Analgesia and Neonatal Respiratory Depression  Academic Article
• Equianalgesic Dose Ratios for Opioids  Academic Article
• European Association for Palliative Care (EAPC) recommended framework for the use of sedation in palliative care  Academic Article
• Evaluation of pain management in medical transfer of trauma patients by air  Academic Article
• Evidence from rats that morphine tolerance is a learned response.  Academic Article
• Evidence-Based Recommendations on the Pharmacological Management of Osteoarthritis and Chronic Low Back Pain: An Asian Consensus  Academic Article
• Factors Associated With Opioid Use in Long-term Cancer Survivors  Academic Article
• Fentanyl by Continuous Subcutaneous Infusion for the Management of Cancer Pain  Academic Article
• GWAS-identified genetic variants associated with medication-assisted treatment outcomes in patients with opioid use disorder: a systematic review and meta-analysis protocol  Academic Article
• Gabapentin, opioids, and the risk of opioid-related death: A population-based nested case–control study  Academic Article
• Guideline for opioid therapy and chronic noncancer pain  Academic Article
• Hamilton acute pain service safety study: using root cause analysis to reduce the incidence of adverse events  Academic Article
• Has Province-Wide Symptom Screening Changed Opioid Prescribing Rates in Older Patients With Cancer?  Academic Article
• Healthcare provider knowledge, attitudes, beliefs, and practices surrounding the prescription of opioids for chronic non-cancer pain in North America: protocol for a mixed-method systematic review  Academic Article
• High percentage of endodontists who participated in a survey prescribe opioids to their patients  Academic Article
• High-Dose Opioid Prescribing and Opioid-Related Hospitalization: A Population-Based Study  Academic Article
• Homology Models of μ-Opioid Receptor with Organic and Inorganic Cations at Conserved Aspartates in the Second and Third Transmembrane Domains  Academic Article
• Hormone Replacement Therapy and Opioid Tapering for Opioid-Induced Hypogonadism Among Patients with Chronic Noncancer Pain: A Systematic Review  Academic Article
• Hydromorphone versus morphine: a historical cohort study to evaluate the quality of postoperative analgesia  Academic Article
• Iatrogenic addiction or dependence as a result of prescription oxycodone use in persons with chronic noncancer pain: A systematic review  Academic Article
• Identifying appropriate outcomes to help evaluate the impact of the Canadian Guideline for Safe and Effective Use of Opioids for Non-Cancer Pain  Academic Article
• Identifying patient-important outcomes in medication-assisted treatment for opioid use disorder patients: a systematic review protocol  Academic Article
• Impact of ABCB1 and CYP2B6 Genetic Polymorphisms on Methadone Metabolism, Dose and Treatment Response in Patients with Opioid Addiction: A Systematic Review and Meta-Analysis  Academic Article
• Impact of Physician and Patient Gender on Pain Management in the Emergency Department—A Multicenter Study  Academic Article
• Impact of a Comprehensive Safety Initiative on Patient-controlled Analgesia Errors  Academic Article
• Impact of delisting high‐strength opioid formulations from a public drug benefit formulary on opioid utilization in Ontario, Canada  Academic Article
• Impact of preoperative opioid use on health outcomes after bariatric surgery  Academic Article
• Impaired gastric emptying in mechanically ventilated, critically ill patients  Academic Article
• Implementation of the quality management system improves postoperative pain treatment: a prospectivepre-/post-interventional questionnaire study  Academic Article
• Individual opioids, and long- versus short-acting opioids, for chronic noncancer pain  Academic Article
• International Stakeholder Community of Pain Experts and Leaders Call for an Urgent Action on Forced Opioid Tapering  Academic Article
• Interventions to Influence Opioid Prescribing Practices for Chronic Noncancer Pain: A Systematic Review and Meta-Analysis  Academic Article
• Intraadministration associations: Conditional hyperalgesia elicited by morphine onset cues.  Academic Article
• Intraarterial Lidocaine for Pain Control in Uterine Artery Embolization: A Prospective, Randomized Study  Academic Article
• Intravenous Morphine and Topical Tetracaine for Treatment of Pain in Preterm Neonates Undergoing Central Line Placement  Academic Article
• Is preoperative opioid utilization an important factor in predicting phantom limb pain?  Academic Article
• Knockdown of spinal metabotropic glutamate receptor 1 (mGluR1) alleviates pain and restores opioid efficacy after nerve injury in rats  Academic Article
• Knowledge, Perceptions and Attitudes toward Chronic Pain and Its Management: A Cross-Sectional Survey of Frontline Pharmacists in Ontario, Canada  Academic Article
• Long-Acting Patient-Controlled Opioids Are Not Associated With More Postoperative Hypoxemia Than Short-Acting Patient-Controlled Opioids After Noncardiac Surgery  Academic Article
• Long-Term Outcome of the Management of Chronic Neuropathic Pain: A Prospective Observational Study  Academic Article
• Management of Acute Pain From Non–Low Back, Musculoskeletal Injuries  Academic Article
• Meta-analysis of Opioids for Chronic Pain—Reply  Academic Article
• Methadone and Fluconazole  Academic Article
• Methadone dosing strategies in preterm neonates can be simplified  Academic Article
• Methylprednisolone Does Not Reduce Acute Postoperative Pain After Cardiac Surgery: Subanalysis of a Randomized Clinical Trial.  Academic Article
• Modified Delphi Process for the Development of Choosing Wisely for Inflammatory Bowel Disease  Academic Article
• Morphine for elective endotracheal intubation in neonates: a randomized trial [ISRCTN43546373]  Academic Article
• Morphine overdose from error propagation on an acute pain service  Academic Article
• Most critically ill patients are perceived to die in comfort during withdrawal of life support: a Canadian multicentre study  Academic Article
• New Canadian guidance on opioid use for chronic pain: necessary but not sufficient  Academic Article
• Non-steroidal or opioid analgesia use for children with musculoskeletal injuries (the No OUCH study): statistical analysis plan  Academic Article
• Nurses' Educational Needs for Pain Management of Post-Cardiac Surgery Patients  Academic Article
• Occurrence, Causes, and Outcome of Delirium in Patients With Advanced Cancer  Academic Article
• Opioid Analgesia for Acute Abdominal Pain in Children: A Systematic Review and Meta‐analysis  Academic Article
• Opioid Dose and Drug-Related Mortality in Patients With Nonmalignant Pain  Academic Article
• Opioid Prescribing Among Cancer and Non-cancer Patients: Time Trend Analysis in the Elderly Using Administrative Data  Academic Article
• Opioid Prescribing for the Treatment of Acute Pain in Children on Hospital Discharge  Academic Article
• Opioid Prescription After Pain Assessment: A Population-Based Cohort of Elderly Patients With Cancer  Academic Article
• Opioid Use in Athletes: A Systematic Review  Academic Article
• Opioid Utilization and Perception of Pain Control in Hospitalized Patients: A Cross-Sectional Study of 11 Sites in 8 Countries  Academic Article
• Opioid and Benzodiazepine Use in End-Stage Renal Disease: A Systematic Review  Academic Article
• Opioid use and risk of liver fibrosis in HIV/hepatitis C virus-coinfected patients in Canada  Academic Article
• Opioid-Free Analgesia for Supratentorial Craniotomies: A Systematic Review  Academic Article
• Opioids and chronic pain.  Academic Article
• Opioids and chronic pain.  Academic Article
• Opioids for Chronic Noncancer Pain: A Systematic Review and Meta-analysis  Academic Article
• Opioids for chronic non-cancer pain: a protocol for a systematic review of randomized controlled trials  Academic Article
• Opioids for chronic noncancer pain: a meta-analysis of effectiveness and side effects  Academic Article
• Pain Management for Nonsyndromic Craniosynostosis: Adequate Analgesia in a Pediatric Cohort?  Academic Article
• Pain and Opioid Addiction: A Systematic Review and Evaluation of Pain Measurement in Patients with Opioid Dependence on Methadone Maintenance Treatment  Academic Article
• Patient Values and Preferences Regarding Opioids for Chronic Noncancer Pain: A Systematic Review  Academic Article
• Patient-Controlled Analgesia Plus Background Opioid Infusion for Postoperative Pain in Children  Academic Article
• Perceptions and Impact of the 2017 Canadian Guideline for Opioid Therapy and Chronic Noncancer Pain: A Cross-Sectional Study of Canadian Physicians  Academic Article
• Perioperative Opioid Administration  Academic Article
• Perioperative Pain and Addiction Interdisciplinary Network (PAIN) clinical practice advisory for perioperative management of buprenorphine: results of a modified Delphi process  Academic Article
• Perioperative gabapentin reduces 24 h opioid consumption and improves in-hospital rehabilitation but not post-discharge outcomes after total knee arthroplasty with peripheral nerve block  Academic Article
• Perioperative nonopioid analgesia reduces postoperative opioid consumption in knee arthroscopy: a systematic review and meta-analysis  Academic Article
• Postoperative pain control following minimally invasive correction of pectus excavatum in pediatric patients: A systematic review  Academic Article
• Predictors of Prolonged Opioid Use After Initial Prescription for Acute Musculoskeletal Injuries in Adults  Academic Article
• Predonation Prescription Opioid Use: A Novel Risk Factor for Readmission After Living Kidney Donation  Academic Article
• Pregabalin and the Risk for Opioid-Related Death: A Nested Case–Control Study  Academic Article
• Pregabalin reduces postoperative opioid consumption and pain for 1 week after hospital discharge, but does not affect function at 6 weeks or 3 months after total hip arthroplasty  Academic Article
• Prescriber adherence to guidelines for chronic noncancer pain management with opioids: Systematic review and meta-analysis.  Academic Article
• Prevalence of Prescribed Opioid Claims Among Persons With Traumatic Spinal Cord Injury in Ontario, Canada: A Population-Based Retrospective Cohort Study  Conference Paper
• Prevalence, Risk Factors, and Outcomes of Delirium in Mechanically Ventilated Adults*  Academic Article
• Prevalence, risk factors, and outcomes associated with physical restraint use in mechanically ventilated adults  Academic Article
• Procedural pain in newborns at risk for neurologic impairment  Academic Article
• Prospective study on Incidence and Functional Impact of Transient Neurologic Symptoms Associated with 1%Versus  5% Hyperbaric Lidocaine in Short Urologic Procedures  Academic Article
• Protocol for a multicenter randomized controlled trial comparing a non-opioid prescription to the standard of care for pain control following arthroscopic knee and shoulder surgery  Academic Article
• Psychological Characteristics, Female Sex, and Opioid Use Predict Acute Postoperative Pain in Patients Surgically Treated for Thumb Base Osteoarthritis: A Cohort Study  Academic Article
• Randomized control trial of ultrasound-guided erector spinae block versus shoulder periarticular anesthetic infiltration for pain control after arthroscopic shoulder surgery  Academic Article
• Randomized controlled trial of gabapentin as an adjunct to perioperative analgesia in total hip arthroplasty patients  Academic Article
• Rebuttal: Will the new opioid guidelines harm more people than they help? Yes.  Academic Article
• Recall of ICU Stay in Patients Managed With a Sedation Protocol or a Sedation Protocol With Daily Interruption  Academic Article
• Recent Developments in Palliative Cancer Care  Academic Article
• Rectal indomethacin reduces postoperative pain and morphine use after cardiac surgery  Academic Article
• Referrals of Cancer versus Non-Cancer Patients to A Palliative Care Consult Team: Do They Differ?  Academic Article
• Reformulation of controlled-release oxycodone and pharmacy dispensing patterns near the US-Canada border.  Academic Article
• Relevance of opioid guidelines in the emergency room (ROGER)  Academic Article
• Remifentanil for endotracheal intubation in neonates: a randomised controlled trial  Academic Article
• Reply to Vozoris: Opioids for Dyspnea in Chronic Obstructive Pulmonary Disease: Short on the Details  Academic Article
• Reporting of IMMPACT-recommended core outcome domains among trials assessing opioids for chronic non-cancer pain  Academic Article
• Response to “Clarification from the College of Physicians and Surgeons of BC on commentary about limitations of the CDC guideline for prescribing opioids”  Academic Article
• Response to “Opioid warning label”  Academic Article
• Response to “Opioids for chronic pain”  Academic Article
• Response to “Role of regulators in safe prescribing of opioids”  Academic Article
• Response to “understanding the behavioural determinants of opioid prescribing among family physicians: a qualitative study”  Academic Article
• Response.  Academic Article
• Risk of medication overuse headache across classes of treatments for acute migraine  Academic Article
• Safety of Morphine in Nonintubated Infants in the Neonatal Intensive Care Unit  Academic Article
• Safety profile of morphine following surgery in neonates  Academic Article
• Satisfactory Analgesia with Minimal Emesis in Day Surgeries (SAME DayS): a protocol for a randomised controlled trial of morphine versus hydromorphone  Academic Article
• Satisfactory analgesia with minimal emesis in day surgeries: a randomised controlled trial of morphine versus hydromorphone  Academic Article
• Sedation Interruption for Mechanically Ventilated Patients—Reply  Academic Article
• Sedation and Analgesia in Adult Patients: Evaluation of a Staged-Dose System Based on Body Weight for Use in Abdominal Interventional Radiology  Academic Article
• Single-incision, minimally invasive total hip arthroplasty*1Length doesnʼt matter  Academic Article
• Some thoughts on curing noncancer chronic pain with opioids.  Academic Article
• Study protocol for two complementary trials of non-steroidal or opioid analgesia use for children aged 6 to 17 years with musculoskeletal injuries (the No OUCH study)  Academic Article
• Study with important limitations does not show important differences in pain and satisfaction between patients who receive opioids and those who do not after tooth extractions  Academic Article
• Successful Reversal of Hyperalgesia/Myoclonus Complex with Low-Dose Ketamine Infusion  Academic Article
• Suprascapular and Interscalene Nerve Block for Shoulder Surgery  Academic Article
• Target-Controlled Dosing of Remifentanil During Cardiac Surgery Reduces Postoperative Hyperalgesia  Academic Article
• Ten-year experience with pediatric laparoscopic appendectomy—are we getting better?  Academic Article
• The Burden of Opioid-Related Mortality in the United States  Academic Article
• The Complications of Scar Formation Associated With Intrathecal Pump Placement  Academic Article
• The Impact of Delirium on the Circadian Distribution of Breakthrough Analgesia in Advanced Cancer Patients  Academic Article
• The Impact of Therapy on Quality of Life and Mood in Neuropathic Pain: What Is the Effect of Pain Reduction?  Academic Article
• The Potential Role of α2Agonists for Noncardiac Surgery  Academic Article
• The analgesic effects of intrathecal morphine in comparison with ultrasound‐guided transversus abdominis plane block after caesarean section: a randomised controlled trial at a Ugandan regional referral hospital  Academic Article
• The analgesic efficacy of pre-operative bilateral erector spinae plane (ESP) blocks in patients having ventral hernia repair  Academic Article
• The association between age of onset of opioid use and comorbidity among opioid dependent patients receiving methadone maintenance therapy  Academic Article
• The authors respond to “Inconsistencies in the 2017 Canadian Guideline for Opioids for Chronic Noncancer Pain”  Academic Article
• The authors respond to “The 2017 Canadian opioid guideline: already time for an overhaul”  Academic Article
• The cancer patient with chronic pain due to herpes zoster  Academic Article
• The future of precision medicine in opioid use disorder: inclusion of patient-important outcomes in clinical trials  Academic Article
• The impact of chronic liver disease in patients receiving active pharmacological therapy for opioid use disorder: One-year findings from a prospective cohort study  Academic Article
• The impact of chronic pain on opioid addiction treatment: a systematic review protocol  Academic Article
• The novel analgesic, F 13640, produces intra- and postoperative analgesia in a rat model of surgical pain  Academic Article
• The perioperative patient on buprenorphine: a systematic review of perioperative management strategies and patient outcomes  Academic Article
• The prescription opioid epidemic: a call to action for our profession  Academic Article
• The risk of infective endocarditis among people who inject drugs: a retrospective, population-based time series analysis  Academic Article
• The role of formalin-induced pain in morphine tolerance, withdrawal, and reward.  Academic Article
• The stigma of low opioid prescription in the hospitalized multimorbid elderly in Italy  Academic Article
• The use of lignocaine to reduce pain on i.v. injection of diluted nalbuphine.  Academic Article
• Treating patients versus numbers.  Academic Article
• Treatment outcomes in patients with opioid use disorder initiated by prescription: a systematic review protocol  Academic Article
• Trends and uptake of new formulations of controlled-release oxycodone in Canada  Academic Article
• Trends in high-dose opioid prescribing in Canada.  Academic Article
• Trends in opioid use and dosing among socio-economically disadvantaged patients.  Academic Article
• Upregulation of an opioid-mediated antinociceptive mechanism in transgenic mice over-expressing substance P in the spinal cord  Academic Article
• Use of local anesthetic (0.25% bupivacaine) for pain control after pediatric cardiac catheterization: A randomized controlled trial  Academic Article
• Use of long-acting, vs short-acting, opioids for chronic pain was linked to unintentional overdose  Academic Article
• Usefulness of the Brief Pain Inventory in Patients with Opioid Addiction Receiving Methadone Maintenance Treatment  Academic Article
• Using placebos as an opioid-sparing method of pain management  Academic Article
• What Epidural Opioid Results in the Best Analgesia Outcomes and Fewest Side Effects After Surgery?  Academic Article
• Will the new opioid guidelines harm more people than they help? Yes.  Academic Article
• Women with Pain due to Osteoarthritis: The Efficacy and Safety of a Once-Daily Formulation of Tramadol  Academic Article