Ram Gupta
Professor Emeritus, Pathology & Molecular Medicine

journal articles

• Biosynthesis of Vitamin B₆ in Yeast. Incorporation Pattern of Trioses..  ChemInform.  34:no-no. 2003
• Biosynthesis of Vitamin B₆ in Yeast. Incorporation Pattern of Trioses.  Journal of Organic Chemistry.  68:3486-3493. 2003
• Determination of Gabapentin in Plasma by Liquid Chromatography with Fluorescence Detection after Solid-Phase Extraction with a C18 Column.  Clinical Chemistry.  48:2259-2261. 2002
• 2‘-Hydroxypyridoxol, a Biosynthetic Precursor of Vitamins B₆ and B₁ in Yeast.  Journal of the American Chemical Society.  124:4542-4543. 2002
• Biosynthesis of Vitamin B₆ in Yeast:  Incorporation Pattern of Glucose.  Journal of the American Chemical Society.  123:11353-11359. 2001
• Incorporation of¹³C glucose into nicotinamide inE. coliand inS. cerevisiae.  Canadian Journal of Chemistry.  79:418-425. 2001
• Serum bupivacaine concentrations during continuous extrapleural infusion.  Canadian Journal of Anaesthesia.  44:367-370. 1997
• Simultaneous Determination of Zopiclone and Its Two Major Metabolites (N-Oxide and N-Desmethyl) in Human Biological Fluids by Column Liquid Chromatography After Solid-Phase Extraction.  Journal of Liquid Chromatography and Related Technologies.  19:699-709. 1996
• Optimization of the determination of 4-aminopyridine in human serum and urine by column liquid chromatography.  Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences.  677:183-189. 1996
• Column liquid chromatographic determination of clozapine and N-desmethylclozapine in human serum using solid-phase extraction.  Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences.  673:311-315. 1995
• Column liquid chromatographic determination of paroxetine in human serum using solid-phase extraction.  Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences.  661:362-365. 1994
• Column liquid chromatographic determination of bupivacaine in human serum using solid-phase extraction.  Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences.  658:113-119. 1994
• Optimization of a column liquid chromatographic procedure for the determination of plasma salbutamol concentration.  Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences.  654:205-211. 1994
• Therapeutic monitoring of sertraline.  Clinical Chemistry.  40:498-499. 1994
• Influence of renal clearance on peripheral homovanillic acid measurements in healthy subjects and schizophrenic patients.  Schizophrenia Research.  11:33-40. 1993
• An Improved Solid Phase Extraction Procedure for the Determination of Antidepressants in Serum by Column Liquid Chromatography.  Journal of Liquid Chromatography and Related Technologies.  16:2751-2765. 1993
• Determination of plasma homovanillic acid by liquid chromatography with electrochemical detection.  Journal of Chromatography - Biomedical Applications.  582:236-241. 1992
• Platelet α₂-Adrenergic Receptors in Depressed Patients and Healthy Volunteers: The Effects of Desipramine.  Pharmacopsychiatry.  25:199-206. 1992
• Drug level monitoring: antidepressants.  Journal of Chromatography - Biomedical Applications.  576:183-211. 1992
• Determination of Fluoxetine and Norfluoxetine in Serum by Liquid Chromatography with Fluorescence Detection.  Journal of Liquid Chromatography and Related Technologies.  13:3785-3797. 1990
• Simplified fluorometric determination of salicylate in plasma.  Clinical Chemistry.  36:1690-1691. 1990
• Improved sample preparation in determination of urinary metanephrines by liquid chromatography with electrochemical detection.  Clinical Chemistry.  36:538-540. 1990
• Determination of trichloroethanol, the active metabolite of chloral hydrate, in plasma by liquid chromatography.  Journal of Chromatography A.  500:655-659. 1990
• Improved stability of phenylbutazone for its determination by liquid chromatography.  Journal of Chromatography - Biomedical Applications.  530:160-163. 1990
• Determination of glyburide in human plasma by liquid chromatography with fluorescene detection.  Journal of Liquid Chromatography and Related Technologies.  12:1741-1758. 1989
• Neuroblastoma and Catecholamines.  Annals of Clinical Biochemistry.  26:456-457. 1989
• Concentration response relationships of amiodarone and desethylamiodarone.  American Heart Journal.  115:1208-1213. 1988
• Determination of catecholamines in body fluids.  Journal of Chromatography - Biomedical Applications.  427:359-359. 1988
• Determination of isoniazid in plasma by liquid chromatography.  Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences.  425:441-443. 1988
• Determination of unconjugated 3-methoxy-4-hydroxyphenylglycol by liquid chromatography for monitoring inhibition of monoamine oxidase activity in plasma..  Clinical Chemistry.  33:2078-2080. 1987
• The role of the laboratory in acute poisoning: case histories.  Clinical Biochemistry.  19:127-131. 1986
• Liquid chromatographic determination of inhibition of monoamine oxidase activity in platelet rich plasma of depressed patients treated with phenelzine.  Clinica Chimica Acta.  152:63-69. 1985
• Drug level monitoring: sedative hypnotics.  Journal of Chromatography - Biomedical Applications.  340:139-172. 1985
• Determination of trazodone in human plasma by liquid chromatography with fluorescence detection.  Journal of Chromatography - Biomedical Applications.  342:442-446. 1985
• Liquid chromatographic determination of mexiletine and tocainide in human plasma with fluorescence detection after reaction with a modified o-phthalaldehyde reagent.  Journal of Chromatography - Biomedical Applications.  344:221-230. 1985
• Specificity of the combined dexamethasone suppression and TRH/TSH tests in melancholia.  Progress in Neuro-Psychopharmacology and Biological Psychiatry.  9:655-659. 1985
• Liquid-chromatographic determination of amiodarone and its N-desethyl metabolite in plasma..  Clinical Chemistry.  30:1423-1424. 1984
• Liquid Chromatographie determination of urinary metanephrines after pre-column oxidation to vanillin.  Clinica Chimica Acta.  135:143-150. 1983
• Colorimetric determination of acetaminophen.  Clinical Biochemistry.  16:220-221. 1983
• Liquid-chromatographic determination of nadolol in plasma..  Clinical Chemistry.  29:1085-1087. 1983
• Determination of tricyclic antidepressant drugs by gas chromatography with the use of a capillary column.  Clinical Biochemistry.  16:94-97. 1983
• Analysis of barbiturates in blood by high-performance liquid chromatography.  Journal of Chromatography - Biomedical Applications.  233:437-437. 1982
• A placebo‐controlled study to determine the efficacy of oral disopyramide phosphate for the prophylaxis of ventricular dysrhythmias after acute myocardial infarction..  British Journal of Clinical Pharmacology.  14:519-527. 1982
• Absorption and antidysrhythmic activity of oral disopyramide phosphate after acute myocardial infarction..  British Journal of Clinical Pharmacology.  14:529-537. 1982
• High-performance liquid chromatographic procedure for simultaneous determination of SKF 78729A and its N-acetyl metabolite.  Journal of Chromatography - Biomedical Applications.  231:492-496. 1982
• Liquid-chromatographic determination of pentobarbital in plasma with use of a resin column and an alkaline mobile phase..  Clinical Chemistry.  28:1772-1774. 1982
• The Pharmacokinetics and Pharmacodynamics of Minaxolone.  Journal of Clinical Pharmacology.  22:316-320. 1982
• Liquid-chromatographic determination of ethylene glycol in plasma..  Clinical Chemistry.  28:32-33. 1982
• Determination of minaxolone (CCI 12923) by gas chromatography with nitrogen-sensitive detection.  Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences.  224:496-499. 1981
• Analysis of chlorpromazine in plasma: Effect of specimen storage.  Clinica Chimica Acta.  109:351-354. 1981
• Oral disopyramide phosphate absorption in acute myocardial infarction.  Annals of the Royal College of Physicians and Surgeons of Canada.  14. 1981
• Theophylline and dyphylline.  CANADIAN MEDICAL ASSOCIATION JOURNAL.  125:425. 1981
• Plasma levels and tricyclic antidepressant therapy: Part 2. Pharmacokinetic, clinical and toxicologic aspects.  Biopharmaceutics and Drug Disposition.  1:283-305. 1980
• THE PHARMACOKINETICS AND PHARMACODYNAMICS OF MINAXOLONE.  Anesthesiology.  53:S48-S48. 1980
• GC and HPLC determination of meprobamate in plasma.  Journal of Separation Science.  3:419-420. 1980
• Identification of misused drugs in the clinical laboratory.  Clinical Biochemistry.  13:184-184. 1980
• Plasma levels and tricyclic antidepressant therapy: Part I. A review of assay methods.  Biopharmaceutics and Drug Disposition.  1:259-278. 1980
• Valproic acid in plasma, as determined by liquid chromatography..  Clinical Chemistry.  25:1984-1985. 1979
• Guidelines for Clinical use in Interpreting Tricyclic Plasma Levels.  Canadian Journal of Psychiatry.  24:532-536. 1979
• Gas-chromatographic analysis for valproic acid as phenacyl esters..  Clinical Chemistry.  25:1303-1305. 1979
• The biosynthesis of the Lythraceae alkaloids. I. The lysine-derived fragment.  Canadian Journal of Chemistry.  57:1606-1614. 1979
• Fluorescence photometric determination of disopyramide and mono-N-dealkylated disopyramide in plasma after separation by thin-layer chromatography.  Analytical Chemistry.  51:455-458. 1979
• The biosynthetic route from ornithine to proline..  Journal of Biological Chemistry.  254:640-647. 1979
• Measurement of Therapeutic Concentrations of Tricyclic Antidepressants in Serum.  Drug Metabolism Reviews.  9:79-97. 1979
• Fluorescence photometric quantitation of procainamide and N-acetylprocainamide in plasma after separation by thin-layer chromatography.  Analytical Chemistry.  50:197-199. 1978
• Estimation of theophylline in plasma by thin-layer chromatography.  Clinical Biochemistry.  11:42-45. 1978
• Estimation of maprotiline in serum by gas-chromatography, with use of a nitrogen-specific detector..  Clinical Chemistry.  23:1849-1852. 1977
• Chemical detection of pheochromocytoma..  CANADIAN MEDICAL ASSOCIATION JOURNAL.  116:1113-1114. 1977
• Determination of carbamazepine in serum..  Clinical Chemistry.  23:616-616. 1977
• Gas-liquid chromatographic determination of primidone in plasma.  Journal of Chromatography A.  132:140-144. 1977
• Thin-layer chromatographic method for the quantitative analysis of paracetamol (N-acetyl-p-aminophenol) in blood plasma.  Journal of Chromatography - Biomedical Applications.  143:112-114. 1977
• Estimation of amitriptyline and its metabolites in serum and urine by GLC using nitrogen-specific detector.  Clinical Biochemistry.  9:247-251. 1976
• Thin layer chromatographic method for the quantitative analysis of paracetamol (N acetyl p aminophenol) in blood plasma.  Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences.  143:112-114. 1976
• Precolumn Methylation of Phenobarbital with Trimethylanilinium Hydroxide.  Clinical Chemistry.  21:1346-1347. 1975
• Screening for the Major Methadone Metabolite and Methamphetamine in Urine.  Journal of Chromatographic Science.  12:67-70. 1974
• General method for the determination of precursor configuration in biosynthetic precursor-product relations. Derivation of pipecolic acid from D-lysine, and of piperidine alkaloids from L-lysine.  Journal of the American Chemical Society.  95:4040-4047. 1973
• Modified Pisano Method for Estimating Urinary Metanephrines.  Clinical Chemistry.  19:611-614. 1973
• Diphenylhydantoin Interference with Spectrophotometric Barbiturate Estimations.  Clinical Chemistry.  19:433-433. 1973
• A rapid method for the radioimmunoassay of urinary aldosterone.  Clinical Biochemistry.  6:285-294. 1973
• Serum gamma glutamyl transpeptidase in liver disorders.  Clinical Biochemistry.  6:41-45. 1973
• The Determination of Plasma Ethanol by Gas Liquid Chromatography using Trichloracetic Acid as the Protein Precipitant.  Journal of Forensic Sciences.  17:453-455. 1972
• Biosynthesis of Vitamin B6.  Journal of Biological Chemistry.  247:1869-1882. 1972
• Additions and Corrections - Biosynthesis of Pyridoxine.  Journal of the American Chemical Society.  93:1828-1828. 1971
• Biosynthesis of pyridoxine.  Journal of the American Chemical Society.  93:518-520. 1971
• Biosynthesis of the piperidine nucleus: The occurrence of two pathways from lysine.  Phytochemistry.  9:2329-2334. 1970
• Biosynthesis of lycopodine. Incorporation of pelletierine.  Journal of the American Chemical Society.  92:1074-1075. 1970
• Biosynthesis of the Lycopodium alkaloids: the origin of cernuine.  Journal of the Chemical Society D: Chemical Communications.  0:409-409. 1970
• Biosynthesis of the lythraceae alkaloids: incorporation of lysine.  Journal of the Chemical Society D: Chemical Communications.  0:396-396. 1970
• Biosynthesis of N-methylpelletierine.  Phytochemistry.  8:1937-1944. 1969
• Biosynthesis of the Piperidine Nucleus.  Journal of Biological Chemistry.  244:88-94. 1969
• Biosynthesis of the piperidine alkaloids.  Journal of natural products.  31:318-326. 1968
• Biosynthesis of lycopodine.  Journal of the American Chemical Society.  90:1360-1361. 1968
• Biosynthesis of the piperidine alkaloids: origin of the piperidine nucleus of N-methylisopelletierine.  Chemical Communications.  0:85-85. 1968
• The biosynthesis of sedamine.  Canadian Journal of Chemistry.  45:1275-1285. 1967
• Biosynthesis of the piperidine alkaloids. The C₆–C₂units of sadamine and lobinaline.  Chemical Communications.  0:893-894. 1966
• BIOSYNTHETIC INCORPORATION OF ONE-CARBON UNITS INTO BERBERINE AND HYDRASTINE.  Canadian Journal of Chemistry.  43:133-144. 1965
• One-carbon units in the biosynthesis of hydrastine and berberine.  Biochemical and Biophysical Research Communications.  13:115-120. 1963
• 3,4-DIHYDRO-β-CARBOLINES: I. THE ALKYLATION OF 1-SUBSTITUTED N_β-ALKYL-3,4-DIHYDRO-β-CARBOLINE ANHYDRO BASES.  Canadian Journal of Chemistry.  40:2041-2048. 1962
• 3,4-DIHYDRO-β-CARBOLINES: II. THE EXHAUSTIVE METHYLATION OF 3,4-DIHYDRO-β-CARBOLINE.  Canadian Journal of Chemistry.  40:2049-2056. 1962