Journal article
The Pharmacokinetics and Pharmacodynamics of Minaxolone
Abstract
Plasma concentrations of minaxolone were measured in 15 female patients during and for up to 3 hours after a minaxolone and nitrous oxide anesthetic. Nine patients received a single dose and six patients two or three doses of minaxolone. Plasma minaxolone decay can be described by two-compartment kinetics. Distribution is rapid, with a mean half-life of 2.1 minutes, and the elimination half-life is short (47 minutes). Plasma clearance is high …
Authors
Dunn GL; Morison DH; McChesney J; Pine W; Kumana CR; Gupta RN
Journal
The Journal of Clinical Pharmacology, Vol. 22, No. 7, pp. 316–320
Publisher
Wiley
Publication Date
7 1982
DOI
10.1002/j.1552-4604.1982.tb02681.x
ISSN
0091-2700