The Pharmacokinetics and Pharmacodynamics of Minaxolone Journal Articles

abstract

• Abstract: Plasma concentrations of minaxolone were measured in 15 female patients during and for up to 3 hours after a minaxolone and nitrous oxide anesthetic. Nine patients received a single dose and six patients two or three doses of minaxolone. Plasma minaxolone decay can be described by two‐compartment kinetics. Distribution is rapid, with a mean half‐life of 2.1 minutes, and the elimination half‐life is short (47 minutes). Plasma clearance is high (1.55 l./min). Plasma levels of minaxolone at recovery were similar in patients receiving both single and multiple doses, suggesting a valid relationship between plasma level and effect. It is suggested that minaxolone may be a suitable agent for administration by continuous infusion.

authors

• DUNN, GL
• MORISON, DH
• McCHESNEY, J
• KUMANA, CR
• Gupta, Ram

status

• published 

publication date

• July 1982

has subject area

• 1115 Pharmacology and Pharmaceutical Sciences (FoR)
• Adult (MeSH)
• Anesthesia (MeSH)
• Anesthetics (MeSH)
• Female (MeSH)
• Genital Diseases, Female (MeSH)
• Hemodynamics (MeSH)
• Humans (MeSH)
• Kinetics (MeSH)
• Pharmacology & Pharmacy (Science Metrix)
• Pregnanes (MeSH)
• Pregnanolone (MeSH)

published in

• Journal of Clinical Pharmacology  Journal

keywords

• Adult
• Anesthesia
• Anesthetics
• Female
• Genital Diseases, Female
• Hemodynamics
• Humans
• Kinetics
• Pregnanes
• Pregnanolone

Digital Object Identifier (DOI)

• 10.1002/j.1552-4604.1982.tb02681.x

PubMed ID

• 7107980

start page

• 316

end page

• 320

volume

• 22

issue

• 7