The Pharmacokinetics and Pharmacodynamics of Minaxolone Journal Articles uri icon

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abstract

  • Abstract: Plasma concentrations of minaxolone were measured in 15 female patients during and for up to 3 hours after a minaxolone and nitrous oxide anesthetic. Nine patients received a single dose and six patients two or three doses of minaxolone. Plasma minaxolone decay can be described by two‐compartment kinetics. Distribution is rapid, with a mean half‐life of 2.1 minutes, and the elimination half‐life is short (47 minutes). Plasma clearance is high (1.55 l./min). Plasma levels of minaxolone at recovery were similar in patients receiving both single and multiple doses, suggesting a valid relationship between plasma level and effect. It is suggested that minaxolone may be a suitable agent for administration by continuous infusion.

authors

  • DUNN, GL
  • MORISON, DH
  • McCHESNEY, J
  • KUMANA, CR
  • Gupta, Ram

publication date

  • July 1982