Modified Pisano Method for Estimating Urinary Metanephrines Academic Article uri icon

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abstract

  • Abstract The Pisano method [Clin. Chim. Acta 5, 406 (1960)] for estimating urinary metanephrine, used in the screening of hypertensive persons for pheochromocytoma, has been modified by replacing ion-exchange chromatography with differential solvent extraction. An internal standard is incorporated to correct for procedural losses. Interference from some related compounds is negligible. Normal-range values obtained for various age groups by the present method compare well with those obtained by Pisano‚Äôs procedure, but are higher than values reported for more specific methods.

publication date

  • June 1, 1973

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