Biosynthesis of Vitamin B₆ in Yeast. Incorporation Pattern of Trioses Journal Articles

abstract

• The biosynthetic origin of the C(3) unit, C-6,5,5', of pyridoxamine was investigated in two yeasts, Candida utilis ATCC 9256 and Saccharomyces cerevisiae ATCC 7752. The incorporation patterns within pyridoxamine bishydrochloride derived from variously multiply (13)C- and (2)H-labeled samples of glycerol and glyceraldehyde, established by NMR spectroscopy, indicate that the three-carbon unit C-6,5,5' of pyridoxamine is derived intact from a triose.

authors

• Zeidler, Johannes
• Gupta, Ram
• Sayer, Brian G
• Spenser, Ian D

status

• published 

publication date

• May 1, 2003

has subject area

• 0304 Medicinal and Biomolecular Chemistry (FoR)
• 0305 Organic Chemistry (FoR)
• Candida (MeSH)
• Carbon Isotopes (MeSH)
• Deuterium (MeSH)
• Escherichia coli (MeSH)
• Glyceraldehyde (MeSH)
• Glycerol (MeSH)
• Molecular Structure (MeSH)
• Nuclear Magnetic Resonance, Biomolecular (MeSH)
• Organic Chemistry (Science Metrix)
• Pyridoxamine (MeSH)
• Saccharomyces cerevisiae (MeSH)
• Trioses (MeSH)
• Vitamin B 6 (MeSH)

published in

• Journal of Organic Chemistry  Journal

keywords

• Candida
• Carbon Isotopes
• Deuterium
• Escherichia coli
• Glyceraldehyde
• Glycerol
• Molecular Structure
• Nuclear Magnetic Resonance, Biomolecular
• Pyridoxamine
• Saccharomyces cerevisiae
• Trioses
• Vitamin B 6

Digital Object Identifier (DOI)

• 10.1021/jo020730k

PubMed ID

• 12713350

start page

• 3486

end page

• 3493

volume

• 68

issue

• 9