Journal article
Optimization of the determination of 4-aminopyridine in human serum and urine by column liquid chromatography
Abstract
Two convenient reversed-phase column liquid chromatographic procedures are described for the determination of 4-aminopyridine in human serum and urine. A 0.5-ml aliquot of serum after the addition of a 0.5-ml solution of 4-(aminomethyl)pyridine in 0.1 M Na2HPO4 as the internal standard is passed through a 1-ml BondElut C18 silica extraction column. The column is selectively washed to remove acidic, neutral and weakly basic compounds. The …
Authors
Gupta RN; Hansebout RR
Journal
Journal of Chromatography B, Vol. 677, No. 1, pp. 183–189
Publisher
Elsevier
Publication Date
February 1996
DOI
10.1016/0378-4347(95)00426-2
ISSN
1570-0232