selected scholarly activity
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academic article
- Deletion of transcription factor AP‐2β from the developing murine trabecular meshwork region leads to progressive glaucomatous changes. Journal of Neuroscience Research. 100:638-652. 2022
- Lens Fibrosis: Understanding the Dynamics of Cell Adhesion Signaling in Lens Epithelial-Mesenchymal Transition. Frontiers in Cell and Developmental Biology. 10:886053. 2022
- MMP9 Differentially Regulates Proteins Involved in Actin Polymerization and Cell Migration during TGF-β-Induced EMT in the Lens. International Journal of Molecular Sciences. 22:11988-11988. 2021
- Progressive Loss of Retinal Ganglion Cells in Activating Protein-2β Neural Crest Cell Knockout Mice. Current Eye Research. 46:1509-1515. 2021
- Conditional Deletion of AP-2β in the Periocular Mesenchyme of Mice Alters Corneal Epithelial Cell Fate and Stratification. International Journal of Molecular Sciences. 22:8730-8730. 2021
- Corneal development: Role of the periocular mesenchyme and bi-directional signaling. Experimental Eye Research. 201:108231-108231. 2020
- AP-2β is required for formation of the murine trabecular meshwork and Schlemm's canal. Experimental Eye Research. 195:108042-108042. 2020
- β-Catenin/Smad3 Interaction Regulates Transforming Growth Factor-β-Induced Epithelial to Mesenchymal Transition in the Lens. International Journal of Molecular Sciences. 20:2078-2078. 2019
- Relationship between neural crest cell specification and rare ocular diseases. Journal of Neuroscience Research. 97:7-15. 2019
- Conditional Deletion of AP-2α and AP-2β in the Developing Murine Retina Leads to Altered Amacrine Cell Mosaics and Disrupted Visual Function. Investigative Ophthalmology and Visual Science. 59:2229-2229. 2018
- Dual function of TGFβ in lens epithelial cell fate: implications for secondary cataract. Molecular Biology of the Cell. 28:907-921. 2017
- Matrix metalloproteinase 9 is associated with peritoneal membrane solute transport and induces angiogenesis through β-catenin signaling. Nephrology Dialysis Transplantation. 32:gfw076-gfw076. 2017
- Aberrant Collagen Composition of the Trabecular Meshwork Results in Reduced Aqueous Humor Drainage and Elevated IOP in MMP-9 Null Mice. Investigative Ophthalmology and Visual Science. 57:5984-5984. 2016
- β-Catenin/CBP–Dependent Signaling Regulates TGF-β–Induced Epithelial to Mesenchymal Transition of Lens Epithelial Cells. Investigative Ophthalmology and Visual Science. 57:5736-5736. 2016
- AP-2β Is a Downstream Effector of PITX2 Required to Specify Endothelium and Establish Angiogenic Privilege During Corneal Development. Investigative Ophthalmology and Visual Science. 57:1072-1072. 2016
- Conditional deletion of AP-2β in the cranial neural crest results in anterior segment dysgenesis and early-onset glaucoma. Disease Models and Mechanisms. 9:849-861. 2016
- RhoA/ROCK Signaling Regulates TGFβ-Induced Epithelial-Mesenchymal Transition of Lens Epithelial Cells through MRTF-A. Molecular Medicine. 22:713-723. 2016
- AP‐2α is required after lens vesicle formation to maintain lens integrity. Developmental Dynamics. 243:1298-1309. 2014
- Matrix Metalloproteinase-9–Null Mice Are Resistant to TGF-β–Induced Anterior Subcapsular Cataract Formation. American Journal of Pathology. 184:2001-2012. 2014
- Altered expression of transforming growth factor beta 1 and matrix metalloproteinase-9 results in elevated intraocular pressure in mice.. Molecular Vision. 19:684-695. 2013
- Nuclear translocation of myocardin-related transcription factor-A during transforming growth factor beta-induced epithelial to mesenchymal transition of lens epithelial cells.. Molecular Vision. 19:1017-1028. 2013
- Activation of the Hedgehog Signaling Pathway in the Developing Lens Stimulates EctopicFoxE3Expression and Disruption in Fiber Cell Differentiation. Investigative Ophthalmology and Visual Science. 53:3316-3316. 2012
- Overlapping expression patterns and redundant roles for AP-2 transcription factors in the developing mammalian retina. Developmental Dynamics. 241:814-829. 2012
- AP-2α knockout mice exhibit optic cup patterning defects and failure of optic stalk morphogenesis. Human Molecular Genetics. 19:1791-1804. 2010
- Development and use of the lens epithelial explant system to study lens differentiation and cataractogenesis. Progress in Retinal and Eye Research. 29:135-143. 2010
- Effect of delivery of MMP inhibitors from PDMS as a model IOL material on PCO markers. Clinical Materials. 31:2399-2407. 2010
- Platelet derived growth factor B and epithelial mesenchymal transition of peritoneal mesothelial cells. Matrix Biology. 29:97-106. 2010
- Ocular Gene Transfer of Active TGF-β Induces Changes in Anterior Segment Morphology and Elevated IOP in Rats. Investigative Ophthalmology and Visual Science. 51:308-308. 2010
- Co-operative roles for E-cadherin and N-cadherin during lens vesicle separation and lens epithelial cell survival. Developmental Biology. 326:403-417. 2009
- Temporal changes in MMP mRNA expression in the lens epithelium during anterior subcapsular cataract formation. Experimental Eye Research. 88:323-330. 2009
- Corneal epithelial cell adhesion and growth on EGF-modified aminated PDMS. Journal of Biomedical Materials Research Part A. 9999A:NA-NA. 2009
- Cell autonomous roles for AP-2α in lens vesicle separation and maintenance of the lens epithelial cell phenotype. Developmental Dynamics. 237:602-617. 2008
- Matrix metalloproteinases as mediators of primary and secondary cataracts. Expert Review of Ophthalmology. 2:931-938. 2007
- The role of Hsp70 and Hsp90 in TGF-beta-induced epithelial-to-mesenchymal transition in rat lens epithelial explants.. Molecular Vision. 13:2248-2262. 2007
- Conditional Deletion of Activating Protein 2α (AP-2α) in the Developing Retina Demonstrates Non-Cell-Autonomous Roles for AP-2α in Optic Cup Development. Molecular and Cellular Biology. 27:7497-7510. 2007
- Genetic analysis indicates that transcription factors AP-2alpha and Pax6 cooperate in the normal patterning and morphogenesis of the lens.. Molecular Vision. 13:1215-1225. 2007
- Adenoviral gene transfer of bioactive TGFbeta1 to the rodent eye as a novel model for anterior subcapsular cataract.. Molecular Vision. 13:457-469. 2007
- The keratocyte: Corneal stromal cell with variable repair phenotypes. American Journal of Ophthalmology. 143:197-197. 2007
- Lens-Specific Expression of TGF-β Induces Anterior Subcapsular Cataract Formation in the Absence of Smad3. Investigative Ophthalmology and Visual Science. 47:3450-3450. 2006
- Matrix Metalloproteinase Inhibitors Suppress Transforming Growth Factor-β-Induced Subcapsular Cataract Formation. American Journal of Pathology. 168:69-79. 2006
- The keratocyte: Corneal stromal cell with variable repair phenotypes. The International Journal of Biochemistry and Cell Biology. 38:1625-1631. 2006
- EGF-grafted PDMS surfaces in artificial cornea applications. Clinical Materials. 26:7286-7296. 2005
- Targeted Deletion ofAP-2α Leads to Disruption in Corneal Epithelial Cell Integrity and Defects in the Corneal Stroma. Investigative Ophthalmology and Visual Science. 46:3623-3623. 2005
- Transient Overexpression of TGF-β1 Induces Epithelial Mesenchymal Transition in the Rodent Peritoneum. Journal of the American Society of Nephrology. 16:425-436. 2005
- Activity and expression ofXenopus laevis matrix metalloproteinases: Identification of a novel role for the hormone prolactin in regulating collagenolysis in both amphibians and mammals. Journal of Cellular Physiology. 201:165-165. 2004
- Activity and expression ofXenopus laevis matrix metalloproteinases: Identification of a novel role for the hormone prolactin in regulating collagenolysis in both amphibians and mammals. Journal of Cellular Physiology. 201:155-164. 2004
- Differential Regulation of Components of the Ubiquitin-Proteasome Pathway during Lens Cell Differentiation. Investigative Ophthalmology and Visual Science. 45:1194-1194. 2004
- Transcription Factors Pax6 and AP-2α Interact To Coordinate Corneal Epithelial Repair by Controlling Expression of Matrix Metalloproteinase Gelatinase B. Molecular and Cellular Biology. 24:245-257. 2004
- Positive influence of AP-2α transcription factor on cadherin gene expression and differentiation of the ocular surface. Differentiation. 71:206-216. 2003
- Ectopic Expression of AP-2α Transcription Factor in the Lens Disrupts Fiber Cell Differentiation. Developmental Biology. 247:406-406. 2002
- Ectopic Expression of AP-2α Transcription Factor in the Lens Disrupts Fiber Cell Differentiation. Developmental Biology. 245:13-27. 2002
- Differential inhibition of collagenase and interleukin-1alpha gene expression in cultured corneal fibroblasts by TGF-beta, dexamethasone, and retinoic acid.. Investigative Ophthalmology and Visual Science. 40:887-896. 1999
- AP-2αTranscription Factor Is Required for Early Morphogenesis of the Lens Vesicle. Developmental Biology. 206:46-62. 1999
- Ap-2 and ocular epithelial morphogenesis. Investigative Ophthalmology and Visual Science. 38. 1997
- Molecular basis for three levels of competence to express genes required for corneal repair. Investigative Ophthalmology and Visual Science. 38. 1997
- Role of Serum Amyloid A as an Intermediate in the IL-1 and PMA-Stimulated Signaling Pathways Regulating Expression of Rabbit Fibroblast Collagenase. Experimental Cell Research. 237:275-287. 1997
- Repair phenotype in corneal fibroblasts is controlled by an interleukin-1 alpha autocrine feedback loop.. Investigative Ophthalmology and Visual Science. 38:1367-1379. 1997
- Perspectives on eye development. Genesis: The Journal of Genetics and Development. 20:175-185. 1997
- Role of matrix metalloproteinases in failure to re-epithelialize after corneal injury.. American Journal of Pathology. 149:1287-1302. 1996
- Autocrine IL-1α controls corneal keratocyte transition to the repair fibroblast phenotype. Investigative Ophthalmology and Visual Science. 37. 1996
- Corneal epithelial repair: Role of AP-2 transcription factor. Investigative Ophthalmology and Visual Science. 37. 1996
- Role of the actin cytoskeleton in controlling the corneal repair fibroblast phenotype. Investigative Ophthalmology and Visual Science. 37. 1996
- Competence for collagenase gene expression by tissue fibroblasts requires activation of an interleukin 1 alpha autocrine loop.. Proceedings of the National Academy of Sciences of USA. 92:6768-6772. 1995
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chapter
- Animal Models of Cataracts. 11-29. 2016
- The Lens Capsule: Synthesis, Remodeling, and MMPs. 39-57. 2014
- Chapter 31 Posterior capsule opacification. 238-242. 2010
- Posterior capsule opacification. 238-242. 2010
- Molecular Mechanisms Controlling the Gene Expression Program for Corneal Repair. 421-436. 1997
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conference paper
- Conditional Deletion of AP-2 beta in the Periocular Mesenchyme of Mice Promotes Corneal Conjunctivalization. Investigative Ophthalmology and Visual Science. 2021
- MMP9 differentially regulates proteins involved in actin polymerization and cell migration during EMT of lens epithelial cells. Investigative Ophthalmology and Visual Science. 2021
- Role of Transcription Factor AP-2 beta in the Development of the Trabecular Meshwork and Schlemm's Canal. Investigative Ophthalmology and Visual Science. 2021
- Phenylboronic Acid Based Mucoadhesive Polymeric Micelles for Reduction in Intra-Ocular Pressure (IOP) during Glaucoma. Investigative Ophthalmology and Visual Science. 2020
- Role of AP-2 beta Transcription Factor in Early Postnatal Development of the Trabecular Meshwork. Investigative Ophthalmology and Visual Science. 2020
- Understanding the Role of Fibroblast Growth Factor 8 (FGF8) in Tumors of the Ocular Adnexa. Investigative Ophthalmology and Visual Science. 2020
- Investigating MRTF-A as a novel anti-fibrotic target in trabecular meshwork cells for open angle glaucoma. Investigative Ophthalmology and Visual Science. 2019
- ScRNA-Seq Identifies The Complex Role Of AP-2 beta In Anterior Segment Development. Investigative Ophthalmology and Visual Science. 2019
- Retinal Ganglion Cell Numbers In Early Post-Natal AP-2 beta Neural Crest Cell Knockout Mice. Investigative Ophthalmology and Visual Science. 2018
- beta-catenin/Smad3 interaction regulates myofibroblast transition of lens epithelial cells. Investigative Ophthalmology and Visual Science. 2018
- beta-catenin/Smad3 interaction regulates epithelial to mesenchymal transition in the lens. Investigative Ophthalmology and Visual Science. 2017
- Inhibition of MRTF-A/SRF-regulated gene transcription prevents TGF beta-mediated EMT in lens explants. Investigative Ophthalmology and Visual Science. 2016
- MMP-9 deficiency results in lack of TGFb-induced fascin and F-actin formation in Lens Epithelial Cells. Investigative Ophthalmology and Visual Science. 2016
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MMP ‐9 null mice display elevatedIOP due to reduced aqueous humor drainage from the trabecular meshwork. Acta Ophthalmologica. 2015 - Gene expression profiling reveals insight into the role of MMP-9 in transforming growth factor beta (TGF beta)-induced epithelial-mesenchymal transition (EMT) in the lens.. Investigative Ophthalmology and Visual Science. 2015
- Glaucomatous Features Observed Following Conditional Deletion of AP-2 beta in Neural Crest Cell Populations. Investigative Ophthalmology and Visual Science. 2015
- Transforming Growth Factor beta (TGF beta) regulates stress fiber formation in lens epithelial cells through Fascin. Investigative Ophthalmology and Visual Science. 2015
- AP-2 alpha and AP-2 beta are Required for Normal Lens Development. Investigative Ophthalmology and Visual Science. 2013
- Altered expreion of TGF beta 1 and MMP-9 results in elevated intraocular preure in mice. Investigative Ophthalmology and Visual Science. 2013
- Role of Rho-ROCK signaling in TGF beta-mediated MRTF-A localization during EMT of LECs. Investigative Ophthalmology and Visual Science. 2013
- Smad3 and MRTF regulation of TGF beta-induced EMT in mouse lens explants. Investigative Ophthalmology and Visual Science. 2013
- The potential redundant roles of AP-2 alpha and AP-2 beta in the developing and postnatal neural retina. Investigative Ophthalmology and Visual Science. 2013
- Excessive Hedgehog Signaling Results in Misexpression of Cell Cycle Proteins and Abnormal Cell Cycle Behaviour During Lens Development. Investigative Ophthalmology and Visual Science. 2010
- Cre-mediated deletion of AP-2a in the developing retina reveals intrinsic role for AP-2a in retinogenesis. Investigative Ophthalmology and Visual Science. 2005
- Effects of the MMP inhibitor, GM6001, on TGF-beta-induced gene expression in a rat subcapsular cataract model. Investigative Ophthalmology and Visual Science. 2005
- Epidermal growth factor-modified polydimethylsiloxane for keratoprostheses. Investigative Ophthalmology and Visual Science. 2005
- Gene transfer of bioactive IL-1b to the anterior chamber of the rodent eye induces a retinal phenotype similar to human proliferative vitreoretinopathy. Investigative Ophthalmology and Visual Science. 2005
- Gene transfer of bioactive TGF-b1 to the anterior chamber of the rodent eye induces anterior subcapsular cataracts and alterations to the trabecular meshwork. Investigative Ophthalmology and Visual Science. 2005
- Lens specific expression of TGF-b induces anterior subcapsular cataract formation in the absence of Smad3 signaling. Investigative Ophthalmology and Visual Science. 2005
- A conditional knockout of AP-2a in the developing lens results in an isolated ocular phenotype demonstrating an intrinsic requirement for AP-2a in the lens and eye development. Investigative Ophthalmology and Visual Science. U289-U289. 2003