Journal article
Temporal changes in MMP mRNA expression in the lens epithelium during anterior subcapsular cataract formation
Abstract
Transforming growth factor beta (TGFbeta) has been known to play a role in anterior subcapsular cataract (ASC) formation and posterior capsule opacification (PCO), both of which are fibrotic pathologies of the lens. Several models have been utilized to study ASC formation, including the TGFbeta1 transgenic mouse model and the ex-vivo rat lens model. A distinct characteristic of ASC development within these models includes the formation of …
Authors
Nathu Z; Dwivedi DJ; Reddan JR; Sheardown H; Margetts PJ; West-Mays JA
Journal
Experimental Eye Research, Vol. 88, No. 2, pp. 323–330
Publisher
Elsevier
Publication Date
February 2009
DOI
10.1016/j.exer.2008.08.014
ISSN
0014-4835
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
ActinsAnimalsCadherinsCataractCell LineCell ProliferationEpithelial CellsHumansImmunohistochemistryLens Capsule, CrystallineMaleMatrix Metalloproteinase 2Matrix Metalloproteinase 9Matrix MetalloproteinasesMicrodissectionModels, AnimalRNA, MessengerRatsRats, WistarRecombinant ProteinsReverse Transcriptase Polymerase Chain ReactionTime FactorsTransforming Growth Factor beta