Journal article
Understanding the Role of Yes-Associated Protein (YAP) Signaling in the Transformation of Lens Epithelial Cells (EMT) and Fibrosis
Abstract
Fibrotic cataracts, posterior capsular opacification (PCO), and anterior subcapsular cataracts (ASC) are mainly attributed to the transforming growth factor-β (TGFβ)-induced epithelial-to-mesenchymal transition (EMT) of lens epithelial cells (LECs). Previous investigations from our laboratory have shown the novel role of non-canonical TGFβ signaling in the progression of EMT in LECs. In this study, we have identified YAP as a critical signaling …
Authors
Taiyab A; Belahlou Y; Wong V; Pandi S; Shekhar M; Chidambaranathan GP; West-Mays J
Journal
Biomolecules, Vol. 13, No. 12,
Publisher
MDPI
DOI
10.3390/biom13121767
ISSN
2218-273X