Journal article
Differential inhibition of collagenase and interleukin-1alpha gene expression in cultured corneal fibroblasts by TGF-beta, dexamethasone, and retinoic acid.
Abstract
PURPOSE: Expression of the genes for collagenase and interleukin-1alpha (IL-1alpha) are induced as stromal cells become activated to the repair fibroblast phenotype after injury to the cornea. This investigation examines the mechanisms whereby expression of these genes is inhibited by transforming growth factor-beta (TGF-beta), dexamethasone (DEX), or retinoic acid (RET A).
METHODS: A model of freshly isolated cultures of corneal stromal cells …
Authors
West-Mays JA; Cook JR; Sadow PM; Mullady DK; Bargagna-Mohan P; Strissel KJ; Fini ME
Journal
Investigative Ophthalmology & Visual Science, Vol. 40, No. 5, pp. 887–896
Publication Date
April 1999
ISSN
0146-0404