Isoquinolines Concept

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A marine microbiome antifungal targets urgent-threat drug-resistant fungi Journal Articles
A novel synthetic C-1 analogue of 7-deoxypancratistatin induces apoptosis in p53 positive and negative human colorectal cancer cells by targeting the mitochondria: enhancement of activity by tamoxifen Journal Articles
A postmarketing surveillance evaluation of quinapril in 3742 Canadian hypertensive patients: the ACCEPT Study. Accupril Canadian Clinical Evaluation and Patient Teaching. Journal Articles
A proposal for an extended dual descriptor: a possible solution when Frontier Molecular Orbital Theory fails Journal Articles
A synthesis of 3-deoxydihydrolycoricidine: Refinement of a structurally minimum pancratistatin pharmacophore Journal Articles
Actions of the sympathomimetic bronchodilator, AQL208, on the cardiovascular, bronchiolar and skeletal muscle systems of the cat Journal Articles
Actions of two dopamine derivatives at adreno- and cholinoceptors Journal Articles
Antagonists of the serotonin receptor 5A target human breast tumor initiating cells Journal Articles
Background illumination reduces horizontal cell receptive-field size in both normal and 6-hydroxydopamine-lesioned goldfish retinas Journal Articles
Cancer Cell Mitochondria Targeting by Pancratistatin Analogs is Dependent on Functional Complex II and III Journal Articles
Central-type benzodiazepine receptors mediate the antidopaminergic effect of clonazepam and melatonin in 6-hydroxydopamine lesioned rats: involvement of a GABAergic mechanism. Journal Articles
Chronic opioids regulate K_ATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2α and protein kinase A Journal Articles
Current Perspectives in the Pharmacological Studies of Store-Operated Ca2+ Entry Blockers. Journal Articles
Cyclic 3’,5’-Adenosine Monophosphate Mediates Dopamine D1-Stimulated Growth Hormone Release from Goldfish Pituitary Cells Journal Articles
Determination of albumin sorption to intraocular lenses by radiolabeling and confocal laser scanning microscopy Journal Articles
Diazepam-Treated Female Rats Journal Articles
Differential effects of putative protein kinase C inhibitors on contraction of rat aortic smooth muscle Journal Articles
Distribution of PK11195 binding sites in porcine brain studied by autoradiography in vitro and by positron emission tomography Journal Articles
Efficacy of Secretagogues in Patients With Irritable Bowel Syndrome With Constipation: Systematic Review and Network Meta-analysis Journal Articles
Guideline for the prevention of acute chemotherapy‐induced nausea and vomiting in pediatric cancer patients: A focused update Journal Articles
In situ recording from gut pacemaker cells Journal Articles
Induction of Apoptotic Cell Death Specifically in Rat and Human Cancer Cells by Pancratistatin Journal Articles
Inhibition of antibodies to CD3 surface antigen and phytohemagglutinin-mediated T cellular responses by inhibiting Ca2+/phospholipid-dependent protein kinase activity with the aid of 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride. Journal Articles
Localization of Lysozyme Sorption to Conventional and Silicone Hydrogel Contact Lenses Using Confocal Microscopy Journal Articles
Mechanisms underlying the antidopaminergic effect of clonazepam and melatonin in striatum Journal Articles
Modulation of Insulin-like Growth Factor (IGF)-I and IGF-Binding Protein Interactions Enhances Skeletal Muscle Regeneration and Ameliorates the Dystrophic Pathology in mdx Mice Journal Articles
Molecular identification and functional characterization of Mdr1a in rat cholangiocytes Journal Articles
Mutants of CHO cells resistant to the protein synthesis inhibitors, cryptopleurine and tylocrebrine: genetic and biochemical evidence for common site of action of emetine, cryptopleurine, tylocrebrine, and tubulosine Journal Articles
PK 11195 blockade of benzodiazepine‐induced inhibition of forskolin‐stimulated adenylate cyclase activity in the striatum Journal Articles
PLANT ALKALOID TETRANDRINE AND ITS ANALOG BLOCK CD28-COSTIMULATED ACTIVITIES OF HUMAN PERIPHERAL BLOOD T CELLS Journal Articles
Pancratistatin Selectively Targets Cancer Cell Mitochondria and Reduces Growth of Human Colon Tumor Xenografts Journal Articles
Pancratistatin causes early activation of caspase-3 and the flipping of phosphatidyl serine followed by rapid apoptosis specifically in human lymphoma cells Journal Articles
Pancratistatin induces apoptosis and autophagy in metastatic prostate cancer cells Journal Articles
Pancratistatin: A natural anti-cancer compound that targets mitochondria specifically in cancer cells to induce apoptosis Journal Articles
Phase II study of amonafide: results of treatment and lessons learned from the study of an investigational agent in previously untreated patients with extensive small-cell lung cancer. Journal Articles
Potent and selective inhibition of human cytochrome P450 3A4 by seco-pancratistatin structural analogs Journal Articles
Regulation of plasminogen activator inhibitor‐1 secretion by urokinase and tissue plasminogen activator in rat epithelioid‐type smooth muscle cells Journal Articles
Relaxin alters cardiac myofilament function through a PKC-dependent pathway Journal Articles
Selective cytochrome P450 3A4 inhibitory activity of Amaryllidaceae alkaloids Journal Articles
Sensitivity to protein kinase C inhibitors of nicardipine‐insensitive component of high K⁺ contracture in rat and guinea‐pig aorta Journal Articles
Sensitization of human melanoma cells by tamoxifen to apoptosis induction by pancratistatin, a nongenotoxic natural compound Journal Articles
Strategies and Synthetic Methods Directed Toward the Preparation of Libraries of Substituted Isoquinolines Journal Articles
Structural determinants responsible for the biological activity of (-)-emetine, (-)-cryptopleurine, and (-)-tylocrebrine: structure-activity relationship among related compounds. Journal Articles
Structure–activity studies on seco-pancratistatin analogs: Potent inhibitors of human cytochrome P450 3A4 Journal Articles
Studies directed towards the refinement of the pancratistatin cytotoxic pharmacophore Journal Articles
Synergy of pancratistatin and tamoxifen on breast cancer cells in inducing apoptosis by targeting mitochondria Journal Articles
Synthesis and Biological Evaluation of Fully Functionalized seco-Pancratistatin Analogues Journal Articles
The chemosensitizing potential of GF120918 is independent of the magnitude of P-glycoprotein-mediated resistance to conventional chemotherapeutic agents in a small cell lung cancer line. Journal Articles
Up‐regulation of PK11195 binding in areas of axonal degeneration coincides with early microglial activation in mouse brain Journal Articles