Journal article
Molecular identification and functional characterization of Mdr1a in rat cholangiocytes
Abstract
BACKGROUND & AIMS: The multidrug resistance P-glycoprotein 170 gene products (mdr1a and 1b) are glycosylated plasma membrane proteins that function as adenosine triphosphate-dependent transmembrane export pumps for lipophilic xenobiotics of widely different structure. We assessed whether these P-glycoproteins are functionally expressed in cholangiocytes.
METHODS: A reverse-transcription polymerase chain reaction was performed on RNA from a …
Authors
Gigliozzi A; Fraioli F; Sundaram P; Lee J; Mennone A; Alvaro D; Boyer JL
Journal
Gastroenterology, Vol. 119, No. 4, pp. 1113–1122
Publisher
Elsevier
Publication Date
10 2000
DOI
10.1053/gast.2000.18156
ISSN
0016-5085
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
ATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1ATP-Binding Cassette TransportersAcridinesAnimalsBile DuctsCell DivisionCell MembraneCytosolDrug Resistance, MultipleIn Vitro TechniquesIsoquinolinesKineticsMaleMicroscopy, ConfocalRNA, MessengerRatsRats, Sprague-DawleyReverse Transcriptase Polymerase Chain ReactionRhodamine 123TetrahydroisoquinolinesTranscription, GeneticVanadatesVerapamil