Journal article
Differential effects of putative protein kinase C inhibitors on contraction of rat aortic smooth muscle
Abstract
We investigated effects of three kinds of putative protein kinase C (PKC) inhibitors, calphostin C, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7), and stauro-sporine, on aortic muscle contractions induced by KCl, phenylephrine, 12-O-tetradecanoylphorbol-13-acetate (TPA), and phorbol 12, 13-dibutyrate (PDBu). Calphostin C noncompetitively inhibited TPA-induced contractions in a concentration-dependent manner. At 10(-6) M, calphostin C …
Authors
Shimamoto Y; Shimamoto H; Kwan CY; Daniel EE
Journal
American Journal of Physiology, Vol. 264, No. 4, pp. h1300–h1306
Publisher
American Physiological Society
Publication Date
April 1, 1993
DOI
10.1152/ajpheart.1993.264.4.h1300
ISSN
0002-9513
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
1-(5-Isoquinolinesulfonyl)-2-MethylpiperazineAlkaloidsAnimalsAortaDose-Response Relationship, DrugIsoquinolinesMaleMuscle, Smooth, VascularNaphthalenesPhenylephrinePhorbol 12,13-DibutyratePiperazinesPolycyclic CompoundsPotassium ChlorideProtein Kinase CRatsRats, WistarStaurosporineTetradecanoylphorbol AcetateTime FactorsVasoconstriction