Journal article
Central-type benzodiazepine receptors mediate the antidopaminergic effect of clonazepam and melatonin in 6-hydroxydopamine lesioned rats: involvement of a GABAergic mechanism.
Abstract
In this study, we examined the effect of the central-type benzodiazepine agonist, clonazepam, and the indoleamine hormone, melatonin, on central dopaminergic function using the 6-hydroxydopamine model of dopamine receptor supersensitivity. Unilateral lesioning of the nigrostriatal pathway with 6-hydroxydopamine was carried out in Sprague-Dawley rats. Two weeks after surgery, the animals were examined for the presence of dopaminergic …
Authors
Tenn CC; Niles LP
Journal
Journal of Pharmacology and Experimental Therapeutics, Vol. 274, No. 1, pp. 84–89
Publisher
Elsevier
Publication Date
July 1995
DOI
10.1016/s0022-3565(25)10705-2
ISSN
0022-3565