Journal article
A marine microbiome antifungal targets urgent-threat drug-resistant fungi
Abstract
New antifungal drugs are urgently needed to address the emergence and transcontinental spread of fungal infectious diseases, such as pandrug-resistant Candida auris. Leveraging the microbiomes of marine animals and cutting-edge metabolomics and genomic tools, we identified encouraging lead antifungal molecules with in vivo efficacy. The most promising lead, turbinmicin, displays potent in vitro and mouse-model efficacy toward …
Authors
Zhang F; Zhao M; Braun DR; Ericksen SS; Piotrowski JS; Nelson J; Peng J; Ananiev GE; Chanana S; Barns K
Journal
Science, Vol. 370, No. 6519, pp. 974–978
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
November 20, 2020
DOI
10.1126/science.abd6919
ISSN
0036-8075