Journal article
Diazepam-Treated Female Rats Flumazenil- and PK 11195-Induced Withdrawal in the Hippocampus CA1
Abstract
Six female rats had a loading dose of 180 mg of diazepam (DZ) contained in two Silastic capsules implanted in their backs. Thereafter, a single 90-mg capsule was implanted weekly for 4 weeks prior to weekly microinjections of 1 microl of flumazenil (6.25, 12.5, or 25 microg) and PK 11195 (3.125, 6.25, or 12.5 microg) or vehicle into the CA1. Three control rats had empty capsules implanted but received only the high dose of flumazenil after 5 …
Authors
Sloan JW; Wala E; Jing X; Holtman JR; Milliken B
Journal
Pharmacology Biochemistry and Behavior, Vol. 61, No. 1, pp. 121–130
Publisher
Elsevier
Publication Date
September 1998
DOI
10.1016/s0091-3057(98)00085-9
ISSN
0091-3057