Drug Discovery Concept

subject area of

• Pseudomonas Aeruginosa : Targeting Cell-Wall Metabolism for New Antibacterial Discovery and Development  Journal Articles
• FVIII inhibitor development according to concentrate: data from the EUHASS registry excluding overlap with other studies  Journal Articles
• A Common Platform for Antibiotic Dereplication and Adjuvant Discovery  Journal Articles
• A Deep Learning Approach to Antibiotic Discovery  Journal Articles
• A brief guide to machine learning for antibiotic discovery  Journal Articles
• A macrophage-stimulating compound from a screen of microbial natural products  Journal Articles
• A new system for profiling drug-induced calcium signal perturbation in human embryonic stem cell-derived cardiomyocytes.  Journal Articles
• A printable hydrogel microarray for drug screening avoids false positives associated with promiscuous aggregating inhibitors  Journal Articles
• AI Methods for Antimicrobial Peptides: Progress and Challenges.  Journal Articles
• AI is a viable alternative to high throughput screening: a 318-target study  Journal Articles
• An Engineered Allele of afsQ1 Facilitates the Discovery and Investigation of Cryptic Natural Products  Journal Articles
• An automated Genomes-to-Natural Products platform (GNP) for the discovery of modular natural products  Journal Articles
• Analgesic targets: today and tomorrow  Journal Articles
• Anti-alarmin approaches entering clinical trials  Journal Articles
• Antibacterial drug discovery in the resistance era  Journal Articles
• Antibiotic Adjuvants: Rescuing Antibiotics from Resistance  Journal Articles
• Antibiotic Dereplication Using the Antibiotic Resistance Platform  Journal Articles
• Antibiotic adjuvants: multicomponent anti-infective strategies  Journal Articles
• Antibiotic discovery in the artificial intelligence era  Journal Articles
• Antibiotic resistance is ancient: implications for drug discovery  Journal Articles
• Anticoagulants: From chance discovery to structure-based design.  Journal Articles
• Applications of machine learning in microbial natural product drug discovery  Journal Articles
• Assessing 15 Proposals for Promoting Innovation and Access to Medicines Globally  Journal Articles
• Bioactive Molecules and Their Mechanisms of Action.  Journal Articles
• Bioinformatic evaluation of the secondary metabolism of antistaphylococcal environmental bacterial isolates  Journal Articles
• Bioinformatics of antimicrobial resistance in the age of molecular epidemiology  Journal Articles
• Canada’s laws on pharmaceutical intellectual property: the case for fundamental reform: Figure 1:  Journal Articles
• Chemical Analyses of Wasp-Associated Streptomyces Bacteria Reveal a Prolific Potential for Natural Products Discovery  Journal Articles
• Chemical genomics reveals mechanistic hypotheses for uncharacterized bioactive molecules in bacteria  Journal Articles
• Chemotherapy-Induced Neuropathy and Drug Discovery Platform Using Human Sensory Neurons Converted Directly from Adult Peripheral Blood  Journal Articles
• Combinatorial strategies for combating invasive fungal infections  Journal Articles
• Comparative Pharmacodynamics and Pharmacokinetics of Oral Direct Thrombin and Factor Xa Inhibitors in Development  Journal Articles
• Could patents interfere with the development of a cardiovascular polypill?  Journal Articles
• Creative targeting of the Gram‐negative outer membrane in antibiotic discovery  Journal Articles
• Current models of pulmonary fibrosis for future drug discovery efforts  Journal Articles
• DRUG DISINVESTMENT FRAMEWORKS: COMPONENTS, CHALLENGES, AND SOLUTIONS  Journal Articles
• DeepRiPP integrates multiomics data to automate discovery of novel ribosomally synthesized natural products  Journal Articles
• Dereplication of Natural Product Antifungals via Liquid Chromatography-Tandem Mass Spectrometry and Chemical Genomics.  Journal Articles
• Determining the mode of action of bioactive compounds  Journal Articles
• Discovery of HDAC6-Selective Inhibitor NN-390 with in Vitro Efficacy in Group 3 Medulloblastoma  Journal Articles
• Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function  Journal Articles
• Discovery of a Novel Series of Tricyclic Oxadiazine 4a-Methyl Esters Based on Indoxacarb as Potential Sodium Channel Blocker/Modulator Insecticides  Journal Articles
• Discovery of a new class of cinnamyl-triazole as potent and selective inhibitors of aromatase (cytochrome P450 19A1)  Journal Articles
• Discovery of a structural class of antibiotics with explainable deep learning  Journal Articles
• Dissecting fibrosis: therapeutic insights from the small-molecule toolbox  Journal Articles
• Do we need a new approach to making vaccine recommendations?  Journal Articles
• Drug combinations: a strategy to extend the life of antibiotics in the 21st century  Journal Articles
• Drug development for chronic lung disease ‐ Mission impossible?  Journal Articles
• Drug repurposing for antimicrobial discovery  Journal Articles
• Emerging evolutionary paradigms in antibiotic discovery  Journal Articles
• Epidermal Growth Factor Receptor: Pathway, Therapies, and Pipeline  Journal Articles
• Evidence-based support for phenotypic drug discovery in acute myeloid leukemia  Journal Articles
• Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling  Journal Articles
• Evolving medicinal chemistry strategies in antibiotic discovery  Journal Articles
• Exploiting the Sensitivity of Nutrient Transporter Deletion Strains in Discovery of Natural Product Antimetabolites  Journal Articles
• Factor XI and factor XII as targets for new anticoagulants  Journal Articles
• Factor Xa and thrombin as targets for new oral anticoagulants  Journal Articles
• Food for thought: Opportunities to target carbon metabolism in antibacterial drug discovery  Journal Articles
• GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery  Journal Articles
• Glycopeptide antibiotic discovery in the genomic era  Chapters
• HSV-2 vaccine: Current state and insights into development of a vaccine that targets genital mucosal protection  Journal Articles
• Heterologous expression-facilitated natural products’ discovery in actinomycetes  Journal Articles
• High-Throughput Discovery of Synthetic Siderophores for Trojan Horse Antibiotics.  Journal Articles
• How should we support pharmaceutical innovation?  Journal Articles
• Human pluripotent stem cell (hPSC)-derived models for autism spectrum disorder drug discovery.  Journal Articles
• Impact of 5-HT3 receptor antagonists on peripheral and central diseases  Journal Articles
• Important challenges to finding new leads for new antibiotics.  Journal Articles
• Informatic search strategies to discover analogues and variants of natural product archetypes  Journal Articles
• Inhibitors of glutamate release from breast cancer cells; new targets for cancer-induced bone-pain  Journal Articles
• Is the GAIN Act a turning point in new antibiotic discovery?  Journal Articles
• Machine Learning-Based Bioactivity Classification of Natural Products Using LC-MS/MS Metabolomics.  Journal Articles
• Machine learning in preclinical drug discovery  Journal Articles
• Mechanisms of Specific versus Nonspecific Interactions of Aggregation-Prone Inhibitors and Attenuators  Journal Articles
• Microfluidic Devices for Automation of Assays on Drosophila Melanogaster for Applications in Drug Discovery and Biological Studies  Journal Articles
• Model‐Informed Drug Development for Anti‐Infectives: State of the Art and Future  Journal Articles
• New chemical tools to probe cell wall biosynthesis in bacteria  Journal Articles
• New developments in anticoagulants: Past, present and future  Journal Articles
• New drug development  Journal Articles
• New oral anticoagulants in development  Journal Articles
• New screens and targets in antibacterial drug discovery  Journal Articles
• Nutrient stress is a target for new antibiotics  Journal Articles
• Opportunities for Synthetic Biology in Antibiotics: Expanding Glycopeptide Chemical Diversity  Journal Articles
• Opportunities for natural products in 21^st century antibiotic discovery  Journal Articles
• Organ-on-a-chip devices advance to market  Journal Articles
• Organ‐On‐A‐Chip Platforms: A Convergence of Advanced Materials, Cells, and Microscale Technologies  Journal Articles
• Perspective: Synthetic biology revives antibiotics  Journal Articles
• Perspectives in allergen immunotherapy: 2017 and beyond  Journal Articles
• Polo-like kinases in AML  Journal Articles
• Potential antidotes for reversal of old and new oral anticoagulants  Journal Articles
• Prospects for Antibacterial Discovery and Development  Journal Articles
• Q&A: Antibiotic resistance: what more do we know and what more can we do?  Journal Articles
• Q&A: Antibiotic resistance: where does it come from and what can we do about it?  Journal Articles
• Radiographic progression by Prostate Cancer Working Group (PCWG)‐2 criteria as an intermediate endpoint for drug development in metastatic castration‐resistant prostate cancer  Journal Articles
• Review of Cytotoxic CA4 Analogues that Do Not Target Microtubules: Implications for CA4 Development.  Journal Articles
• Revisiting the potential of natural products in antimycobacterial therapy: advances in drug discovery and semisynthetic solutions.  Journal Articles
• Roles of Reconstituted High-Density Lipoprotein Nanoparticles in Cardiovascular Disease: A New Paradigm for Drug Discovery.  Journal Articles
• Solid-Phase Biological Assays for Drug Discovery  Journal Articles
• Something old, something new: revisiting natural products in antibiotic drug discovery  Journal Articles
• Strategies for target identification of antimicrobial natural products  Journal Articles
• Stroke genetics informs drug discovery and risk prediction across ancestries  Journal Articles
• Sulfonation of glycopeptide antibiotics by sulfotransferase StaL depends on conformational flexibility of aglycone scaffold  Journal Articles
• Systems-Level Chemical Biology to Accelerate Antibiotic Drug Discovery  Journal Articles
• Tackling antibiotic resistance  Journal Articles
• The Antibiotic Resistome: A Guide for the Discovery of Natural Products as Antimicrobial Agents  Journal Articles
• The Therapeutic Pipeline for Pseudomonas aeruginosa Infections  Journal Articles
• The Urgent Need for Clinical Research Reform to Permit Faster, Less Expensive Access to New Therapies for Lethal Diseases  Journal Articles
• The cost of drug development: A systematic review  Journal Articles
• The discovery and characterization of a novel scaffold as a potent hepatitis C virus inhibitor  Journal Articles
• The new oral anticoagulants  Journal Articles
• Thiopeptides: antibiotics with unique chemical structures and diverse biological activities  Journal Articles
• Unconventional screening approaches for antibiotic discovery  Journal Articles
• Unlocking the potential of natural products in drug discovery  Journal Articles
• Use of Allosteric Targets in the Discovery of Safer Drugs  Journal Articles
• Use of genetic and chemical synthetic lethality as probes of complexity in bacterial cell systems  Journal Articles
• Winners of the 2014 JA Medals for excellence  Journal Articles
• iPSC Technology: Platform for Drug Discovery  Journal Articles