Drug Discovery
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Pseudomonas aeruginosa: targeting cell-wall metabolism for new antibacterial discovery and development Academic Article
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A Common Platform for Antibiotic Dereplication and Adjuvant Discovery Academic Article
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A Deep Learning Approach to Antibiotic Discovery Academic Article
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A brief guide to machine learning for antibiotic discovery Academic Article
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A macrophage-stimulating compound from a screen of microbial natural products Academic Article
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A printable hydrogel microarray for drug screening avoids false positives associated with promiscuous aggregating inhibitors Academic Article
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An Engineered Allele of afsQ1 Facilitates the Discovery and Investigation of Cryptic Natural Products Academic Article
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An automated Genomes-to-Natural Products platform (GNP) for the discovery of modular natural products Academic Article
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Analgesic targets: today and tomorrow Academic Article
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Anti-alarmin approaches entering clinical trials Academic Article
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Antibacterial drug discovery in the resistance era Academic Article
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Antibiotic Adjuvants: Rescuing Antibiotics from Resistance Academic Article
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Antibiotic Dereplication Using the Antibiotic Resistance Platform Academic Article
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Antibiotic adjuvants: multicomponent anti-infective strategies Academic Article
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Antibiotic discovery in the artificial intelligence era Academic Article
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Antibiotic resistance is ancient: implications for drug discovery Academic Article
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Assessing 15 Proposals for Promoting Innovation and Access to Medicines
Globally Academic Article
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Bioinformatic evaluation of the secondary metabolism of antistaphylococcal environmental bacterial isolates Academic Article
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Bioinformatics of antimicrobial resistance in the age of molecular epidemiology Academic Article
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Canada’s laws on pharmaceutical intellectual property: the case for fundamental reform: Figure 1: Academic Article
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Chemical genomics reveals mechanistic hypotheses for uncharacterized bioactive molecules in bacteria Academic Article
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Chemotherapy-Induced Neuropathy and Drug Discovery Platform Using Human Sensory Neurons Converted Directly from Adult Peripheral Blood Academic Article
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Combinatorial strategies for combating invasive fungal infections Academic Article
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Comparative Pharmacodynamics and Pharmacokinetics of Oral Direct Thrombin and Factor Xa Inhibitors in Development Academic Article
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Could patents interfere with the development of a cardiovascular polypill? Academic Article
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Creative targeting of the Gram‐negative outer membrane in antibiotic discovery Academic Article
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Current models of pulmonary fibrosis for future drug discovery efforts Academic Article
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DRUG DISINVESTMENT FRAMEWORKS: COMPONENTS, CHALLENGES, AND SOLUTIONS Academic Article
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DeepRiPP integrates multiomics data to automate discovery of novel ribosomally synthesized natural products Academic Article
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Determining the mode of action of bioactive compounds Academic Article
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Discovery of HDAC6-Selective Inhibitor NN-390 with in Vitro Efficacy in Group 3 Medulloblastoma Academic Article
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Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function Academic Article
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Discovery of a Novel Series of Tricyclic Oxadiazine 4a-Methyl Esters Based on Indoxacarb as Potential Sodium Channel Blocker/Modulator Insecticides Academic Article
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Discovery of a new class of cinnamyl-triazole as potent and selective inhibitors of aromatase (cytochrome P450 19A1) Academic Article
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Dissecting fibrosis: therapeutic insights from the small-molecule toolbox Academic Article
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Do we need a new approach to making vaccine recommendations? Academic Article
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Drug Development: From Concept to Marketing! Academic Article
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Drug combinations: a strategy to extend the life of antibiotics in the 21st century Academic Article
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Drug development for chronic lung disease - Mission impossible? Academic Article
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Drug repurposing for antimicrobial discovery Academic Article
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Epidermal Growth Factor Receptor: Pathway, Therapies, and Pipeline Academic Article
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Evidence-based support for phenotypic drug discovery in acute myeloid leukemia Academic Article
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Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling Academic Article
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Evolving medicinal chemistry strategies in antibiotic discovery Academic Article
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Exploiting the Sensitivity of Nutrient Transporter Deletion Strains in Discovery of Natural Product Antimetabolites Academic Article
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FVIII inhibitor development according to concentrate: data from the EUHASS registry excluding overlap with other studies Academic Article
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Factor XI and factor XII as targets for new anticoagulants Academic Article
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Factor Xa and thrombin as targets for new oral anticoagulants Academic Article
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Food for thought: Opportunities to target carbon metabolism in antibacterial drug discovery Academic Article
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GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery Academic Article
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Glycopeptide antibiotic discovery in the genomic era Chapter
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HSV-2 vaccine: Current state and insights into development of a vaccine that targets genital mucosal protection Academic Article
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Heterologous expression-facilitated natural products’ discovery in actinomycetes Academic Article
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How should we support pharmaceutical innovation? Academic Article
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Impact of 5-HT3 receptor antagonists on peripheral and central diseases Academic Article
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In Vitro Screening for Drug Repositioning Academic Article
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Informatic search strategies to discover analogues and variants of natural product archetypes Academic Article
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Inhibitors of glutamate release from breast cancer cells; new targets for cancer-induced bone-pain Academic Article
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Is the GAIN Act a turning point in new antibiotic discovery? Academic Article
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Mechanisms of Specific versus Nonspecific Interactions of Aggregation-Prone Inhibitors and Attenuators Academic Article
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Microfluidic Devices for Automation of Assays on Drosophila Melanogaster for Applications in Drug Discovery and Biological Studies Academic Article
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Model‐Informed Drug Development for Anti‐Infectives: State of the Art and Future Academic Article
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New chemical tools to probe cell wall biosynthesis in bacteria Academic Article
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New developments in anticoagulants: Past, present and future Academic Article
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New drug development Academic Article
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New oral anticoagulants in development Academic Article
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New screens and targets in antibacterial drug discovery Academic Article
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Nutrient stress is a target for new antibiotics Academic Article
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Opportunities for Synthetic Biology in Antibiotics: Expanding Glycopeptide Chemical Diversity Academic Article
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Opportunities for natural products in 21st century antibiotic discovery Academic Article
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Organ-on-a-chip devices advance to market Academic Article
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Organ‐On‐A‐Chip Platforms: A Convergence of Advanced Materials, Cells, and Microscale Technologies Academic Article
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Perspective: Synthetic biology revives antibiotics Academic Article
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Perspectives in allergen immunotherapy: 2017 and beyond Academic Article
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Polo-like kinases in AML Academic Article
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Potential antidotes for reversal of old and new oral anticoagulants Academic Article
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Prospects for Antibacterial Discovery and Development Academic Article
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Q&A: Antibiotic resistance: what more do we know and what more can we do? Academic Article
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Q&A: Antibiotic resistance: where does it come from and what can we do about it? Academic Article
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Radiographic progression by Prostate Cancer Working Group (PCWG)-2 criteria as an intermediate endpoint for drug development in metastatic castration-resistant prostate cancer Academic Article
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Review of Cytotoxic CA4 Analogues that Do Not Target Microtubules: Implications for CA4 Development. Academic Article
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Solid-Phase Biological Assays for Drug Discovery Academic Article
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Something old, something new: revisiting natural products in antibiotic drug discovery Academic Article
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Strategies for target identification of antimicrobial natural products Academic Article
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Stroke genetics informs drug discovery and risk prediction across ancestries Academic Article
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Sulfonation of glycopeptide antibiotics by sulfotransferase StaL depends on conformational flexibility of aglycone scaffold Academic Article
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Systems-Level Chemical Biology to Accelerate Antibiotic Drug Discovery Academic Article
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Tackling antibiotic resistance Academic Article
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The Antibiotic Resistome: A Guide for the Discovery of Natural Products as Antimicrobial Agents Academic Article
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The Therapeutic Pipeline for Pseudomonas aeruginosa Infections Academic Article
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The Urgent Need for Clinical Research Reform to Permit Faster, Less Expensive Access to New Therapies for Lethal Diseases Academic Article
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The cost of drug development: A systematic review Academic Article
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The discovery and characterization of a novel scaffold as a potent hepatitis C virus inhibitor Academic Article
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The new oral anticoagulants Academic Article
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Thiopeptides: antibiotics with unique chemical structures and diverse biological activities Academic Article
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Unconventional screening approaches for antibiotic discovery Academic Article
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Unlocking the potential of natural products in drug discovery Academic Article
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Use of Allosteric Targets in the Discovery of Safer Drugs Academic Article
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Use of genetic and chemical synthetic lethality as probes of complexity in bacterial cell systems Academic Article
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Winner's curse: The sad aftermath of the discovery of insulin Academic Article
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Winners of the 2014 JA Medals for excellence Academic Article
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iPSC Technology: Platform for Drug Discovery Academic Article