Drug Discovery Concept

subject area of

• Pseudomonas aeruginosa: targeting cell-wall metabolism for new antibacterial discovery and development  Academic Article
• A Common Platform for Antibiotic Dereplication and Adjuvant Discovery  Academic Article
• A Deep Learning Approach to Antibiotic Discovery  Academic Article
• A brief guide to machine learning for antibiotic discovery  Academic Article
• A macrophage-stimulating compound from a screen of microbial natural products  Academic Article
• A printable hydrogel microarray for drug screening avoids false positives associated with promiscuous aggregating inhibitors  Academic Article
• An Engineered Allele of afsQ1 Facilitates the Discovery and Investigation of Cryptic Natural Products  Academic Article
• An automated Genomes-to-Natural Products platform (GNP) for the discovery of modular natural products  Academic Article
• Analgesic targets: today and tomorrow  Academic Article
• Anti-alarmin approaches entering clinical trials  Academic Article
• Antibacterial drug discovery in the resistance era  Academic Article
• Antibiotic Adjuvants: Rescuing Antibiotics from Resistance  Academic Article
• Antibiotic Dereplication Using the Antibiotic Resistance Platform  Academic Article
• Antibiotic adjuvants: multicomponent anti-infective strategies  Academic Article
• Antibiotic discovery in the artificial intelligence era  Academic Article
• Antibiotic resistance is ancient: implications for drug discovery  Academic Article
• Assessing 15 Proposals for Promoting Innovation and Access to Medicines Globally  Academic Article
• Bioinformatic evaluation of the secondary metabolism of antistaphylococcal environmental bacterial isolates  Academic Article
• Bioinformatics of antimicrobial resistance in the age of molecular epidemiology  Academic Article
• Canada’s laws on pharmaceutical intellectual property: the case for fundamental reform: Figure 1:  Academic Article
• Chemical genomics reveals mechanistic hypotheses for uncharacterized bioactive molecules in bacteria  Academic Article
• Chemotherapy-Induced Neuropathy and Drug Discovery Platform Using Human Sensory Neurons Converted Directly from Adult Peripheral Blood  Academic Article
• Combinatorial strategies for combating invasive fungal infections  Academic Article
• Comparative Pharmacodynamics and Pharmacokinetics of Oral Direct Thrombin and Factor Xa Inhibitors in Development  Academic Article
• Could patents interfere with the development of a cardiovascular polypill?  Academic Article
• Creative targeting of the Gram‐negative outer membrane in antibiotic discovery  Academic Article
• Current models of pulmonary fibrosis for future drug discovery efforts  Academic Article
• DRUG DISINVESTMENT FRAMEWORKS: COMPONENTS, CHALLENGES, AND SOLUTIONS  Academic Article
• DeepRiPP integrates multiomics data to automate discovery of novel ribosomally synthesized natural products  Academic Article
• Determining the mode of action of bioactive compounds  Academic Article
• Discovery of HDAC6-Selective Inhibitor NN-390 with in Vitro Efficacy in Group 3 Medulloblastoma  Academic Article
• Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function  Academic Article
• Discovery of a Novel Series of Tricyclic Oxadiazine 4a-Methyl Esters Based on Indoxacarb as Potential Sodium Channel Blocker/Modulator Insecticides  Academic Article
• Discovery of a new class of cinnamyl-triazole as potent and selective inhibitors of aromatase (cytochrome P450 19A1)  Academic Article
• Dissecting fibrosis: therapeutic insights from the small-molecule toolbox  Academic Article
• Do we need a new approach to making vaccine recommendations?  Academic Article
• Drug Development: From Concept to Marketing!  Academic Article
• Drug combinations: a strategy to extend the life of antibiotics in the 21st century  Academic Article
• Drug development for chronic lung disease - Mission impossible?  Academic Article
• Drug repurposing for antimicrobial discovery  Academic Article
• Epidermal Growth Factor Receptor: Pathway, Therapies, and Pipeline  Academic Article
• Evidence-based support for phenotypic drug discovery in acute myeloid leukemia  Academic Article
• Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling  Academic Article
• Evolving medicinal chemistry strategies in antibiotic discovery  Academic Article
• Exploiting the Sensitivity of Nutrient Transporter Deletion Strains in Discovery of Natural Product Antimetabolites  Academic Article
• FVIII inhibitor development according to concentrate: data from the EUHASS registry excluding overlap with other studies  Academic Article
• Factor XI and factor XII as targets for new anticoagulants  Academic Article
• Factor Xa and thrombin as targets for new oral anticoagulants  Academic Article
• Food for thought: Opportunities to target carbon metabolism in antibacterial drug discovery  Academic Article
• GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery  Academic Article
• Glycopeptide antibiotic discovery in the genomic era  Chapter
• HSV-2 vaccine: Current state and insights into development of a vaccine that targets genital mucosal protection  Academic Article
• Heterologous expression-facilitated natural products’ discovery in actinomycetes  Academic Article
• How should we support pharmaceutical innovation?  Academic Article
• Impact of 5-HT3 receptor antagonists on peripheral and central diseases  Academic Article
• In Vitro Screening for Drug Repositioning  Academic Article
• Informatic search strategies to discover analogues and variants of natural product archetypes  Academic Article
• Inhibitors of glutamate release from breast cancer cells; new targets for cancer-induced bone-pain  Academic Article
• Is the GAIN Act a turning point in new antibiotic discovery?  Academic Article
• Mechanisms of Specific versus Nonspecific Interactions of Aggregation-Prone Inhibitors and Attenuators  Academic Article
• Microfluidic Devices for Automation of Assays on Drosophila Melanogaster for Applications in Drug Discovery and Biological Studies  Academic Article
• Model‐Informed Drug Development for Anti‐Infectives: State of the Art and Future  Academic Article
• New chemical tools to probe cell wall biosynthesis in bacteria  Academic Article
• New developments in anticoagulants: Past, present and future  Academic Article
• New drug development  Academic Article
• New oral anticoagulants in development  Academic Article
• New screens and targets in antibacterial drug discovery  Academic Article
• Nutrient stress is a target for new antibiotics  Academic Article
• Opportunities for Synthetic Biology in Antibiotics: Expanding Glycopeptide Chemical Diversity  Academic Article
• Opportunities for natural products in 21^st century antibiotic discovery  Academic Article
• Organ-on-a-chip devices advance to market  Academic Article
• Organ‐On‐A‐Chip Platforms: A Convergence of Advanced Materials, Cells, and Microscale Technologies  Academic Article
• Perspective: Synthetic biology revives antibiotics  Academic Article
• Perspectives in allergen immunotherapy: 2017 and beyond  Academic Article
• Polo-like kinases in AML  Academic Article
• Potential antidotes for reversal of old and new oral anticoagulants  Academic Article
• Prospects for Antibacterial Discovery and Development  Academic Article
• Q&A: Antibiotic resistance: what more do we know and what more can we do?  Academic Article
• Q&A: Antibiotic resistance: where does it come from and what can we do about it?  Academic Article
• Radiographic progression by Prostate Cancer Working Group (PCWG)-2 criteria as an intermediate endpoint for drug development in metastatic castration-resistant prostate cancer  Academic Article
• Review of Cytotoxic CA4 Analogues that Do Not Target Microtubules: Implications for CA4 Development.  Academic Article
• Solid-Phase Biological Assays for Drug Discovery  Academic Article
• Something old, something new: revisiting natural products in antibiotic drug discovery  Academic Article
• Strategies for target identification of antimicrobial natural products  Academic Article
• Stroke genetics informs drug discovery and risk prediction across ancestries  Academic Article
• Sulfonation of glycopeptide antibiotics by sulfotransferase StaL depends on conformational flexibility of aglycone scaffold  Academic Article
• Systems-Level Chemical Biology to Accelerate Antibiotic Drug Discovery  Academic Article
• Tackling antibiotic resistance  Academic Article
• The Antibiotic Resistome: A Guide for the Discovery of Natural Products as Antimicrobial Agents  Academic Article
• The Therapeutic Pipeline for Pseudomonas aeruginosa Infections  Academic Article
• The Urgent Need for Clinical Research Reform to Permit Faster, Less Expensive Access to New Therapies for Lethal Diseases  Academic Article
• The cost of drug development: A systematic review  Academic Article
• The discovery and characterization of a novel scaffold as a potent hepatitis C virus inhibitor  Academic Article
• The new oral anticoagulants  Academic Article
• Thiopeptides: antibiotics with unique chemical structures and diverse biological activities  Academic Article
• Unconventional screening approaches for antibiotic discovery  Academic Article
• Unlocking the potential of natural products in drug discovery  Academic Article
• Use of Allosteric Targets in the Discovery of Safer Drugs  Academic Article
• Use of genetic and chemical synthetic lethality as probes of complexity in bacterial cell systems  Academic Article
• Winner's curse: The sad aftermath of the discovery of insulin  Academic Article
• Winners of the 2014 JA Medals for excellence  Academic Article
• iPSC Technology: Platform for Drug Discovery  Academic Article