Journal article
Anti-alarmin approaches entering clinical trials.
Abstract
PURPOSE OF REVIEW: The alarmins, thymic stromal lymphopoietin (TSLP), interleukin (IL)-25 and IL-33, are upstream regulators of T2 (type 2) inflammation and found to be expressed at high levels in airway epithelium of patients with T2 asthma. This review will summarize how alarmins regulate the inflamed asthmatic airways through previously described and newly identified mechanisms.
RECENT FINDINGS: Alarmins drive allergic and nonallergic asthma …
Authors
Gauvreau GM; White L; Davis BE
Journal
Current Opinion in Pulmonary Medicine, Vol. 26, No. 1, pp. 69–76
Publisher
Wolters Kluwer
Publication Date
January 2020
DOI
10.1097/mcp.0000000000000615
ISSN
1070-5287