Critical Care - McMaster Experts

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Clonidine for sedation in the critically ill: a systematic review and meta-analysis 2017
Multimodal strategies to improve APACHE II score documentation 2005
Post-insufflation diaphragm contractions in patients receiving various modes of mechanical ventilation.. 28:310. 2024
Comparative effectiveness of alternative spontaneous breathing trial techniques: a systematic review and network meta-analysis of randomized trials. 28:194. 2024
Towards personalized medicine: a scoping review of immunotherapy in sepsis. 28:183. 2024
Respiratory drive heterogeneity associated with systemic inflammation and vascular permeability in acute respiratory distress syndrome. 28:136. 2024
The long-term intercorrelation between post-burn pain, anxiety, and depression: a post hoc analysis of the “RE-ENERGIZE” double-blind, randomized, multicenter placebo-controlled trial. 28:95. 2024
Extracorporeal cardiopulmonary resuscitation versus conventional CPR in cardiac arrest: an updated meta-analysis and trial sequential analysis. 28:57. 2024
An international RAND/UCLA expert panel to determine the optimal diagnosis and management of burn inhalation injury. 27:459. 2023
Response to the Letter by Spurling and Colleagues. 27:65. 2023
Efficacy and safety of corticosteroids in cardiac arrest: a systematic review, meta-analysis and trial sequential analysis of randomized control trials. 27:12. 2023
Efficacy and safety of baricitinib in hospitalized adults with severe or critical COVID-19 (Bari-SolidAct): a randomised, double-blind, placebo-controlled phase 3 trial. 27:9. 2023
Authors` response to “Efficacy of noninvasive ventilation in patients with COVID-19”. 26:399. 2022
Predicting neurological outcome in adult patients with cardiac arrest: systematic review and meta-analysis of prediction model performance. 26:382. 2022
Evolving outcomes of extracorporeal membrane oxygenation during the first 2 years of the COVID-19 pandemic: a systematic review and meta-analysis. 26:147. 2022
The PROMIZING trial enrollment algorithm for early identification of patients ready for unassisted breathing. 26:188. 2022
The sit-to-stand test as a patient-centered functional outcome for critical care research: a pooled analysis of five international rehabilitation studies. 26:175. 2022
High-flow nasal cannula versus non-invasive ventilation for acute hypercapnic respiratory failure in adults: a systematic review and meta-analysis of randomized trials. 26:348. 2022
Public awareness and knowledge of sepsis: a cross-sectional survey of adults in Canada. 26:337. 2022
A novel capnogram analysis to guide ventilation during cardiopulmonary resuscitation: clinical and experimental observations. 26:287. 2022
Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study. 26:276. 2022
A Bayesian reanalysis of the Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial. 26:255. 2022
Noninvasive ventilation in COVID-19 patients aged ≥ 70 years—a prospective multicentre cohort study. 26:224. 2022
Andexanet alfa versus four-factor prothrombin complex concentrate for the reversal of apixaban- or rivaroxaban-associated intracranial hemorrhage: a propensity score-overlap weighted analysis. 26:180. 2022
The prognostic utility of protein C as a biomarker for adult sepsis: a systematic review and meta-analysis. 26:21. 2022
Correction to: Extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis. 25:375. 2021
Cost impact of procalcitonin-guided decision making on duration of antibiotic therapy for suspected early-onset sepsis in neonates. 25:367. 2021
Relationship between the Clinical Frailty Scale and short-term mortality in patients ≥ 80 years old acutely admitted to the ICU: a prospective cohort study. 25:231. 2021
Restricted visitation policies in acute care settings during the COVID-19 pandemic: a scoping review. 25:347. 2021
The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study. 25:149. 2021
The management of multi-morbidity in elderly patients: Ready yet for precision medicine in intensive care?. 25:330. 2021
Validation of the Critical-Care Pain Observation Tool-Neuro in brain-injured adults in the intensive care unit: a prospective cohort study. 25:142. 2021
Differences in mortality in critically ill elderly patients during the second COVID-19 surge in Europe. 25:344. 2021
Extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis. 25:211. 2021
Automated detection and quantification of reverse triggering effort under mechanical ventilation. 25:60. 2021
Long-term survival and costs following extracorporeal membrane oxygenation in critically ill children—a population-based cohort study. 24:131. 2020
New-onset atrial fibrillation and associated outcomes and resource use among critically ill adults—a multicenter retrospective cohort study. 24:15. 2020
Systematic assessment of fluid responsiveness during early septic shock resuscitation: secondary analysis of the ANDROMEDA-SHOCK trial. 24:23. 2020
The unique characteristics of COVID-19 coagulopathy. 24:360. 2020
Outcomes of hospitalized hematologic oncology patients receiving rapid response system activation for acute deterioration. 23:286. 2019
Prevalence of post-traumatic stress disorder symptoms in adult critical care survivors: a systematic review and meta-analysis. 23:213. 2019
Prognostic accuracy of the Hamilton Early Warning Score (HEWS) and the National Early Warning Score 2 (NEWS2) among hospitalized patients assessed by a rapid response team. 23:60. 2019
The effect of diabetes on burn patients: a retrospective cohort study. 23:28. 2019
Transfusion practice in the non-bleeding critically ill: an international online survey—the TRACE survey. 23:309. 2019
Emergency Department disposition decisions and associated mortality and costs in ICU patients with suspected infection. 22:172. 2018
Prolonged corticosteroid treatment in acute respiratory distress syndrome: impact on mortality and ventilator-free days. 22:135. 2018
Carbonic anhydrase inhibitors in patients with respiratory failure and metabolic alkalosis: a systematic review and meta-analysis of randomized controlled trials. 22:275-275. 2018
Erratum to: Cardiac ischemia in patients with septic shock randomized to vasopressin or norepinephrine. 21:98. 2017
Plasma metabolomics for the diagnosis and prognosis of H1N1 influenza pneumonia. 21:97. 2017
Recovery after critical illness: putting the puzzle together—a consensus of 29. 21:296. 2017
Communication tools for end-of-life decision-making in the intensive care unit: a systematic review and meta-analysis. 20:97. 2016
Efficacy and safety of proton pump inhibitors for stress ulcer prophylaxis in critically ill patients: a systematic review and meta-analysis of randomized trials. 20:120. 2016
Efficacy of prothrombin complex concentrates for the emergency reversal of dabigatran-induced anticoagulation. 20:115. 2016
Surviving critical illness: what is next? An expert consensus statement on physical rehabilitation after hospital discharge. 20:354. 2016
The influence of corticosteroid treatment on the outcome of influenza A(H1N1pdm09)-related critical illness. 20:75. 2016
Variation in diurnal sedation in mechanically ventilated patients who are managed with a sedation protocol alone or a sedation protocol and daily interruption. 20:233. 2016
Critical care capacity in Canada: results of a national cross-sectional study. 19:133. 2015
Human severe sepsis cytokine mixture increases β2-integrin-dependent polymorphonuclear leukocyte adhesion to cerebral microvascular endothelial cells in vitro. 19:149. 2015
Prognostic value of procalcitonin in respiratory tract infections across clinical settings. 19:74. 2015
Virtuous laughter: we should teach medical learners the art of humor. 19:222. 2015
Adjunct prednisone therapy for patients with community-acquired pneumonia: a randomized, placebo-controlled multicenter trial. 19:P125-P125. 2015
Validation of an electronic early warning score using decision tree analysis: proposal. 19:p503. 2015
The efficacy and safety of plasma exchange in patients with sepsis and septic shock: a systematic review and meta-analysis. 18:699. 2014
High-volume hemofiltration for septic acute kidney injury: a systematic review and meta-analysis. 18:R7-R7. 2014
Implementing a multifaceted tailored intervention to improve nutrition adequacy in critically ill patients: results of a multicenter feasibility study. 18:R96-R96. 2014
Predictors of physical restraint use in Canadian intensive care units. 18:R46-R46. 2014
Thromboprophylaxis patterns and determinants in critically ill patients: a multicenter audit. 18:R82-R82. 2014
Risk factors of pituitary disorders following traumatic brain injury. 17:p332. 2013
Cardiac ischemia in patients with septic shock randomized to vasopressin or norepinephrine. 17:R117-R117. 2013
Clinical review: Clinical management of new oral anticoagulants: a structured review with emphasis on the reversal of bleeding complications. 17:230-230. 2013
Clinical review: Glucose control in severely burned patients - current best practice. 17:232-232. 2013
Co-enrollment of critically ill patients into multiple studies: patterns, predictors and consequences. 17:R1-R1. 2013
Critical care resource allocation: trying to PREEDICCT outcomes without a crystal ball. 17:107-107. 2013
Neuromuscular blocking agents in acute respiratory distress syndrome: a systematic review and meta-analysis of randomized controlled trials. 17:R43-R43. 2013
Randomized controlled trials in pediatric critical care: a scoping review. 17:R256-R256. 2013
Risk factors for intra-abdominal hypertension and abdominal compartment syndrome among adult intensive care unit patients: a systematic review and meta-analysis. 17:R249-R249. 2013
Skeletal muscle predicts ventilator-free days, ICU-free days, and mortality in elderly ICU patients. 17:R206-R206. 2013
Small bowel feeding and risk of pneumonia in adult critically ill patients: a systematic review and meta-analysis of randomized trials. 17:R127-R127. 2013
Usefulness and limitations of single-slice computed tomography analysis at the third lumbar region in the assessment of sarcopenia. 17:466-466. 2013
Feasibility of a multicenter prospective cohort study on the evaluation of prognosis in severe traumatic brain injury. 16:p310. 2012
Prevalence of pituitary disorders associated with traumatic brain injury: a systematic review. 16:p299. 2012
A microbiome approach to sepsis: development and case-study application of novel methods for detection and isolation of microbes from whole blood. 16:p111. 2012
Consequences of suspected heparin-induced thrombocytopenia in the ICU. 16:p423. 2012
Corticosteroids for critically ill patients: an international survey of intensivists. 16:P101-P101. 2012
In medical-surgical ICU patients, major bleeding is common but independent of heparin prophylaxis. 16:P435-P435. 2012
Potential association of gender with mortality and withdrawal of life-sustaining therapies in patients with severe TBI: a Canadian multicentre cohort study. 16:p500. 2012
Economic analyses of venous thromboembolism prevention strategies in hospitalized patients: a systematic review. 16:R43-R43. 2012
Insulin therapy improves protein metabolism in the critically ill. 16:125-125. 2012
Optimal Mode of clearance in critically ill patients with Acute Kidney Injury (OMAKI) - a pilot randomized controlled trial of hemofiltration versus hemodialysis: a Canadian Critical Care Trials Group project. 16:R205-R205. 2012
Prognostic utility and characterization of cell-free DNA in patients with severe sepsis. 16:R151-R151. 2012
Factors associated with withdrawal of life-sustaining therapy in severe traumatic brain injury patients. 15:p520. 2011
Pulmonary embolism in medical-surgical ICU patients. 15:p19. 2011
Multicentre validation of the bedside paediatric early warning system score: a severity of illness score to detect evolving critical illness in hospitalised children. 15:R184-R184. 2011
Red blood cell transfusion and increased length of storage are not associated with deep vein thrombosis in medical and surgical critically ill patients: a prospective observational cohort study. 15:R263-R263. 2011
Transpulmonary thermodilution for hemodynamic measurements in severely burned children. 15:R118-R118. 2011
Clinical review: Intra-abdominal hypertension: does it influence the physiology of prone ventilation?. 14:232. 2010
Beta 2 antagonism in acute respiratory failure. 14:1012-1012. 2010
Higher versus lower positive end-expiratory pressure in acute lung injury and acute respiratory distress syndrome: systematic review and individual patient data meta-analysis. 14:P182-P182. 2010
Resuscitation fluid use in critically ill adults: an international cross sectional study in 391 intensive care units. 14:R185-R185. 2010
The use of exenatide in severely burned pediatric patients. 14:R153-R153. 2010
A retrospective cohort pilot study to evaluate a triage tool for use in a pandemic. 13:R170-R170. 2009
Determining neurological prognosis in patients with severe traumatic brain injury: a survey of Canadian intensivists. 13:p88. 2009
Risk factors of earthquake inpatient death: a case control study. 13:R24-R24. 2009
The leading causes of death after burn injury in a single pediatric burn center. 13:R183-R183. 2009
A long-term follow-up study investigating health-related quality of life and resource use in survivors of severe sepsis: comparison of recombinant human activated protein C with standard care. 12:429-429. 2008
Are serum cytokines early predictors for the outcome of burn patients with inhalation injuries who do not survive?. 12:R81-R81. 2008
Detecting myocardial infarction in critical illness using screening troponin measurements and ECG recordings. 12:R36-R36. 2008
Geographic variation in the reversal of vitamin K antagonist-associated coagulopathy. 12:P220-P220. 2008
Relaunching the Pro–Con section at Critical Care. 12:140-140. 2008
Venous thromboembolism and bleeding in critically ill patients with severe renal insufficiency receiving dalteparin prophylaxis: prevalence, incidence and risk factors. 12:R32-R32. 2008
A long-term follow-up study investigating health-related quality of life and resource use in survivors of severe sepsis: comparison of recombinant human activated protein C with standard care. 11:R128-R128. 2007
A randomized trial of combination therapy versus monotherapy for the empiric treatment of suspected ventilator-associated pneumonia. 11:P95-P95. 2007
A survey of Canadian intensivists' resuscitation practices in early septic shock. 11:R74-R74. 2007
Burn size determines the inflammatory and hypermetabolic response. 11:R90-R90. 2007
Inhalation injury in severely burned children does not augment the systemic inflammatory response. 11:R22-R22. 2007
Outcomes from ventilator-associated pneumonia caused by multidrug-resistant organisms or Pseudomonas: results from 28 intensive care units. 11:P89-P89. 2007
Surfactant therapy for acute respiratory failure in children: a systematic review and meta-analysis. 11:R66-R66. 2007
Activated protein C improves intestinal microcirculation in experimental endotoxaemia in the rat.. 10:R157-R157. 2006
Drotrecogin alfa (activated) in patients with severe sepsis and a high risk of death.. 10:427-427. 2006
Drotrecogin alfa (activated): does current evidence support treatment for any patients with severe sepsis?. 10:145-145. 2006
Drotrecogin alfa (activated): down and not out, but not really in either.. 10:420-420. 2006
Effects of coagulation factor XIII on intestinal functional capillary density, leukocyte adherence and mesenteric plasma extravasation in experimental endotoxemia.. 10:R29-R29. 2006
Effects of dopexamine on the intestinal microvascular blood flow and leukocyte activation in a sepsis model in rats.. 10:R117-R117. 2006
Measuring the anticoagulant effect of low molecular weight heparins in the critically ill.. 10:150-150. 2006
Outcomes of interfacility critical care adult patient transport: a systematic review.. 10:R6-R6. 2006
Acute myocardial infarction: incidence and outcomes in an intensive care unit. 9:P315-P315. 2005
Alpha-1-acid glycoprotein reduces hepatic leukocyte recruitment in early sepsis. 9:P189-P189. 2005
Clinical review: Mechanical ventilation in severe asthma.. 9:581-581. 2005
Clinical review: SARS - lessons in disaster management.. 9:384-384. 2005
Elevated troponin and myocardial infarction in the intensive care unit: a prospective study.. 9:R636-R636. 2005
ICU research coordinator activities: a time-in-motion multicenter study. 9:P267-P267. 2005
Prevalence, incidence and risk factors for acute renal failure in the intensive care unit. 9:P356-P356. 2005
Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility. Con: the hazards of stopping for futility.. 9:P34-P34. 2005
The reliability of electrocardiogram interpretation in critically ill patients. 9:P320-P320. 2005
Tissue engineered fetal skin constructs for pediatric burns.. 9:533-533. 2005
Troponin incidence, prevalence and prognosis among critically ill patients. 9:P311-P311. 2005
Albumin in critical care: SAFE, but worth its salt?. 8:297-297. 2004
Burden of Illness in ThromboEmbolism in Critical Care (BITEC) study: a multicenter Canadian study. 8:P103-P103. 2004
Clinically important deep vein thrombosis in the intensive care unit: a survey of intensivists.. 8:R145-R145. 2004
Critical care procedure logging using handheld computers.. 8:R336-R336. 2004
Hand washing compliance in the intensive care unit. 8:p215. 2004
Lowering of Glucose in Critical Care (LOGIC): pilot trial in medical–surgical ICU patients. 8:P251-P251. 2004
Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility. Pro: Futility stopping can speed up the development of effective treatments.. 9:34-34. 2004
Prospective evaluation of an internet-linked handheld computer critical care knowledge access system.. 8:R414-R414. 2004
Thrombocytopenia in medical–surgical ICU patients. 8:P125-P125. 2004
Web report: SARS resources. 7:464. 2003
Clinical review: high-frequency oscillatory ventilation in adults--a review of the literature and practical applications.. 7:385-385. 2003
Communication in the Toronto critical care community: important lessons learned during SARS.. 7:405-405. 2003
Deep venous thrombosis in medical–surgical ICU patients: prevalence, incidence and risk factors. 7:P111-P111. 2003
Influencing advance directive completion rates in nonterminally ill patients: a systematic review. 7:P254-P254. 2003
Predictors of clinician discomfort with daily life support plans for mechanically ventilated patients. 7:P252-P252. 2003
Relationship between peak anti-Xa levels and calculated creatinine clearance in ICU patients receiving low molecular weight heparin. 7:P112-P112. 2003
Use of a rapid arterial blood gas analyzer to estimate blood hemoglobin concentration among critically ill adults. 6:72-75. 2002
Practising evidence-based medicine: the design and implementation of a multidisciplinary team-driven extubation protocol. 5:349-354. 2001
Prevention and diagnosis of venous thromboembolism in critically ill patients: a Canadian survey. 5:336-342. 2001
The attributable mortality and length of intensive care unit stay of clinically important gastrointestinal bleeding in critically ill patients. 5:368-375. 2001
Handheld computers in critical care. 5:227-231. 2001
The attributable mortality and length of intensive care unit stay of clinically important gastrointestinal bleeding in critically ill patients. 5:369-U3. 2001
The sound of silence: rationing resources for critically ill patients.. 3:R1-R1. 1999
Systematic review: Intra-aortic balloon counterpulsation pump therapy: a critical appraisal of the evidence for patients with acute myocardial infarction. 2:3-8. 1998
The relation between nutrition and nosocomial pneumonia: randomized trials in critically ill patients.. 1:3-3. 1997

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