Journal article
Efficacy and safety of proton pump inhibitors for stress ulcer prophylaxis in critically ill patients: a systematic review and meta-analysis of randomized trials
Abstract
BackgroundThe relative efficacy and safety of proton pump inhibitors (PPIs) compared to histamine-2-receptor antagonists (H2RAs) should guide their use in reducing bleeding risk in the critically ill.MethodsWe searched the Cochrane library, MEDLINE, EMBASE, ACPJC, clinical trials registries, and conference proceedings through November 2015 without language or publication date restrictions. Only randomized controlled trials (RCTs) of PPIs vs …
Authors
Alshamsi F; Belley-Cote E; Cook D; Almenawer SA; Alqahtani Z; Perri D; Thabane L; Al-Omari A; Lewis K; Guyatt G
Journal
Critical Care, Vol. 20, No. 1,
Publisher
Springer Nature
Publication Date
12 2016
DOI
10.1186/s13054-016-1305-6
ISSN
1364-8535