Troponin I Concept

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• 2007 Universal Myocardial Infarction Definition Change Criteria for Risk Stratification by Use of a High-Sensitivity Cardiac Troponin I Assay  Journal Articles
• 4 hs-cTnI algorithms had high sensitivity and low failure rates for ruling out acute MI in the ED  Journal Articles
• Post Exercise Cardiac Troponin I Release and Clearance in Normal Standardbred Racehorses  Journal Articles
• A Three-Site Immunoassay for High-Sensitivity Cardiac Troponin I with Low Immunoreactivity for Macrocomplexes  Journal Articles
• A heterophile antibody affecting a contemporary but not a high-sensitivity cardiac troponin assay  Journal Articles
• Abnormal Cardiac Biomarkers in Patients with Systemic Lupus Erythematosus and No Prior Heart Disease: A Consequence of Antimalarials?  Journal Articles
• Acceptable Analytical Variation May Exceed High-Sensitivity Cardiac Troponin I Cutoffs in Early Rule-Out and Rule-In Acute Myocardial Infarction Algorithms  Journal Articles
• Additional approaches for identifying non-reproducible cardiac troponin results  Journal Articles
• An Approach to Investigating Discordant High-Sensitivity Cardiac Troponin I Results  Journal Articles
• An approach to rule-out an acute cardiovascular event or death in emergency department patients using outcome-based cutoffs for high-sensitivity cardiac troponin assays and glucose  Journal Articles
• An interference yielding divergent high-sensitivity cardiac troponin results on different instruments from the same manufacturer  Journal Articles
• Analytic and Clinical Utility of a Next-Generation, Highly Sensitive Cardiac Troponin I Assay for Early Detection of Myocardial Injury  Journal Articles
• Analytical Variation and Abbott Diagnostics High-Sensitivity Cardiac Troponin I Risk Categories in Asymptomatic Individuals  Journal Articles
• Analytical assessment of ortho clinical diagnostics high-sensitivity cardiac troponin I assay  Journal Articles
• Analytical characterization of the Siemens Dimension EXL high-sensitivity cardiac troponin I assay  Journal Articles
• Analytical comparison of three different versions of a high-sensitivity cardiac troponin I assay over 10 years  Journal Articles
• Analytical factors to consider when assessing a high-sensitivity cardiac troponin I assay compared to a contemporary assay in clinical studies  Journal Articles
• Analytical validation of cardiac troponin I assays in horses  Journal Articles
• Antimalarial-induced Cardiomyopathy in Systemic Lupus Erythematosus: As Rare as Considered?  Journal Articles
• Application of High-Sensitivity Troponin in Suspected Myocardial Infarction  Journal Articles
• Approaching 2020 acuity for high-sensitivity cardiac troponin assays in Clinical Biochemistry  Journal Articles
• Assessing matrix, interferences and comparability between the Abbott Diagnostics and the Beckman Coulter high-sensitivity cardiac troponin I assays  Journal Articles
• Assessing the Requirement for the 6-Hour Interval between Specimens in the American Heart Association Classification of Myocardial Infarction in Epidemiology and Clinical Research Studies  Journal Articles
• Assessment of the 99th or 97.5th Percentile for Cardiac Troponin I in a Healthy Pediatric Cohort  Journal Articles
• Assessment of the European Society of Cardiology 0-Hour/1-Hour Algorithm to Rule-Out and Rule-In Acute Myocardial Infarction  Journal Articles
• Association of High-Sensitivity Cardiac Troponin I Concentration With Cardiac Outcomes in Patients With Suspected Acute Coronary Syndrome  Journal Articles
• Association of cardiac biomarkers with acute kidney injury after cardiac surgery: A multicenter cohort study  Journal Articles
• Authors' response to Apple editorial  Journal Articles
• Best Practices for Monitoring Cardiac Troponin in Detecting Myocardial Injury  Journal Articles
• Between-day versus within-day imprecision using the Abbott high-sensitivity cardiac troponin I assay at concentrations around 5 ng/l  Journal Articles
• Calpain inhibitors exhibit matrix metalloproteinase-2 inhibitory activity  Journal Articles
• Capability of ischemia-modified albumin to predict serious cardiac outcomes in the short term among patients with potential acute coronary syndrome  Journal Articles
• Cardiac Biomarkers Are Associated With an Increased Risk of Stroke and Death in Patients With Atrial Fibrillation  Journal Articles
• Cardiac Biomarkers and Left Ventricular Hypertrophy in Relation to Outcomes in Patients With Atrial Fibrillation: Experiences From the RE‐LY Trial  Journal Articles
• Cardiac Troponin Cutoffs: The Importance of Assay Sensitivity and the Patient Population  Journal Articles
• Cardiac biomarkers and left ventricular hypertrophy in relation to outcomes in patients with atrial fibrillation: experiences from the RELY trial  Conferences
• Cardiac troponin I, a possible predictor of survival in patients with stable congestive heart failure.  Journal Articles
• Cardiac troponin and natriuretic peptide analytical interferences from hemolysis and biotin: educational aids from the IFCC Committee on Cardiac Biomarkers (IFCC C-CB)  Journal Articles
• Cardiotoxicity associated with sunitinib  Journal Articles
• Caution When Using High-Sensitivity Cardiac Troponin I Assay to Rule Out Acute Ischemia: When the Delta to Rule In Is Within Analytical Variation  Journal Articles
• Centrifugation — an important pre-analytical factor for the Abbott Architect high-sensitivity cardiac troponin I assay  Journal Articles
• Clinical Laboratory Practice Recommendations for the Use of Cardiac Troponin in Acute Coronary Syndrome: Expert Opinion from the Academy of the American Association for Clinical Chemistry and the Task Force on Clinical Applications of Cardiac Bio-Markers of the International Federation of Clinical Chemistry and Laboratory Medicine  Journal Articles
• Clinical Use of Ultrasensitive Cardiac Troponin I Assay in Intermediate- and High-Risk Surgery Patients  Journal Articles
• Clinical chemistry score versus high-sensitivity cardiac troponin I and T tests alone to identify patients at low or high risk for myocardial infarction or death at presentation to the emergency department  Journal Articles
• Clinical evaluation of Ortho Clinical Diagnostics high-sensitivity cardiac Troponin I assay in patients with symptoms suggestive of acute coronary syndrome  Journal Articles
• Clinical outcomes for chest pain patients discharged home from emergency departments using high-sensitivity versus conventional cardiac troponin assays  Journal Articles
• Combination of lymphocyte count and not the serological response with high-sensitivity cardiac troponin for risk stratification in patients with possible COVID-19  Journal Articles
• Combining presentation high-sensitivity cardiac troponin I and glucose measurements to rule-out an acute myocardial infarction in patients presenting to emergency department with chest pain  Journal Articles
• Commentary on Macrotroponin Complex as a Cause for Cardiac Troponin Increase after COVID-19 Vaccination and Infection  Journal Articles
• Comparison of hs-cTnI, hs-cTnT, hFABP and GPBB for identifying early adverse cardiac events in patients presenting within six hours of chest pain-onset  Journal Articles
• Comparison of two biomarker only algorithms for early risk stratification in patients with suspected acute coronary syndrome  Journal Articles
• Comprehensive Age and Sex 99th Percentiles for a High-Sensitivity Cardiac Troponin I Assay  Journal Articles
• Cord-Blood High-Sensitivity Troponin-I Reference Interval and Association with Early Neonatal Outcomes  Journal Articles
• Detection of repeated positive result biases for a high-sensitivity cardiac troponin I assay  Journal Articles
• Determination of Clinically Acceptable Analytical Variation of Cardiac Troponin at Decision Thresholds  Journal Articles
• Determination of Troponin I Release After CABG Surgery  Conferences
• Discordant High-Sensitivity Cardiac Troponin I Concentrations in the General Population  Journal Articles
• Discrepant high-sensitivity cardiac troponin I concentrations when measured on the Abbott Alinity ci versus the Abbott Architect system  Journal Articles
• Economic Considerations of Early Rule-In/Rule-Out Algorithms for The Diagnosis of Myocardial Infarction in The Emergency Department Using Cardiac Troponin and Glycemic Biomarkers  Journal Articles
• Editorial commentary: High-sensitivity cardiac troponin: Like every new tool there is a learning curve  Journal Articles
• Effect of Repeat Measurements of High-Sensitivity Cardiac Troponin on the Same Sample Using the European Society of Cardiology 0-Hour/1-Hour or 2-Hour Algorithms for Early Rule-Out and Rule-In for Myocardial Infarction  Journal Articles
• Effect of Rheumatoid Factor on Cardiac Troponin I Measurement Using Two Commercial Measurement Systems  Journal Articles
• Effect of Trimetazidine in Patients Undergoing Percutaneous Coronary Intervention: A Meta-Analysis  Journal Articles
• Effect of a low glycemic index diet versus a high-cereal fibre diet on markers of subclinical cardiac injury in healthy individuals with type 2 diabetes mellitus: An exploratory analysis of a randomized dietary trial  Journal Articles
• Effect of racing on cardiac troponin I concentration and associations with cardiac rhythm disturbances in Standardbred racehorses  Journal Articles
• Effectiveness of platelet inhibition on major adverse cardiac events in non-cardiac surgery after percutaneous coronary intervention: a prospective cohort study  Journal Articles
• Effects of contemporary troponin assay sensitivity on the utility of the early markers myoglobin and CKMB isoforms in evaluating patients with possible acute myocardial infarction  Journal Articles
• Elevated Cardiac Troponin Levels in Critically Ill Patients: Prevalence, Incidence, and Outcomes  Journal Articles
• Evaluation of the Siemens ADVIA Centaur high-sensitivity cardiac troponin I assay in serum  Journal Articles
• External Quality Assessment Testing Near the Limit of Detection for High-Sensitivity Cardiac Troponin Assays  Journal Articles
• Factors independently associated with cardiac troponin I levels in young and healthy adults from the general population  Journal Articles
• Health Outcomes Categorized by Current and Previous Definitions of Acute Myocardial Infarction in an Unselected Cohort of Troponin-Naïve Emergency Department Patients  Journal Articles
• High-Sensitivity Cardiac Troponin I Measurement for Risk Stratification in a Stable High-Risk Population  Journal Articles
• High-Sensitivity Cardiac Troponin I Thresholds to Identify Myocardial Injury After Noncardiac Surgery: A Cohort Study  Journal Articles
• High-Sensitivity Cardiac Troponin I for Predicting Death in a Female Emergency Department Population  Journal Articles
• High-Sensitivity Cardiac Troponin Risk Cutoffs for Acute Cardiac Outcomes at Emergency Department Presentation  Journal Articles
• High-Sensitivity Cardiac Troponin—Optimizing the Diagnosis of Acute Myocardial Infarction/Injury in Women (CODE-MI): Rationale and design for a multicenter, stepped-wedge, cluster-randomized trial  Journal Articles
• High-Sensitivity Generation 5 Cardiac Troponin T Sex- and Age-Specific 99th Percentiles in the CALIPER Cohort of Healthy Children and Adolescents  Journal Articles
• High-Sensitivity Troponin I after Cardiac Surgery and 30-Day Mortality  Journal Articles
• High-sensitivity Troponin I Predicts Major Cardiovascular Events after Non-Cardiac Surgery: A Vascular Events in Non-Cardiac Surgery Patients Cohort Evaluation (VISION) Substudy  Journal Articles
• High-sensitivity cardiac troponin and the importance of cutoffs in patients with prior coronary artery bypass grafting with suspected NSTEMI  Journal Articles
• High-sensitivity cardiac troponin concentrations at emergency department presentation in females and males with an acute cardiac outcome  Journal Articles
• High-sensitivity troponin testing months after an acute coronary syndrome: noise or notable results  Journal Articles
• Histidine-Rich Glycoprotein Modulates the Toxic Effects of High-Dose Polyphosphate in Mice  Journal Articles
• Hospital Admission and Myocardial Injury Prevalence after the Clinical Introduction of a High-Sensitivity Cardiac Troponin I Assay  Journal Articles
• Impact of Switching Sample Types for High-Sensitivity Cardiac Troponin I Assays in the 0/1 Hour Algorithms  Journal Articles
• Imprecision and Delta Criteria for a New ESC 0/2-Hour Algorithm  Journal Articles
• Incidence and outcomes of perioperative myocardial infarction/injury diagnosed by high-sensitivity cardiac troponin I  Journal Articles
• Incidence, predictors, and clinical significance of troponin-I elevation without creatine kinase elevation following percutaneous coronary interventions  Journal Articles
• Increasing Cardiac Troponin Changes Measured by a Research High-Sensitivity Troponin I Assay: Absolute vs Percentage Changes and Long-Term Outcomes in a Chest Pain Cohort  Journal Articles
• Independent and combined effects of biotin and hemolysis on high-sensitivity cardiac troponin assays  Journal Articles
• Inhibition of delta-protein kinase C by delcasertib as an adjunct to primary percutaneous coronary intervention for acute anterior ST-segment elevation myocardial infarction: results of the PROTECTION AMI Randomized Controlled Trial  Journal Articles
• Is a Pattern of Increasing Biomarker Concentrations Important for Long-Term Risk Stratification in Acute Coronary Syndrome Patients Presenting Early after the Onset of Symptoms?  Journal Articles
• Letter by Kavsak and MacRae Regarding Article, “Utility of Absolute and Relative Changes in Cardiac Troponin Concentrations in the Early Diagnosis of Acute Myocardial Infarction”  Journal Articles
• Long-Term Health Outcomes Associated with Detectable Troponin I Concentrations  Journal Articles
• Long-term quality control testing on a high-sensitivity cardiac troponin I assay  Journal Articles
• Longitudinal High-Sensitivity Cardiac Troponin I Measurements in Patients With Breast Cancer Receiving Trastuzumab  Journal Articles
• Lot-to-Lot Variation for Commercial High-Sensitivity Cardiac Troponin: Can We Realistically Report Down to the Assay’s Limit of Detection?  Journal Articles
• Lot-to-lot bias for high-sensitivity cardiac troponin I concentrations ≥1000 ng/L  Journal Articles
• Macrocomplexes and discordant high-sensitivity cardiac troponin concentrations  Journal Articles
• Macrocomplexes and high-sensitivity cardiac troponin assays in samples stored for over 15 years  Journal Articles
• Matrix and bilirubin interference for high-sensitivity cardiac troponin I  Journal Articles
• Matrix metalloproteinase-2 in oncostatin M-induced sarcomere degeneration in cardiomyocytes  Journal Articles
• Measurement in different sample types may aid in detecting interferences and macrocomplexes affecting cardiac troponin measurements  Journal Articles
• Mechanisms of cytosolic targeting of matrix metalloproteinase‐2  Journal Articles
• Misclassification of Myocardial Injury by a High-Sensitivity Cardiac Troponin I Assay  Journal Articles
• Multicenter comparison of imprecision at low concentrations of two regulatory approved high-sensitivity cardiac troponin I assays  Journal Articles
• Ninety-Minute vs 3-h Performance of High-Sensitivity Cardiac Troponin Assays for Predicting Hospitalization for Acute Coronary Syndrome  Journal Articles
• Patient with macrocomplexes for both creatine kinase and cardiac troponin reveals the importance of immunoassay methods for macrotroponin detection  Journal Articles
• Performance of high-sensitivity cardiac troponin in the emergency department for myocardial infarction and a composite cardiac outcome across different estimated glomerular filtration rates  Journal Articles
• Personalized diagnosis in suspected myocardial infarction  Journal Articles
• Pre-analytical variables affecting discordant results on repeat sample testing for cardiac troponin I  Journal Articles
• Preconditioning Shields Against Vascular Events in Surgery (SAVES), a multicentre feasibility trial of preconditioning against adverse events in major vascular surgery: study protocol for a randomised control trial  Journal Articles
• Prognostic use of cardiac troponin T and troponin I in patients with heart failure.  Journal Articles
• Protocol for Improving Care by FAster risk-STratification through use of high sensitivity point-of-care troponin in patients presenting with possible acute coronary syndrome in the EmeRgency department (ICare-FASTER): a stepped-wedge cluster randomised quality improvement initiative  Journal Articles
• Quantitative troponin and death, cardiogenic shock, cardiac arrest and new heart failure in patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS): insights from the Global Registry of Acute Coronary Events  Journal Articles
• Reality check for cardiac troponin testing – Sometimes the result is wrong  Journal Articles
• Relation between cardiac troponin I and mortality in acute decompensated heart failure  Journal Articles
• Relation of Troponin Elevation to Outcome in Patients With Infective Endocarditis  Journal Articles
• Relationship Between High-Sensitivity Cardiac Troponin I and Blood Pressure Among Young and Healthy Adults  Journal Articles
• Repeat measurements on patient samples identifies unpredictable and poorly reproducible cardiac troponin results with a high-sensitivity cardiac troponin assay  Journal Articles
• Response to Letter Regarding Article, “Cardiac Biomarkers Are Associated With an Increased Risk of Stroke and Death in Patients With Atrial Fibrillation: A Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) Substudy”  Journal Articles
• Role of first-drawn indeterminate troponin-I levels in the Emergency Department  Journal Articles
• Rule-In and Rule-Out of Myocardial Infarction Using Cardiac Troponin and Glycemic Biomarkers in Patients with Symptoms Suggestive of Acute Coronary Syndrome  Journal Articles
• Sample matrix and high-sensitivity cardiac troponin I assays  Journal Articles
• Sensitive and high sensitivity cardiac troponin I concentrations in the Heart Outcomes Prevention Evaluation (HOPE) study — A high risk population  Journal Articles
• Sex Differences in the Clinical Presentation and Natural History of Dilated Cardiomyopathy  Journal Articles
• Sex-Specific Kinetics of High-Sensitivity Cardiac Troponin I and T following Symptom Onset and Early Presentation in Non-ST-Segment Elevation Myocardial Infarction  Journal Articles
• Sex-specific cutoffs for cardiac troponin using high-sensitivity assays — Is there clinical equipoise?  Journal Articles
• Short- and Long-Term Risk Stratification Using a Next-Generation, High-Sensitivity Research Cardiac Troponin I (hs-cTnI) Assay in an Emergency Department Chest Pain Population  Journal Articles
• Should detectable cardiac troponin concentrations in a healthy population be the only criterion for classifying high-sensitivity cardiac troponin assays?  Journal Articles
• Simulation Models of Misclassification Error for Single Thresholds of High-Sensitivity Cardiac Troponin I Due to Assay Bias and Imprecision  Journal Articles
• Single troponin to rule-out MI in early presenters, perhaps, but not major adverse cardiac events  Journal Articles
• Storage conditions, sample integrity, interferences, and a decision tool for investigating unusual high-sensitivity cardiac troponin results  Journal Articles
• The Need to Develop Clinical Guidance for the Use of High-Sensitivity Cardiac Troponin in Pediatric and Neonatal Patients  Journal Articles
• The PROTROPIC feasibility study: prognostic value of elevated troponins in critical illness  Conferences
• The Utility of Four Biochemical Markers in the Triage of Chest Pain Patients  Journal Articles
• The impact of the ESC/ACC redefinition of myocardial infarction and new sensitive troponin assays on the frequency of acute myocardial infarction  Journal Articles
• The imprecision for a high-sensitivity cardiac troponin assay and a CA 19-9 assay in samples with high C-reactive protein concentrations  Journal Articles
• The incidence and prognostic significance of elevated cardiac troponins in patients with submassive pulmonary embolism  Journal Articles
• The potential role of a turbidimetric heart-type fatty acid-binding protein assay to aid in the interpretation of persistently elevated, non-changing, cardiac troponin I concentrations  Journal Articles
• Troponin I after Cardiac Surgery and 30-Day Mortality  Journal Articles
• Troponin elevations after non-cardiac, non-vascular surgery are predictive of major adverse cardiac events and mortality: a systematic review and meta-analysis  Journal Articles
• Troponin levels in hemodialysis patients: interpretation based on guidelines, changing concentrations and high-sensitivity assays  Journal Articles
• Using the clinical chemistry score in the emergency department to detect adverse cardiac events: a diagnostic accuracy study  Journal Articles
• Validation of presentation and 3 h high-sensitivity troponin to rule-in and rule-out acute myocardial infarction  Journal Articles
• Validation of the ORIGIN Cardiovascular Biomarker Panel and the Value of Adding Troponin I in Dysglycemic People  Journal Articles
• Value of MRI in patients with a clinical suspicion of acute myocarditis  Journal Articles
• Variability Between Reagent Lots for High-Sensitivity Cardiac Troponin I May Affect Performance of Early Rule Out Strategies  Journal Articles
• Variability in Cardiac Biomarkers during Hemodialysis: A Prospective Cohort Study  Journal Articles
• Within-run precision and outlier detection for the Abbott ARCHITECT cardiac troponin I assay  Journal Articles