subject area of
- Activated protein C generation is greatly decreased in plasma from newborns compared to adults in the presence or absence of endothelium Journal Articles
- Alpha-1 proteinase inhibitor M358R reduces thrombin generation when displayed on the surface of cells expressing tissue factor Journal Articles
- Alpha1-proteinase inhibitor in the newborn - A comment. Journal Articles
- Characterization of α1-antitrypsin as a heme oxygenase-1 suppressor in Alzheimer plasma Journal Articles
- Common coding variant in SERPINA1 increases the risk for large artery stroke Journal Articles
- Comparison of mammalian and bacterial expression library screening to detect recombinant alpha-1 proteinase inhibitor variants with enhanced thrombin inhibitory capacity☆ Journal Articles
- Conformational Changes in Thrombin When Complexed by Serpins Journal Articles
- Copd. Journal Articles
- Development of an assay for in vivo human neutrophil elastase activity. Increased elastase activity in patients with alpha 1-proteinase inhibitor deficiency. Journal Articles
- Elafin/elastase-specific inhibitor in bronchoalveolar lavage of normal subjects and farmer's lung. Journal Articles
- Engineering the serpin α1‐antitrypsin: A diversity of goals and techniques Journal Articles
- Enhancement of plasma kallikrein specificity of antitrypsin variants identified by phage display and partial reversion. Journal Articles
- Expression screening of bacterial libraries of recombinant alpha-1 proteinase inhibitor variants for candidates with thrombin inhibitory capacity Journal Articles
- Full or Partial Substitution of the Reactive Center Loop of α-1-Proteinase Inhibitor by that of Heparin Cofactor II: P1 Arg Is Required for Maximal Thrombin Inhibition Journal Articles
- Fusion of the C-terminal triskaidecapeptide of hirudin variant 3 to alpha1-proteinase inhibitor M358R increases the serpin-mediated rate of thrombin inhibition Journal Articles
- Gene Therapy for Pulmonary Diseases Journal Articles
- Genetic Modifiers of Liver Disease in Cystic Fibrosis Journal Articles
- Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin Journal Articles
- Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity Journal Articles
- High Doses of a Helper-Dependent Adenoviral Vector Yield Supraphysiological Levels ofα1-Antitrypsin with Negligible Toxicity Journal Articles
- Human kallikrein 4: enzymatic activity, inhibition, and degradation of extracellular matrix proteins Conferences
- Hypercoagulability. Journal Articles
- Identification of Functional and Expression Polymorphisms Associated With Risk for Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis Journal Articles
- Identification of an alpha-1 antitrypsin variant with enhanced specificity for factor XIa by phage display, bacterial expression, and combinatorial mutagenesis Journal Articles
- Immunohistochemical localization of alpha 1-antitrypsin in normal mouse liver and pancreas. Journal Articles
- Inhibitory effect of human recombinant interferon gamma on synthesis of acute phase proteins in human hepatoma Hep G2 cells stimulated by leukocyte cytokines, TNF alpha and IFN-beta 2/BSF-2/IL-6. Journal Articles
- Isolation and partial characterization of rabbit plasma α1-antitrypsin Journal Articles
- Microfluidic device for single step measurement of protein C in plasma samples for sepsis prognosis Journal Articles
- Modularity of protein function: Chimeric interleukin 1.beta.s containing specific protease inhibitor loops retain function of both molecules Journal Articles
- Modulation of types I and II acute phase reactants with insulin-like growth factor-1/binding protein-3 complex in severely burned children Journal Articles
- Oncostatin M, but Not Interleukin-6 or Leukemia Inhibitory Factor, Stimulates Expression of Alpha1-Proteinase Inhibitor in A549 Human Alveolar Epithelial Cells Journal Articles
- Ontogeny and tissue distribution of alpha-1-antitrypsin of the mouse Journal Articles
- Patients with severe sepsis vary markedly in their ability to generate activated protein C Journal Articles
- Phage Display of the Serpin Alpha-1 Proteinase Inhibitor Randomized at Consecutive Residues in the Reactive Centre Loop and Biopanned with or without Thrombin Journal Articles
- Reduction of thrombus size in murine models of thrombosis following administration of recombinant α1-proteinase inhibitor mutant proteins Journal Articles
- Secretory leukocyte proteinase inhibitor is preferentially increased in patients with acute respiratory distress syndrome Journal Articles
- Some observations on the affinity chromatography of rabbit plasminogen Journal Articles
- Synthesis of alpha 1-protease inhibitor by resident and activated mouse alveolar macrophages. Journal Articles
- Synthesis of antithrombin III and alpha-1-antitrypsin by the perfused rat liver Journal Articles
- The M358R variant of α 1 -proteinase inhibitor inhibits coagulation factor VIIa Journal Articles
- The Transferable Tail: Fusion of the N-Terminal Acidic Extension of Heparin Cofactor II to α1-Proteinase Inhibitor M358R Specifically Increases the Rate of Thrombin Inhibition Journal Articles
- The acute phase response in parasite infection. Nippostrongylus brasiliensis in the mouse. Journal Articles
- The appended tail region of heparin cofactor II and additional reactive centre loop mutations combine to increase the reactivity and specificity of α1-proteinase inhibitor M358R for thrombin Journal Articles
- Therapeutic serum concentrations of human alpha-1-antitrypsin after adenoviral-mediated gene transfer into mouse hepatocytes. Journal Articles
- Toxicity Associated with Repeated Administration of First-Generation Adenovirus Vectors Does Not Occur with a Helper-Dependent Vector Journal Articles
- Treatment of endothelium with the chemotherapy agent vincristine affects activated protein C generation to a greater degree in newborn plasma than in adult plasma Journal Articles
- Use of a Liver-Specific Promoter Reduces Immune Response to the Transgene in Adenoviral Vectors Journal Articles
- α1-Antitrypsin Deficiency Alleles in Cystic Fibrosis Lung Disease Journal Articles