subject area of
- Activated protein C generation is greatly decreased in plasma from newborns compared to adults in the presence or absence of endothelium Academic Article
- Alpha-1 proteinase inhibitor M358R reduces thrombin generation when displayed on the surface of cells expressing tissue factor Academic Article
- Alpha1-proteinase inhibitor in the newborn - A comment. Academic Article
- Characterization of α1-antitrypsin as a heme oxygenase-1 suppressor in Alzheimer plasma Academic Article
- Common coding variant in SERPINA1 increases the risk for large artery stroke Academic Article
- Comparison of mammalian and bacterial expression library screening to detect recombinant alpha-1 proteinase inhibitor variants with enhanced thrombin inhibitory capacity☆ Academic Article
- Conformational Changes in Thrombin When Complexed by Serpins Academic Article
- Copd. Academic Article
- Development of an assay for in vivo human neutrophil elastase activity. Increased elastase activity in patients with alpha 1-proteinase inhibitor deficiency. Academic Article
- Elafin/elastase-specific inhibitor in bronchoalveolar lavage of normal subjects and farmer's lung. Academic Article
- Engineering the serpin α 1 ‐antitrypsin: A diversity of goals and techniques Academic Article
- Expression screening of bacterial libraries of recombinant alpha-1 proteinase inhibitor variants for candidates with thrombin inhibitory capacity Academic Article
- Full or Partial Substitution of the Reactive Center Loop of α-1-Proteinase Inhibitor by that of Heparin Cofactor II: P1 Arg Is Required for Maximal Thrombin Inhibition Academic Article
- Fusion of the C-terminal triskaidecapeptide of hirudin variant 3 to alpha1-proteinase inhibitor M358R increases the serpin-mediated rate of thrombin inhibition Academic Article
- Gene Therapy for Pulmonary Diseases Academic Article
- Genetic Modifiers of Liver Disease in Cystic Fibrosis Academic Article
- Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin Academic Article
- Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity Academic Article
- High Doses of a Helper-Dependent Adenoviral Vector Yield Supraphysiological Levels ofα1-Antitrypsin with Negligible Toxicity Academic Article
- Human kallikrein 4: enzymatic activity, inhibition, and degradation of extracellular matrix proteins Conference Paper
- Hypercoagulability. Academic Article
- Identification of Functional and Expression Polymorphisms Associated With Risk for Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis Academic Article
- Identification of an alpha-1 antitrypsin variant with enhanced specificity for factor XIa by phage display, bacterial expression, and combinatorial mutagenesis Academic Article
- Immunohistochemical localization of alpha 1-antitrypsin in normal mouse liver and pancreas. Academic Article
- Inhibitory effect of human recombinant interferon gamma on synthesis of acute phase proteins in human hepatoma Hep G2 cells stimulated by leukocyte cytokines, TNF alpha and IFN-beta 2/BSF-2/IL-6. Academic Article
- Isolation and partial characterization of rabbit plasma α1-antitrypsin Academic Article
- Microfluidic device for single step measurement of protein C in plasma samples for sepsis prognosis Academic Article
- Modularity of protein function: Chimeric interleukin 1.beta.s containing specific protease inhibitor loops retain function of both molecules Academic Article
- Oncostatin M, but Not Interleukin-6 or Leukemia Inhibitory Factor, Stimulates Expression of Alpha1-Proteinase Inhibitor in A549 Human Alveolar Epithelial Cells Academic Article
- Ontogeny and tissue distribution of alpha-1-antitrypsin of the mouse Academic Article
- Patients with severe sepsis vary markedly in their ability to generate activated protein C Academic Article
- Phage Display of the Serpin Alpha-1 Proteinase Inhibitor Randomized at Consecutive Residues in the Reactive Centre Loop and Biopanned with or without Thrombin Academic Article
- Reduction of thrombus size in murine models of thrombosis following administration of recombinant α1-proteinase inhibitor mutant proteins Academic Article
- Secretory leukocyte proteinase inhibitor is preferentially increased in patients with acute respiratory distress syndrome Academic Article
- Some observations on the affinity chromatography of rabbit plasminogen Academic Article
- Synthesis of alpha 1-protease inhibitor by resident and activated mouse alveolar macrophages. Academic Article
- Synthesis of antithrombin III and alpha-1-antitrypsin by the perfused rat liver Academic Article
- The M358R variant of α 1 -proteinase inhibitor inhibits coagulation factor VIIa Academic Article
- The Transferable Tail: Fusion of the N-Terminal Acidic Extension of Heparin Cofactor II to α1-Proteinase Inhibitor M358R Specifically Increases the Rate of Thrombin Inhibition Academic Article
- The acute phase response in parasite infection. Nippostrongylus brasiliensis in the mouse. Academic Article
- The appended tail region of heparin cofactor II and additional reactive centre loop mutations combine to increase the reactivity and specificity of α1-proteinase inhibitor M358R for thrombin Academic Article
- Therapeutic serum concentrations of human alpha-1-antitrypsin after adenoviral-mediated gene transfer into mouse hepatocytes. Academic Article
- Toxicity Associated with Repeated Administration of First-Generation Adenovirus Vectors Does Not Occur with a Helper-Dependent Vector Academic Article
- Treatment of endothelium with the chemotherapy agent vincristine affects activated protein C generation to a greater degree in newborn plasma than in adult plasma Academic Article
- Use of a Liver-Specific Promoter Reduces Immune Response to the Transgene in Adenoviral Vectors Academic Article
- α1-Antitrypsin Deficiency Alleles in Cystic Fibrosis Lung Disease Academic Article