Journal article
Use of a Liver-Specific Promoter Reduces Immune Response to the Transgene in Adenoviral Vectors
Abstract
Previous studies using adenoviral (Ad) vectors expressing human alpha1-antitrypsin (hAAT) under the control of ubiquitous promoters (RSV, mPGK) elicited the production of antibodies to hAAT in some mouse strains (C3H/HeJ and BALB/c) but not in others (C57BL/6J). In contrast, when a helper-dependent Ad vector (AdSTK109) with all viral coding sequences deleted and expressing hAAT from human genomic DNA with the endogenous promoter was used, …
Authors
Pastore L; Morral N; Zhou H; Garcia R; Parks RJ; Kochanek S; Graham FL; Lee B; Beaudet AL
Journal
Human Gene Therapy, Vol. 10, No. 11, pp. 1773–1781
Publisher
Mary Ann Liebert
Publication Date
July 20, 1999
DOI
10.1089/10430349950017455
ISSN
1043-0342