Journal article
Genetic Modifiers of Liver Disease in Cystic Fibrosis
Abstract
CONTEXT: A subset (approximately 3%-5%) of patients with cystic fibrosis (CF) develops severe liver disease with portal hypertension.
OBJECTIVE: To assess whether any of 9 polymorphisms in 5 candidate genes (alpha(1)-antitrypsin or alpha(1)-antiprotease [SERPINA1], angiotensin-converting enzyme [ACE], glutathione S-transferase [GSTP1], mannose-binding lectin 2 [MBL2], and transforming growth factor beta1 [TGFB1]) are associated with severe …
Authors
Bartlett JR; Friedman KJ; Ling SC; Pace RG; Bell SC; Bourke B; Castaldo G; Castellani C; Cipolli M; Colombo C
Journal
JAMA: The Journal of the American Medical Association, Vol. 302, No. 10, pp. 1076–1083
Publisher
American Medical Association (AMA)
Publication Date
September 9, 2009
DOI
10.1001/jama.2009.1295
ISSN
0098-7484
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdolescentAdultAge FactorsChildChild, PreschoolCystic FibrosisFemaleGlutathione S-Transferase piHumansHypertension, PortalInfantLiver CirrhosisLiver DiseasesLogistic ModelsMaleMannose-Binding LectinPeptidyl-Dipeptidase APolymorphism, GeneticRiskTransforming Growth Factor beta1Young Adultalpha 1-Antitrypsin