Microtubules, mitochondria, and molecular chaperones: a new hypothesis for in vivo assembly of microtubules

In Chinese hamster ovary cells, a number of independent mutants selected for resistance to antimitotic drugs have been found to be specifically altered in two major cellular proteins, designated P1 (relative mass (Mr) approximately 60-63 kilodaltons (kDa] and P2 (Mr approximately 69-70 kDa), which appeared microtubule related by a number of genetic and biochemical criteria. Antibodies to P1 have been found to bind specifically to mitochondria …