selected scholarly activity
-
chapters
- Vagal Pathways for Microbiome-Brain-Gut Axis Communication. Advances in Experimental Medicine and Biology. 115-133. 2014
- Afferente intestinale Sensibilität während des postoperativen Ileus bei der Maus — ein neues in vitro Modell. 291-293. 2003
- Enteric Reflexes that Influence Motility. 1-55. 2002
- Synthesis and biological activity of a series of single-loop iberiotoxin analogues. 597-598. 1995
-
conferences
- Low-dose penicillin exposure in adolescent mice has long-term effects on gut function. Neurogastroenterology and Motility. 2019
- Antibiotic driven changes in gut motility suggest direct modulation of enteric nervous system. Frontiers in Neuroscience. 138-138. 2017
- Lactobacillus rhamnosus JB-1 reverses old-age-related reduction in murine vagal afferent firing frequency. Neurogastroenterology and Motility. 97-97. 2017
- Oxytocin decreases mesenteric afferent impulses via a nNOS-NO-KATP pathway in rat. Neurogastroenterology and Motility. 27-27. 2014
- Squalamine Reverses Age and Loperamide Associated Dysmotility in a Mouse Biomarker Model of Constipation. Gastroenterology. S356-S356. 2014
- A D-galactose mouse model of dysmotility: Spatiotemporal motility mapping and intrinsic primary afferent neuron function. Neurogastroenterology and Motility. 47-48. 2012
- Enteric intrinsic primary afferent neurons may modulate the gut-brain axis by synaptic transmission to extrinsic mesenteric afferent fibres. Neurogastroenterology and Motility. 70-70. 2012
- Myenteric intrinsic primary afferent neuron function correlates with altered motility in aged mice. Neurogastroenterology and Motility. 119-119. 2012
- Oxytocin hyperpolarizes cultured duodenum myenteric intrinsic primary afferent neurons by opening BKCa channels through IP3 pathway. Neurogastroenterology and Motility. 46-47. 2012
- Oxytocin hyperpolarizes cultured duodenum myenteric intrinsic primary afferent neurons by opening BKCa channels through IP3 pathway. Neurogastroenterology and Motility. 147-147. 2012
- Mouse colon peristalsis as biomarker for clinically relevant probiotics. Neurogastroenterology and Motility. 46-46. 2011
- The microbiome is necessary for normal gut intrinsic primary afferent neuron excitability. Neurogastroenterology and Motility. 12-13. 2011
- Neuroimmune aspects of food intake. International Dairy Journal. 253-258. 2010
- Effect of lactobacillus SP (Lb) probiotic ingestion on membrane properties of intrinsic sensory neurons in rat colon. Gastroenterology. A401-A401. 2007
- Inflammation of mouse jejunum induces long term excitation in DRG neurons projecting to the viscera. Gastroenterology. A128-A128. 2004
- Na-v 1.9 but not 1.8 current is augmented in DRG neurons innervating the viscera 3-5 weeks after transient inflammation of mouse jejunum. Gastroenterology. A429-A429. 2004
- Afferent intestinal mechanosensitivity during postoperative ileus in the mouse jejunum. Gastroenterology. A800-A800. 2003
- Enteric sensory neurons in the mouse: Identification, electrophysiology and morphology. Gastroenterology. A39-A39. 2003
- Role of calcium channels in extrinsic afferent sensitivity in the mouse jejunum. Gastroenterology. A39-A39. 2003
- Extrinsic visceral afferent responses to luminal stimuli in mouse small bowel. Gastroenterology. A42-A42. 2002
- Low frequency presynaptic stimulation selectively excites S neurons with descending axons in the guinea pig ileum. Gastroenterology. A332-A332. 2001
- Direct mechanosensory responses of myenteric neurons in the guinea pig duodenum. Gastroenterology. A973-A973. 1999
- Sustained increases of excitability of guinea pig myenteric AH neurons following their synaptic activation. Gastroenterology. A734-A734. 1998
- Correlation of electrophysiology, morphology, chemistry and projections of myenteric neurons in the duodenum of the guinea pig.. Gastroenterology. A713-A713. 1997
- Characterization of 5-HT and H+ sensitive sensory pathways within the guinea-pig ileum. Gastroenterology. A633-A633. 1996
- Experimental basis for realistic large scale computer simulation of the enteric nervous system. PROCEEDINGS OF THE AUSTRALIAN PHYSIOLOGICAL AND PHARMACOLOGICAL SOCIETY, VOL 27, NO 1, APRIL, 1996. 1-11. 1996
- Cholinergic, somatostatin-immunoreactive interneurons in the guinea pig intestine: morphology, ultrastructure, connections and projections.. Journal of Anatomy. 303-321. 1995
- OLFACTORY-BULB INFLUENCE ON NEURONS OF VENTRAL STRIATUM. BASAL GANGLIA IV. 285-296. 1994
- SPINAL-CORD MONITORING WITH A NEW DEVICE FOR AUTOMATED SIGNAL ANALYSIS. HANDBOOK OF SPINAL CORD MONITORING. 167-170. 1994
- Structure and function of chemically specified enteric neurons in the guinea pig intestine. Peptides. 151-151. 1992
-
journal articles
- Therapeutic Value of Lactobacillus gasseri 345A in Chronic Constipation.. Neurogastroenterology and Motility. 37:e70012. 2025
- Adolescence, the Microbiota-Gut-Brain Axis, and the Emergence of Psychiatric Disorders. Biological Psychiatry. 95:310-318. 2024
- Squalamine reverses age-associated changes of firing patterns of myenteric sensory neurons and vagal fibres. Communications Biology. 7:80. 2024
- Regulatory T Cell Modulation by Lactobacillus rhamnosus Improves Feather Damage in Chickens. Frontiers in Veterinary Science. 9:855261. 2022
- Identification of SSRI-evoked antidepressant sensory signals by decoding vagus nerve activity. Scientific Reports. 11:21130. 2021
- L. rhamnosus improves the immune response and tryptophan catabolism in laying hen pullets. Scientific Reports. 11:19538. 2021
- Ingestion of Lactobacillus rhamnosus modulates chronic stress-induced feather pecking in chickens. Scientific Reports. 11:17119. 2021
- Squalamine Restores the Function of the Enteric Nervous System in Mouse Models of Parkinson’s Disease. Journal of Parkinson's Disease. 10:1477-1491. 2020
- Cecal motility and the impact of Lactobacillus in feather pecking laying hens. Scientific Reports. 10:12978. 2020
- The vagus nerve is necessary for the rapid and widespread neuronal activation in the brain following oral administration of psychoactive bacteria. Neuropharmacology. 170:108067-108067. 2020
- Mo1141 SQUALAMINE, AN AMINOSTEROL POTENTIALLY USEFUL IN TREATING PARKINSON'S DISEASE, ACTIVATES THE AFFERENT VAGUS NERVE VIA ACTION ON THE ENTERIC NERVOUS SYSTEM. Gastroenterology. 158:S-801. 2020
- The Vagus Nerve Is Critical for the Rapid and Widespread Response in the Brain Following Oral Administration of a Physiologically Active Bacteria (1556). Neurology. 94. 2020
- A121 SILENCING ENTERIC SENSORY NEURONS ABOLISHES THE EXCITATORY EFFECT OF SERTRALINE ON VAGAL AFFERENTS. Journal of the Canadian Association of Gastroenterology. 3:141-142. 2020
- Microvesicles from Lactobacillus reuteri (DSM-17938) completely reproduce modulation of gut motility by bacteria in mice. PLoS ONE. 15:e0225481-e0225481. 2020
- Oral selective serotonin reuptake inhibitors activate vagus nerve dependent gut-brain signalling. Scientific Reports. 9:14290. 2019
- 1018 – Translational Studies of Lactobacillus Gasseri Effects on Trpv1 and Motility, and Therapeutic Value in Women with Chronic Constipation. Gastroenterology. 156:S-221. 2019
- Antibiotics and the nervous system: More than just the microbes?. Brain, Behavior, and Immunity. 77:7-15. 2019
- Colonic Motility and Jejunal Vagal Afferent Firing Rates Are Decreased in Aged Adult Male Mice and Can Be Restored by an Aminosterol. Frontiers in Neuroscience. 13:955. 2019
- Effects of Acute Tryptophan Depletion on Repetitive Behavior in Laying Hens. Frontiers in Veterinary Science. 6:230. 2019
- Restraint stress induced gut dysmotility is diminished by a milk oligosaccharide (2′-fucosyllactose) in vitro. PLoS ONE. 14:e0215151-e0215151. 2019
- The Role of Tryptophan-Kynurenine in Feather Pecking in Domestic Chicken Lines. Frontiers in Veterinary Science. 6:209. 2019
- Differences in cecal microbiome of selected high and low feather-pecking laying hens. Poultry Science. 97:3009-3014. 2018
- A293 SQUALAMINE INCREASES VAGAL AFFERENT FIRING FREQUENCY IN AGING MICE. Journal of the Canadian Association of Gastroenterology. 1:421-421. 2018
- A301 ANTIBIOTICS INCREASE VAGAL AFFERENT FIRING IN THE MOUSE JEJUNUM. Journal of the Canadian Association of Gastroenterology. 1:432-432. 2018
- A306 LACTOBACILLUS RHAMNOSUS JB-1 AMELIORATES COLONIC AGE-RELATED DYSMOTILITY. Journal of the Canadian Association of Gastroenterology. 1:531-532. 2018
- A307 EFFECT OF SLOW SYNAPTIC EXCITATION ON MYENTERIC INTRINSIC PRIMARY AFFERENT NEURON BKCA CHANNEL ACTIVITY. Journal of the Canadian Association of Gastroenterology. 1:533-533. 2018
- A309 ANTIBIOTIC DRIVEN CHANGES IN GUT MOTILITY HIGHLIGHT DIRECT MODULATION OF ENTERIC NERVOUS SYSTEM. Journal of the Canadian Association of Gastroenterology. 1:536-536. 2018
- Disruptive physiology: olfaction and the microbiome–gut–brain axis. Biological Reviews. 93:390-403. 2018
-
Lactobacillus rhamnosus strain
JB ‐1 reverses restraint stress‐induced gut dysmotility. Neurogastroenterology and Motility. 29. 2017 - Antibiotic Driven Changes in Gut Motility Suggest Direct Modulation of Enteric Nervous System. Frontiers in Neuroscience. 11:588. 2017
- Moody microbes or fecal phrenology: what do we know about the microbiota-gut-brain axis?. BMC Medicine. 14:58. 2016
- The Microbiome–Gut–Brain Axis and the Consequences of Infection and Dysbiosis. American Journal of Gastroenterology Supplements. 3:33-40. 2016
- Effects ofSaccharomyces cerevisiaeorboulardiiyeasts on acute stress induced intestinal dysmotility. World Journal of Gastroenterology. 22:10532-10532. 2016
- Superior Cervical Ganglia Neurons Induce Foxp3+ Regulatory T Cells via Calcitonin Gene-Related Peptide. PLoS ONE. 11:e0152443-e0152443. 2016
- The TRPV1 channel in rodents is a major target for antinociceptive effect of the probiotic Lactobacillus reuteri DSM 17938. Journal of Physiology. 593:3943-3957. 2015
- Microbiota and the gut–brain axis. Nutrition Reviews. 73:28-31. 2015
- The gut microbiome restores intrinsic and extrinsic nerve function in germ‐free mice accompanied by changes in calbindin. Neurogastroenterology and Motility. 27:627-636. 2015
- Oxytocin-induced membrane hyperpolarization in pain-sensitive dorsal root ganglia neurons mediated by Ca2+/nNOS/NO/KATP pathway. Neuroscience. 289:417-428. 2015
- Gut commensal microvesicles reproduce parent bacterial signals to host immune and enteric nervous systems. The FASEB Journal. 29:684-695. 2015
-
Oxytocin down‐regulates mesenteric afferent sensitivity via the enteric
OTR /nNOS /NO /KATP pathway in rat. Neurogastroenterology and Motility. 27:51-62. 2015 - Enteric sensory neurons communicate with interstitial cells of Cajal to affect pacemaker activity in the small intestine. Pflugers Archiv European Journal of Physiology. 466:1467-1475. 2014
- The gut‐brain axis rewired: adding a functional vagal nicotinic “sensory synapse”. The FASEB Journal. 28:3064-3074. 2014
- Sa2019 Squalamine Reverses Age and Loperamide Associated Dysmotility in a Mouse Biomarker Model of Constipation. Gastroenterology. 146:S-356. 2014
- The origin of segmentation motor activity in the intestine. Nature Communications. 5:3326. 2014
-
Bifidobacterium longum
NCC 3001 inhibitsAH neuron excitability. Neurogastroenterology and Motility. 25:e478-e484. 2013 - Lactobacillus rhamnosus Ingestion Promotes Innate Host Defense in an Enteric Parasitic Infection. Clinical and Vaccine Immunology. 20:818-826. 2013
- Spatiotemporal maps reveal regional differences in the effects on gut motility for Lactobacillus reuteri and rhamnosus strains. Neurogastroenterology and Motility. 25:e205-e214. 2013
- The microbiome is essential for normal gut intrinsic primary afferent neuron excitability in the mouse. Neurogastroenterology and Motility. 25:183-183. 2013
- Psychoactive bacteriaLactobacillus rhamnosus(JB-1) elicits rapid frequency facilitation in vagal afferents. American Journal of Physiology - Gastrointestinal and Liver Physiology. 304:G211-G220. 2013
- Bacteroides fragilis polysaccharide A is necessary and sufficient for acute activation of intestinal sensory neurons. Nature Communications. 4:1465. 2013
- Fucosylated but Not Sialylated Milk Oligosaccharides Diminish Colon Motor Contractions. PLoS ONE. 8:e76236-e76236. 2013
- Voices from within: gut microbes and the CNS. Cellular and Molecular Life Sciences. 70:55-69. 2013
- Communication between gastrointestinal bacteria and the nervous system. Current Opinion in Pharmacology. 12:667-672. 2012
- The microbiota and the gut-brain axis: insights from the temporal and spatial mucosal alterations during colonisation of the germfree mouse intestine. Beneficial microbes. 3:251-259. 2012
- On communication between gut microbes and the brain. Current Opinion in Gastroenterology. 28:557-562. 2012
- Oxytocin hyperpolarizes cultured duodenum myenteric intrinsic primary afferent neurons by opening BKCa channels through IP3 pathway. Journal of Neurochemistry. 121:516-525. 2012
- Maxi-channels recorded in situ from ICC and pericytes associated with the mouse myenteric plexus. American Journal of Physiology - Cell Physiology. 302:C1055-C1069. 2012
- Systemic Effects of Ingested Lactobacillus Rhamnosus: Inhibition of Mast Cell Membrane Potassium (IKCa) Current and Degranulation. PLoS ONE. 7:e41234-e41234. 2012
- The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication. Neurogastroenterology and Motility. 23:1132-1139. 2011
- What do commensal bacteria have to do with allergy, pain and behaviour?. European Journal of Pharmacology. 668:e13-e14. 2011
- Corrigendum. American Journal of Physiology - Gastrointestinal and Liver Physiology. 301:G195-G195. 2011
- Luminal administrationex vivoof a liveLactobacillusspecies moderates mouse jejunal motility within minutes. The FASEB Journal. 24:4078-4088. 2010
- T2021 Mouse Myenteric Ah Cells Sense Lactobacillus reuteri Within Minutes of Their Application to the Epithelial Layer, Ex Vivo. Gastroenterology. 138:S-615. 2010
- Evidence for neuronal expression of functional Fc (ε and γ) receptors. Journal of Allergy and Clinical Immunology. 125:757-760. 2010
- Lactobacillus reuteri ingestion and IKCa channel blockade have similar effects on rat colon motility and myenteric neurones. Neurogastroenterology and Motility. 22:98-98. 2010
- Lactobacillus reuteri enhances excitability of colonic AH neurons by inhibiting calcium‐dependent potassium channel opening. Journal of Cellular and Molecular Medicine. 13:2261-2270. 2009
- Lactobacillus reuteri ingestion prevents hyperexcitability of colonic DRG neurons induced by noxious stimuli. American Journal of Physiology - Gastrointestinal and Liver Physiology. 296:G868-G875. 2009
- In situ recording from gut pacemaker cells. Pflugers Archiv European Journal of Physiology. 457:243-251. 2008
- Nitric oxide mediates the inhibitory effect of ethanol on the motility of isolated longitudinal muscle of proximal colon in rats. Neurogastroenterology and Motility. 19:515-521. 2007
- Characterization of Myenteric Sensory Neurons in the Mouse Small Intestine. Journal of Neurophysiology. 96:998-1010. 2006
- Sensitization of enteric reflexes in the rat colon in vitro. Autonomic Neuroscience: Basic and Clinical. 97:19-25. 2002
- Responses of myenteric S neurones to low frequency stimulation of their synaptic inputs. Neuroscience. 110:361-373. 2002
- Analysis of whole‐cell currents by patch clamp of guinea‐pig myenteric neurones in intact ganglia. Journal of Physiology. 538:447-463. 2002
- Afterhyperpolarization Current in Myenteric Neurons of the Guinea Pig Duodenum. Journal of Neurophysiology. 85:1941-1951. 2001
- Comparison of the effects of neurokinin-3 receptor blockade on two forms of slow synaptic transmission in myenteric AH neurons. Neuroscience. 104:263-269. 2001
- Low frequency presynaptic stimulation selectively excites S neurons with descending axons in the guinea pig ileum. Gastroenterology. 120:A332-A332. 2001
- Memory in the enteric nervous system. Gut. 47:60iv-62. 2000
- The terminals of myenteric intrinsic primary afferent neurons of the guinea-pig ileum are excited by 5-hydroxytryptamine acting at 5-hydroxytryptamine-3 receptors. Neuroscience. 101:459-469. 2000
- The soma and neurites of primary afferent neurons in the guinea‐pig intestine respond differentially to deformation. Journal of Physiology. 526:375-385. 2000
- Shapes and projections of tertiary plexus neurons of the guinea-pig small intestine. Cell and Tissue Research. 300:383-387. 2000
- A simple mathematical model of second-messenger mediated slow excitatory postsynaptic potentials.. Journal of Computational Neuroscience. 8:127-142. 2000
- II. The intestine as a sensory organ: neural, endocrine, and immune responses. American Journal of Physiology. 277:G922-G928. 1999
- Nutrient tasting and signaling mechanisms in the gut II. The intestine as a sensory organ: neural, endocrine, and immune responses. American Journal of Physiology - Gastrointestinal and Liver Physiology. 277:G922-G928. 1999
- Contractile activity in intestinal muscle evokes action potential discharge in guinea‐pig myenteric neurons. Journal of Physiology. 517:547-561. 1999
- THE ENTERIC NERVOUS SYSTEM AND REGULATION OF INTESTINAL MOTILITY. Annual Review of Physiology. 61:117-142. 1999
- Long-term effects of synaptic activation at low frequency on excitability of myenteric AH neurons. Neuroscience. 90:279-289. 1999
- Electrical mapping of the projections of intrinsic primary afferent neurones to the mucosa of the guinea‐pig small intestine. Neurogastroenterology and Motility. 10:533-542. 1998
- A mobile intracellular microelectrode designed to record from neurons in contracting tissue. Brain Research. 3:94-99. 1998
- Morphological and immunohistochemical identification of neurons and their targets in the guinea-pig duodenum. Neuroscience. 86:679-694. 1998
- Intracellular recording from myenteric neurons of the guinea‐pig ileum that respond to stretch. Journal of Physiology. 506:827-842. 1998
- Intrinsic primary afferent neuronsof the intestine. Progress in Neurobiology. 54:1-18. 1998
- Correlation of electrophysiological and morphological characteristics of myenteric neurons of the duodenum in the guinea-pig. Neuroscience. 82:899-914. 1997
- Analysis of the responses of myenteric neurons in the small intestine to chemical stimulation of the mucosa. American Journal of Physiology. 273:G422-G435. 1997
- Analysis of the responses of myenteric neurons in the small intestine to chemical stimulation of the mucosa. American Journal of Physiology - Gastrointestinal and Liver Physiology. 273:G422-G435. 1997
- Influence of the mucosa on the excitability of myenteric neurons. Neuroscience. 76:619-634. 1997
- EXPERIMENTAL BASIS FOR REALISTIC LARGE‐SCALE COMPUTER SIMULATION OF THE ENTERIC NERVOUS SYSTEM. Clinical and Experimental Pharmacology and Physiology. 23:786-792. 1996
- Identification of sensory nerve cells in a peripheral organ (the intestine) of a mammal. Neuroscience. 66:1-4. 1995
- Synthesis and biological characterisation of a series of iberiotoxin analogues. Chemical Biology and Drug Design. 45:320-325. 1995
- Plurichemical transmission and chemical coding of neurons in the digestive tract. Gastroenterology. 108:554-563. 1995
- The circuitry of the enteric nervous system. Neurogastroenterology and Motility. 6:241-253. 1994
- Electrophysiological characterization of myenteric neurons: how do classification schemes relate?. Autonomic Neuroscience: Basic and Clinical. 48:1-15. 1994
- Charybdotoxin and iberiotoxin but not apamin abolish the slow after-hyperpolarization in myenteric plexus neurons. Pflugers Archiv European Journal of Physiology. 428:300-306. 1994
- Combined intracellular injection of Neurobiotin and pre-embedding immunocytochemistry using silver-intensified gold probes in myenteric neurons. Journal of Neuroscience Methods. 51:39-45. 1994
- Simultaneous intracellular recordings from enteric neurons reveal that myenteric ah neurons transmit via slow excitatory postsynaptic potentials. Neuroscience. 55:685-694. 1993
- 第35回日本平滑筋学会総会講演抄録 (I). Journal of Smooth Muscle Research. 29:143-145. 1993
- Olfactory bulb output neurons excited from a basal forebrain magnocellular nucleus. Brain Research. 583:327-331. 1992
- Intracellular responses of olfactory bulb granule cells to stimulating the horizontal diagonal band nucleus. Neuroscience. 48:363-369. 1992
- Effect of stimulating the nucleus of the horizontal limb of the diagonal band on single unit activity in the olfactory bulb. Neuroscience. 40:21-27. 1991
- [Exogenous allergic alveolitis in childhood].. Kinderarztliche Praxis. 54:363-368. 1986
- Multiunit bursts in rat pallidum during grooming and sterotyped jaw movements. Brain Research Bulletin. 13:493-496. 1984
- A new aspect of the collision test principle: Cell body distance from recording site. Brain Research Bulletin. 4:867-869. 1979
- An electrophysiological study of thalamo-caudate neurones in the cat. Experimental Brain Research. 36:233-244. 1979
-
preprints
- Gut-Brain rejuvenation: Identification of age associated changes in the neural firing pattern of myenteric primary afferent neurons and vagal fibres that are reversed by the aminosterol, squalamine 2023
- The vagus nerve is necessary for the rapid and widespread neuronal activation in the brain following oral administration of psychoactive bacteria 2019