Journal article
A Simple Mathematical Model of Second-Messenger Mediated Slow Excitatory Postsynaptic Potentials
Abstract
We have developed a novel and simple mathematical model of a slow excitatory postsynaptic potential (EPSP) based on an abstraction of the processes of activation, inactivation, and summation of a cAMP, protein kinase A (PKA)-dependent second-messenger cascade. The model describes the activation of receptors, G-proteins, and production of cAMP as the first stage and uses first-order, non-rate-limited kinetics. The second stage corresponds to the …
Authors
Bertrand PP; Thomas EA; Kunze WAA; Bornstein JC
Journal
Journal of Computational Neuroscience, Vol. 8, No. 2, pp. 127–142
Publisher
Springer Nature
Publication Date
March 2000
DOI
10.1023/a:1008969115017
ISSN
0929-5313