A301 ANTIBIOTICS INCREASE VAGAL AFFERENT FIRING IN THE MOUSE JEJUNUM

Accumulating evidence from animal studies suggests antibiotics administered to the gut lumen may act directly on the host nervous system. For instance, we have previously shown that introduction of bacitracin, neomycin and penicillin V antibiotics in mouse jejunum and colon, results in short-latency changes to neurally-dependent enteric reflexes (Frontiers in Neuroscience, in press). However, it remains to be determined whether antibiotics …