Pyrrolidinones Concept

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A novel method to enhance the stability of alginate-poly-L-lysine-alginate microcapsules Journal Articles
ATP stimulates Ca2+-waves and gene expression in cultured human pulmonary fibroblasts Journal Articles
An in Vivo Comparison of the Kinetics of Protein and Lipid Deposition on Group II and Group IV Frequent-Replacement Contact Lenses Journal Articles
Biocompatible poly(N-vinyllactam)-based materials with environmentally-responsive permeability Journal Articles
Biological properties of photocrosslinked alginate microcapsules Journal Articles
Change in expression of vesicular protein synapsin II by chronic treatment with D2 allosteric modulator PAOPA Journal Articles
Design, Synthesis, X-ray Analysis, and Dopamine Receptor-Modulating Activity of Mimics of the "C5" Hydrogen-Bonded Conformation in the Peptidomimetic 2-Oxo-3(R)-[(2(S)-pyrrolidinylcarbonyl)amino]-1-pyrrolidineacetamide Journal Articles
Discovery of 1-arylpyrrolidone derivatives as potent p53–MDM2 inhibitors based on molecule fusing strategy Journal Articles
EGFR-PLCγ1 signaling mediates high glucose-induced PKCβ1-Akt activation and collagen I upregulation in mesangial cells Journal Articles
Effects of the Dopamine D2 Allosteric Modulator, PAOPA, on the Expression of GRK2, Arrestin-3, ERK1/2, and on Receptor Internalization Journal Articles
Emesis induced by inhibitors of type IV cyclic nucleotide phosphodiesterase (PDE IV) in the ferret Journal Articles
Hydrophobically-modified poly(vinyl pyrrolidone) as a physically-associative, shear-responsive ophthalmic hydrogel Journal Articles
In vitro antineoplastic effects of brivaracetam and lacosamide on human glioma cells Journal Articles
Intracellular targeting, interaction with Src homology 3 (SH3) domains and rolipram-detected conformational switches in cAMP-specific PDE4A phosphodiesterase Journal Articles
Lipid and protein deposition of N-vinyl pyrrolidone-containing group II and group IV frequent replacement contact lenses. Journal Articles
Modulation of Dopamine Receptor Agonist-Induced Rotational Behavior in 6-OHDA-Lesioned Rats by a Peptidomimetic Analogue of Pro-Leu-Gly-NH2 (PLG) Journal Articles
Modulation of agonist stimulated adenylyl cyclase and GTPase activity by l-pro-l-leu-glycinamide and its peptidomimetic analogue in rat striatal membranes Journal Articles
Modulation of high-affinity CNS dopamine D2 receptor by l-pro-l-leu-glycinamide (PLG) analogue Conferences
PAOPA, a potent analogue of Pro-Leu-glycinamide and allosteric modulator of the dopamine D2 receptor, prevents NMDA receptor antagonist (MK-801)-induced deficits in social interaction in the rat: Implications for the treatment of negative symptoms in schizophrenia Journal Articles
PAOPA, a potent dopamine D2 receptor allosteric modulator, prevents and reverses behavioral and biochemical abnormalities in an amphetamine-sensitized preclinical animal model of schizophrenia Journal Articles
Platelet derived growth factor-evoked Ca2+ wave and matrix gene expression through phospholipase C in human pulmonary fibroblast Journal Articles
Preclinical pharmacokinetic and toxicological evaluation of MIF-1 peptidomimetic, PAOPA: Examining the pharmacology of a selective dopamine D2 receptor allosteric modulator for the treatment of schizophrenia Journal Articles
Pro-Leu-glycinamide and its peptidomimetic, PAOPA, attenuate haloperidol induced vacuous chewing movements in rat: A model of human tardive dyskinesia Journal Articles
Protection Against MPTP Treatment by an Analog of Pro-Leu-Gly-NH2 (PLG, MIF-1) Journal Articles
Quantitative chemical mapping of sodium acrylate- and N-vinylpyrrolidone-enhanced alginate microcapsules Journal Articles
The Effect of PAOPA, a Novel Allosteric Modulator of Dopamine D2 Receptors, on Signaling Proteins Following Sub-Chronic Administration in Rats Journal Articles
U73122 affects the equilibria between the phosphoinositides as well as phospholipase C activity in unstimulated and thrombin-stimulated human and rabbit platelets. Journal Articles
iso-Lactam and reduced amide analogues of the peptidomimetic dopamine receptor modulator 3(R)-[(2(S)-Pyrrolidinylcarbonyl)amino]-2-oxo-1-pyrrolidineacetamide Journal Articles
l-Prolyl-l-leucyl-glycinamide and its peptidomimetic analog 3(R)-[(2(S)-pyrrolidylcarbonyl)amino]-2-oxo-1-pyrrolidineacetamide (PAOPA) attenuate haloperidol-induced c-fos expression in the striatum☆ Journal Articles