Protection Against MPTP Treatment by an Analog of Pro-Leu-Gly-NH2 (PLG, MIF-1) Journal Articles

abstract

• 3(R)-[(2(S)-Pyrrolidinyl-carbonyl)amino]-2-oxo-1-pyrrolidineacetamide (PAOPA) is a peptidomimetic analog of Pro-Leu-Gly-NH2 (PLG or MIF-1) that has previously been demonstrated to be more potent and efficacious that MIF-1 in enhancing dopamine receptor activity. Given the ability of MIF-1 to protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) lesioning in C57 BL/6 mice, the present study was undertaken to evaluate the neuroprotective effect of PAOPA in this model. PAOPA was found to be more potent and efficacious that MIF-1 in sparing dopamine and its metabolite levels following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration. Whether the enhanced neuroprotective effect of PAOPA is due to dopamine receptor stimulation, or a result of reduced oxidative stress through normalization of dopamine turnover, remains to be determined.

authors

• Marcotte, Eric R
• Chugh, Anita
• Mishra, Ram
• Johnson, Rodney L

status

• published 

publication date

• February 1998

has subject area

• 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MeSH)
• 11 Medical and Health Sciences (FoR)
• Animals (MeSH)
• Corpus Striatum (MeSH)
• Disease Models, Animal (MeSH)
• Dopamine (MeSH)
• Endocrinology & Metabolism (Science Metrix)
• Hormone Antagonists (MeSH)
• MPTP Poisoning (MeSH)
• MSH Release-Inhibiting Hormone (MeSH)
• Male (MeSH)
• Mice (MeSH)
• Mice, Inbred C57BL (MeSH)
• Nerve Degeneration (MeSH)
• Neuroprotective Agents (MeSH)
• Neurotoxins (MeSH)
• Parkinson Disease, Secondary (MeSH)
• Pyrrolidinones (MeSH)
• Receptors, Dopamine (MeSH)

published in

• Regulatory Peptides  Journal

keywords

• 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
• Animals
• Corpus Striatum
• Disease Models, Animal
• Dopamine
• Hormone Antagonists
• MPTP Poisoning
• MSH Release-Inhibiting Hormone
• Male
• Mice
• Mice, Inbred C57BL
• Nerve Degeneration
• Neuroprotective Agents
• Neurotoxins
• Parkinson Disease, Secondary
• Pyrrolidinones
• Receptors, Dopamine

Digital Object Identifier (DOI)

• 10.1016/s0196-9781(97)00321-5

PubMed ID

• 9493876

start page

• 403

end page

• 406

volume

• 19

issue

• 2