Piperazines Concept

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• 5-HT2A/C receptors do not mediate the attenuation of compulsive checking by mCPP in the quinpirole sensitization rat model of obsessive–compulsive disorder (OCD)  Journal Articles
• A PET study of effects of chronic 3,4‐methylenedioxymethamphetamine (MDMA, “ecstasy”) on serotonin markers in Göttingen minipig brain  Journal Articles
• An optimum prophylactic dose of prasugrel monotherapy may safely and effectively prevent the development of experimental thrombotic strokes  Journal Articles
• Antidotes for Novel Oral Anticoagulants  Journal Articles
• Antimanic Response to Aripiprazole in Bipolar I Disorder Patients Is Independent of the Agitation Level at Baseline  Journal Articles
• Antiplatelet Therapy and Cardiac Surgery: Review of Recent Evidence and Clinical Implications  Journal Articles
• Antiviral activity and safety of aplaviroc, a CCR5 antagonist, in combination with lopinavir/ritonavir in HIV‐infected, therapy‐naïve patients: results of the EPIC study (CCR100136)^*  Journal Articles
• Aripiprazole Reduces Alcohol Use  Journal Articles
• Aripiprazole-Associated QTc Prolongation in a Geriatric Patient  Journal Articles
• Assessing exertional dyspnea in patients with idiopathic pulmonary fibrosis  Journal Articles
• Bulbocavernosus reflex testing: a preliminary study on the prognostic factors for potency and response to sildenafil citrate after bilateral nerve-sparing radical prostatectomy  Journal Articles
• CSB interacts with BRCA1 in late S/G2 to promote MRN- and CtIP-mediated DNA end resection  Journal Articles
• Can an Educational Program Optimize PDE5i Therapy? A Study of Canadian Primary Care Practices  Journal Articles
• Characterization of α-Adrenoceptors in Canine Mesenteric Vein  Journal Articles
• Ciraparantag as a potential universal anticoagulant reversal agent  Journal Articles
• Ciraparantag for enoxaparin reversal: Adding to the evidence  Journal Articles
• Clinical Implications of Reversal Agents for Direct Oral Anticoagulants  Journal Articles
• Clinical and Molecular Studies of the Effect of Imatinib on Advanced Aggressive Fibromatosis (desmoid tumor)  Journal Articles
• Clinical effectiveness and safety of olaparib in BRCA-mutated, HER2-negative metastatic breast cancer in a real-world setting: final analysis of LUCY.  Journal Articles
• Commentary: sildenafil in phallometric testing--an evidence-based assessment of sexual offenders.  Journal Articles
• Comparative In Vitro Activities of Ciprofloxacin, Gemifloxacin, Grepafloxacin, Moxifloxacin, Ofloxacin, Sparfloxacin, Trovafloxacin, and Other Antimicrobial Agents against Bloodstream Isolates of Gram-Positive Cocci  Journal Articles
• Comparative efficacy and safety of first-line antiretroviral therapy for the treatment of HIV infection: a systematic review and network meta-analysis  Journal Articles
• Corrected QT interval prolongation after an overdose of escitalopram, morphine, oxycodone, zopiclone and benzodiazepines  Journal Articles
• Correlation between serotonin synthesis and 5-HT1A receptor binding in the living human brain: A combined α-[11C]MT and [18F]MPPF positron emission tomography study  Conferences
• Current Incidence and Outcomes of Gastrointestinal Mesenchymal Tumors Including Gastrointestinal Stromal Tumors  Journal Articles
• Current Perspectives in the Pharmacological Studies of Store-Operated Ca2+ Entry Blockers.  Journal Articles
• Deep molecular responses achieved in patients with CML-CP who are switched to nilotinib after long-term imatinib  Journal Articles
• Design, Synthesis, and Dopamine Receptor Modulating Activity of Diketopiperazine Peptidomimetics ofl-Prolyl-l-leucylglycinamide  Journal Articles
• Development and initial validation of a new preference-based disease-specific health-related quality of life instrument for erectile function  Journal Articles
• Differences in the Mechanisms of Proapoptotic BH3 Proteins Binding to Bcl-XL and Bcl-2 Quantified in Live MCF-7 Cells  Journal Articles
• Differential effects of putative protein kinase C inhibitors on contraction of rat aortic smooth muscle  Journal Articles
• Dual antiplatelets for 30 mo after drug-eluting stents reduced stent thrombosis and CV and cerebrovascular events  Journal Articles
• Effectin vitroon platelet function of two compounds developed from the pyrimido-pyrimidines  Journal Articles
• Effects of Asm‐024, A Modulator of Acetylcholine Receptor Function, On Airway Responsiveness and Allergen‐Induced Responses in Patients with Mild Asthma  Journal Articles
• Effects of AttM lactonase on the pathogenicity ofStreptomyces scabies  Journal Articles
• Effects of oxatomide compared with chlorpheniramine in allergic rhinoconjunctivitis  Journal Articles
• Effects of the serotonergic agonist mCPP on male rats in the quinpirole sensitization model of obsessive–compulsive disorder (OCD)  Journal Articles
• Energy-stress-mediated AMPK activation inhibits ferroptosis  Journal Articles
• Erectile dysfunction in spinal cord injury: a cost-utility analysis  Journal Articles
• Esophageal gastrointestinal stromal tumor: report of 7 patients  Journal Articles
• Focused 2012 Update of the Canadian Cardiovascular Society Guidelines for the Use of Antiplatelet Therapy  Journal Articles
• Haloperidol (but not ziprasidone) withdrawal potentiates sensitization to the hyperlocomotor effect of cocaine in mice  Journal Articles
• Hormonal and Subjective Responses to Intravenous m-Chlorophenylpiperazine in Women With Seasonal Affective Disorder  Journal Articles
• Hormonal and Subjective Responses to Intravenous meta-Chlorophenylpiperazine in Bulimia Nervosa  Journal Articles
• Imatinib Mesylate in Patients With Adenoid Cystic Cancers of the Salivary Glands Expressing c-kit: A Princess Margaret Hospital Phase II Consortium Study  Journal Articles
• Imatinib for Melanomas Harboring Mutationally Activated or Amplified KIT Arising on Mucosal, Acral, and Chronically Sun-Damaged Skin  Journal Articles
• Imatinib mesylate in children and adolescents with cancer  Journal Articles
• Implications of variability in definition and reporting of major bleeding in randomized trials of oral P2Y12 inhibitors for acute coronary syndromes  Journal Articles
• Inhibition of antibodies to CD3 surface antigen and phytohemagglutinin-mediated T cellular responses by inhibiting Ca2+/phospholipid-dependent protein kinase activity with the aid of 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride.  Journal Articles
• Interaction of NMDA and Dopamine D_2L Receptors in Human Neuroblastoma SH‐SY5Y Cells  Journal Articles
• Interactions of pro-apoptotic BH3 proteins with anti-apoptotic Bcl-2 family proteins measured in live MCF-7 cells using FLIM FRET  Journal Articles
• Is Chronic Sildenafil Therapy Safe and Clinically Beneficial in Patients With Systolic Heart Failure?  Journal Articles
• Lack of effect of antipsychotics on BNDF and NGF levels in hippocampus of Wistar rats  Journal Articles
• Measuring quality of life: The development and initial validation of the Patient-Reported Erectile Function Assessment instrument  Journal Articles
• Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants  Journal Articles
• Melatonin and zopiclone as pharmacologic aids to facilitate crew rest.  Journal Articles
• Metabolic response by FDG-PET to imatinib correlates with exon 11 KIT mutation and predicts outcome in patients with mucosal melanoma  Journal Articles
• Mitapivat versus Placebo for Pyruvate Kinase Deficiency  Journal Articles
• Modelling the Cost Effectiveness of Antidepressant Treatment in Primary Care  Journal Articles
• Modulation of Dopamine D₂ Receptor Expression by an NMDA Receptor Antagonist in Rat Brain  Journal Articles
• Modulation ofN-methyl-d-aspartate (NMDA) antagonist-induced darting behaviour by the peptidomimetic PAMTA  Journal Articles
• NOAC monitoring, reversal agents, and post-approval safety and effectiveness evaluation: A cardiac safety research consortium think tank  Journal Articles
• Nefazodone in Social Phobia  Journal Articles
• Nefazodone in the Treatment of Generalized Social Phobia  Journal Articles
• New antithrombotic agents—insights from clinical trials  Journal Articles
• Novel oral anticoagulants and reversal agents: Considerations for clinical development  Journal Articles
• Olaparib combined with chemotherapy for recurrent platinum-sensitive ovarian cancer: a randomised phase 2 trial  Journal Articles
• Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study  Journal Articles
• Olaparib tablets as maintenance therapy in patients with platinum-sensitive relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a final analysis of a double-blind, randomised, placebo-controlled, phase 3 trial  Journal Articles
• Olaparib tablets as maintenance therapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a double-blind, randomised, placebo-controlled, phase 3 trial  Journal Articles
• Oral, Direct Factor Xa Inhibitors in Development for the Prevention and Treatment of Thromboembolic Diseases  Journal Articles
• Osimertinib in UntreatedEGFR-Mutated Advanced Non–Small-Cell Lung Cancer  Journal Articles
• Palbociclib plus letrozole versus placebo plus letrozole in Asian postmenopausal women with oestrogen receptor–positive/human epidermal growth factor receptor 2–negative advanced breast cancer: Primary results from PALOMA-4  Journal Articles
• Persistent Pulmonary Hypertension of the Newborn: Should Sildenafil and Inhaled Nitric Oxide at Medium Concentration Be the Standard of Treatment?*  Journal Articles
• Persistent genital arousal disorder: a clinical challenge  Journal Articles
• Pharmacokinetics, safety, activity, and biomarker analysis of palbociclib plus letrozole as first-line treatment for ER+/HER2– advanced breast cancer in Chinese women  Journal Articles
• Pharmacological and immunocytochemical characterization of subtypes of alpha-1 adrenoceptors in dog aorta.  Journal Articles
• Platelet ADP-receptor antagonists for cardiovascular disease: past, present and future  Journal Articles
• Preparation, Characterization, and Screening of a High Affinity Organometallic Probe for α-Adrenergic Receptors  Journal Articles
• Prevalence of Emergent Dolutegravir Resistance Mutations in People Living with HIV: A Rapid Scoping Review  Journal Articles
• Quantitative autoradiography of ligands for dopamine receptors and transporters in brain of Göttingen minipig: Comparison with results in vivo  Journal Articles
• Randomized, double-blind study of short-course (5 day) grepafloxacin versus 10 day clarithromycin in patients with acute bacterial exacerbations of chronic bronchitis  Journal Articles
• Reversal agents for non-vitamin K antagonist oral anticoagulants  Journal Articles
• Reversal of direct oral anticoagulants: guidance from the SSC of the ISTH  Journal Articles
• Role of phenotypic and genetic testing in managing clopidogrel therapy  Journal Articles
• Safety of Sildenafil in Infants*  Journal Articles
• Secondary Prevention of HAPE in a Mount Everest Summiteer  Journal Articles
• Sensitivity to protein kinase C inhibitors of nicardipine‐insensitive component of high K⁺ contracture in rat and guinea‐pig aorta  Journal Articles
• Separate mechanisms for development and performance of compulsive checking in the quinpirole sensitization rat model of obsessive-compulsive disorder (OCD)  Journal Articles
• Serotonergic agents in the treatment of social phobia in children and adolescents: A case series  Journal Articles
• Serotonin Syndrome Associated With Nefazodone and Paroxetine  Journal Articles
• Stability strengths oncogenic activity  Journal Articles
• Thaxtomin A-deficient endophytic Streptomyces sp. enhances plant disease resistance to pathogenic Streptomyces scabies  Journal Articles
• The Non-Vitamin K Antagonist Oral Anticoagulants in Heart Disease: Section V—Special Situations  Journal Articles
• The Pursuit of Clinically Relevant Measures of Platelet Function After Antiplatelet Drug Therapy⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.  Journal Articles
• The Treatment of Heart Failure  Journal Articles
• The effect of intravenously administered almitrine, a peripheral chemoreceptor agonist, on patients with chronic air-flow obstruction.  Journal Articles
• Treatment Satisfaction with Sildenafil in a Canadian Real-Life Setting. A 6-Month Prospective Observational Study of Primary Care Practices  Journal Articles
• Treatment of primary insomnia.  Journal Articles
• Uptake and binding of the serotonin 5-HT1A antagonist [18F]-MPPF in brain of rats: Effects of the novel P-glycoprotein inhibitor tariquidar  Journal Articles
• Vardenafil Improves Erectile Function in Men with Erectile Dysfunction Irrespective of Disease Severity and Disease Classification  Journal Articles
• Vardenafil Improves Patient Satisfaction with Erection Hardness, Orgasmic Function, and Overall Sexual Experience, While Improving Quality of Life in Men with Erectile Dysfunction  Journal Articles
• Vardenafil and Weaning from Inhaled Nitric Oxide: Effect on Pulmonary Hypertension in ARDS  Journal Articles
• When and how to use antidotes for the reversal of direct oral anticoagulants: guidance from the SSC of the ISTH  Journal Articles
• Will prasugrel supersede clopidogrel for acute coronary syndromes?  Journal Articles
• XXIII International Association for Comparative Research on Leukemia and Related Diseases Symposium: from Molecular Pathogenesis to Targeted Therapy in Leukemia and Solid Tumors  Conferences
• p53: The pivot between cell cycle arrest and senescence  Journal Articles