ORIGINAL RESEARCH—ED PHARMACOTHERAPY: Can an Educational Program Optimize PDE5i Therapy? A Study of Canadian Primary Care Practices Academic Article uri icon

  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All


  • INTRODUCTION: The importance of patient instructions, designed to optimize therapy with phosphodiesterase type 5 inhibitors for the treatment of erectile dysfunction (ED), has recently been demonstrated. AIM: To evaluate the impact of an educational program for new sildenafil users against usual ED management in Canadian primary care practices. METHODS: This multicenter, 6-month cluster randomized prospective study was conducted across Canada in general practitioners' offices where sites were randomized to receive a treatment optimization program (TOP) tool at visit 1 (TOP sites) or not to receive the TOP tool (non-TOP sites) while continuing with usual practice. Study participants were men seeking medical attention for ED and who were sildenafil naïve. The TOP tool consisted of a tear-off sheet, a brochure, and a video. Study drug was not provided to the patients. Sildenafil samples and prescriptions were dispensed as per usual care practices. MAIN OUTCOME MEASURES: The Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) questionnaire was used to determine treatment satisfaction at visit 2 (month 3) and visit 3 (month 6). Patient and physician satisfaction with the TOP tool was assessed using self-reported questionnaires. RESULTS: The intent-to-treat (ITT) population consisted of 2,573 patients from 231 primary care sites. At visits 2 and 3, treatment satisfaction with sildenafil was high with almost 9 patients out of 10 satisfied with treatment. No significant statistical differences were observed in the EDITS scores between the TOP and the non-TOP groups at visits 2 and 3. More than 80% of the participants were satisfied or very satisfied with the video and the brochure. More than 8 out of 10 participating physicians (84%) would use the TOP tool in their current practice if available. CONCLUSIONS: TOP is a valuable and time-efficient ED management tool providing benefits to newly diagnosed ED patients and to their physicians.


  • Brock, Gerald
  • Carrier, Serge
  • Casey, Richard
  • Tarride, Jean-Eric
  • Elliott, Stacey
  • Dugré, Hélène
  • Rousseau, Catherine
  • D'Angelo, Pina
  • Defoy, Isabelle

publication date

  • September 2007

has subject area