Guillaume Pare - McMaster Experts

Affiliations

Faculty of Health Sciences, McMaster University
Associate Member, Biochemistry & Biomedical Sciences, Faculty of Health Sciences
Joint Appointment, Health Research Methods, Evidence, and Impact, Faculty of Health Sciences
Associate Member, Medicine, Faculty of Health Sciences
Professor, Pathology & Molecular Medicine, Faculty of Health Sciences
Member, Centre for Metabolism, Obesity, and Diabetes Research (MODR), Faculty of Health Sciences
Member, Chanchlani Research Centre, Faculty of Health Sciences
Canada Research Chair in Genetic and Molecular Epidemiology, McMaster University,

Scholarly Activity in McMaster Experts

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chapters
- Genetic Association Studies and Next Generation Sequencing in Stroke: Methods. 25-50. 2024
- Genetic Association Studies and Next Generation Sequencing in Stroke: Methods. 21-52. 2017
- Genome-Wide Association Studies (GWAS). 25-50. 2013
conferences
- F5. GENE-ENVIRONMENTAL MODIFIERS USING POLYGENIC RISK AND STRUCTURAL EQUATION MODELLING IN LATE-LIFE DEPRESSION. European Neuropsychopharmacology. S222-S223. 2023
- Identification of PAM as a novel monogenic diabetes gene. Diabetologia. S209-S209. 2023
- Diagnostic and predictive value of circulating microRNAs and their regulation of BDNF signaling pathway in stroke patients. Journal of Pharmacology and Experimental Therapeutics. 2023
- Vascular–Parenchymal Cross-Talk Promotes Lung Fibrosis through BMPR2 Signaling. American Journal of Respiratory and Critical Care Medicine. 1498-1514. 2023
- Cell-free Tumor DNA in Blood and Bronchoalveolar Lavage (BAL) as a Biomarker in Non-Small Cell Lung Cancer. American Journal of Respiratory and Critical Care Medicine. 2023
- Proteome-wide Mendelian Randomization Screen Identifies Circulating Protein Mediators Of Early-onset Ischemic Stroke. Stroke. 2023
- Sex-stratified Transethnic GWAS Meta-analysis Identifies Novel Candidates For Early Onset Ischemic Stroke. Stroke. 2023
- Contribution of rare coding variants to complex trait heritability. Genetic Epidemiology. 523-523. 2022
- Multi-Ancestry Proteo-Genomic Association Study of eGFR. Journal of the American Society of Nephrology. 259-259. 2022
- Phosphoinositide 3-kinase and airway infections in severe asthmatics. European Respiratory Journal. 2022
- Waist-to-hip ratio is a stronger, more consistent predictor of all-cause mortality than BMI. Diabetologia. S34-S35. 2022
- 1102-P: Identifying Blood Biomarkers for Type 2 Diabetes Subtyping: A Report from the ORIGIN Trial. Diabetes. 2022
- 725-P: Protein Biomarkers Associated with Dulaglutide and Cardiovascular Events in REWIND. Diabetes. 2022
- 731-P: Metabolite Biomarkers and Cardiovascular Events in REWIND: A Post Hoc Analysis. Diabetes. 2022
- GENOME-WIDE STUDIES REVEAL FACTORS ASSOCIATED WITH CIRCULATING UROMODULIN AND ITS RELATIONS WITH COMPLEX DISEASES. Nephrology Dialysis Transplantation. I28-I29. 2022
- Abstract 154: Sex-specific Genome Wide Association Study Of Early-onset Ischemic Stroke. Stroke. 2022
- Validation of the classification for type 2 diabetes into five subgroups: a report from the ORIGIN trial. Diabetologia. 206-215. 2022
- Depict Analysis Suggests Enrichment of Heart Valve Tissue Expression in African Rheumatic Heart Disease Patients From the RHDGen GWAS Study Cohort. Circulation. 2021
- Fingerprint of novel circulating microRNAs identify patients with stroke-embolic stroke of undetermined source. European Heart Journal. 2061-2061. 2021
- High-Throughput Analysis of Changes in Protein Biomarkers During Hemodialysis. Journal of the American Society of Nephrology. 317-317. 2021
- Less is More: An Unbiased and Versatile Estimator of Genetic Variance Using Summary Statistics. Genetic Epidemiology. 752-753. 2021
- A versatile, fast and unbiased method for estimation of gene-by-environment interaction effects on biobank-scale datasets. Genetic Epidemiology. 490-490. 2021
- CLEC12A Expression as a Potential Predictor of Disease Activity in Early Rheumatoid Arthritis. Arthritis & Rheumatology. 2020
- GWAS transethnic meta-analysis of BMI in similar to 700k individuals reveals novel gene-smoking interaction in African populations. Genetic Epidemiology. 475-476. 2020
- Influence of Genetic Ancestry on Human Serum Proteome. American Journal of Human Genetics. 303-314. 2020
- Genome-wide Association Study of Early-Onset Ischemic Stroke Identifies Novel Locus on Chromosome 12 Near BCL7A/MLXIP. Stroke. 2020
- Leveraging External Repositories to Generate Calibrated Rare Variant Gene Risk Scores. Genetic Epidemiology. 890-890. 2019
- Angiotensin-converting enzyme and type 2 diabetes risk: a Mendelian randomisation study. Diabetologia. S108-S108. 2019
- Genome-wide polygenic risk scores and prediction of gestational diabetes in South Asian women. Diabetologia. S131-S131. 2019
- Novel biomarkers predicting renal decline in people with dysglycaemia in the ORIGIN trial. Diabetologia. S98-S98. 2019
- 240-LB: Angiotensin-Converting Enzyme and Type 2 Diabetes Risk: A Mendelian Randomization Study. Diabetes. 2019
- 254-OR: Novel Biomarkers Predicting Renal Dysfunction in People with Dysglycemia in the ORIGIN Trial. Diabetes. 2019
- The Development of a Novel, Targeted and Less Toxic Anti-Inflammatory Drug for the Treatment of Gout. European Journal of Clinical Investigation. 66-66. 2019
- Residual Pure and Predominantly Pure Intralymphatic Breast Carcinoma Post Neoadjuvant Chemotherapy: Case Series and Next Generation Sequencing of a Rare Pattern of Disease. Laboratory Investigation. 2019
- Residual Pure and Predominantly Pure Intralymphatic Breast Carcinoma Post Neoadjuvant Chemotherapy: Case Series and Next Generation Sequencing of a Rare Pattern of Disease. Modern Pathology. 2019
- A15374 Genetic Variant of Human Cholesterol Ester Transfer Protein (CETP) Raises HDL levels and Is Associated with Increased Risk for Large Vessel and Small Vessel Stroke in Chinese Patients. Journal of Hypertension. e83-e83. 2018
- 48 Trials and tribulations of establishing treatment effectiveness in addiction research. BMJ Evidence-Based Medicine. a24-a24. 2018
- Digital PCR (Polymerase Chain Reaction): A Novel Technique for C-MYC Detection in Vascular Lesions. Modern Pathology. 808-809. 2018
- IGFBP-3 is a marker of impaired adipose tissue function and a novel causal mediator of type 2 diabetes risk: a report from the ORIGIN study. Diabetologia. S99-S99. 2017
- Novel biomarkers predicting heart failure hospitalisation in people with dysglycaemia in the ORIGIN trial. Diabetologia. S40-S40. 2017
- Gene Expression Profiles for the Identification of Prevalent Atrial Fibrillation. Journal of the American Heart Association. e006057. 2017
- Novel Biomarkers Predicting Heart Failure Hospitalization in People with Dysglycemia in the ORIGIN Trial. Diabetes. A405-A405. 2017
- Statistical considerations for analyzing multiplex biomarker data from prospective studies. Trials. 2017
- Molecular Genetics of Left Ventricular Noncompaction Cardiomyopathy. Modern Pathology. 83A-83A. 2017
- Molecular Genetics of Left Ventricular Noncompaction Cardiomyopathy. Laboratory Investigation. 83A-83A. 2017
- Bleeding Risks Associated with Confirmed Platelet Dense Granule Deficiency and/or Impaired Aggregation Responses. Blood. 3728-3728. 2016
- Clinical Utilization of Genome-Wide Methylation Testing in Pediatric Patients. Journal of Molecular Diagnostics. 938-939. 2016
- Mendelian Randomization (MR) Predicts a Causal Role for Serum ACE, APOC-1, APOE, Clusterin, and GDF-15 in Alzheimer Disease (AD). Genetic Epidemiology. 626-627. 2016
- Identification of blood CSF1 and CXCL12 as new causal mediators of coronary artery disease using Mendelian randomization in the ORIGIN trial. European Heart Journal. 458-458. 2016
- Novel biomarkers predicting a microvascular composite outcome in people with dysglycaemia in the ORIGIN trial. Diabetologia. S161-S161. 2016
- Performance of the validated ORIGIN cardiovascular biomarker panel in HOPE study participants with diabetes. Diabetologia. S31-S31. 2016
- Abstract 521: c-MYC as a differentiating marker between angiosarcoma and atypical vascular lesion. Cancer Research. 521-521. 2016
- Novel Biomarkers Predicting a Microvascular Composite Outcome in People with Dysglycemia in the ORIGIN Trial. Diabetes. A388-A388. 2016
- Performance of the Validated ORIGIN Cardiovascular Biomarker Panel in HOPE Study Participants with Diabetes. Diabetes. A363-A363. 2016
- Biological Rational for the Use of Heparin in Septic Shock: Translational Data from the Halo Pilot RCT. Blood. 2336-2336. 2015
- Novel RUNX1 Mutation in a Family with an Uncharacterized Secretion Defect. Blood. 3458-3458. 2015
- Novel method to estimate regional genetic associations improves genetic scores performance. Genetic Epidemiology. 573-574. 2015
- Twice-daily dosing of ASA overcomes reduced platelet response to once-daily ASA after coronary artery bypass graft surgery: a randomized controlled trial. Journal of Thrombosis and Haemostasis. 928-929. 2015
- Exome array analysis on cerebral venous thrombosis: preliminary results. International Journal of Stroke. 219-219. 2015
- Retrospective Evaluation of Patients Referred for Hemochromatosis Genetic Testing. Blood. 4035-4035. 2014
- Pharmacogenomics: Using genetics to guide current stroke therapy. International Journal of Stroke. 12-12. 2014
- The Role of Testosterone in Men and Women Undergoing Methadone Maintenance Treatment (MMT) for Opioid Addiction. Biological Psychiatry. 396S-396S. 2014
- Influenza Virus-Containing Immune Complexes Activate Platelets Through FcγRIIa Resulting In Bioactive Lipid Synthesis and Microparticle Release. Blood. 1056-1056. 2013
- Randomized trial to examine the effect of ASA dose or ASA dosing frequency on ASA resistance after coronary artery bypass graft surgery. European Heart Journal. 22-23. 2013
- EFFECT OF DABIGATRAN ON SERUM APOLIPOPROTEIN B AND APOLIPOPROTEIN A1 CONCENTRATIONS. Journal of the American College of Cardiology. E300-E300. 2013
- A Maximum Likelihood Approach to Prioritize SNPs for Interactions Using Variance per Genotype. Genetic Epidemiology. 754-754. 2012
- Prioritizing SNPs for Gene-Environment and Gene-Gene Interactions: A method to Meta-analyze Levene's Test of Homogeneity of Variance. Genetic Epidemiology. 757-758. 2012
- A Maximum Likelihood Approach to Prioritize SNPs for Interactions Using Variance per Genotype. Genetic Epidemiology. 141-142. 2012
- Genetic associations of pulmonary embolism among those with a deep vein thrombosis. Journal of Thrombosis and Haemostasis. 606-607. 2011
- EFFICACY AND SAFETY OF CLOPIDOGREL COMPARED WITH PLACEBO ACCORDING TO CYP2C19 GENOTYPE IN OVER 6000 PATIENTS WITH NON-ST-ELEVATION ACUTE CORONARY SYNDROMES (CURE TRIAL) AND ATRIAL FIBRILLATION (ACTIVE TRIAL). Canadian Journal of Cardiology. 146D-146D. 2010
- Finding that Elusive Gene-Environment or Gene-Gene Interaction: Prioritizing SNPs for Quantitative Trait Interaction Testing. Genetic Epidemiology. 759-759. 2009
- Does Lifestyle Modify the Genetic Risk of Obesity? An Association Study of Lifestyle Interactions With FTO Genotype in 21,675 Caucasian Women. Circulation. S605-S606. 2009
- Prospective Evaluation of a Comprehensive Genetic Risk Score for Future Cardiovascular Events Among 19,313 Initially Healthy Women: The Women's Genome Health Study. Circulation. S607-S607. 2009
- STATINS AND EZETIMIBE UPREGULATE PLASMA PCSK9. Atherosclerosis Plus. 186-186. 2008
- Mo-P6:391 Identification of a chromosome 8P locus for coronary heart disease in the French Canadian founder population. Atherosclerosis Plus. 131-132. 2006
- Nitric oxide synthase mediates the vascular protective effect of estrogen on medial area in the mouse carotid artery injury model. Arteriosclerosis, Thrombosis and Vascular Biology. A4-A4. 2002
journal articles
- Kidney Volume and Risk of Incident CKD. Journal of the American Society of Nephrology. 35:10.1681/asn.20247yxhaz9x. 2024
- Corrigendum to "PCSK7: A novel regulator of apolipoprotein B and a potential target against non-alcoholic fatty liver disease" [Metabolism Volume 150, January 2024, 155736, PMID: 7967646].. Metabolism: Clinical and Experimental. 161:156032. 2024
- Neuromedin-U Mediates Rapid Activation of Airway Group 2 Innate Lymphoid Cells in Mild Asthma. American Journal of Respiratory and Critical Care Medicine. 210:755-765. 2024
- Human milk oligosaccharides are associated with maternal genetics and respiratory health of human milk-fed children.. Nature Communications. 15:7735. 2024
- The role of mitochondrial genes in ischemia-reperfusion injury: A systematic review of experimental studies. Mitochondrion. 78:101908-101908. 2024
- Determinants of serious health outcome‐free status in middle‐aged and older people with dysglycaemia: Exploratory analysis of the ORIGIN trial. Diabetes, Obesity and Metabolism. 26:3272-3280. 2024
- Genetic Determinants of Vascular Dementia. Canadian Journal of Cardiology. 40:1412-1423. 2024
- Stroke Genetics, Genomics, and Precision Medicine. Stroke. 55:2163-2168. 2024
- Clonal hematopoiesis of indeterminate potential contributes to accelerated chronic kidney disease progression. medRxiv. 5:2024.06.19.24309181. 2024
- Gene-Gene Interaction Between Factor- XI and ABO Genes in Cerebral Venous Thrombosis. Neurology. 102:e209445. 2024
- Kidney Volume and Risk of Incident Kidney Outcomes. Journal of the American Society of Nephrology. 35:1240-1251. 2024
- Consistent cord blood DNA methylation signatures of gestational age between South Asian and white European cohorts. Clinical Epigenetics. 16:74. 2024
- Phosphoinositide‐3 kinase activity in severe eosinophilic asthma with recurrent airway infections and neutrophilic exacerbations. Clinical and Experimental Allergy. 54:428-431. 2024
- Prioritization of Kidney Cell Types Highlights Myofibroblast Cells in Regulating Human Blood Pressure. Kidney International Reports. 9:1849-1859. 2024
- What Causes Premature Coronary Artery Disease?. Current Atherosclerosis Reports. 26:189-203. 2024
- Variability of polygenic prediction for body mass index in Africa. Genome Medicine. 16:74. 2024
- The circulating proteome and brain health: Mendelian randomisation and cross-sectional analyses. Translational Psychiatry. 14:204. 2024
- Tobacco use and risk of acute stroke in 32 countries in the INTERSTROKE study: a case–control study. EClinicalMedicine. 70:102515-102515. 2024
- A method to estimate the contribution of rare coding variants to complex trait heritability. Nature Communications. 15:1245. 2024
- Vaspin: A Novel Biomarker Linking Gluteofemoral Body Fat and Type 2 Diabetes Risk. Diabetes Reviews. 47:259-266. 2024
- Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity. Human Reproduction. 39:240-257. 2024
- Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas. Cell Genomics. 4:100468-100468. 2024
- PCSK7: A novel regulator of apolipoprotein B and a potential target against non-alcoholic fatty liver disease. Metabolism: Clinical and Experimental. 150:155736-155736. 2024
- Proteome-Wide Changes in Blood Biomarkers During Hemodialysis. Kidney International Reports. 9:177-181. 2024
- A novel multi-ancestry proteome-wide Mendelian randomization study implicates extracellular proteins, tubular cells, and fibroblasts in estimated glomerular filtration rate regulation. Kidney International. 104:1170-1184. 2023
- Genetic predisposition to high blood pressure and out-of-office hypertension: insights from a population sample in Liechtenstein. European Heart Journal. 44. 2023
- Clonal Hematopoiesis of Indeterminate Potential Is Associated with Kidney Disease Progression in a Multi-Cohort Meta-Analysis of Individuals with CKD. Journal of the American Society of Nephrology. 34:473-473. 2023
- IDENTIFICATION OF PAM AS NOVEL MONOGENIC DIABETES GENE. Canadian Journal of Diabetes. 47:S169-S170. 2023
- Individual- and supply-level macronutrient intakes are well correlated over a 50-year period (1961–2011) in 18 countries in Asia, North America, and Europe. Progress in Food and Nutrition Science. 119:109-118. 2023
- IDENTIFICATION OF PAM AS NOVEL MONOGENIC DIABETES GENE. Canadian Journal of Cardiology. 39:S205-S206. 2023
- Surrogate Adiposity Markers and Mortality. JAMA network open. 6:e2334836-e2334836. 2023
- Combination of an ACLY inhibitor with a GLP-1R agonist exerts additive benefits on nonalcoholic steatohepatitis and hepatic fibrosis in mice. Cell Reports Medicine. 4:101193-101193. 2023
- A versatile, fast and unbiased method for estimation of gene-by-environment interaction effects on biobank-scale datasets. Nature Communications. 14:5196. 2023
- SNP Panel and Genomic Sex Identification in Atlantic Halibut (Hippoglossus hippoglossus). Marine Biotechnology. 25:580-587. 2023
- GDF15 promotes weight loss by enhancing energy expenditure in muscle. Nature. 619:143-150. 2023
- Biomarkers Associated With Severe COVID-19 Among Populations With High Cardiometabolic Risk. JAMA network open. 6:e2325914-e2325914. 2023
- A DNA methylation based measure outperforms circulating CRP as a marker of chronic inflammation and partly reflects the monocytic response to long‐term inflammatory exposure: A Canadian Longitudinal Study on Aging analysis. Aging Cell. 22:e13863. 2023
- 221-LB: Identification of PAM as Novel Monogenic Diabetes Gene. Diabetes. 72. 2023
- Validation of Urinary Thiocyanate as a Robust Biomarker of Active Tobacco Smoking in the Prospective Urban and Rural Epidemiological Study. Nicotine and Tobacco Research. 25:1291-1301. 2023
- Current State and Future of Polygenic Risk Scores in Cardiometabolic Disease: A Scoping Review. Circulation. Genomic and precision medicine. 16:286-313. 2023
- Identifying blood biomarkers for type 2 diabetes subtyping: a report from the ORIGIN trial. Diabetologia. 66:1045-1051. 2023
- Leveraging related health phenotypes for polygenic prediction of impulsive choice, impulsive action, and impulsive personality traits in 1534 European ancestry community adults. Genes, Brain and Behavior. 22:e12848. 2023
- Biomarker Changes Associated With Both Dulaglutide and Cardiovascular Events in the REWIND Randomized Controlled Trial: A Nested Case-Control Post Hoc Analysis. Diabetes Reviews. 46:1046-1051. 2023
- Changes in energy, macronutrient, and food consumption in 47 countries over the last 70 years (1950-2019): a systematic review and meta-analysis. Nutrition. 108:111941-111941. 2023
- Thyroid Dysfunction and Cardiovascular Events in Patients With Dysglycemia. Canadian Journal of Diabetes. 47:257-262. 2023
- Identifying individuals at extreme risk of venous thromboembolism using polygenic risk scores. Nature Genetics. 55:358-360. 2023
- Abstract P339: The Clinical Application and Ancestral Diversity of Cardiometabolic Polygenic Risk Scores. Circulation. 147. 2023
- From ‘Omics to Multi-omics Technologies: the Discovery of Novel Causal Mediators. Current Atherosclerosis Reports. 25:55-65. 2023
- Rationale, Design, and the Baseline Characteristics of the RHDGen (The Genetics of Rheumatic Heart Disease) Network Study†. Circulation. Genomic and precision medicine. 16:e003641. 2023
- Anti-Epileptic Drug Target Perturbation and Intracranial Aneurysm Risk: Mendelian Randomization and Colocalization Study. Stroke. 54:208-216. 2023
- Fibroblast Growth Factor-23 and Risk of Cardiovascular Diseases. American Society of Nephrology. Clinical Journal. 18:17-27. 2023
- Pharmacogenomics in Stroke and Cardiovascular Disease: State of the Art. Stroke. 54:270-278. 2023
- The 10th Santorini conference: Systems medicine, personalised health and therapy. “The odyssey from hope to practice: Patient first. Keep Ithaca always in your mind”, Santorini, Greece, 23–26 May 2022. Frontiers in Genetics. 14:1171131. 2023
- Effects of routine early treatment with PCSK9 inhibitors in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: a randomised, double-blind, sham-controlled trial . EuroIntervention. 18:e888-e896. 2022
- DNA methylation changes in cord blood and the developmental origins of health and disease – a systematic review and replication study. BMC Genomics. 23:221. 2022
- Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries. Nature. 612:E7-E7. 2022
- The genetic risk of gestational diabetes in South Asian women. eLife. 11:e81498. 2022
- Evaluation of DNA Methylation Array for Glioma Tumor Profiling and Description of a Novel Epi-Signature to Distinguish IDH1/IDH2 Mutant and Wild-Type Tumors. Genes. 13:2075-2075. 2022
- Stroke genetics informs drug discovery and risk prediction across ancestries. Nature. 611:115-123. 2022
- Identifying Blood Biomarkers for Type 2 Diabetes Subtyping: A Report From the ORIGIN Trial. Canadian Journal of Diabetes. 46:S5-S5. 2022
- Multi-Ancestry Proteo-Genomic Association Study of eGFR. Journal of the American Society of Nephrology. 33:259-259. 2022
- Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke. Neurology. 99:e1738-e1754. 2022
- Cost-Effectiveness of Polygenic Risk Scores to Guide Statin Therapy for Cardiovascular Disease Prevention. Circulation. Genomic and precision medicine. 15:e003423. 2022
- Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways. Nature Communications. 13:5144. 2022
- Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention. Nature Genetics. 54:1332-1344. 2022
- Reply. Journal of the American College of Cardiology. 80:e51-e51. 2022
- The Genetic Risk of Gestational Diabetes in South Asian women 2022
- ACLY and CKD: A Mendelian Randomization Analysis. Kidney International Reports. 7:1673-1681. 2022
- 1276-P: Transancestral Genomic Analysis Links Dysregulation of Valine Metabolism to the Development of Heart Failure in Type 2 Diabetes. Diabetes. 71. 2022
- 190-LB: Vaspin—A Novel Predictor of Type 2 Diabetes Risk. Diabetes. 71. 2022
- Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia. Cell Metabolism. 34:919-936.e8. 2022
- Association of Lipids, Lipoproteins, and Apolipoproteins with Stroke Subtypes in an International Case Control Study (INTERSTROKE). Journal of Stroke. 24:224-235. 2022
- Biomarkers of Prevalent and Incident Cognitive Dysfunction in People with Dysglycemia: Data from the ORIGIN Trial. Journal of Alzheimer's Disease. 87:1143-1150. 2022
- Genome-wide studies reveal factors associated with circulating uromodulin and its relationships to complex diseases. JCI insight. 7:e157035. 2022
- Author Correction: Identification of genetic effects underlying type 2 diabetes in South Asian and European populations. Communications Biology. 5:441. 2022
- Association of Clonal Hematopoiesis of Indeterminate Potential with Worse Kidney Function and Anemia in Two Cohorts of Patients with Advanced Chronic Kidney Disease. Journal of the American Society of Nephrology. 33:985-995. 2022
- Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation. Nature Genetics. 54:560-572. 2022
- Fibroblast Growth Factor-23 and Risk of Cardiovascular Diseases: a Mendelian Randomisation study 2022
- Identification of genetic effects underlying type 2 diabetes in South Asian and European populations. Communications Biology. 5:329. 2022
- Elevated Lipoprotein(a) and Risk of Atrial Fibrillation. Journal of the American College of Cardiology. 79:1579-1590. 2022
- Cohort profile: genomic data for 26 622 individuals from the Canadian Longitudinal Study on Aging (CLSA). BMJ Open. 12:e059021-e059021. 2022
- Lipoprotein(a) Cholesterol Masquerading as Low-Density Lipoprotein Cholesterol. Journal of the American College of Cardiology. 79:1047-1049. 2022
- Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance. Nature Communications. 13:770. 2022
- Abstract WMP99: Proteomics Study Of Stroke In Young Adults. Stroke. 53:awmp99-awmp99. 2022
- Genetically proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers: A mendelian randomization analysis. PLoS Medicine. 19:e1003897-e1003897. 2022
- Mitochondrial DNA Copy Number as a Marker and Mediator of Stroke Prognosis. Neurology. 98:e470-e482. 2022
- Variations in risks from smoking between high-income, middle-income, and low-income countries: an analysis of data from 179 000 participants from 63 countries. The Lancet Global Health. 10:e216-e226. 2022
- Dysbetalipoproteinemia: Differentiating Multifactorial Remnant Cholesterol Disease From Genetic ApoE Deficiency. Journal of Clinical Endocrinology and Metabolism (JCEM). 107:538-548. 2022
- GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia. eLife. 11:e70382. 2022
- Van Rensselaer Potter : penser la bioéthique autrement. Canadian Journal of Bioethics. 5:79-79. 2022
- Epigenetic Age and the Risk of Incident Atrial Fibrillation. Circulation. 144:1899-1911. 2021
- A systematic review of GWAS identified SNPs associated with outcomes of medications for opioid use disorder. Addiction Science & Clinical Practice. 16:70. 2021
- Epigenetic age is associated with baseline and 3-year change in frailty in the Canadian Longitudinal Study on Aging. Clinical Epigenetics. 13:163. 2021
- Polygenic risk score for Alzheimer’s disease in Caribbean Hispanics. Alzheimer's and Dementia. 17:e055031. 2021
- The genomics of heart failure: design and rationale of the HERMES consortium. ESC heart failure. 8:5531-5541. 2021
- Abstract 13644: Depict Analysis Suggests Enrichment of Heart Valve Tissue Expression in African Rheumatic Heart Disease Patients From the RHDGen GWAS Study Cohort. Circulation. 144:a13644-a13644. 2021
- Genetic Contributions to Early and Late Onset Ischemic Stroke 2021
- Genome‐Wide Association Study Identifies First Locus Associated with Susceptibility to Cerebral Venous Thrombosis. Annals of Neurology. 90:777-788. 2021
- ATP-citrate lyase as a therapeutic target in chronic kidney disease: a Mendelian Randomization analysis 2021
- Calibrated rare variant genetic risk scores for complex disease prediction using large exome sequence repositories. Nature Communications. 12:5852. 2021
- Editorial Comment. Investigative Urology. 206:958-959. 2021
- High-Throughput Analysis of Changes in Protein Biomarkers During Hemodialysis. Journal of the American Society of Nephrology. 32:317-317. 2021
- Factor V Leiden and the Risk of Bleeding in Patients With Acute Coronary Syndromes Treated With Antiplatelet Therapy: Pooled Analysis of 3 Randomized Clinical Trials. Journal of the American Heart Association. 10:e021115. 2021
- Association of Novel Locus With Rheumatic Heart Disease in Black African Individuals. JAMA cardiology. 6:1000-1000. 2021
- Polygenic Risk Score for Alzheimer's Disease in Caribbean Hispanics. Annals of Neurology. 90:366-376. 2021
- Causal Effect of MMP-1 (Matrix Metalloproteinase-1), MMP-8, and MMP-12 Levels on Ischemic Stroke. Stroke. 52:e316-e320. 2021
- NT-proBNP versus routine clinical risk factors as a predictor of cardiovascular events or death in people with dysglycemia – A brief report from the ORIGIN trial. Journal of Diabetes and its Complications. 35:107928-107928. 2021
- Important Differences Between Manufacturers When Transitioning From a Contemporary Cardiac Troponin Assay to a High-Sensitivity Cardiac Troponin Assay. CJC OPEN. 3:841-842. 2021
- Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Nature Genetics. 53:762-762. 2021
- Genetic Risk for Dengue Hemorrhagic Fever and Dengue Fever in Multiple Ancestries (vol 51, 102584, 2020). EBioMedicine. 66. 2021
- Postneoadjuvant Pure and Predominantly Pure Intralymphatic Breast Carcinoma. American Journal of Surgical Pathology. 45:537-542. 2021
- Acute Phase Response and Non-Reproducible Elevated Concentrations with a High-Sensitivity Cardiac Troponin I Assay. Journal of Clinical Medicine. 10:1014-1014. 2021
- Testosterone and sex hormone-binding globulin in dysglycemic women at high cardiovascular risk: A report from the Outcome Reduction with an Initial Glargine Intervention trial. Diabetes and Vascular Disease Research. 18:147916412110024-147916412110024. 2021
- Whole exome sequencing reveals a biallelic frameshift mutation in GRXCR2 in hearing impairment in Cameroon. Molecular genetics & genomic medicine. 9:e1609. 2021
- Polygenic Risk Score for Low-Density Lipoprotein Cholesterol Is Associated With Risk of Ischemic Heart Disease and Enriches for Individuals With Familial Hypercholesterolemia. Circulation. Genomic and precision medicine. 14:e003106. 2021
- The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury. Journal of Clinical Investigation. 131:128650. 2021
- Admission High-Sensitivity Cardiac Troponin vs a Biochemical Score for Predicting Mortality in Patients With COVID-19. CJC OPEN. 3:130-131. 2021
- Genome-wide association study identifies 48 common genetic variants associated with handedness. Nature Human Behaviour. 5:59-70. 2021
- Implications of OPRM1 and CYP2B6 variants on treatment outcomes in methadone-maintained patients in Ontario: Exploring sex differences. PLoS ONE. 16:e0261201-e0261201. 2021
- Renal Impairment and Risk of Acute Stroke: The INTERSTROKE Study. Neuroepidemiology. 55:206-215. 2021
- Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Nature Genetics. 52:1314-1332. 2020
- GWAS-identified genetic variants associated with medication-assisted treatment outcomes in patients with opioid use disorder: a systematic review and meta-analysis protocol. Systematic Reviews. 9:200. 2020
- Genetic determinants of cannabis use: a systematic review protocol. Systematic Reviews. 9:190. 2020
- Effects of lifelong testosterone exposure on health and disease using Mendelian randomization. eLife. 9:e58914. 2020
- Beyond the Brain. Stroke. 51:3007-3017. 2020
- Plasma ACE2 and risk of death or cardiometabolic diseases: a case-cohort analysis. The Lancet. 396:968-976. 2020
- Tracing risk of multiple cardiovascular diseases to smoking-related genes. European Heart Journal. 41:3311-3313. 2020
- Novel Outcome Biomarkers Identified With Targeted Proteomic Analyses of Plasma From Critically Ill Coronavirus Disease 2019 Patients. Critical Care Explorations. 2:e0189-e0189. 2020
- Association of Factor V Leiden With Subsequent Atherothrombotic Events. Circulation. 142:546-555. 2020
- Genome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke. Stroke. 51:2454-2463. 2020
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