Influenza virus H1N1 activates platelets through FcγRIIA signaling and thrombin generation Journal Articles

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abstract

Key PointsIn influenza-immune subjects, H1N1 influenza virus–containing immune complexes can activate platelets through FcγRIIA. H1N1 can also activate platelets through thrombin, independently of FcγRIIA, pointing to a role of coagulation in influenza infection.

authors

Boilard, Eric
Pare, Guillaume
Rousseau, Matthieu
Cloutier, Nathalie
Dubuc, Isabelle
Lévesque, Tania
Borgeat, Pierre
Flamand, Louis

status

published

publication date

May 1, 2014

has subject area

1102 Cardiorespiratory Medicine and Haematology (FoR)
1103 Clinical Sciences (FoR)
1114 Paediatrics and Reproductive Medicine (FoR)
Animals (MeSH)
Antibodies, Viral (MeSH)
Antigen-Antibody Complex (MeSH)
Blood Platelets (MeSH)
Humans (MeSH)
Immunity, Innate (MeSH)
Immunology (Science Metrix)
Immunophenotyping (MeSH)
Influenza A Virus, H1N1 Subtype (MeSH)
Mice (MeSH)
Mice, Transgenic (MeSH)
Orthomyxoviridae Infections (MeSH)
Phenotype (MeSH)
Platelet Activation (MeSH)
Receptors, IgG (MeSH)
Signal Transduction (MeSH)
Thrombin (MeSH)

published in

Blood Journal