Journal article
Activin A and Cell-Surface GRP78 Are Novel Targetable RhoA Activators for Diabetic Kidney Disease
Abstract
Diabetic kidney disease (DKD) is the leading cause of kidney failure. RhoA/Rho-associated protein kinase (ROCK) signaling is a recognized mediator of its pathogenesis, largely through mediating the profibrotic response. While RhoA activation is not feasible due to the central role it plays in normal physiology, ROCK inhibition has been found to be effective in attenuating DKD in preclinical models. However, this has not been evaluated in …
Authors
Soomro A; Trink J; O’Neil K; Li R; Naiel S; Gao B; Ask K; Krepinsky JC
Journal
International Journal of Molecular Sciences, Vol. 22, No. 6,
Publisher
MDPI
DOI
10.3390/ijms22062839
ISSN
1661-6596
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
ActivinsAnimalsAntibodies, NeutralizingDiabetes Mellitus, ExperimentalDiabetic NephropathiesDisease Models, AnimalEndoplasmic Reticulum Chaperone BiPFollistatinGene Expression RegulationHeat-Shock ProteinsHumansMaleMesangial CellsMiceMice, Inbred C57BLNephrectomyPrimary Cell CultureSignal TransductionStreptozocinrho-Associated KinasesrhoA GTP-Binding Protein