selected scholarly activity
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conferences
- Abstract P3001: Regulation Of Perivascular Adipose Tissue By Follistatin In Hypertension. Circulation Research. 2023
- TDAG51 is a Key Modulator of Vascular Calcification and Osteogenic Transdifferentiation of Arterial Smooth Muscle Cells. Atherosclerosis Plus. 100-100. 2018
- Restoration of hepatic TDAG51 expression improves insulin signaling and reduces weight gain in mouse models of non‐alcoholic fatty liver disease. The FASEB Journal. 2018
- TDAG51 is a key modulator of vascular calcification and osteogenic transdifferentiation of arterial smooth muscle cells. The FASEB Journal. 2018
- Tdag51 Deficiency Protects Against Aortic Vascular Calcification by Attenuating Smooth Muscle Cell Death and Osteoblastic Trans-Differentiation. Circulation. 2013
- Loss of TDAG51 attenuates aorta smooth muscle to osteoblast trans-differentiation and calcification. The FASEB Journal. 2011
- Stretch-induced Raf-1 activation in mesangial cells requires focal adhesion-cytoskeletal integrity.. Journal of the American Society of Nephrology. 336A-336A. 2003
- Stretch-induced MAPK activation in mesangial cells requires Rho-mediated cytoskeletal reorganization.. Journal of the American Society of Nephrology. 87A-87A. 2002
- N-METHYL-N-NITROSOUREA MEDIATED CONVERSION OF 06-METHYLGUANINE TO XANTHINE. Proceedings / Annual Meeting of the American Association for Cancer Research [and] Annual Meeting of the American Society of Clinical Oncology. American Association for Cancer Research. Meeting. 39-39. 1978
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journal articles
- Follistatin lowers blood pressure and improves vascular structure and function in essential and secondary hypertension.. Hypertension Research. 47:3158-3172. 2024
- GDF10 is a negative regulator of vascular calcification.. Journal of Biological Chemistry. 300:107805. 2024
- Abstract P448: Follistatin Improves Vascular Function by Regulating Perivascular Adipose Tissue in Essential Hypertension. Hypertension. 81:ap448-ap448. 2024
- Whole body resistance training on functional outcomes of patients with Stage 4 or 5 chronic kidney disease: A systematic review. Physiological Reports. 12:e16151. 2024
- Restoration of the ER stress response protein TDAG51 in hepatocytes mitigates NAFLD in mice. Journal of Biological Chemistry. 300:105655-105655. 2024
- A novel multi-ancestry proteome-wide Mendelian randomization study implicates extracellular proteins, tubular cells, and fibroblasts in estimated glomerular filtration rate regulation. Kidney International. 104:1170-1184. 2023
- Cell Surface GRP78 and α2M* Are Important Mediators of Tubulointerstitial Fibrosis in CKD. Journal of the American Society of Nephrology. 34:494-494. 2023
- Inhibition of ATP-Citrate Lyase Improves CKD Through Multiple Mechanisms. Journal of the American Society of Nephrology. 34:695-695. 2023
- microRNA (miR)-299a-5p Promotes Apoptosis of Tubular Cells Through Erk5 Inhibition. Journal of the American Society of Nephrology. 34:500-500. 2023
- Both sexes develop DKD in the CD1 uninephrectomized streptozotocin mouse model. Scientific Reports. 13:16635. 2023
- Abstract P104: EXAMINING THE EFFECTS OF FOLLISTATIN ON CONTRACTION OF VESSELS FROM NORMOTENSIVE AND HYPERTENSIVE RATS. Hypertension. 80. 2023
- A therapeutic target for CKD: activin A facilitates TGFβ1 profibrotic signaling. Cellular and Molecular Biology Letters. 28:10. 2023
- Cell surface GRP78 regulates TGFβ1-mediated profibrotic responses via TSP1 in diabetic kidney disease. Frontiers in Pharmacology. 14:1098321. 2023
- Abstract 14157: Effects of Follistatin on the Regulation of Vascular Function by Perivascular Adipose Tissue in a Model of Essential Hypertension. Circulation. 146:a14157-a14157. 2022
- Activin A Is a Potential Mediator of TGFβ1-Induced Tubulointerstitial Fibrosis. Journal of the American Society of Nephrology. 33:815-815. 2022
- Assessing the Influence of Sex on the CD1 Nephrectomized Streptozoto-cin-Induced Diabetic Kidney Disease Model. Journal of the American Society of Nephrology. 33:101-101. 2022
- Cell Surface GRP78 and Integrin β1 Regulate TGFβ1-Mediated Profibrotic Responses in Diabetic Kidney Disease. Journal of the American Society of Nephrology. 33:104-104. 2022
- Multi-Ancestry Proteo-Genomic Association Study of eGFR. Journal of the American Society of Nephrology. 33:259-259. 2022
- Integrin β1/Cell Surface GRP78 Complex Regulates TGFβ1 and Its Profibrotic Effects in Response to High Glucose. Biomedicines. 10:2247-2247. 2022
- Inhibitory Antibodies against PCSK9 Reduce Surface CD36 and Mitigate Diet-Induced Renal Lipotoxicity. Kidney360. 3:1394-1410. 2022
- ACLY and CKD: A Mendelian Randomization Analysis. Kidney International Reports. 7:1673-1681. 2022
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Activin
B , a new player in kidney fibrosis?†. Journal of Pathology. 256:363-365. 2022 - ATP-citrate lyase as a therapeutic target in chronic kidney disease: a Mendelian Randomization analysis 2021
- Activins Facilitate TGF-β1 Profibrotic Signaling in Kidneys. Journal of the American Society of Nephrology. 32:753-753. 2021
- Cell Surface GRP78 Regulates TGF-β1-Mediated Profibrotic Responses via TSP-1 in Diabetic Kidney Disease. Journal of the American Society of Nephrology. 32:239-239. 2021
- Follistatin Is a Potential Novel Therapeutic Agent for Essential Hypertension. Journal of the American Society of Nephrology. 32:550-550. 2021
- miR299a-5p Is a Novel Mediator of Fibrosis in Diabetic Kidney Disease. Journal of the American Society of Nephrology. 32:247-247. 2021
- Activated Alpha 2-Macroglobulin Is a Novel Mediator of Mesangial Cell Profibrotic Signaling in Diabetic Kidney Disease. Biomedicines. 9:1112-1112. 2021
- Activin A and Cell-Surface GRP78 Are Novel Targetable RhoA Activators for Diabetic Kidney Disease. International Journal of Molecular Sciences. 22:2839-2839. 2021
- miR299a-5p promotes renal fibrosis by suppressing the antifibrotic actions of follistatin. Scientific Reports. 11:88. 2021
- TDAG51 (T-Cell Death-Associated Gene 51) Is a Key Modulator of Vascular Calcification and Osteogenic Transdifferentiation of Arterial Smooth Muscle Cells. Arteriosclerosis, Thrombosis and Vascular Biology. 40:1664-1679. 2020
- The emerging role of activins in renal disease. Current Opinion in Nephrology and Hypertension. 29:136-144. 2020
- Caveolin-1 regulation of Sp1 controls production of the antifibrotic protein follistatin in kidney mesangial cells. Cell Communication and Signaling. 17:37. 2019
- The caveolin-1 regulated protein follistatin protects against diabetic kidney disease. Kidney International. 96:1134-1149. 2019
- Follistatin Protects Against Glomerular Mesangial Cell Apoptosis and Oxidative Stress to Ameliorate Chronic Kidney Disease. Antioxidants and Redox Signaling. 31:551-571. 2019
- GDF10 blocks hepatic PPARγ activation to protect against diet-induced liver injury. Molecular Metabolism. 27:62-74. 2019
- SUN-188 FOLLISTATIN IS A NOVEL THERAPEUTIC AGENT IN CHRONIC KIDNEY DISEASE. Kidney International Reports. 4:S236-S237. 2019
- SUN-189 FOLLISTATIN PROTECTS AGAINST ER STRESS-INDUCED OXIDATIVE STRESS AND APOPTOSIS BOTH IN VITRO AND IN VIVO IN CKD. Kidney International Reports. 4:S237-S237. 2019
- Cell surface expression of 78-kDa glucose-regulated protein (GRP78) mediates diabetic nephropathy. Journal of Biological Chemistry. 294:7755-7768. 2019
- Parathyroid hormone-related protein induces fibronectin up-regulation in rat mesangial cells through reactive oxygen species/Src/EGFR signaling. Bioscience Reports. 39:BSR20182293. 2019
- Anti-GRP78 autoantibodies induce endothelial cell activation and accelerate the development of atherosclerotic lesions. JCI insight. 3:99363. 2018
- TDAG51 is a key modulator of vascular calcification and osteogenic transdifferentiation of arterial smooth muscle cells. The FASEB Journal. 32:533.90-533.90. 2018
- Inhibition of SREBP With Fatostatin Does Not Attenuate Early Diabetic Nephropathy in Male Mice. Molecular Endocrinology. 159:1479-1495. 2018
- Regulation of profibrotic responses by ADAM17 activation in high glucose requires its C-terminus and FAK. Journal of Cell Science. 131:jcs208629. 2018
- Dual roles of parathyroid hormone related protein in TGF-β1 signaling and fibronectin up-regulation in mesangial cells. Bioscience Reports. 37:BSR20171061. 2017
- Caveolin-1 in the Pathogenesis of Diabetic Nephropathy: Potential Therapeutic Target?. Current Diabetes Reports. 17:19. 2017
- Endoplasmic reticulum stress inhibition attenuates hypertensive chronic kidney disease through reduction in proteinuria. Scientific Reports. 7:41572. 2017
- Sterol Regulatory Element Binding Protein (SREBP)-1 is a novel regulator of the Transforming Growth Factor (TGF)-β receptor I (TβRI) through exosomal secretion. Cellular Signalling. 29:158-167. 2017
- SREBP inhibition ameliorates renal injury after unilateral ureteral obstruction. American Journal of Physiology - Renal Physiology. 311:F614-F625. 2016
- High Glucose Up-regulates ADAM17 through HIF-1α in Mesangial Cells. Journal of Biological Chemistry. 290:21603-21614. 2015
- SREBP-1 Mediates Angiotensin II-Induced TGF-β1 Upregulation and Glomerular Fibrosis. Journal of the American Society of Nephrology. 26:1839-1854. 2015
- SREBP-1 is a novel mediator of TGFβ1 signaling in mesangial cells. Journal of Molecular Cell Biology. 6:516-530. 2014
- Abstract 18333: Tdag51 Deficiency Protects Against Aortic Vascular Calcification by Attenuating Smooth Muscle Cell Death and Osteoblastic Trans-Differentiation. Circulation. 128. 2013
- Colchicine attenuates renal injury in a model of hypertensive chronic kidney disease. American Journal of Physiology - Renal Physiology. 305:F1466-F1476. 2013
- Caveolin-1 deficiency protects against mesangial matrix expansion in a mouse model of type 1 diabetic nephropathy. Diabetologia. 56:2068-2077. 2013
- TGFβ receptor I transactivation mediates stretch-induced Pak1 activation and CTGF upregulation in mesangial cells. Journal of Cell Science. 126:3697-3712. 2013
- SREBP‐1 Mediates Angiotensin II‐induced TGFβ Upregulation in Kidney Mesangial Cells. The FASEB Journal. 27:601.8-601.8. 2013
- SREBP‐1 Regulates TGFβ Signaling in Kidney Mesangial Cells. The FASEB Journal. 27:601.7-601.7. 2013
- Pantoprazole-induced acute interstitial nephritis. CANADIAN MEDICAL ASSOCIATION JOURNAL. 185:56-59. 2013
- SREBP-1 activation by glucose mediates TGF-β upregulation in mesangial cells. American Journal of Physiology - Renal Physiology. 302:F329-F341. 2012
- High glucose-induced RhoA activation requires caveolae and PKCβ1-mediated ROS generation. American Journal of Physiology - Renal Physiology. 302:F159-F172. 2012
- HB-EGF release mediates glucose-induced activation of the epidermal growth factor receptor in mesangial cells. American Journal of Physiology - Renal Physiology. 300:F921-F931. 2011
- Redox-Induced Src Kinase and Caveolin-1 Signaling in TGF-β1-Initiated SMAD2/3 Activation and PAI-1 Expression. PLoS ONE. 6:e22896-e22896. 2011
- Mechanical Strain-Induced RhoA Activation Requires NADPH Oxidase-Mediated ROS Generation in Caveolae. Antioxidants and Redox Signaling. 13:959-973. 2010
- Mechanical stretch-induced RhoA activation is mediated by the RhoGEF Vav2 in mesangial cells. Cellular Signalling. 22:34-40. 2010
- EGFR-PLCγ1 signaling mediates high glucose-induced PKCβ1-Akt activation and collagen I upregulation in mesangial cells. American Journal of Physiology - Renal Physiology. 297:F822-F834. 2009
- Endoplasmic Reticulum Stress and Renal Disease. Antioxidants and Redox Signaling. 11:2341-2352. 2009
- PKC-β1 Mediates Glucose-Induced Akt Activation and TGF-β1 Upregulation in Mesangial Cells. Journal of the American Society of Nephrology. 20:554-566. 2009
- Mechanical Stretch-Induced Signal Transduction in Cultured Mesangial Cells. Methods in molecular biology (Clifton, N.J.). 466:205-221. 2009
- TGFβ-induced RhoA activation and fibronectin production in mesangial cells require caveolae. American Journal of Physiology - Renal Physiology. 295:F153-F164. 2008
- RhoA/Rho-Kinase Contribute to the Pathogenesis of Diabetic Renal Disease. Diabetes. 57:1683-1692. 2008
- CONTRACTILITY OF THE RENAL GLOMERULUS AND MESANGIAL CELLS: LINGERING DOUBTS AND STRATEGIES FOR THE FUTURE.. Medical hypotheses and research : MHR. 4:1-9. 2008
- Collagen I induction by high glucose levels is mediated by epidermal growth factor receptor and phosphoinositide 3-kinase/Akt signalling in mesangial cells. Diabetologia. 50:2008-2018. 2007
- Caveolin-1 phosphorylation is required for stretch-induced EGFR and Akt activation in mesangial cells. Cellular Signalling. 19:1690-1700. 2007
- RhoA Activation in Mesangial Cells by Mechanical Strain Depends on Caveolae and Caveolin-1 Interaction. Journal of the American Society of Nephrology. 18:189-198. 2007
- Detecting the polymorphisms of paraoxonase (PON) cluster in Chinese Han population based on a rapid method. Clinica Chimica Acta. 365:98-103. 2006
- Association study between fibronectin and coronary heart disease. Clinical Chemistry and Laboratory Medicine. 44:37-42. 2006
- Akt Mediates Mechanical Strain-Induced Collagen Production by Mesangial Cells. Journal of the American Society of Nephrology. 16:1661-1672. 2005
- Stretch-induced Raf-1 activation in mesangial cells requires actin cytoskeletal integrity. Cellular Signalling. 17:311-320. 2005
- Activation of mesangial cell MAPK in responseto homocysteine. Kidney International. 66:733-745. 2004
- Nitric Oxide Inhibits Stretch-Induced MAPK Activation in Mesangial Cells Through RhoA Inactivation. Journal of the American Society of Nephrology. 14:2790-2800. 2003
- Developments in mitogen-induced extracellular kinase 1 inhibitors and their use in the treatment of disease. Expert Opinion on Therapeutic Patents. 12:1795-1811. 2002
- 17β-Estradiol Modulates Mechanical Strain-induced MAPK Activation in Mesangial Cells. Journal of Biological Chemistry. 277:9387-9394. 2002
- Metabolic investigation of recurrent nephrolithiasis: compliance with recommendations. Urology. 56:915-920. 2000
- Prolonged sulfonylurea-induced hypoglycemia in diabetic patients with end-stage renal disease. American Journal of Kidney Diseases. 35:500-505. 2000
- Structural determinants responsible for the biological activity of (-)-emetine, (-)-cryptopleurine, and (-)-tylocrebrine: structure-activity relationship among related compounds.. Molecular Pharmacology. 18:136-143. 1980
- NEW PHYTOECDYSONES FROM KALADANA .1. STRUCTURE OF MURISTERONE-A AND KALADASTERONE. Gazzetta Chimica Italiana. 107:123-130. 1977
- NEW PHYTOECDYSONES FROM KALADANA .2. STRUCTURE OF CALONYSTERONE. Gazzetta Chimica Italiana. 107:229-235. 1977
- Synthesis of d,l-epiramulosin and the configuration of ramulosin. Canadian Journal of Chemistry. 54:3419-3423. 1976
- [Spectrophotometric and colorimetric determination of papverinol and papaveraldine in papaverine].. Ceska a Slovenska Farmacie. 11:205-210. 1962