selected scholarly activity
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academic article
- The importance of interventional timing in the bleomycin model of pulmonary fibrosis.. European Respiratory Journal European Respiratory Journal, Supplement. 55. 2020
- Sub-optimal treatment response to anti-IL-5 monoclonal antibodies in severe eosinophilic asthmatics with airway autoimmune phenomena. European Respiratory Journal European Respiratory Journal, Supplement. 2000117-2000117. 2020
- Current models of pulmonary fibrosis for future drug discovery efforts. Expert Opinion on Drug Discovery. 1-11. 2020
- Protein Misfolding and Endoplasmic Reticulum Stress in Chronic Lung Disease. Chest. 157:1207-1220. 2020
- Expression of the endocannabinoid system in the human airway epithelial cells – Impact of sex and chronic respiratory disease status 2020
- TACAN Is an Ion Channel Involved in Sensing Mechanical Pain. Cell. 180:956-967.e17. 2020
- ABCF1 regulates dsDNA-induced immune responses in human airway epithelial cells 2020
- Microbial Regulation of Enteric Eosinophils and Its Impact on Tissue Remodeling and Th2 Immunity. Frontiers in Immunology. 11:155. 2020
- Cell surface expression of 78-kDa glucose-regulated protein (GRP78) mediates diabetic nephropathy. Journal of Biological Chemistry. 294:7755-7768. 2019
- IL-6 mediates ER expansion during hyperpolarization of alternatively activated macrophages. Immunology and Cell Biology. 97:203-217. 2019
- Microbial regulation of enteric eosinophils and its impact on tissue remodeling and Th2 immunity 2019
- Cadherin-11–mediated adhesion of macrophages to myofibroblasts establishes a profibrotic niche of active TGF-β. Science Signaling. 12:eaao3469-eaao3469. 2019
- Macitentan reduces progression of TGF-β1-induced pulmonary fibrosis and pulmonary hypertension. European Respiratory Journal European Respiratory Journal, Supplement. 52:1701857-1701857. 2018
- Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis. eLife. 7. 2018
- Lysyl Oxidase–Like 1 Protein Deficiency Protects Mice from Adenoviral Transforming Growth Factor-β1–induced Pulmonary Fibrosis. American Journal of Respiratory Cell and Molecular Biology. 58:461-470. 2018
- Separate roles of IL-6 and oncostatin M in mouse macrophage polarizationin vitroandin vivo. Immunology and Cell Biology. 96:257-272. 2018
- Synergistic role of HSP90α and HSP90β to promote myofibroblast persistence in lung fibrosis. European Respiratory Journal European Respiratory Journal, Supplement. 51:1700386-1700386. 2018
- Overexpression of OSM and IL-6 impacts the polarization of pro-fibrotic macrophages and the development of bleomycin-induced lung fibrosis. Scientific Reports. 7:13281. 2017
- Endoplasmic reticulum stress inhibition attenuates hypertensive chronic kidney disease through reduction in proteinuria. Scientific Reports. 7:41572. 2017
- Endoplasmic reticulum stress inhibition limits the progression of chronic kidney disease in the Dahl salt-sensitive rat. American Journal of Physiology - Renal Fluid and Electrolyte Physiology American Journal of Physiology - Renal Physiology. 312:F230-F244. 2017
- Fibroblast growth factor-1 attenuates TGF-β1-induced lung fibrosis. Journal of Pathology Diagnostic Histopathology The Journal of pathology and bacteriology. 240:197-210. 2016
- Characterization of Proliferating Lesion‐Resident Cells During All Stages of Atherosclerotic Growth. Journal of the American Heart Association. 5. 2016
- Endoplasmic reticulum stress inhibition reduces hypertension through the preservation of resistance blood vessel structure and function. Journal of Hypertension. 34:1556-1569. 2016
- GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin-induced pulmonary fibrosis. Journal of Pathology Diagnostic Histopathology The Journal of pathology and bacteriology. 239:411-425. 2016
- Stretch-induced Activation of Transforming Growth Factor-β1in Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine. 194:84-96. 2016
- Disruption of Calcium Signaling in Fibroblasts and Attenuation of Bleomycin-Induced Fibrosis by Nifedipine. American Journal of Respiratory Cell and Molecular Biology. 53:450-458. 2015
- Biomarkers in interstitial lung disease: moving towards composite indexes and multimarkers?. Current pulmonology reports. 4:125-129. 2015
- Calcium Homeostasis and Ionic Mechanisms in Pulmonary Fibroblasts. American Journal of Respiratory Cell and Molecular Biology. 53:135-148. 2015
- The therapeutic effects of 4-phenylbutyric acid in maintaining proteostasis. International Journal of Biochemistry and Cell Biology International Journal of Biochemistry. 61:45-52. 2015
- Development of a Model of Chronic Kidney Disease in the C57BL/6 Mouse with Properties of Progressive Human CKD. BioMed Research International. 2015:1-10. 2015
- Drug development for chronic lung disease - Mission impossible?. Respirology. 20:13-14. 2015
- 4-Phenylbutyrate Inhibits Tunicamycin-Induced Acute Kidney Injury via CHOP/GADD153 Repression. PLoS ONE. 9:e84663-e84663. 2014
- Mechanisms linked to differences in the mutagenic potential of 1,3-dinitropyrene and 1,8-dinitropyrene. Toxicology Reports. 1:459-473. 2014
- Granzyme B Deficiency Exacerbates Lung Inflammation in Mice after Acute Lung Injury. American Journal of Respiratory Cell and Molecular Biology. 49:453-462. 2013
- Protein Misfolding and Endoplasmic Reticulum Stress in Chronic Lung Disease. Chest. 143:1098-1105. 2013
- Adenoviral-Mediated Gene Transfer into Bone Marrow: An Effective Surgical Technique in Rat. European Surgical Research. 50:282-291. 2013
- Local Delivery of GM-CSF Protects Mice from Lethal Pneumococcal Pneumonia. Journal of Immunology. 187:5346-5356. 2011
- In VivoRole of Platelet-Derived Growth Factor–BB in Airway Smooth Muscle Proliferation in Mouse Lung. American Journal of Respiratory Cell and Molecular Biology. 45:566-572. 2011
- Micro-computed tomography of pulmonary fibrosis in mice induced by adenoviral gene transfer of biologically active transforming growth factor-β1. Respiratory Research. 11:181. 2010
- Have advanced research technologies made real impact on respiratory medicine?. Respirology. 15:876-880. 2010
- Essential Role of Osteopontin in Smoking-Related Interstitial Lung Diseases. American Journal of Pathology. 174:1683-1691. 2009
- VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats. Journal of Clinical Investigation. 119:1298-1311. 2009
- Circulating Fibrocytes Are an Indicator of Poor Prognosis in Idiopathic Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine. 179:588-594. 2009
- Role of STAT6 and SMAD2 in a model of chronic allergen exposure: a mouse strain comparison study. Clinical and Experimental Allergy. 39:147-158. 2009
- 1-Nitropyrene (1-NP) induces apoptosis and apparently a non-apoptotic programmed cell death (paraptosis) in Hepa1c1c7 cells. Toxicology and Applied Pharmacology. 230:175-186. 2008
- Targeting fibrosis in respiratory lung disease. Drug Discovery Today: Therapeutic Strategies. 5:97-100. 2008
- The use of small animal imaging in respiratory disease drug discovery. Drug Discovery Today: Therapeutic Strategies. 5:81-85. 2008
- Comparison between conventional and "clinical" assessment of experimental lung fibrosis. Journal of Translational Medicine. 6:16-16. 2008
- Progressive pulmonary fibrosis is mediated by TGF-β isoform 1 but not TGF-β3. International Journal of Biochemistry and Cell Biology International Journal of Biochemistry. 40:484-495. 2008
- The bleomycin animal model: A useful tool to investigate treatment options for idiopathic pulmonary fibrosis?. International Journal of Biochemistry and Cell Biology International Journal of Biochemistry. 40:362-382. 2008
- Three-dimensional computed tomography imaging in an animal model of emphysema. European Respiratory Journal European Respiratory Journal, Supplement. 30:1082-1089. 2007
- TGF-β, Smad3 and the process of progressive fibrosis. Biochemical Society Transactions. 35:661-664. 2007
- TGFβ and Smad3 link inflammation to progressive fibrosis. International Congress Series. 1302:103-113. 2007
- Smad3 Signaling Involved in Pulmonary Fibrosis and Emphysema. Proceedings of the American Thoracic Society. 3:696-702. 2006
- Gene Therapy for Pulmonary Diseases. Chest. 130:879-884. 2006
- Strategies targeting fibrosis in pulmonary disease. Drug Discovery Today: Therapeutic Strategies. 3:389-394. 2006
- Targeting Genes for Treatment in Idiopathic Pulmonary Fibrosis: Challenges and Opportunities, Promises and Pitfalls. Proceedings of the American Thoracic Society. 3:389-393. 2006
- The transforming growth factor-beta (TGF-β) family and pulmonary fibrosis. Drug Discovery Today: Disease Mechanisms. 3:99-103. 2006
- Metabolism of nilutamide in rat lung. Biochemical Pharmacology. 71:377-385. 2006
- TGF-β and Smad3 Signaling Link Inflammation to Chronic Fibrogenesis. Journal of Immunology. 175:5390-5395. 2005
- Connective Tissue Growth Factor Is Crucial to Inducing a Profibrotic Environment in “Fibrosis-Resistant” Balb/c Mouse Lungs. American Journal of Respiratory Cell and Molecular Biology. 31:510-516. 2004
- Distribution of nitroreductive activity toward nilutamide in rat. Toxicology and Applied Pharmacology. 201:1-9. 2004
- Reduction of Nilutamide by NO Synthases: Implications for the Adverse Effects of This Nitroaromatic Antiandrogen Drug. Chemical Research in Toxicology. 16:1547-1554. 2003
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chapter
- Growth Factors. 353-361. 2009
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conference paper
- Mechanical stress-induced mast cell degranulation activates TGF-β1 signalling pathway in pulmonary fibrosis. Thorax. 455-465. 2019
- Antifibrotic Effect of PBI-4050 in Human Normal and IPF Lung Fibroblasts, and in AdTGF-b1-Induced Pulmonary Fibrosis Rat Model. American Journal of Respiratory and Critical Care Medicine. 2019
- Assessing the Role of ATF6 alpha in the Alternative Activation of Macrophages in the Progression of Fibrotic Lung Diseases. American Journal of Respiratory and Critical Care Medicine. 2019
- Dectin-1 Is a Marker of Alternatively Activated Macrophages and a Therapeutic Target in Interstitial Fibrotic Lung Diseases. American Journal of Respiratory and Critical Care Medicine. 2019
- Investigating the Expression of CCL18 in Alternatively Activated Macrophages and in the Progression of Different Fibrotic Lung Diseases. American Journal of Respiratory and Critical Care Medicine. 2019
- The IRE/XBP1 Pathway Is Activated in Alternatively Activated Macrophages in Interstitial Fibrotic Lung Disease. American Journal of Respiratory and Critical Care Medicine. 2019
- The Vascular-Parenchymal Crosstalk Regulates Lung Fibrosis Through Bmpr2 and Ctgf Signaling. American Journal of Respiratory and Critical Care Medicine. 2019
- A NEW MECHANISM OF LATENT TGF-B1 PRESENTATION IN LUNG. Wound Repair and Regeneration. A14-A14. 2018
- A New Mechanism of Latent Tgf-b1 Presentation in Lung. Wound Repair and Regeneration. A34-A34. 2018
- Identification And Validation Of Unique And Shared M2 Macrophage Biomarkers Between Murine Models And Human Disease Using Bioinformatic Gene Expression Analysis. American Journal of Respiratory and Critical Care Medicine. 2017
- Loxl1 Null Mice Are Protected From Tgf-beta 1 Induced Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine. 2017
- Nintedanib Attenuates The Polarization Of Profibrotic Macrophages Through The Inhibition Of Tyrosine Phosphorylation On Csf1 Receptor. American Journal of Respiratory and Critical Care Medicine. 2017
- Silica-Induced Pulmonary Fibrosis Occurs With The Activation Of Macrophage Polarization Through Marco And In A Tgf-beta 1-Independent Manner. American Journal of Respiratory and Critical Care Medicine. 2017
- The Hsp90 Inhibitor Radicicol As A Bioinformatically-Derived Drug For M2 Macrophage Phenotype Inhibition. American Journal of Respiratory and Critical Care Medicine. 2017
- Characterizing The Maturation Of Tgf-beta Induced Pulmonary Fibrotic Scar: Quantitation Of Extracellular Matrix Protein Synthesis, Remodeling And Crosslinking Rates. American Journal of Respiratory and Critical Care Medicine. 2016
- How Basic Science Methodology Has Changed In The Context Of The Bleomycin Model Of Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine. 2016
- Il-6 Mediated Hyperpolarization Of Profibrotic Macrophages Is Dependent On Spliced Xbp1. American Journal of Respiratory and Critical Care Medicine. 2016
- Macitentan Prevents Pulmonary Fibrosis Progression And Secondary Pulmonary Hypertension Induced By Tgf-beta 1 Overexpression In Rats. American Journal of Respiratory and Critical Care Medicine. 2016
- Requirement Of Il-6 For Maximal M2 Macrophage Accumulation, And Growth Of Ectopically Delivered B16 Melanoma, In Mouse Lungs Upon Oncostatin M Overexpression. American Journal of Respiratory and Critical Care Medicine. 2016
- Effect Of Allergen Challenge On Inflammation Induced By Toll-Like Receptor Stimulation In A Nasal Challenge Model. American Journal of Respiratory and Critical Care Medicine. 2015
- Ire1 Mediated Xbp1 Splicing Is Critical For Pulmonary Fibroblast Proliferation And Differentiation. American Journal of Respiratory and Critical Care Medicine. 2015
- Differential effects of ambient diesel carcinogens on inflammation and DNA damage response in cells relevant for lung toxicity. Toxicology Letters. S25-S25. 2014
- Fkbp13 Deficiency Leads To Increased Pulmonary Er Stress, Inflammation And Fibrosis After Bleomycin Administration. American Journal of Respiratory and Critical Care Medicine. 2014
- Grp78 Heterozygosity Abrogates Bleomycin-Induced Lung Fibrosis By Modulating Er-Resident Protein Folding Capacity. American Journal of Respiratory and Critical Care Medicine. 2014
- Inhaled Pirfenidone Improves Animal Efficacy Through Superior Pulmonary And Vascular Pharmacokinetics. American Journal of Respiratory and Critical Care Medicine. 2014
- Nifedipine Attenuates Bleomycin-Induced Fibrosis By Blocking Calcium Wave Activity. American Journal of Respiratory and Critical Care Medicine. 2014
- Interdependence of HIF1 alpha/TGF beta 1 activity in induction of pulmonary fibrosis. European Respiratory Journal European Respiratory Journal, Supplement. 2013
- 4-Phenylbutyrate Prevents Upr Activation And Myofibroblast Differentiation In Experimental Bleomycin-Induced Lung Fibrosis. American Journal of Respiratory and Critical Care Medicine. 2013
- Fkbp13 Deficiency Leads To An Exacerbated Inflammatory Response And Increased Lung Compliance Following Cigarette Smoke Exposure. American Journal of Respiratory and Critical Care Medicine. 2013
- Grp78 Heterozygosity Protects Against Bleomycin-Induced Lung Fibrosis And Inflammation. American Journal of Respiratory and Critical Care Medicine. 2013
- O001 Regulation of tissue remodelling by Oncostatin M in mouse lung is IL-6- and SMAD3-independent. Cytokine. 497-497. 2012
- Adenoviral Gene Transfer Of Granulocyte/Macrophage Colony Stimulating Factor Enhances Pulmonary Host Defense And Survival From Pneumococcal Pneumonia In Mice. American Journal of Respiratory and Critical Care Medicine. 2011
- Effects of Bacterial Infection with Pseudomonas aeruginosa on Experimental Pulmonary Fibrosis.. American Journal of Respiratory and Critical Care Medicine. 2009
- TGF-beta Antagonist Antibody 1D11 Blocks Experimental Progressive Pulmonary Fibrosis.. American Journal of Respiratory and Critical Care Medicine. 2009
- VEGF Overexpression during Fibrogenesis Reduces Endothelial Cell Apoptosis and Improves Pulmonary Hypertension. American Journal of Respiratory and Critical Care Medicine. 2009
- Metabolism of nitro-polycyclic aromatic hydrocarbons elicits apoptotic and necrotic responses in Hepa1c1c7 cells. Toxicology and Applied Pharmacology. 308-308. 2004
- Metabolism of the nitroaromatic nilutamide by freshly isolated lung cells and by recombinant NO synthase. Drug Metabolism Reviews. 112-112. 2003
- Drug-induced infiltrative lung disease.. European Respiratory Journal European Respiratory Journal, Supplement. 93s-100s. 2001