Kjetil Ask - McMaster Experts

Affiliations

Faculty of Health Sciences, McMaster University
Member, McMaster Immunology Research Centre (MIRC), Faculty of Health Sciences
Associate Professor, Medicine, Faculty of Health Sciences
Assistant Professor, Medicine, McMaster University

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selected scholarly activity

academic article
- Cell-Specific Drug Targeting in the Lung. Biochemical Pharmacology. 114577-114577. 2021
- Circulating fibrocytes are not disease-specific prognosticators in idiopathic pulmonary fibrosis. European Respiratory Journal European Respiratory Journal, Supplement. 2100172-2100172. 2021
- Activin A and Cell-Surface GRP78 Are Novel Targetable RhoA Activators for Diabetic Kidney Disease. International Journal of Molecular Sciences. 22:2839-2839. 2021
- Mononuclear phagocytic system and fibrosis: back to the future?. European Respiratory Journal European Respiratory Journal, Supplement. 57:2004466-2004466. 2021
- FK506-Binding Protein 13 Expression Is Upregulated in Interstitial Lung Disease and Correlated with Clinical Severity. A Potentially Protective Role. American Journal of Respiratory Cell and Molecular Biology. 64:235-246. 2021
- High-intensity cycling re-warm up within a very short time-frame increases the subsequent intermittent sprint performance. European Journal of Sport Science. 20:1307-1317. 2020
- Potentiation of Long-Acting β2-Agonist and Glucocorticoid Responses in Human Airway Epithelial Cells by Modulation of Intracellular cAMP 2020
- Expression of endocannabinoid system components in human airway epithelial cells: impact of sex and chronic respiratory disease status. ERJ Open Research. 6:00128-2020. 2020
- Suboptimal treatment response to anti-IL-5 monoclonal antibodies in severe eosinophilic asthmatics with airway autoimmune phenomena. European Respiratory Journal European Respiratory Journal, Supplement. 56:2000117-2000117. 2020
- Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue. European Respiratory Journal European Respiratory Journal, Supplement. 56:2001123-2001123. 2020
- Current models of pulmonary fibrosis for future drug discovery efforts. Expert Opinion on Drug Discovery. 15:931-941. 2020
- Inhalation: A means to explore and optimize nintedanib's pharmacokinetic/pharmacodynamic relationship. Pulmonary Pharmacology and Therapeutics. 63:101933-101933. 2020
- Connective-Tissue Growth Factor (CTGF/CCN2) Contributes to TGF-β1-Induced Lung Fibrosis 2020
- The importance of interventional timing in the bleomycin model of pulmonary fibrosis. European Respiratory Journal European Respiratory Journal, Supplement. 55:1901105-1901105. 2020
- Protein Misfolding and Endoplasmic Reticulum Stress in Chronic Lung Disease. Chest. 157:1207-1220. 2020
- Expression of the endocannabinoid system in the human airway epithelial cells – Impact of sex and chronic respiratory disease status 2020
- TACAN Is an Ion Channel Involved in Sensing Mechanical Pain. Cell. 180:956-967.e17. 2020
- ABCF1 regulates dsDNA-induced immune responses in human airway epithelial cells 2020
- ABCF1 Regulates dsDNA-induced Immune Responses in Human Airway Epithelial Cells. Frontiers in cellular and infection microbiology. 10:487. 2020
- Galectin-3 levels are elevated following nintedanib treatment. Therapeutic Advances in Chronic Disease. 11:204062232096841-204062232096841. 2020
- Microbial Regulation of Enteric Eosinophils and Its Impact on Tissue Remodeling and Th2 Immunity. Frontiers in Immunology. 11:155. 2020
- Cell surface expression of 78-kDa glucose-regulated protein (GRP78) mediates diabetic nephropathy. Journal of Biological Chemistry. 294:7755-7768. 2019
- IL-6 mediates ER expansion during hyperpolarization of alternatively activated macrophages. Immunology and Cell Biology. 97:203-217. 2019
- Microbial regulation of enteric eosinophils and its impact on tissue remodeling and Th2 immunity 2019
- Cadherin-11–mediated adhesion of macrophages to myofibroblasts establishes a profibrotic niche of active TGF-β. Science Signaling. 12:eaao3469-eaao3469. 2019
- Macitentan reduces progression of TGF-β1-induced pulmonary fibrosis and pulmonary hypertension. European Respiratory Journal European Respiratory Journal, Supplement. 52:1701857-1701857. 2018
- Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis. eLife. 7. 2018
- Lysyl Oxidase–Like 1 Protein Deficiency Protects Mice from Adenoviral Transforming Growth Factor-β1–induced Pulmonary Fibrosis. American Journal of Respiratory Cell and Molecular Biology. 58:461-470. 2018
- Separate roles of IL-6 and oncostatin M in mouse macrophage polarizationin vitroandin vivo. Immunology and Cell Biology. 96:257-272. 2018
- Synergistic role of HSP90α and HSP90β to promote myofibroblast persistence in lung fibrosis. European Respiratory Journal European Respiratory Journal, Supplement. 51:1700386-1700386. 2018
- Overexpression of OSM and IL-6 impacts the polarization of pro-fibrotic macrophages and the development of bleomycin-induced lung fibrosis. Scientific Reports. 7:13281. 2017
- Endoplasmic reticulum stress inhibition attenuates hypertensive chronic kidney disease through reduction in proteinuria. Scientific Reports. 7:41572. 2017
- Endoplasmic reticulum stress inhibition limits the progression of chronic kidney disease in the Dahl salt-sensitive rat. American Journal of Physiology - Renal Fluid and Electrolyte Physiology American Journal of Physiology - Renal Physiology. 312:F230-F244. 2017
- Fibroblast growth factor-1 attenuates TGF-β1-induced lung fibrosis. Journal of Pathology Diagnostic Histopathology The Journal of pathology and bacteriology. 240:197-210. 2016
- Characterization of Proliferating Lesion‐Resident Cells During All Stages of Atherosclerotic Growth. Journal of the American Heart Association. 5. 2016
- Endoplasmic reticulum stress inhibition reduces hypertension through the preservation of resistance blood vessel structure and function. Journal of Hypertension. 34:1556-1569. 2016
- GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin-induced pulmonary fibrosis. Journal of Pathology Diagnostic Histopathology The Journal of pathology and bacteriology. 239:411-425. 2016
- Stretch-induced Activation of Transforming Growth Factor-β1in Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine. 194:84-96. 2016
- Disruption of Calcium Signaling in Fibroblasts and Attenuation of Bleomycin-Induced Fibrosis by Nifedipine. American Journal of Respiratory Cell and Molecular Biology. 53:450-458. 2015
- Biomarkers in interstitial lung disease: moving towards composite indexes and multimarkers?. Current Pulmonology Reports. 4:125-129. 2015
- Calcium Homeostasis and Ionic Mechanisms in Pulmonary Fibroblasts. American Journal of Respiratory Cell and Molecular Biology. 53:135-148. 2015
- The therapeutic effects of 4-phenylbutyric acid in maintaining proteostasis. International Journal of Biochemistry and Cell Biology International Journal of Biochemistry. 61:45-52. 2015
- Development of a Model of Chronic Kidney Disease in the C57BL/6 Mouse with Properties of Progressive Human CKD. BioMed Research International. 2015:1-10. 2015
- Drug development for chronic lung disease - Mission impossible?. Respirology. 20:13-14. 2015
- 4-Phenylbutyrate Inhibits Tunicamycin-Induced Acute Kidney Injury via CHOP/GADD153 Repression. PLoS ONE. 9:e84663-e84663. 2014
- Mechanisms linked to differences in the mutagenic potential of 1,3-dinitropyrene and 1,8-dinitropyrene. Toxicology Reports. 1:459-473. 2014
- Granzyme B Deficiency Exacerbates Lung Inflammation in Mice after Acute Lung Injury. American Journal of Respiratory Cell and Molecular Biology. 49:453-462. 2013
- Protein Misfolding and Endoplasmic Reticulum Stress in Chronic Lung Disease. Chest. 143:1098-1105. 2013
- Adenoviral-Mediated Gene Transfer into Bone Marrow: An Effective Surgical Technique in Rat. European Surgical Research. 50:282-291. 2013
- Local Delivery of GM-CSF Protects Mice from Lethal Pneumococcal Pneumonia. Journal of Immunology. 187:5346-5356. 2011
- In VivoRole of Platelet-Derived Growth Factor–BB in Airway Smooth Muscle Proliferation in Mouse Lung. American Journal of Respiratory Cell and Molecular Biology. 45:566-572. 2011
- Micro-computed tomography of pulmonary fibrosis in mice induced by adenoviral gene transfer of biologically active transforming growth factor-β1. Respiratory Research. 11:181. 2010
- Have advanced research technologies made real impact on respiratory medicine?. Respirology. 15:876-880. 2010
- Essential Role of Osteopontin in Smoking-Related Interstitial Lung Diseases. American Journal of Pathology. 174:1683-1691. 2009
- VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats. Journal of Clinical Investigation. 119:1298-1311. 2009
- Circulating Fibrocytes Are an Indicator of Poor Prognosis in Idiopathic Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine. 179:588-594. 2009
- Role of STAT6 and SMAD2 in a model of chronic allergen exposure: a mouse strain comparison study. Clinical and Experimental Allergy. 39:147-158. 2009
- 1-Nitropyrene (1-NP) induces apoptosis and apparently a non-apoptotic programmed cell death (paraptosis) in Hepa1c1c7 cells. Toxicology and Applied Pharmacology. 230:175-186. 2008
- Targeting fibrosis in respiratory lung disease. Drug Discovery Today: Therapeutic Strategies. 5:97-100. 2008
- The use of small animal imaging in respiratory disease drug discovery. Drug Discovery Today: Therapeutic Strategies. 5:81-85. 2008
- Comparison between conventional and "clinical" assessment of experimental lung fibrosis. Journal of Translational Medicine. 6:16-16. 2008
- Progressive pulmonary fibrosis is mediated by TGF-β isoform 1 but not TGF-β3. International Journal of Biochemistry and Cell Biology International Journal of Biochemistry. 40:484-495. 2008
- The bleomycin animal model: A useful tool to investigate treatment options for idiopathic pulmonary fibrosis?. International Journal of Biochemistry and Cell Biology International Journal of Biochemistry. 40:362-382. 2008
- Three-dimensional computed tomography imaging in an animal model of emphysema. European Respiratory Journal European Respiratory Journal, Supplement. 30:1082-1089. 2007
- TGF-β, Smad3 and the process of progressive fibrosis. Biochemical Society Transactions. 35:661-664. 2007
- TGFβ and Smad3 link inflammation to progressive fibrosis. International Congress Series. 1302:103-113. 2007
- Smad3 Signaling Involved in Pulmonary Fibrosis and Emphysema. Proceedings of the American Thoracic Society. 3:696-702. 2006
- Gene Therapy for Pulmonary Diseases. Chest. 130:879-884. 2006
- Strategies targeting fibrosis in pulmonary disease. Drug Discovery Today: Therapeutic Strategies. 3:389-394. 2006
- Targeting Genes for Treatment in Idiopathic Pulmonary Fibrosis: Challenges and Opportunities, Promises and Pitfalls. Proceedings of the American Thoracic Society. 3:389-393. 2006
- The transforming growth factor-beta (TGF-β) family and pulmonary fibrosis. Drug Discovery Today: Disease Mechanisms. 3:99-103. 2006
- Metabolism of nilutamide in rat lung. Biochemical Pharmacology. 71:377-385. 2006
- TGF-β and Smad3 Signaling Link Inflammation to Chronic Fibrogenesis. Journal of Immunology. 175:5390-5395. 2005
- Connective Tissue Growth Factor Is Crucial to Inducing a Profibrotic Environment in “Fibrosis-Resistant” Balb/c Mouse Lungs. American Journal of Respiratory Cell and Molecular Biology. 31:510-516. 2004
- Distribution of nitroreductive activity toward nilutamide in rat. Toxicology and Applied Pharmacology. 201:1-9. 2004
- Reduction of Nilutamide by NO Synthases: Implications for the Adverse Effects of This Nitroaromatic Antiandrogen Drug. Chemical Research in Toxicology. 16:1547-1554. 2003
chapter
- Growth Factors. 353-361. 2009
conference paper
- Anti-Inflammatory/Anti-Fibrotic Compound PBI-4425 Alleviates Bleomycin- and TGF-beta 1-Induced Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine. 2020
- Characterizing the Role of ABCF1 in dsDNA Antiviral Responses in Human Airway Epithelial Cells. American Journal of Respiratory and Critical Care Medicine. 2020
- Characterizing the Transcriptomic Signature in Circulating Monocytes and Alternatively Activated Macrophages in Idiopathic Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine. 2020
- Integrative -Omics Identify Potential Biomarkers and Therapeutic Targets for Idiopathic Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine. 2020
- Intrinsic BMP Inhibitor Gremlin Regulates Lung Alveolar Stem Cell Proliferation and Differentiation. American Journal of Respiratory and Critical Care Medicine. 2020
- The Expression and Genetic Mutation of BMPR2 in the Fibrotic Lung Diseases. American Journal of Respiratory and Critical Care Medicine. 2020
- Mechanical stress-induced mast cell degranulation activates TGF-β1 signalling pathway in pulmonary fibrosis. Thorax. 455-465. 2019
- Antifibrotic Effect of PBI-4050 in Human Normal and IPF Lung Fibroblasts, and in AdTGF-b1-Induced Pulmonary Fibrosis Rat Model. American Journal of Respiratory and Critical Care Medicine. 2019
- Assessing the Role of ATF6 alpha in the Alternative Activation of Macrophages in the Progression of Fibrotic Lung Diseases. American Journal of Respiratory and Critical Care Medicine. 2019
- Dectin-1 Is a Marker of Alternatively Activated Macrophages and a Therapeutic Target in Interstitial Fibrotic Lung Diseases. American Journal of Respiratory and Critical Care Medicine. 2019
- Investigating the Expression of CCL18 in Alternatively Activated Macrophages and in the Progression of Different Fibrotic Lung Diseases. American Journal of Respiratory and Critical Care Medicine. 2019
- The IRE/XBP1 Pathway Is Activated in Alternatively Activated Macrophages in Interstitial Fibrotic Lung Disease. American Journal of Respiratory and Critical Care Medicine. 2019
- The Vascular-Parenchymal Crosstalk Regulates Lung Fibrosis Through Bmpr2 and Ctgf Signaling. American Journal of Respiratory and Critical Care Medicine. 2019
- A NEW MECHANISM OF LATENT TGF-B1 PRESENTATION IN LUNG. Wound Repair and Regeneration. A14-A14. 2018
- A New Mechanism of Latent Tgf-b1 Presentation in Lung. Wound Repair and Regeneration. A34-A34. 2018
- Identification And Validation Of Unique And Shared M2 Macrophage Biomarkers Between Murine Models And Human Disease Using Bioinformatic Gene Expression Analysis. American Journal of Respiratory and Critical Care Medicine. 2017
- Loxl1 Null Mice Are Protected From Tgf-beta 1 Induced Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine. 2017
- Nintedanib Attenuates The Polarization Of Profibrotic Macrophages Through The Inhibition Of Tyrosine Phosphorylation On Csf1 Receptor. American Journal of Respiratory and Critical Care Medicine. 2017
- Silica-Induced Pulmonary Fibrosis Occurs With The Activation Of Macrophage Polarization Through Marco And In A Tgf-beta 1-Independent Manner. American Journal of Respiratory and Critical Care Medicine. 2017
- The Hsp90 Inhibitor Radicicol As A Bioinformatically-Derived Drug For M2 Macrophage Phenotype Inhibition. American Journal of Respiratory and Critical Care Medicine. 2017
- Characterizing The Maturation Of Tgf-beta Induced Pulmonary Fibrotic Scar: Quantitation Of Extracellular Matrix Protein Synthesis, Remodeling And Crosslinking Rates. American Journal of Respiratory and Critical Care Medicine. 2016
- How Basic Science Methodology Has Changed In The Context Of The Bleomycin Model Of Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine. 2016
- Il-6 Mediated Hyperpolarization Of Profibrotic Macrophages Is Dependent On Spliced Xbp1. American Journal of Respiratory and Critical Care Medicine. 2016
- Macitentan Prevents Pulmonary Fibrosis Progression And Secondary Pulmonary Hypertension Induced By Tgf-beta 1 Overexpression In Rats. American Journal of Respiratory and Critical Care Medicine. 2016
- Requirement Of Il-6 For Maximal M2 Macrophage Accumulation, And Growth Of Ectopically Delivered B16 Melanoma, In Mouse Lungs Upon Oncostatin M Overexpression. American Journal of Respiratory and Critical Care Medicine. 2016
- Effect Of Allergen Challenge On Inflammation Induced By Toll-Like Receptor Stimulation In A Nasal Challenge Model. American Journal of Respiratory and Critical Care Medicine. 2015
- Ire1 Mediated Xbp1 Splicing Is Critical For Pulmonary Fibroblast Proliferation And Differentiation. American Journal of Respiratory and Critical Care Medicine. 2015
- Differential effects of ambient diesel carcinogens on inflammation and DNA damage response in cells relevant for lung toxicity. Toxicology Letters. S25-S25. 2014
- Fkbp13 Deficiency Leads To Increased Pulmonary Er Stress, Inflammation And Fibrosis After Bleomycin Administration. American Journal of Respiratory and Critical Care Medicine. 2014
- Grp78 Heterozygosity Abrogates Bleomycin-Induced Lung Fibrosis By Modulating Er-Resident Protein Folding Capacity. American Journal of Respiratory and Critical Care Medicine. 2014
- Inhaled Pirfenidone Improves Animal Efficacy Through Superior Pulmonary And Vascular Pharmacokinetics. American Journal of Respiratory and Critical Care Medicine. 2014
- Nifedipine Attenuates Bleomycin-Induced Fibrosis By Blocking Calcium Wave Activity. American Journal of Respiratory and Critical Care Medicine. 2014
- Interdependence of HIF1 alpha/TGF beta 1 activity in induction of pulmonary fibrosis. European Respiratory Journal European Respiratory Journal, Supplement. 2013
- 4-Phenylbutyrate Prevents Upr Activation And Myofibroblast Differentiation In Experimental Bleomycin-Induced Lung Fibrosis. American Journal of Respiratory and Critical Care Medicine. 2013
- Fkbp13 Deficiency Leads To An Exacerbated Inflammatory Response And Increased Lung Compliance Following Cigarette Smoke Exposure. American Journal of Respiratory and Critical Care Medicine. 2013
- Grp78 Heterozygosity Protects Against Bleomycin-Induced Lung Fibrosis And Inflammation. American Journal of Respiratory and Critical Care Medicine. 2013
- O001 Regulation of tissue remodelling by Oncostatin M in mouse lung is IL-6- and SMAD3-independent. Cytokine. 497-497. 2012
- Adenoviral Gene Transfer Of Granulocyte/Macrophage Colony Stimulating Factor Enhances Pulmonary Host Defense And Survival From Pneumococcal Pneumonia In Mice. American Journal of Respiratory and Critical Care Medicine. 2011
- Effects of Bacterial Infection with Pseudomonas aeruginosa on Experimental Pulmonary Fibrosis.. American Journal of Respiratory and Critical Care Medicine. 2009
- TGF-beta Antagonist Antibody 1D11 Blocks Experimental Progressive Pulmonary Fibrosis.. American Journal of Respiratory and Critical Care Medicine. 2009
- VEGF Overexpression during Fibrogenesis Reduces Endothelial Cell Apoptosis and Improves Pulmonary Hypertension. American Journal of Respiratory and Critical Care Medicine. 2009
- Metabolism of nitro-polycyclic aromatic hydrocarbons elicits apoptotic and necrotic responses in Hepa1c1c7 cells. Toxicology and Applied Pharmacology. 308-308. 2004
- Metabolism of the nitroaromatic nilutamide by freshly isolated lung cells and by recombinant NO synthase. Drug Metabolism Reviews. 112-112. 2003
- Drug-induced infiltrative lung disease.. European Respiratory Journal European Respiratory Journal, Supplement. 93s-100s. 2001