selected scholarly activity
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conferences
- Airway autoimmunity in asthma is associated with an aggravated inflammatory response to viral stimulation of the bronchial epithelium. European Respiratory Journal. 2023
- Assessment of eosinophilic airway inflammation using formalin-fixed, paraffin-embedded sputum plugs. European Respiratory Journal. 2023
- Charcot-Leyden crystals are associated with airway autoimmune responses in severe asthma. European Respiratory Journal. 2023
- Effectiveness and cost of a comprehensive severe asthma management strategy guided by airway inflammometry. European Respiratory Journal. 2023
- Non-T2 cytokines post Benralizumab associate with residual symptoms. European Respiratory Journal. 2023
- Cell-free Tumor DNA in Blood and Bronchoalveolar Lavage (BAL) as a Biomarker in Non-Small Cell Lung Cancer. American Journal of Respiratory and Critical Care Medicine. 2023
- Dupilumab Reduces Sputum Eosinophils, Mucus Plugging and Improves Ventilation in Patients With Moderate-to-Severe Asthma. American Journal of Respiratory and Critical Care Medicine. 2023
- Increased Numbers of Group 3 Innate Lymphoid Cells and C-kit-positive ILC2s Expressing IL-17A in Sputum From Severe Asthmatics With Neutrophilic or Mixed Granulocytic Bronchitis. American Journal of Respiratory and Critical Care Medicine. 2023
- Reduced Peripheral CD5+Regulatory B Cells Are Associated With Sputum Autoantibodies in Eosinophilic Asthma. American Journal of Respiratory and Critical Care Medicine. 2023
- Respiratory Post Acute COVID-19 Sequelae (PACS)-A Phenotype of Long COVID. American Journal of Respiratory and Critical Care Medicine. 2023
- Sputum Tryptase in Patients With Moderate to Severe Asthma. American Journal of Respiratory and Critical Care Medicine. 2023
- VQ-SPECT/CT Following Recovery From Non-critical COVID-19: 6 Month Longitudinal Follow-up. American Journal of Respiratory and Critical Care Medicine. 2023
- Elevated CD27-IgD- B cells in Post-Acute COVID-19 Sequalae Patients with Rheumatological Symptoms. 10.01 - Respiratory infections and bronchiectasis. 205. 2023
- Benralizumab attenuates blood and airway eosinophilia in severe asthmatics with inadequate response to anti-IL-5 neutralizing antibodies. European Respiratory Journal. 2022
- Nasal polyposis in severe asthma is associated with airway autoimmunity towards eosinophils and macrophages. European Respiratory Journal. 2022
- Phosphoinositide 3-kinase and airway infections in severe asthmatics. European Respiratory Journal. 2022
- Phosphoinositide-3 kinase antagonism does not reverse steroid insensitivity in severe asthma. European Respiratory Journal. 2022
- Respiratory system resistance and reactance following recovery from non-critical COVID-19. European Respiratory Journal. 2022
- Post-Acute COVID-19 Sequalae (PACS) with New-onset Rheumatological Complications. Arthritis & Rheumatology. 1583-1585. 2022
- A Polyclonal Airway Autoimmune Response Is Associated with Clinical Indices of Asthma Severity. American Journal of Respiratory and Critical Care Medicine. 2022
- Circulating Autoantibodies in Post-Acute Sequelae of COVID-19. American Journal of Respiratory and Critical Care Medicine. 2022
- Eosinophil-Independent IL-5 Increase in Critically Ill COVID-19 Patients Associates with Favourable Outcome. American Journal of Respiratory and Critical Care Medicine. 2022
- Innate Lymphoid Cells Populations in Prednisone Dependent Severe Asthmatics with Differential Inflammatory Profiles in Sputum - Evidence for In Situ Cell Plasticity. American Journal of Respiratory and Critical Care Medicine. 2022
- The Inability to Limit Autoimmune Pathology Is Associated with COVID-19 Hospital Fatality. American Journal of Respiratory and Critical Care Medicine. 2022
- Ventilation and Perfusion Abnormalities Following Recovery from Non-Critical COVID-19. C30. LIFE AND LUNGS AFTER COVID: FUNCTIONAL RECOVERY AND OUTCOMES FOLLOWING SARS-CoV2 INFECTION. a3920-a3920. 2022
- Expansion of a double-negative (CD27-IgD-) B cell population in the sputum of severe eosinophilic asthmatic patients. Journal of Allergy and Clinical Immunology. AB224-AB224. 2022
- Clinical Indices of Autoimmunity Do Not Predict Sputum Autoantibodies in Patients with Severe Eosinophilic Asthma: A Prospective Study. American Journal of Respiratory and Critical Care Medicine. 2021
- Intact Cell Differential Count on a Single Occasion Underestimates Sputum Eosinophilic Activity. American Journal of Respiratory and Critical Care Medicine. 2021
- Airway autoimmunity and response to a 14-day course of oral corticosteroids in patients with severe eosinophilic asthma. European Respiratory Journal. 2020
- CD6-ALCAM Pathway is Elevated in Patients with Severe Asthma. European Respiratory Journal. 2020
- Differential treatment response to mepolizumab in severe eosinophilic asthma with nasal polyps. European Respiratory Journal. 2020
- Development and implementation of a nurse-led allergy clinic model in primary care: A feasibility trial. Allergy. European Journal of Allergy and Clinical Immunology. 584-585. 2020
- Suboptimal response to benralizumab is not associated with inadequate eosinophil suppression. Allergy. European Journal of Allergy and Clinical Immunology. 405-406. 2020
- TL1A/DR3 Axis Promotes Group 2 Innate Lymphocyte Activation in Eosinophilic Asthmatics. American Journal of Respiratory and Critical Care Medicine. 2020
- The Role of Excess Airway Macrophage Iron on Infective Exacerbations of Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine. 2020
- A single-center observational study assessing response to mepolizumab in severe eosinophilic asthma. European Respiratory Journal. 2019
- Airway Luminal Contributors to Magnetic Resonance Imaging Ventilation Heterogeneity in Severe Asthma. American Journal of Respiratory and Critical Care Medicine. 2019
- Increased B-Cells in the Airways of Patients with Severe Eosinophilic Asthma: A Local Auto-Inflammatory Process. American Journal of Respiratory and Critical Care Medicine. 2019
- Omalizumab in Patients with Severe Asthma and Persistent Sputum Eosinophilia. Journal of Allergy and Clinical Immunology. AB434-AB434. 2019
- Sputum and serum immunoglobulins in patients with asthma and recurrent neutrophilic bronchitis. Journal of Allergy and Clinical Immunology. AB227-AB227. 2019
- Sputum autoantibody-mediated macrophage dysfunction in severe eosinophilic asthmatics with recurrent infections. Journal of Allergy and Clinical Immunology. AB189-AB189. 2019
- Autoantigen Array Reveals Decreased Expression of Autoantibodies in Sputum of Patients with Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine. 2019
- High Failure Rate of Anti-IL-5 Therapies in Prednisone-Dependent Asthma Is Associated with Airway Autoimmune Responses. American Journal of Respiratory and Critical Care Medicine. 2019
- Increased sputum B cells in severe eosinophilic asthma: a local auto-inflammatory process. European Respiratory Journal. 2018
- Benralizumab attenuates airway eosinophilopoietic processes in prednisone-dependent asthma. European Respiratory Journal. 2017
- Weight-adjusted Intravenous Reslizumab Attenuates Airway Eosinophilia in Severe Asthmatics compared to 100 mg Subcutaneous Mepolizumab. European Respiratory Journal. 2017
- Sputum anti-neutrophil cytoplasmic antibodies in eosinophilic granulomatosis and polyangiitis patients with respiratory involvement. Allergy. European Journal of Allergy and Clinical Immunology. 756-756. 2017
- SPUTUM ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODIES (ANCA) IN EOSINOPHILIC GRANULAMATOSIS AND POLYANGIITIS (EGPA). Rheumatology. 17-17. 2017
- Pathogenic sputum autoantibodies in eosinophilic severe asthma: a novel autoimmune endotype. Allergy. European Journal of Allergy and Clinical Immunology. 30-30. 2016
- Pathogenic Autoantibodies in Patients with Severe Asthma and Sputum Eosinophils. Journal of Allergy and Clinical Immunology. AB409-AB409. 2016
- Eosinophil Peroxidase As an Autoimmune Target in Eosinophilic Airway Disorders. Journal of Allergy and Clinical Immunology. AB221-AB221. 2015
- Human Bronchial Epithelial Cell-Derived Factors from Severe Asthmatics Can Stimulate Local Eosinophilopoetic Responses. Journal of Allergy and Clinical Immunology. AB148-AB148. 2015
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journal articles
- The Bronchodilator and Anti-Inflammatory Effect of Long-Acting Muscarinic Antagonists in Asthma: An EAACI Position Paper.. Acta Allergologica. 2024
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Response of sputum periostin to
anti‐T2 biologics treatment in severe asthma. Acta Allergologica. 79:2842-2844. 2024 - Up-dosing of reslizumab in severe asthmatics with persistent sputum eosinophilia: A feasibility study.. Acta Allergologica. 2024
- Sputum cytokines associated with raised FeNO after anti‐IL5 biologic therapy in severe asthma. Acta Allergologica. 79:2244-2247. 2024
- Eosinophil-mucus interplay in severe asthma: Implications for treatment with biologicals. Allergology International. 73:351-361. 2024
- Eosinophilic mucus diseases. Allergology International. 73:362-374. 2024
- Phosphoinositide‐3 kinase activity in severe eosinophilic asthma with recurrent airway infections and neutrophilic exacerbations. Clinical and Experimental Allergy. 54:428-431. 2024
- Effect of dupilumab on sputum eosinophils in patients with moderate‐to‐severe asthma. Acta Allergologica. 79:509-513. 2024
- Barriers to multisite research in Canada: Experiences from a minimal risk COVID-19 study. Canadian Journal of Respiratory, Critical Care, and Sleep Medicine. 8:1-4. 2024
- Benralizumab Normalizes Sputum Eosinophilia in Severe Asthma Uncontrolled by Anti–IL-5 Antibodies: A Single-Blind, Placebo-controlled Clinical Trial. American Journal of Respiratory and Critical Care Medicine. 208:1330-1335. 2023
- Eosinophils—from cradle to grave. Acta Allergologica. 78:3077-3102. 2023
- A Rapid Sputum‐based Lateral Flow Assay for Airway Eosinophilia using an RNA‐cleaving DNAzyme Selected for Eosinophil Peroxidase. Angewandte Chemie International Edition. 62:e202307451. 2023
- A Rapid Sputum‐based Lateral Flow Assay for Airway Eosinophilia using an RNA‐cleaving DNAzyme Selected for Eosinophil Peroxidase. Angewandte Chemie International Edition. 135. 2023
- Eosinophil-independent IL-5 levels are increased in critically ill COVID-19 patients who survive. Allergy, Asthma and Clinical Immunology. 19:58. 2023
- A novel take on idiopathic pulmonary fibrosis disease progression: localised autoimmunity. European Respiratory Journal. 61:2300653-2300653. 2023
- Autoantibody-mediated Macrophage Dysfunction in Patients with Severe Asthma with Airway Infections. American Journal of Respiratory and Critical Care Medicine. 207:427-437. 2023
- A case series of dual biologics therapy for severe asthma. Journal of Allergy and Clinical Immunology: In Practice. 11:335-340.e2. 2023
- Circulating anti-nuclear autoantibodies in COVID-19 survivors predict long-COVID symptoms. European Respiratory Journal. 61:2200970-2200970. 2023
- A sputum bioassay for airway eosinophilia using an eosinophil peroxidase aptamer. Scientific Reports. 12:22476. 2022
- Airway autoantibodies are determinants of asthma severity. European Respiratory Journal. 60:2200442-2200442. 2022
- Airway autoimmunity, asthma exacerbations, and response to biologics. Clinical and Experimental Allergy. 52:1365-1378. 2022
- Iron in airway macrophages and infective exacerbations of chronic obstructive pulmonary disease. Respiratory Research. 23:8. 2022
- A Unique CD27-IgD- B Cell Population in the Sputum of Severe Eosinophilic Asthma Associated with Airway Autoimmunity. American Journal of Respiratory Cell and Molecular Biology. 67:506-511. 2022
- Impact of former smoking exposure on airway eosinophilic activation and autoimmunity in patients with severe asthma. European Respiratory Journal. 60:2102446-2102446. 2022
- Ventilation and perfusion abnormalities following recovery from noncritical COVID-19. Canadian Journal of Respiratory, Critical Care, and Sleep Medicine. 6:304-313. 2022
- Benralizumab's anti-eosinophil efficacy may be decreased by impaired NK cell activity. European Respiratory Journal. 59:2102210-2102210. 2022
- A unique CD27 - IgD - B-cells population in the sputum of severe eosinophilic asthma associated with airway autoimmunity. American Journal of Respiratory Cell and Molecular Biology. 67:506-511. 2022
- Clinical relevance of sputum bronchial epithelial cells: A retrospective cross-sectional study. Canadian Journal of Respiratory, Critical Care, and Sleep Medicine. 6:35-40. 2022
- Eosinophils as potential mediators of autoimmunity in eosinophilic lung disease. ERS Monograph. 2022:219-237. 2022
- Detecting immunoglobulins in processed sputa. Acta Allergologica. 76:3798-3800. 2021
- Notch4, uncovering an immunomodulator in allergic asthma. Acta Allergologica. 76:3852-3854. 2021
- Underestimation of airway luminal eosinophilia by quantitative sputum cytometry. Allergy, Asthma and Clinical Immunology. 17:63. 2021
- Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections. Viruses. 13:2239-2239. 2021
- Evidence of autoimmunity triggered by SARS-CoV-2 in acute and Post-acute COVID-19: a systematic literature review 2021
- IL‐13 signature in severe adult asthmatics with airway neutrophilia: A new endotype to treat!. Acta Allergologica. 76:1964-1966. 2021
- Differential expression of sputum and serum autoantibodies in patients with chronic obstructive pulmonary disease. American Journal of Physiology - Lung Cellular and Molecular Physiology. 320:L1169-L1182. 2021
- Notch4, uncovering an immunomodulator in allergic asthma 2021
- Notch4, uncovering an immunomodulator in allergic asthma 2021
- Monitoring eosinophils to guide therapy with biologics in asthma: does the compartment matter?. Acta Allergologica. 76:1294-1297. 2021
- Underestimation of Luminal Eosinophilia by Quantitative Sputum Cytometry 2021
- Dupilumab, severe asthma airway responses, and SARS‐CoV‐2 serology. Acta Allergologica. 76:957-958. 2021
- IL-13 signature in severe adult asthmatics with airway neutrophilia: a new endotype to treat! 2021
- Asthma exacerbations on benralizumab are largely non‐eosinophilic. Acta Allergologica. 76:375-379. 2021
- Biologics in Asthma: A Molecular Perspective to Precision Medicine. Frontiers in Pharmacology. 12:793409. 2021
- Functionally Active Eosinophil Purification from Peripheral Blood. Methods in molecular biology (Clifton, N.J.). 2241:15-25. 2021
- The Role of the TL1A/DR3 Axis in the Activation of Group 2 Innate Lymphoid Cells in Subjects with Eosinophilic Asthma. American Journal of Respiratory and Critical Care Medicine. 202:1105-1114. 2020
- Exacerbations of Severe Asthma While on Anti–IL-5 Biologics. Journal of Investigational Allergology and Clinical Immunology. 30:307-316. 2020
- Suboptimal treatment response to anti-IL-5 monoclonal antibodies in severe eosinophilic asthmatics with airway autoimmune phenomena. European Respiratory Journal. 56:2000117-2000117. 2020
- Non-Malignant Respiratory Illnesses in Association with Occupational Exposure to Asbestos and Other Insulating Materials: Findings from the Alberta Insulator Cohort. International Journal of Environmental Research and Public Health. 17:7085-7085. 2020
- Sputum and serum immunoglobulins in adult asthmatics with recurrent respiratory tract infections. Acta Allergologica. 75:2105-2108. 2020
- Luminal Eosinophil Cell Death as a Biomarker for Loss of Asthma Control?. Chest. 157:1680-1681. 2020
- New paradigm in asthma management: Switching between biologics!. Acta Allergologica. 75:743-745. 2020
- Omalizumab in patients with severe asthma and persistent sputum eosinophilia. Allergy, Asthma and Clinical Immunology. 15:21. 2019
- CT and Functional MRI to Evaluate Airway Mucus in Severe Asthma. Chest. 155:1178-1189. 2019
- Rapid quantification of sputum eosinophil peroxidase on a lateral flow test strip. Acta Allergologica. 74:1176-1178. 2019
- Eosinophil-derived IL-13 promotes emphysema. European Respiratory Journal. 53:1801291-1801291. 2019
- Sputum Antineutrophil Cytoplasmic Antibodies in Serum Antineutrophil Cytoplasmic Antibody–Negative Eosinophilic Granulomatosis with Polyangiitis. American Journal of Respiratory and Critical Care Medicine. 199:158-170. 2019
- Modulation of human airway smooth muscle biology by human adipocytes. Respiratory Research. 19:33. 2018
- Airway Eosinophilopoietic and Autoimmune Mechanisms of Eosinophilia in Severe Asthma. Immunology and Allergy Clinics of North America. 38:639-654. 2018
- Benralizumab attenuates airway eosinophilia in prednisone-dependent asthma. Journal of Allergy and Clinical Immunology. 141:1529-1532.e8. 2018
- Sputum autoantibodies in patients with severe eosinophilic asthma. Journal of Allergy and Clinical Immunology. 141:1269-1279. 2018
- Endogenous peroxidases in sputum interfere with horse-radish peroxidase-based ELISAs. Journal of Immunological Methods. 454:76-79. 2018
- Autoimmune Responses in Severe Asthma. Allergy, Asthma and Immunology Research. 10:428-428. 2018
- Eosinophil Extracellular Traps and Inflammatory Pathologies—Untangling the Web!. Frontiers in Immunology. 9:2763. 2018
- Human Bronchial Epithelial Cell–derived Factors from Severe Asthmatic Subjects Stimulate Eosinophil Differentiation. American Journal of Respiratory Cell and Molecular Biology. 58:99-106. 2018
- Weight-adjusted Intravenous Reslizumab in Severe Asthma with Inadequate Response to Fixed-Dose Subcutaneous Mepolizumab. American Journal of Respiratory and Critical Care Medicine. 197:38-46. 2018
- Airway autoimmune responses in severe eosinophilic asthma following low-dose Mepolizumab therapy. Allergy, Asthma and Clinical Immunology. 13:2. 2017
- Improved recovery of functionally active eosinophils and neutrophils using novel immunomagnetic technology. Journal of Immunological Methods. 449:44-55. 2017
- Enhanced expression of Organic Cation Transporters in bronchial epithelial cell layers following insults associated with asthma – Impact on salbutamol transport. European Journal of Pharmaceutical Sciences. 106:62-70. 2017
- WS1_1 Sputum Anti-neutrophil Cytoplasmic Antibodies (ANCA) in Eosinophilic Granulamatosis and Polyangiitis (eGPA). Rheumatology. 56:iii17-iii19. 2017
- Glucocortiosteroid subsensitivity and asthma severity. Current Opinion in Pulmonary Medicine. 23:78-88. 2017
- Blood or sputum eosinophils to guide asthma therapy?. The Lancet Respiratory Medicine. 3:824-825. 2015
- Thymic stromal lymphopoietin and IL-33 modulate migration of hematopoietic progenitor cells in patients with allergic asthma. Journal of Allergy and Clinical Immunology. 135:1594-1602. 2015
- Anti-IL5 therapy for asthma and beyond. World Allergy Organization Journal. 7:32-32. 2014
- In-cell Western™ detection of organic cation transporters in bronchial epithelial cell layers cultured at an air–liquid interface on Transwell ® inserts. Journal of Pharmacological and Toxicological Methods. 68:184-189. 2013
- Evaluation of air-interfaced Calu-3 cell layers for investigation of inhaled drug interactions with organic cation transporters in vitro. International Journal of Pharmaceutics. 426:7-14. 2012
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preprints